Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling

Journal of Biological Chemistry

Volumn 289, Issue 37, 2014, Pages 25925-25935

  Zhang, Deqiang ^a   Tong, Xin ^a   Arthurs, Blake ^a   Guha, Anirvan ^a   Rui, Liangyou ^a   Kamath, Avani ^a   Inoki, Ken ^a   Yin, Lei ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CLOCKS; ENZYMES; GENE EXPRESSION; GENES; INSULIN; MAMMALS; METABOLISM; PROTEINS;

CIRCADIAN REGULATION; CONSTITUTIVELY ACTIVES; INSULIN SIGNALING; LIPID METABOLISMS; LIPID SYNTHESIS; LIPOGENIC ENZYMES; METABOLIC FUNCTION; OVER-EXPRESSION;

BIOSYNTHESIS;

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN C2; MESSENGER RNA; PROTEIN BMAL1; UNCLASSIFIED DRUG; ARNTL PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; PROTEIN KINASE B; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2; TRANSCRIPTION FACTOR ARNTL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CLOCK GENE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; LIPOGENESIS; LIVER CELL; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; EATING; GENE EXPRESSION REGULATION; GENETICS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; METABOLISM;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; EATING; GENE EXPRESSION REGULATION; HEPATOCYTES; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIVER; MICE; MULTIPROTEIN COMPLEXES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84907164609     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.567628     Document Type: Article

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