2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity

Human and Experimental Toxicology

Volumn 26, Issue 9, 2007, Pages 705-713

  Pelclová, Daniela ^a   Prázný, Martin ^a   Škrha, Jan ^a   Fenclová, Zdenka ^a,b   Kalousová, Marta ^a   Urban, Pavel ^a,b   Navrátil, Tomás ^a,c   Šenholdová, Zdenka ^a   Šmerhovský, Zdeněk ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^c J HEYROVSKÝ INSTITUTE OF PHYSICAL CHEMISTRY   (Czech Republic)

Author keywords

2,3,7,8 TCDD; Endothelial dysfunction; Oxidative stress; Superoxide dismutase

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; SUPEROXIDE DISMUTASE;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; EXPOSURE; FOLLOW UP; HUMAN; HYPEREMIA; INDUSTRIAL WORKER; MALE; PRIORITY JOURNAL; SKIN MANIFESTATION;

AGED; BLOOD FLOW VELOCITY; CARDIOVASCULAR DISEASES; E-SELECTIN; ENDOTHELIUM, VASCULAR; FOLLOW-UP STUDIES; FOREARM; HUMANS; HYPEREMIA; INTERCELLULAR ADHESION MOLECULE-1; LASER-DOPPLER FLOWMETRY; LIPIDS; MALE; MICROCIRCULATION; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PESTICIDES; PLASMINOGEN ACTIVATOR INHIBITOR 1; REGIONAL BLOOD FLOW; SKIN; SUPEROXIDE DISMUTASE; TETRACHLORODIBENZODIOXIN; TIME FACTORS;

EID: 36348965886     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327107083971     Document Type: Article

References (35)

