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Volumn 390, Issue 12, 2009, Pages 1225-1235

The mammalian aryl hydrocarbon (Ah) receptor: From mediator of dioxin toxicity toward physiological functions in skin and liver

Author keywords

Ah receptor ligands; Ah receptor target genes; Apoptosis; Cell differentiation; Cell proliferation; Inflammation

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BILIRUBIN; CYTOCHROME P450 1A1; DIOXIN; GLUCURONOSYLTRANSFERASE 1A1;

EID: 72949115099     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2009.138     Document Type: Review
Times cited : (83)

References (83)
  • 2
    • 0030850098 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor knockout mice (AHR(-/-)) exhibit liver retinoid accumulation and reduced retinoic acid metabolism
    • Andreola, F., Fernandez-Salguero, P.M., Chiantore, M.V., Petkovich, M.P., Gonzalez, F.J., and De Luca, L.M. (1997). Aryl hydrocarbon receptor knockout mice (AhR-/-) exhibit liver retinoid accumulation and reduced retinoid metabolism. Cancer Res. 57, 2835-2838. (Pubitemid 27315022)
    • (1997) Cancer Research , vol.57 , Issue.14 , pp. 2835-2838
    • Andreola, F.1    Fernandez-Salguero, P.M.2    Chiantore, M.V.3    Petkovich, M.P.4    Gonzalez, F.J.5    De Luca, L.M.6
  • 4
    • 4944239129 scopus 로고    scopus 로고
    • 2,3,7,8-tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation
    • Barnes-Ellerbe, S., Knudsen, K.E., and Puga, A. (2004). 2,3,7,8-tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation. Mol. Pharmacol. 66, 502-511.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 502-511
    • Barnes-Ellerbe, S.1    Knudsen, K.E.2    Puga, A.3
  • 5
    • 34447511096 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein
    • Barouki, R., Coumoul, X., and Fernandez-Salguero, P. (2007). The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Lett. 581, 3608-3615.
    • (2007) FEBS Lett , vol.581 , pp. 3608-3615
    • Barouki, R.1    Coumoul, X.2    Fernandez-Salguero, P.3
  • 6
    • 0028028534 scopus 로고
    • The aryl hydrocarbon (Ah) or dioxin receptor: Biologic and toxic responses
    • Bock, K.W. (1993). The aryl hydrocarbon (Ah) or dioxin receptor: biologic and toxic responses. Rev. Physiol. Biochem. Pharmacol. 125, 1-42.
    • (1993) Rev. Physiol. Biochem. Pharmacol. , vol.125 , pp. 1-42
    • Bock, K.W.1
  • 7
    • 18044374985 scopus 로고    scopus 로고
    • Ah receptor-and TCDD-mediated liver tumor promotion: Clonal selection and expansion of cells evading growth arrest and apoptosis
    • Bock, K.W. and Kö hle, C. (2005). Ah receptor- and TCDD-mediated liver tumor promotion: clonal selection and expansion of cells evading growth arrest and apoptosis. Biochem. Pharmacol. 69, 1403-1408.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1403-1408
    • Bock, K.W.1    Köhle, C.2
  • 8
    • 33745965633 scopus 로고    scopus 로고
    • Ah receptor: Dioxin-mediated toxic responses as hints to deregulated physiologic functions
    • Bock, K.W. and Kö hle, C. (2006). Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochem. Pharmacol. 72, 393-404.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 393-404
    • Bock, K.W.1    Köhle, C.2
  • 9
    • 0015926539 scopus 로고
    • Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase
    • Bock, K.W., Frö hling, W., Remmer, H., and Rexer, B. (1973). Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase. Biochim. Biophys. Acta 327, 46-56.
    • (1973) Biochim. Biophys. Acta , vol.327 , pp. 46-56
    • Bock, K.W.1    Fröhling, W.2    Remmer, H.3    Rexer, B.4
  • 10
    • 54349090870 scopus 로고    scopus 로고
    • Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo- pdioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor
    • Bunger, M.K., Glover, E., Moran, S.M., Walisser, J.A., Lahvis, G.P., Hsu, E.L., and Bradfield, C.A. (2008). Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-pdioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor. Toxicol. Sci. 106, 83-92.
