The cutaneous lesions of dioxin exposure: Lessons from the poisoning of Victor Yushchenko

Toxicological Sciences

Volumn 125, Issue 1, 2012, Pages 310-317

  Saurat, Jean Hilaire ^a,b   Kaya, Guerkan ^a,b   Saxer Sekulic, Nikolina ^a,b   Pardo, Bruno ^a   Becker, Minerva ^b   Fontao, Lionel ^b   Mottu, Florence ^a,b   Carraux, Pierre ^b   Pham, Xuan Cuong ^b   Barde, Caroline ^b   Fontao, Fabienne ^a   Zennegg, Markus ^c   Schmid, Peter ^c   Schaad, Olivier ^a   Descombes, Patrick ^a   Sorg, Olivier ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c SWISS FEDERAL LABORATORIES FOR MATERIALS SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

Dioxin; Hamartoma; Morphology; Skin; Toxicity

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BONE MORPHOGENETIC PROTEIN; CYTOCHROME P450;

ADULT; ARTICLE; BODY SURFACE; CASE REPORT; ENZYME ACTIVITY; GENE EXPRESSION; HAMARTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; LIVER; MALE; MORPHOGENESIS; SCORING SYSTEM; SEBACEOUS GLAND; SIGNAL TRANSDUCTION; SKIN DEFECT; TRANSCRIPTOMICS; XENOBIOTIC METABOLISM;

EID: 84555178167     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr223     Document Type: Article

References (32)