1. Pazderová-Vejlupková J, Lukáš E, Němcová M, Pícková J, Jirásek L. The development and prognosis of chronic intoxication by 2,3,7,8-tetrachlordibenzo- p-dioxine in men. Arch Environ Health 1981; 36: 5-11.
2. Pelclová D, Fenclová Z, Dlasková Z, Urban P, Lukáš E, Procházka B, Rappe C, Preiss J, Kočan A, Vejlupková J. Biochemical, neuropsychological, and neurological abnormalities following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. Arch Environ Health 2001; 56: 493-500.
3. Pelclová D, Fenclová Z, Preiss J, Procházka B, Spáčil J, Dubská Z, Okrouhlík B, Lukáš E, Urban P. Lipid metabolism and neuropsychological follow-up study of workers exposed to 2,3,7,8-TCDD. Int Arch Occup Environ Health 2002; 75(Suppl): 60-6.
4. Rappe C, Nygren M, Marklund S, Keller LO, Berggvist PA, Hansson M. Assessment of human exposure to polychlorinated dibenzofurans and dioxins. Environ Health Perspect 1985; 60: 303-4.
5. Pelclová D, Urban P, Preiss J, Lukáš E, Fenclová Z, Navrátil T, Dubská Z, Šenholdová Z. Adverse health effects in humans exposed to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD). Rev Environ Health 2006; 21: 121-40.
6. Institute of Medicine of the National Academics. Veterans and agent orange. Update 2002. IOM, 2003: 619.
7. Zober A, Messerer P, Huber P. Thirty-four-year mortality follow-up of BASF employees exposed to 2,3,7,8-TCDD after the 1953 accident. Int Arch Occup Environ Health 1990; 62: 139-57.
8. Ott MG, Zober A. Cause specific mortality and cancer incidence among employees exposed to 2,3,7,8-TCDD after a 1953 reactor accident. Occup Environ Med 1996; 53: 606-12.
9. Calvert GM, Wall DK, Sweeney MH, Fingerhut MA. Evaluation of cardiovascular outcomes among U.S. workers exposed to 2,3,7,8- tetrachlorodibenzo-p-dioxin. Environ Health Perspect 1998; 106(Suppl 2): 635-43.
10. Michalek JE, Wolfe WH, Miner JC. Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. II. Mortality. JAMA 1990; 264: 1832-36.
11. Bertazzi PA, Consonni D, Bachetti S, Rubagotti M, Baccarelli A, Zocchetti C, Pesatori AC. Health effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 2001; 153: 1031-44.
12. Flesch-Janys D, Berger J, Gum P, Manz A, Nagel S, Waltsgott H, Dwyer JH. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. Am J Epidemiol 1995; 142: 1165-75.
13. Vena J, Boffetta P, Becher H, Benn T, Bueno-de-Mesquita HB, Coggon D, Colin D, Flesch-Janys D, Green L, Kauppinen T, Littorin M, Lynge E, Mathews JD, Neuberger M, Pearce N, Pesatori AC, Saracci R, Steenland K, Kogevinas M. Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers. Environ Health Perspect 1998; 106(Suppl 2): 645-53.
14. Kim JS, Lim HS, Cho SI, Cheong HK, Lim MK. Impact of Agent Orange exposure among Korean Vietnam Veterans. Ind Health 2003; 41: 149-57.
15. Dalton TP, Kerzee JK, Wang B, MILLER M, Dieter MZ, Lorenz JN, Shertzer HG, Nebert DW, Puga A. Dioxin exposure is an environmental risk factor for ischemic hearth disease. Cardiovasc Toxicol 2001; 1: 285-98.
16. Vogel CFA, Sciullo E, Matsumura F. Activation of inflammatory mediators and potential role of Ah-Receptor ligands in foam cell formation. Cardiovasc Toxicol 2004; 4: 363-73.
17. Shaban Z, El-Shazly S, Abdelhady S, Fattouh I, Muzandu K, Ishizuka M, Kimura K, Kazusaka A, Fujita S. Down regulation of hepatic PPARα function by AhR ligand. J Vet Med Sci 2004; 66: 1377-86.
18. Kono Y, Okada S, Tazawa Y, Kanzaki S, Mura T, Ueta E, Nanba E, Otsuka Y. Response of anti-oxidant enzymes mRNA in the neonatal liver exposed to 1,2,3,4-tetrachlorodibenzo-p-dioxin via lactation. Pediatric Int 2002; 44: 481-7.
19. Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. Presence and functional activity of the AhR in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology 2004; 25: 605-16.
20. Kern PA, Fishman RB, Song W, Brown AD, Fonseca V. The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver. Toxicology 2002; 171: 117-25.
21. National Toxicology Program Technical Report Series. NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage Studies). 2006; 521: 4-232.
22. Nedeljkovic ZS, Gokce N, Loscalzo J. Mechanisms of oxidative stress and vascular dysfunction. Postgrad Med 2003; 79: 195-200.
23. Laufs U. Beyond lipid-lowering: effects of statins on endothelial nitric oxide. Eur J Clin Pharmacol 2003; 58: 719-31.
24. Aylward LL, Brunet RC, Carrier G, Hays SM, Cushing CA, Needham LL, Patterson DG Jr, Gerthoux PM, Brambilla P, Mocarelli P. Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modelling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort. J Exp Anal Environ Epidemiol 2005; 15: 51-65.
25. McCord JM, Fridovich I. Superoxide dismutase. J Biol Chem 1969; 244: 6049-55.
26. Witko-Sarsat V, Friedlander M, Capeillere-Blandin C. Advanced oxidation protein products as a novel marker of oxidative stress in ureamia. Kidney Int 1996; 49: 1304-13.
27. Petrofsky J, Lee S. The effects of type 2 diabetes and aging on vascular endothelial and autonomic function. Med Sci Monitor 2005; 11: 247-54.
28. Aylward LL, Hays SM. Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels. J Exp Anal Environ Epidemiol 2002; 12: 319-28.
29. MICROMEDEX Healthcare Series 2006 http://www.thomsonhc.com/hcs/librarian/ PFPUI/RR1mNLT1IGcCFS.
30. Bradberry SM, Proudfoot AT, Vale JA. Poisoning due to chlorophenoxy herbicides. Toxicol Rev 2004; 23: 65-73.
31. Nebert DW, Roe AL, Dieter MZ, Solis WA, Yand Y, Dalton TP. Role of the aromatic hydrocarbon receptor and [Ah] Gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem Pharmacol 2000; 59: 65-85.
32. Kern PA, Said S, Jackson WG Jr, Michalek JE. Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Clin Endocrinol Metabolism 2004; 89: 4665-72.
33. Neuberger M, Landvoigt W, Derntl F. Blood levels of 2,3,7,8- tetrachlorodibenzo-p-dioxin in chemical workers after chloracne and in comparison groups. Int Arch Occup Environ Health 1991; 63: 325-7.
34. Michalek JE, Pirkle JL, Needham LL, Patterson Jr. DG, Caudill SP, Tripathi RC, Mocarelli P. Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Hanch Hand. J Exp Anal Environ Epidemiol 2002; 12: 44-53.
35. Cífková R. Arterial hypertension as a public health issue in the Czech Republic. Blood Pressure 2005; 14(Suppl 2): 25-8.