    • (2008) Toxicol. Sci. , vol.106 , pp. 83-92
    • Bunger, M.K.1    Glover, E.2    Moran, S.M.3    Walisser, J.A.4    Lahvis, G.P.5    Hsu, E.L.6    Bradfield, C.A.7
  • 11
    • 0026725943 scopus 로고
    • Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
    • Burbach, K.M., Poland, A., and Bradfield, C.A. (1992). Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc. Natl. Acad. Sci. USA 89, 8185-8189.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8185-8189
    • Burbach, K.M.1    Poland, A.2    Bradfield, C.A.3
  • 12
    • 0031972786 scopus 로고    scopus 로고
    • Constitutive activation of the aromatic hydrocarbon receptor
    • Chang, C.Y. and Puga, A. (1998). Constitutive activation of the aromatic hydrocarbon receptor. Mol. Cell. Biol. 18, 525-535.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 525-535
    • Chang, C.Y.1    Puga, A.2
  • 14
    • 35548946775 scopus 로고    scopus 로고
    • Evidence for an aryl hydrocarbon receptor-mediated cytochrome P450 autoregulatory pathway
    • Chiaro, C.R., Patel, R.D., Marcus, C.B., and Perdew, G.H. (2007). Evidence for an aryl hydrocarbon receptor-mediated cytochrome P450 autoregulatory pathway. Mol. Pharmacol. 72, 1369-1379.
    • (2007) Mol. Pharmacol. , vol.72 , pp. 1369-1379
    • Chiaro, C.R.1    Patel, R.D.2    Marcus, C.B.3    Perdew, G.H.4
  • 15
    • 49449091484 scopus 로고    scopus 로고
    • Leukotriene A4 metabolites are endogenous ligands for the Ah receptor
    • Chiaro, C.R., Morales, J.L., Prabhu, S., and Perdew, G.H. (2008). Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry 47, 8445-8455.
    • (2008) Biochemistry , vol.47 , pp. 8445-8455
    • Chiaro, C.R.1    Morales, J.L.2    Prabhu, S.3    Perdew, G.H.4
  • 16
    • 33749606662 scopus 로고    scopus 로고
    • In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter
    • Choi, S.S.H., Miller, M.A., and Harper, P.A. (2006). In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter. Toxicol. Sci. 94, 163-174.
    • (2006) Toxicol. Sci. , vol.94 , pp. 163-174
    • Choi, S.S.H.1    Miller, M.A.2    Harper, P.A.3
  • 17
    • 0033564553 scopus 로고    scopus 로고
    • Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially
    • Ciolino, H.P., Daschner, P.J., and Yeh, G.C. (1999). Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. Biochem. J. 340, 715-722.
    • (1999) Biochem. J. , vol.340 , pp. 715-722
    • Ciolino, H.P.1    Daschner, P.J.2    Yeh, G.C.3
  • 18
    • 33144477599 scopus 로고    scopus 로고
    • Sunlight generates multiple tryptophan photoproducts eliciting high efficacy CYP1A induction in chick hepatocytes and in vivo
    • Diani-Moore, S., Labitzke, E., Brown, R., Garvin, A., Wong, L., and Rifkind, A.B. (2006). Sunlight generates multiple tryptophan photoproducts eliciting high efficacy CYP1A induction in chick hepatocytes and in vivo. Toxicol. Sci. 90, 96-110.
    • (2006) Toxicol. Sci. , vol.90 , pp. 96-110
    • Diani-Moore, S.1    Labitzke, E.2    Brown, R.3    Garvin, A.4    Wong, L.5    Rifkind, A.B.6
  • 19
    • 33748422203 scopus 로고    scopus 로고
    • Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism
    • Diry, M., Tomkiewicz, C., Koehle, C., Coumoul, X., Bock, K.W., Barouki, R., and Transy, C. (2006). Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism. Oncogene 25, 5570-5574.
    • (2006) Oncogene , vol.25 , pp. 5570-5574
    • Diry, M.1    Tomkiewicz, C.2    Koehle, C.3    Coumoul, X.4    Bock, K.W.5    Barouki, R.6    Transy, C.7
  • 20
    • 45749119506 scopus 로고    scopus 로고
    • Roles of cytosolic phospholipase A2 and Src kinase in the early action of 2,3,7,8-tetrachlorobibenzo-p-dioxin through a nongenomic pathway in MCF10A cells
    • Dong, B. and Matsumura, F. (2008). Roles of cytosolic phospholipase A2 and Src kinase in the early action of 2,3,7,8-tetrachlorobibenzo-p-dioxin through a nongenomic pathway in MCF10A cells. Mol. Pharmacol. 74, 255-263.
