Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 680-692

  Shearn, C T ^a   Smathers, R L ^a   Backos, D S ^a   Reigan, P ^a   Orlicky, D J ^b   Petersen, Dennis R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Alcoholic liver disease; Free radicals; Lipid peroxidation; PTEN; Steatosis

Indexed keywords

ALCOHOL; GLUTATHIONE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B BETA; AKT2 PROTEIN, MOUSE; PROTEIN KINASE B; PTEN PROTEIN, MOUSE;

ALCOHOL CONSUMPTION; ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; LIPID STORAGE; MICHAEL ADDITION; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; DISEASE MODEL; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; METABOLISM; PATHOLOGY; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING;

ANIMALIA; MURINAE; MUS;

ANIMALS; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FATTY LIVER, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PROTEIN CARBONYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TANDEM MASS SPECTROMETRY;

EID: 84883177695     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.07.011     Document Type: Article

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