Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in Macrophages

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Zhang, Xiaoxuan ^a,b   Wang, Guangji ^a   Gurley, Emily C ^b   Zhou, Huiping ^b,c,d  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; FLAVONOID; INFLAMMASOME;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE CONTROL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; INTRACELLULAR SIGNALING; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA STABILITY; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DOWN REGULATION; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APIGENIN; CELLS, CULTURED; DOWN-REGULATION; FLAVONOIDS; HEK293 CELLS; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84906996460     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107072     Document Type: Article

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