    • (2008) Mol. Pharmacol. , vol.74 , pp. 255-263
    • Dong, B.1    Matsumura, F.2
  • 26
  • 27
    • 0034116376 scopus 로고    scopus 로고
    • The PAS superfamily: Sensors of environmental and developmental signals
    • Gu, Y.Z., Hogenesch, J.B., and Bradfield, C.A. (2000). The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40, 519-561.
    • (2000) Annu. Rev. Pharmacol. Toxicol. , vol.40 , pp. 519-561
    • Gu, Y.Z.1    Hogenesch, J.B.2    Bradfield, C.A.3
  • 28
    • 0028987872 scopus 로고
    • The aryl hydrocarbon receptor complex
    • Hankinson, O. (1995). The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35, 307-340.
    • (1995) Annu. Rev. Pharmacol. Toxicol. , vol.35 , pp. 307-340
    • Hankinson, O.1
  • 29
    • 33645808261 scopus 로고    scopus 로고
    • Liver deformation in Ahr-null mice. Evidence for aberrant hepatic perfusion in early development
    • Harstad, E.B., Guite, C.A., Thomae, T.L., and Bradfield, C.A. (2006). Liver deformation in Ahr-null mice. Evidence for aberrant hepatic perfusion in early development. Mol. Pharmacol. 69, 1534-1541.
    • (2006) Mol. Pharmacol. , vol.69 , pp. 1534-1541
    • Harstad, E.B.1    Guite, C.A.2    Thomae, T.L.3    Bradfield, C.A.4
  • 30
    • 0030296584 scopus 로고    scopus 로고
    • Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and-independent pathways
    • Hoffer, A., Chang, C.Y., and Puga, A. (1996). Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. Toxicol. Appl. Pharmacol. 141, 238-247.
    • (1996) Toxicol. Appl. Pharmacol. , vol.141 , pp. 238-247
    • Hoffer, A.1    Chang, C.Y.2    Puga, A.3
  • 31
    • 0029611136 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits DNA synthesis in primary hepatocytes
    • Hushka, D.R. and Greenlee, W.F. (1995). 2,3,7,8-Tetrachlorodibenzo-p- dioxin inhibits DNA synthesis in primary hepatocytes. Mutation Res. 333, 89-99.
    • (1995) Mutation Res , vol.333 , pp. 89-99
    • Hushka, D.R.1    Greenlee, W.F.2
  • 33
    • 0034671615 scopus 로고    scopus 로고
    • The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor. A member of the evolutionaryly conserved bHLH-PAS transcription factor family
    • Jeon, M.S. and Esser, C. (2000). The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor. A member of the evolutionaryly conserved bHLH-PAS transcription factor family. J. Immunol. 165, 6975-6983.
    • (2000) J. Immunol. , vol.165 , pp. 6975-6983
    • Jeon, M.S.1    Esser, C.2
  • 34
    • 0019917133 scopus 로고
    • Quercetin, flavonoids, and the life span of mice
    • Jones, E. and Hughes, R.E. (1982). Quercetin, flavonoids, and the life span of mice. Exp. Gerontol. 117, 213-217.
    • (1982) Exp. Gerontol. , vol.117 , pp. 213-217
    • Jones, E.1    Hughes, R.E.2
  • 35
    • 0027299613 scopus 로고
    • Marked endogenous activation of the CYP1A1 and Cyp1A2 genes in the congenitally jaundized Gunn rat
    • Kapitulnik, J. and Gonzalez, F.J. (1993). Marked endogenous activation of the CYP1A1 and Cyp1A2 genes in the congenitally jaundized Gunn rat. Mol. Pharmacol. 43, 722-725.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 722-725
    • Kapitulnik, J.1    Gonzalez, F.J.2
  • 36
    • 59149104736 scopus 로고    scopus 로고
    • AHR-mediated immunomodulation: The role of altered gene transcription
    • Kerkvliet, N.I. (2009). AHR-mediated immunomodulation: the role of altered gene transcription. Biochem. Pharmacol. 77, 746-760.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 746-760
    • Kerkvliet, N.I.1
  • 37
    • 84961028063 scopus 로고
    • Berufliche Akne (sog. Chlorakne) durch chlorierte aromatische zyklische Ä ther
    • Kimmig, J. and Schulz, K.H. (1957). Berufliche Akne (sog. Chlorakne) durch chlorierte aromatische zyklische Ä ther. Dermatologica 115, 540-546.