1. Agarwal, P., and Sahu, S. (2010). Determination of hand and palm area as a ratio of body surface area in Indian population. Indian J. Plast. Surg. 43, 49-53.
2. Albrecht, E. (1904). Über hamartome. Dtsch. Ges. Pathol. 7, 153-157.
3. Aylward, L. L., Lamb, J. C., and Lewis, S. C. (2005). Issues in risk assessment for developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Toxicol. Sci. 87, 3-10.
4. Barouti, N., Fontao, L., Pardo, B., Sorg, O., and Saurat, J. H. (2009). AhR pathway as a novel pharmacological target for wound healing. J. Invest. Dermatol. 129, S80.
5. Brembilla, N. C., Ramirez, J. M., Chicheportiche, R., Sorg, O., Saurat, J. H., and Chizzolini, C. (2011). In vivo dioxin favors interleukin-22 production by human CD4{thorn} T cells in an aryl hydrocarbon receptor (AhR)-dependent manner. PLoS One 6, e18741.
6. Caputo, R., Monti, M., Ermacora, E., Carminati, G., Gelmetti, C., Gianotti, R., Gianni, E., and Puccinelli, V. (1988). Cutaneous manifestations of tetrachlorodibenzo-p-dioxin in children and adolescents. Follow-up 10 years after the Seveso, Italy, accident. J. Am. Acad. Dermatol. 19, 812-819.
7. Cartharius, K., Frech, K., Grote, K., Klocke, B., Haltmeier, M., Klingenhoff, A., Frisch, M., Bayerlein, M., and Werner, T. (2005). MatInspector and beyond: Promoter analysis based on transcription factor binding sites. Bioinformatics 21, 2933-2942.
8. Connor, K. T., Harris, M. A., Edwards, M. R., Budinsky, R. A., Clark, G. C., Chu, A. C., Finley, B. L., and Rowlands, J. C. (2008). AH receptor agonist activity in human blood measured with a cell-based bioassay: Evidence for naturally occurring AH receptor ligands in vivo. J. Expo. Sci. Environ. Epidemiol. 18, 369-380.
9. de Viragh, P. A. (1995). The 'mantle hair of Pinkus.' A review on the occasion of its centennial. Dermatology 191, 82-87.
10. Fujita, P. A., Rhead, B., Zweig, A. S., Hinrichs, A. S., Karolchik, D., Cline, M. S., Goldman, M., Barber, G. P., Clawson, H., Coelho, A., et al. (2010). The UCSC Genome Browser database: Update 2011. Nucleic Acids Res. 39, D876-D882.
11. Geusau, A., Tschachler, E., Meixner, M., Sandermann, S., Päpke, O., Wolf, C., Valic, E., Stingl, G., and McLachlan, M. (1999). Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Lancet 354, 1266-1267.
12. Gies, A., Neumeier, G., Rappolder, M., and Konietzka, R. (2007). Risk assessment of dioxins and dioxin-like PCBs in food-Comments by the German Federal Environmental Agency. Chemosphere 67, S344-S349.
13. IARC Monograph on the Evaluation of Carcinogenic Risks to Humans. (1997). Polychlorinated Dibenzo-Para-Dioxins and Polychlorinated Dibenzofurans, pp. 33-343. IARC, Lyon, France.
14. Kangsamaksin, T., and Morris, R. J. (2011). Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice. J. Invest. Dermatol. 131, 580-585.
15. Lebeau, S., Masouyé, I., Berti, M., Augsburger, E., Saurat, J. H., Borradori, L., and Fontao, L. (2005). Comparative analysis of the expression of ERBIN and Erb-B2 in normal human skin and cutaneous carcinomas. Br. J. Dermatol. 152, 1248-1255.
16. Marshall, N. B., and Kerkvliet, N. I. (2010). Dioxin and immune regulation: Emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells. Ann. N. Y. Acad. Sci. 1183, 25-37.
17. Montagna, W. (1963). In The Sebaceous Glands (W. Montagna, R. A. Ellis and A.F. Silver, Eds.), pp. 167-187. Pergamon Press, Oxford, U.K.
18. Panteleyev, A. A., Thiel, R., Wanner, R., Zhang, J., Roumak, V. S., Paus, R., Neubert, D., Henz, B. M., and Rosenbach, T. (1997). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCCD) affects keratin 1 and keratin 17 gene expression and differentially induces keratinization in hairless mouse skin. J. Invest. Dermatol. 108, 330-335.
19. Passarini, B., Infusino, S. D., and Kasapi, E. (2010). Chloracne: Still cause for concern. Dermatology 221, 63-70.
20. Plewig, G., and Kligman, A. M. (1993). In Acne and Rosacea. Springer-Verlag, Berlin, Germany.
21. Ramirez, J. M., Brembilla, N. C., Sorg, O., Chicheportiche, R., Matthes, T., Dayer, J. M., Saurat, J. H., Roosnek, E., and Chizzolini, C. (2010). Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur. J. Immunol. 40, 2450-2459.
22. Rifkind, A. B. (2006). CYP1A in TCDD toxicity and in physiology-With particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates. Drug Metab. Rev. 38, 291-335.
23. Rowe, J. M., Welsh, C., Pena, R. N., Wolf, C. R., Brown, K., and Whitelaw, C. B. (2008). Illuminating role of CYP1A1 in skin function. J. Invest. Dermatol. 128, 1866-1868.
24. Ryan, J. J. (2011). In The Yushchenko Dioxin Poisoning: Chronology and Pharmacokinetics. Wiley, Hoboken, NJ.
25. Saurat, J. H., and Sorg, O. (2010). Chloracne, a misnomer and its implications. Dermatology 221, 23-26.
26. Schecter, A. J., Sheu, S. U., Birnbaum, L. S., DeVito, M. J., Denison, M. S., and Päpke, O. (1999). A comparison and discussion of two different methods of measuring dioxin-like compounds: Gas chromatography-mass spectrometry and the CALUX bioassay F implications for health studies. Organohal. Compounds 40, 247-250.
27. Shimba, S., Hayashi, M., Ohno, T., and Tezuka, M. (2003). Transcriptional regulation of the AhR gene during adipose differentiation. Biol. Pharm. Bull. 26, 1266-1271.
28. Sneddon, J. B., Zhen, H. H., Montgomery, K., van de Rijn, M., Tward, A. D., West, R., Gladstone, H., Chang, H. Y., Morganroth, G. S., Oro, A. E., et al. (2006). Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 103, 14842-14847.
29. Sorg, O., Tran, C., Carraux, P., Grand, D., Barraclough, C., Arrighi, J. F., Descombes, P., Piguet, V., and Saurat, J. H. (2008). Metabolism and biological activities of topical 4-oxoretinoids in mouse skin. J. Invest. Dermatol. 128, 999-1008.
30. Sorg, O., Zennegg, M., Schmid, P., Fedosyuk, R., Valikhnovskyi, R., Gaide, O., Kniazevych, V., and Saurat, J. H. (2009). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: Identification and measurement of TCDD metabolites. Lancet 374, 1179-1185.
31. Steenland, K., Deddens, J., and Piacitelli, L. (2001). Risk assessment for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on an epidemiologic study. Am. J. Epidemiol. 154, 451-458.
32. Suskind, R. R. (1985). Chloracne, "the hallmark of dioxin intoxication." Scand. J. Work Environ. Health 11, 165-171.