2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites

The Lancet

Volumn 374, Issue 9696, 2009, Pages 1179-1185

  Sorg, O ^a   Zennegg, M ^b   Schmid, P ^b   Fedosyuk, R ^c   Valikhnovskyi, R ^c   Gaide, O ^a   Kniazevych, V ^c   Saurat, J H ^a  

^a Swiss Centre for Applied Human Toxicology   (Switzerland)

^b SWISS FEDERAL LABORATORIES FOR MATERIALS SCIENCE AND TECHNOLOGY   (Switzerland)

^c Feofania Hospital   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,7,8 TETRACHLORO 2 HYDROXYDIBENZO PARA DIOXIN; 2,3,7 TRICHLORO 8 HYDROXYDIBENZO PARA DIOXIN; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DRUG METABOLITE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; ARTICLE; CASE REPORT; CRIME; FECES; GAS CHROMATOGRAPHY; HALF LIFE TIME; HUMAN; INTOXICATION; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SERUM; SKIN; SWEAT; TISSUE DISTRIBUTION; TOXICOKINETICS; URINE;

ADIPOSE TISSUE; BIOPSY; DRUG RESIDUES; FATAL OUTCOME; FECES; FORENSIC MEDICINE; HALF-LIFE; HOMICIDE; HUMANS; MALE; MIDDLE AGED; POLITICS; SUBSTANCE ABUSE DETECTION; SWEAT; TETRACHLORODIBENZODIOXIN; TIME FACTORS; UKRAINE;

EID: 70349587834     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(09)60912-0     Document Type: Article

References (36)

1. Holt E. Doctor sues clinic over Yushchenko poisoning claims. Lancet 365 (2005) 1375
2. Rosenthal E. Liberal leader from Ukraine was poisoned. New York Times, (Dec 12, 2004). http://www.nytimes.com/2004/12/12/international/europe/12ukraine.html?_r =1&scp=1&sq=Liberal leader from Ukraine was poisoned Dec 12 2004&st=cs (accessed July 23, 2009).
3. BBC News. Tests confirm Yushchenko poison (June 2, 2006). http://news.bbc.co.uk/2/hi/europe/5040378.stm (accessed July 7, 2009).
4. Poland A., and Knutson J.C. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 22 (1982) 517-554
5. Van den Berg M., De Jongh J., Poiger H., and Olson J.R. The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol 24 (1994) 1-74
6. Denison M.S., and Nagy S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43 (2003) 309-334
7. Mimura J., and Fujii-Kuriyama Y. Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619 (2003) 263-268
8. Rifkind A.B. CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates. Drug Metab Rev 38 (2006) 291-335
9. Kohle C., and Bock K.W. Coordinate regulation of phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 73 (2007) 1853-1862
10. Sulistyaningdyah W.T., Ogawa J., Li Q.S., et al. Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant. Biotechnol Lett 26 (2004) 1857-1860
11. McKinley M.K., Kedderis L.B., and Birnbaum L.S. The effect of pretreatment on the biliary excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 3,3′,4,4′-tetrachlorobiphenyl in the rat. Fundam Appl Toxicol 21 (1993) 425-432
12. Olson J.R., McGarrigle B.P., Gigliotti P.J., Kumar S., and McReynolds J.H. Hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran. Fundam Appl Toxicol 22 (1994) 631-640
13. Kedderis L.B., Andersen M.E., and Birnbaum L.S. Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Fundam Appl Toxicol 21 (1993) 405-411
14. Landi M.T., Bertazzi P.A., Baccarelli A., et al. TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident. Carcinogenesis 24 (2003) 673-680
15. Okino S.T., Quattrochi L.C., Pookot D., Iwahashi M., and Dahiya R. A dioxin-responsive enhancer 3′ of the human CYP1A2 gene. Mol Pharmacol 72 (2007) 1457-1465
16. Aylward L.L., Brunet R.C., Carrier G., et al. Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort. J Expo Anal Environ Epidemiol 15 (2005) 51-65
17. Wittsiepe J., Furst P., Schrey P., et al. PCDD/F and dioxin-like PCB in human blood and milk from German mothers. Chemosphere 67 (2007) S286-S294
18. Brouwer A., Botschuiver S., Veerhoek D., et al. Observation of an extremely high dioxin level in a human serum sample from Ukraine by DR CALUX which was confirmed to be 2,3,7,8-tetrachlorodibenzo-p-dioxin by GC-HRMS. Organohalogen Compounds 67 (2005) 1705-1708
19. Poiger H., Buser H.R., Weber H., Zweifel U., and Schlatter C. Structure elucidation of mammalian TCDD-metabolites. Experientia 38 (1982) 484-486
20. Gallagher D., Heymsfield S.B., Heo M., Jebb S.A., Murgatroyd P.R., and Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr 72 (2000) 694-701
21. Geusau A., Tschachler E., Meixner M., et al. Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Lancet 354 (1999) 1266-1267
22. Steele E.J., Bellet A.J., McCullagh P.J., and Selinger B. Reappraisal of the findings on Agent Orange by the Australian Royal Commission. Toxicol Lett 51 (1990) 261-268
23. Michalek J.E., Pirkle J.L., Needham L.L., et al. Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. J Expo Anal Environ Epidemiol 12 (2002) 44-53
24. Kerger B.D., Leung H.W., Scott Jr. P., et al. Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children. Environ Health Perspect 114 (2006) 1596-1602
25. Yoshimura T. Yusho in Japan. Ind Health 41 (2003) 139-148
26. Geusau A., Schmaldienst S., Derfler K., Papke O., and Abraham K. Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients. Arch Toxicol 76 (2002) 316-325
27. Patterson Jr. D.G., Needham L.L., Pirkle J.L., et al. Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri. Arch Environ Contam Toxicol 17 (1988) 139-143
28. Pohjanvirta R., Vartiainen T., Uusi-Rauva A., Monkkonen J., and Tuomisto J. Tissue distribution, metabolism, and excretion of 14C-TCDD in a TCDD-susceptible and a TCDD-resistant rat strain. Pharmacol Toxicol 66 (1990) 93-100
29. Jackson J.A., Birnbaum L.S., and Diliberto J.J. Effects of age, sex, and pharmacologic agents on the biliary elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in F344 rats. Drug Metab Dispos 26 (1998) 714-719
30. Abraham K., Wiesmuller T., Brunner H., Krowke R., Hagenmaier H., and Neubert D. Elimination of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in rat faeces. Arch Toxicol 63 (1989) 75-78
31. Chainuvati S., Nafziger A.N., Leeder J.S., et al. Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail". Clin Pharmacol Ther 74 (2003) 437-447
32. Walker N.J., Crofts F.G., Li Y., et al. Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. Carcinogenesis 19 (1998) 395-402
33. Poiger H., and Schlatter C. Biological degradation of TCDD in rats. Nature 281 (1979) 706-707
34. Wendling J.M., Orth R.G., and Poiger H. Determination of [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin in human feces to ascertain its relative metabolism in man. Anal Chem 62 (1990) 796-800
35. De Jongh J., Buser H.R., and Poiger H. The metabolism of 2,3,7,8-tetrabromodibenzodioxin in the rat. Xenobiotica 23 (1993) 19-26
36. Nicholson J.K., and Lindon J.C. Systems biology: metabonomics. Nature 455 (2008) 1054-1056