    • (1957) Dermatologica , vol.115 , pp. 540-546
    • Kimmig, J.1    Schulz, K.H.2
  • 38
    • 34247603065 scopus 로고    scopus 로고
    • Coordinate regulation of Phase I and II xenobiotic metabolism by the Ah receptor and Nrf2
    • Kö hle, C. and Bock, K.W. (2007). Coordinate regulation of Phase I and II xenobiotic metabolism by the Ah receptor and Nrf2. Biochem. Pharmacol. 73, 1853-1862.
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 1853-1862
    • Köhle, C.1    Bock, K.W.2
  • 39
    • 59149090185 scopus 로고    scopus 로고
    • Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor
    • Kö hle, C. and Bock, K.W. (2009). Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor. Biochem. Pharmacol. 77, 689-699.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 689-699
    • Köhle, C.1    Bock, K.W.2
  • 40
    • 0033003606 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated membrane translocation of c-Src-protein kinase in liver WB-F344 cells
    • Kö hle, C., Gschaidmeier, H., Lauth, D., Topell, S., Zitzer, H., and Bock, K.W. (1999). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated membrane translocation of c-Src-protein kinase in liver WB-F344 cells. Arch. Toxicol. 73, 152-158.
    • (1999) Arch. Toxicol. , vol.73 , pp. 152-158
    • Köhle, C.1    Gschaidmeier, H.2    Lauth, D.3    Topell, S.4    Zitzer, H.5    Bock, K.W.6
  • 41
    • 0033166447 scopus 로고    scopus 로고
    • P27Kip1 induction and inhibition of proliferation by intracellular Ah receptor in developing thymus and hepatoma cells
    • Kolluri, S.K., Weis, C., Koff, A., and Göttlicher, M. (1999). p27Kip1 induction and inhibition of proliferation by intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13, 1742-1753.
    • (1999) Genes Dev , vol.13 , pp. 1742-1753
    • Kolluri, S.K.1    Weis, C.2    Koff, A.3    Göttlicher, M.4
  • 42
    • 1642579495 scopus 로고    scopus 로고
    • Cytochrome P4501A1 promotes G1 phase cell cycle progression by controlling aryl hydrocarbon receptor activity
    • Levine-Fridman, A., Chen, L., and Elferink, C.J. (2004). Cytochrome P4501A1 promotes G1 phase cell cycle progression by controlling aryl hydrocarbon receptor activity. Mol. Pharmacol. 65, 461-469.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 461-469
    • Levine-Fridman, A.1    Chen, L.2    Elferink, C.J.3
  • 43
  • 44
    • 0036667369 scopus 로고    scopus 로고
    • In utero exposure to 2,3,7,8-tetrachlorodibenzop-dioxin causes accelerated terminal differentiation in fetal mouse skin
    • Loertscher, J.A., Lin, T.M., Peterson, R.E., and Allen-Hoffmann, B.L. (2002). In utero exposure to 2,3,7,8-tetrachlorodibenzop-dioxin causes accelerated terminal differentiation in fetal mouse skin. Toxicol. Sci. 68, 465-472.
    • (2002) Toxicol. Sci. , vol.68 , pp. 465-472
    • Loertscher, J.A.1    Lin, T.M.2    Peterson, R.E.3    Allen-Hoffmann, B.L.4
  • 45
    • 0034663171 scopus 로고    scopus 로고
    • Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on initiation and promotion of GST-Ppositive foci in rat liver: A quantitative analysis of experimental data using a stochastic model
    • Luebeck, E.G., Buchmann, A., Stinchcombe, S., Moolgavkar, S.H., and Schwarz, M. (2000). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on initiation and promotion of GST-Ppositive foci in rat liver: a quantitative analysis of experimental data using a stochastic model. Toxicol. Appl. Pharmacol. 167, 63-73.
    • (2000) Toxicol. Appl. Pharmacol. , vol.167 , pp. 63-73
    • Luebeck, E.G.1    Buchmann, A.2    Stinchcombe, S.3    Moolgavkar, S.H.4    Schwarz, M.5
  • 46
    • 0029963257 scopus 로고    scopus 로고
    • The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin
    • Ma, Q. and Whitlock, J.P. (1996). The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol. Cell. Biol. 16, 2144-2150.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2144-2150
    • Ma, Q.1    Whitlock, J.P.2
  • 47
    • 33644831336 scopus 로고    scopus 로고
    • Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
    • Machado, F.S., Johndrow, J.E., Esper, L., Dias, A., Bafica, A., Serhan, C.N., and Aliberti, J. (2006). Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat. Med. 12, 330-334.
    • (2006) Nat. Med. , vol.12 , pp. 330-334
    • MacHado, F.S.1    Johndrow, J.E.2    Esper, L.3    Dias, A.4    Bafica, A.5    Serhan, C.N.6    Aliberti, J.7
  • 48
    • 28844493391 scopus 로고    scopus 로고
    • New insights into biliverdin reductase functions: Linking heme metabolism to cell signaling
    • Maines, M.D. (2005). New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology 20, 382-389.
    • (2005) Physiology , vol.20 , pp. 382-389
    • Maines, M.D.1
  • 49
    • 54249157595 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis
    • Marlowe, J.L. and Puga, A. (2008). The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol. Biol. Cell 19, 3263-3271.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3263-3271
    • Marlowe, J.L.1    Puga, A.2
  • 50
    • 0028093471 scopus 로고
    • How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals
    • Matsumura, F. (1994). How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals. Biochem. Pharmacol. 48, 215-224.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 215-224
    • Matsumura, F.1
  • 51
    • 33846572931 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor is activated by modified low-density lipoprotein
    • McMillan, B.J. and Bradfield, C.A. (2007). The aryl hydrocarbon receptor is activated by modified low-density lipoprotein. Proc. Natl. Acad. Sci. USA 104, 1412-1417.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 1412-1417
    • McMillan, B.J.1    Bradfield, C.A.2
  • 53
    • 60649095638 scopus 로고    scopus 로고
    • Timing is everything: Consequences of transient and sustained AhR activity
    • Mitchell, K.A. and Elferink, C.J. (2009). Timing is everything: consequences of transient and sustained AhR activity. Biochem. Pharmacol. 77, 947-956.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 947-956
    • Mitchell, K.A.1    Elferink, C.J.2
  • 54
  • 55
    • 0029878852 scopus 로고    scopus 로고
    • Growth modulation of hepatocytes and rat liver epithelial cells (WB-F344) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    • Mü nzel, P., Bock-Hennig, B., Schieback, S., Gschaidmeier, H., Beck-Gschaidmeier, S., and Bock, K.W. (1996). Growth modulation of hepatocytes and rat liver epithelial cells (WB-F344) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Carcinogenesis 17, 197-202.
    • (1996) Carcinogenesis , vol.17 , pp. 197-202
    • Münzel, P.1    Bock-Hennig, B.2    Schieback, S.3    Gschaidmeier, H.4    Beck-Gschaidmeier, S.5    Bock, K.W.6
  • 56
    • 0345486974 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6
    • Mü nzel, P.A., Lehmkö ster, T., Brü ck, M., Ritter, J.K., Bock, K.W. (1998). Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6. Arch. Biochem. Biophys. 350, 72-78.
    • (1998) Arch. Biochem. Biophys. , vol.350 , pp. 72-78
    • Münzel, P.A.1    Lehmköster, T.2    Brück, M.3    Ritter, J.K.4    Bock, K.W.5
  • 57
    • 0026376260 scopus 로고
    • Proposed role of drug metabolizing enzymes: Regulation of steady state levels of ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions
    • Nebert, D.W. (1991). Proposed role of drug metabolizing enzymes: regulation of steady state levels of ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. Mol. Endocrinol. 5, 1203-1214.
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1203-1214
    • Nebert, D.W.1
  • 58
    • 59149101810 scopus 로고    scopus 로고
    • Endogenous functions of the aryl hydrocarbon receptor: Intersection of cytochrome P450 (CYP1)-metabolized eicosanoids and AHR biology
    • Nebert, D.W. and Karp, C.L. (2008). Endogenous functions of the aryl hydrocarbon receptor: intersection of cytochrome P450 (CYP1)-metabolized eicosanoids and AHR biology. J. Biol. Chem. 283, 36061-36065.
    • (2008) J. Biol. Chem. , vol.283 , pp. 36061-36065
    • Nebert, D.W.1    Karp, C.L.2
  • 59
    • 2642510760 scopus 로고    scopus 로고
    • Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    • Nebert, D.W., Dalton, T.P., Okey, A.B., and Gonzalez, F.J. (2004). Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J. Biol. Chem. 279, 23847-23850.
    • (2004) J. Biol. Chem. , vol.279 , pp. 23847-23850
    • Nebert, D.W.1    Dalton, T.P.2    Okey, A.B.3    Gonzalez, F.J.4
  • 60
    • 38949097735 scopus 로고    scopus 로고
    • The search for endogenous activators of the aryl hydrocarbon receptor
    • Nguyen, L.P. and Bradfield, C.A. (2008). The search for endogenous activators of the aryl hydrocarbon receptor. Chem. Res. Toxicol. 21, 102-106.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 102-106
    • Nguyen, L.P.1    Bradfield, C.A.2
  • 61
    • 63849137120 scopus 로고    scopus 로고
    • The role of the dioxin-responsive element cluster between Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology
    • Nukaya, M., Moran, S., and Bradfield, C.A. (2009). The role of the dioxin-responsive element cluster between Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc. Natl. Acad. Sci. USA 106, 4923-4928.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4923-4928
    • Nukaya, M.1    Moran, S.2    Bradfield, C.A.3
  • 63
    • 59149093141 scopus 로고    scopus 로고
    • AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions
    • Ohtake, F., Fujii-Kuriyama, Y., and Kato, S. (2009). AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochem. Pharmacol. 77, 474-484.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 474-484
    • Ohtake, F.1    Fujii-Kuriyama, Y.2    Kato, S.3
  • 64
    • 0017399329 scopus 로고
    • Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice
    • Owens, I.S. (1977). Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. J. Biol. Chem. 252, 2827-2833.
    • (1977) J. Biol. Chem. , vol.252 , pp. 2827-2833
    • Owens, I.S.1
  • 65
    • 33746622171 scopus 로고    scopus 로고
    • Dioxin-mediated chloracne - Reconstructing the cellular and molecular mechanisms of a classic environmental disease
    • Panteleyev, A.A. and Bickers, D.R. (2006). Dioxin-mediated chloracne - reconstructing the cellular and molecular mechanisms of a classic environmental disease. Exp. Dermatol. 15, 705-730.
    • (2006) Exp. Dermatol. , vol.15 , pp. 705-730
    • Panteleyev, A.A.1    Bickers, D.R.2
  • 66
    • 14944348442 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis
    • Park, K.T., Mitchell, K.A., Huang, G. and Elferink, C.J. (2005). The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis. Mol. Pharmacol. 67, 612-622.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 612-622
    • Park, K.T.1    Mitchell, K.A.2    Huang, G.3    Elferink, C.J.4
  • 67
    • 33846383124 scopus 로고    scopus 로고
    • Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-Hsp90 complex as part of Ah receptor signaling in MCF10A cells
    • Park, S., Dong, B., and Matsumura, F. (2007). Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-Hsp90 complex as part of Ah receptor signaling in MCF10A cells. Biochemistry 46, 899-908.
    • (2007) Biochemistry , vol.46 , pp. 899-908
    • Park, S.1    Dong, B.2    Matsumura, F.3
  • 68
    • 0032169723 scopus 로고    scopus 로고
    • Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin
    • Phelan, D., Winter, G.M., Rogers, W.J., Lam, J.C., and Denison, M.S. (1998). Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. Arch. Biochem. Biophys. 357, 155-163.
    • (1998) Arch. Biochem. Biophys. , vol.357 , pp. 155-163
    • Phelan, D.1    Winter, G.M.2    Rogers, W.J.3    Lam, J.C.4    Denison, M.S.5
  • 69
    • 0018932459 scopus 로고
    • Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p- dioxin of hepatocarcinogenesis from diethylnitrosamine
    • Pitot, H.C., Goldsworthy, T.L., Campbell, H.A., and Poland, A. (1980). Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine. Cancer Res. 40, 3616-3620.
    • (1980) Cancer Res , vol.40 , pp. 3616-3620
    • Pitot, H.C.1    Goldsworthy, T.L.2    Campbell, H.A.3    Poland, A.4
  • 70
    • 0020010617 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzop-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
    • Poland, A. and Knutson, J.C. (1982). 2,3,7,8-Tetrachlorodibenzop-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554.
    • (1982) Annu. Rev. Pharmacol. Toxicol. , vol.22 , pp. 517-554
    • Poland, A.1    Knutson, J.C.2
  • 71
    • 0017145975 scopus 로고
    • Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p- dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase
    • Poland, A., Glover, E., and Kende, A.S. (1976). Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J. Biol. Chem. 251, 4936-4946.
    • (1976) J. Biol. Chem. , vol.251 , pp. 4936-4946
    • Poland, A.1    Glover, E.2    Kende, A.S.3
  • 72
    • 59149097969 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways
    • Puga, A., Ma, C., and Marlowe, J.L. (2009). The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem. Pharmacol. 77, 713-722.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 713-722
    • Puga, A.1    Ma, C.2    Marlowe, J.L.3
  • 73
    • 0002689295 scopus 로고
    • Autoregulation plus positive and negative elements controlling transcription of genes in the wAhx battery
    • Robertson, J.A., Nebert, D.W., and Hankinson, O. (1987). Autoregulation plus positive and negative elements controlling transcription of genes in the wAhx battery. Chem. Scr. 27A, 83-87.
    • (1987) Chem. Scr. , vol.27 A , pp. 83-87
    • Robertson, J.A.1    Nebert, D.W.2    Hankinson, O.3
  • 74
    • 0028116593 scopus 로고
    • Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway
    • Sadek, C.M., Allen-Hoffmann, B.L. (1994). Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway. J. Biol. Chem. 269, 31505-31509.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31505-31509
    • Sadek, C.M.1    Allen-Hoffmann, B.L.2
  • 75
    • 0041307080 scopus 로고    scopus 로고
    • Inhibitory aryl hydrocarbon receptor-estrogen receptor α cross-talk and mechanisms of action
    • Safe, S. and Wormke, M. (2003). Inhibitory aryl hydrocarbon receptor - estrogen receptor a cross-talk and mechanisms of action. Chem. Res. Toxicol. 16, 807-816. (Pubitemid 36898994)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.7 , pp. 807-816
    • Safe, S.1    Wormke, M.2
  • 76
    • 84981756437 scopus 로고
    • Ü ber die Pyrolyse des Pentachlorphenols
    • Sandermann, W., Stockmann, H., and Casten, R. (1957). Ü ber die Pyrolyse des Pentachlorphenols. Chem. Ber. 90, 690-692.
    • (1957) Chem. Ber. , vol.90 , pp. 690-692
    • Sandermann, W.1    Stockmann, H.2    Casten, R.3
  • 77
    • 0033535843 scopus 로고    scopus 로고
    • Lipoxin A4: A new class of ligand for the Ah receptor
    • Schaldach, C.M., Riby, J., and Bjeldanes, F. (1999). Lipoxin A4: a new class of ligand for the Ah receptor. Biochemistry 38, 7594-7600.
    • (1999) Biochemistry , vol.38 , pp. 7594-7600
    • Schaldach, C.M.1    Riby, J.2    Bjeldanes, F.3
  • 78
    • 0030015421 scopus 로고    scopus 로고
    • Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
    • Schmidt, J.V., Su, G.H.T., Reddy, J.K., Simon, M.C., and Bradfield, C.A. (1996). Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. USA 93, 6731-6736.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6731-6736
    • Schmidt, J.V.1    Su, G.H.T.2    Reddy, J.K.3    Simon, M.C.4    Bradfield, C.A.5
  • 81
    • 0030861704 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptordependent induction of CYP1a1 by bilirubin in mouse hepatoma 1c1c7 cells
    • Sinal, C.P. and Bend, J.P. (1997). Aryl hydrocarbon receptordependent induction of CYP1a1 by bilirubin in mouse hepatoma 1c1c7 cells. Mol. Pharmacol. 52, 590-599.
    • (1997) Mol. Pharmacol. , vol.52 , pp. 590-599
    • Sinal, C.P.1    Bend, J.P.2
  • 82
    • 0029010526 scopus 로고
    • Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin- mediated tumour promotion in rat liver
    • Stinchcombe, S., Buchmann, A., Bock, K.W., and Schwarz, M. (1995). Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver. Carcinogenesis 16, 1271-1275.
    • (1995) Carcinogenesis , vol.16 , pp. 1271-1275
    • Stinchcombe, S.1    Buchmann, A.2    Bock, K.W.3    Schwarz, M.4
  • 83
    • 0021844262 scopus 로고
    • Chloracne, 'the hallmark of dioxin intoxication'
    • Suskind, R.R. (1985). Chloracne, 'the hallmark of dioxin intoxication'. Scand. J. Work Environ. Health 11, 165-171.
    • (1985) Scand. J. Work Environ. Health , vol.11 , pp. 165-171
    • Suskind, R.R.1


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