Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma

Immunopharmacology and Immunotoxicology

Volumn 32, Issue 3, 2010, Pages 364-370

  Li, Ruo Ran ^a   Pang, Ling Ling ^a   Du, Qiang ^b   Shi, Ying ^a   Dai, Wen Jing ^a   Yin, Kai Sheng ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apigenin; Asthma; GATA 3; Immune response; T bet

Indexed keywords

ALLERGEN; APIGENIN; BETA ACTIN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; OVALBUMIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; FEMALE; IMMUNE RESPONSE; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ALLERGENS; ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; APIGENIN; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; FEMALE; IMMUNOGLOBULIN E; MICE; MICE, INBRED BALB C; TH1 CELLS;

MURINAE;

EID: 77955492155     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923970903420566     Document Type: Article

References (34)

1. Kay, A.B. The role of T lymphocytes in asthma. Chem. Immunol. Allergy 2006, 91, 59-75.
2. Larche, M., Robinson, D.S., Kay, A.B. The role of T lymphocytes in the pathogenesis of asthma. J. Allergy. Clin. Immunol. 2003, 111, 450-463; quiz 64.
3. Zhu, J., Yamane, H., Cote-Sierra, J., Guo, L., Paul, W.E. GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. Cell Res. 2006, 16, 3-10.
4. Szabo, S.J., Kim, S.T., Costa, G.L., Zhang, X., Fathman, C.G., Glimcher, L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000, 100, 655-669.
5. Finotto, S., Neurath, M.F., Glickman, J.N., Qin, S., Lehr, H.A., Green, F.H., Ackerman, K., Haley, K., Galle, P.R., Szabo, S.J., Drazen, J.M., De Sanctis, G.T., Glimcher, L.H. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002, 295, 336-338.
6. Shi, H.Z., Xiao, C.Q., Li, C.Q., Mo, X.Y., Yang, Q.L., Leng, J., Chen, Y.Q. Endobronchial eosinophils preferentially stimulate T helper cell type 2 responses. Allergy. 2004, 59, 428-435.
7. MacKenzie, J.R., Mattes, J., Dent, L.A., Foster, P.S. Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte function. J. Immunol. 2001, 167, 3146-3155.
8. Nath, P., Leung, S.Y., Williams, A.S., Noble, A., Xie, S., McKenzie, A.N., Chung, K.F. Complete inhibition of allergic airway inflammation and remodelling in quadruple IL-4/5/9/13-/- mice. Clin. Exp. Allergy 2007, 37, 1427-1435.
9. Foster, J.M., Sanderman, R., van der Molen, T., Mueller, T., van Sonderen, E. Personality influences the reporting of side effects of inhaled corticosteroids in asthma patients. J. Asthma 2008, 45, 664-669.
10. Foster, J.M., Aucott, L., van der Werf, R.H., van der Meijden, M.J., Schraa, G., Postma, D.S., van der Molen, T. Higher patient perceived side effects related to higher daily doses of inhaled corticosteroids in the community: a cross-sectional analysis. Respir. Med. 2006, 100, 1318-1336.
11. de Vries, T.W., de Langen-Wouterse, J.J., de Jong-Van den Berg, L.T., Duiverman, E.J. Hypertrichosis as a side effect of inhaled steroids in children. Pediatr. Pulmonol. 2007, 42, 370-373.
12. Dubus, J.C., Marguet, C., Deschildre, A., Mely, L., Le Roux, P., Brouard, J., Huiart, L.; Réseau de Recherche Clinique en Pneumonologie Pédiatrique. Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device. Allergy. 2001, 56, 944-948.
13. Ramos, S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J. Nutr. Biochem. 2007, 18, 427-442.
14. Rogers, J., Perkins, I., van Olphen, A., Burdash, N., Klein, T.W., Friedman, H. Epigallocatechin gallate modulates cytokine production by bone marrow-derived dendritic cells stimulated with lipopolysaccharide or muramyldipeptide, or infected with Legionella pneumophila. Exp. Biol. Med. (Maywood) 2005, 230, 645-651.
15. Ahn, S.C., Kim, G.Y., Kim, J.H., Baik, S.W., Han, M.K., Lee, H.J., Moon, D.O., Lee, C.M., Kang, J.H., Kim, B.H., Oh, Y.H., Park, Y.M. Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-κ B. Biochem. Biophys. Res. Commun. 2004, 313, 148-155.
16. Wang, T.Y., Li, J., Ge, J.F., Li, C.Y., Jin, Y., Lü, X.W., Cheng, W.M., Tang, J.H. Preliminary study of total flavonoids from Litsea coreana Levl. on experimental adjuvant-induced arthritis in rats. Am. J. Chin. Med. 2008, 36, 899-912.
17. Duthie, G., Crozier, A. Plant-derived phenolic antioxidants. Curr. Opin. Lipidol. 2000, 11, 43-47.
18. Gerritsen, M.E., Carley, W.W., Ranges, G.E., Shen, C.P., Phan, S.A., Ligon, G.F., Perry, C.A. Flavonoids inhibit cytokineinduced endothelial cell adhesion protein gene expression. Am. J. Pathol. 1995, 147, 278-292.
19. Smolinski, A.T., Pestka, J.J. Modulation of lipopolysaccharideinduced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). Food Chem. Toxicol. 2003, 41, 1381-1390.
20. Wang, W., Heideman, L., Chung, C.S., Pelling, J.C., Koehler, K.J., Birt, D.F. Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. Mol. Carcinog. 2000, 28, 102-110.
21. Yano, S., Umeda, D., Maeda, N., Fujimura, Y., Yamada, K., Tachibana, H. Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice. J. Agric. Food Chem. 2006, 54, 5203-5207.
22. Yano, S., Umeda, D., Yamashita, T., Ninomiya, Y., Sumida, M., Fujimura, Y., Yamada, K., Tachibana, H. Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice. Eur. J. Nutr. 2007, 46, 257-263.
23. Yano, S., Umeda, D., Yamashita, S., Yamada, K., Tachibana, H. Dietary apigenin attenuates the development of atopic dermatitis- like skin lesions in NC/Nga mice. J. Nutr. Biochem. 2009, 20, 876-881.
24. Du, Q., Zhou, L.F., Chen, Z., Gu, X.Y., Huang, M., Yin, K.S. Imiquimod, a toll-like receptor 7 ligand, inhibits airway remodelling in a murine model of chronic asthma. Clin. Exp. Pharmacol. Physiol. 2009, 36, 43-48.
25. Hougee, S., Sanders, A., Faber, J., Graus, Y.M., van den Berg, W.B., Garssen, J., Smit, H.F., Hoijer, M.A. Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. Biochem. Pharmacol. 2005, 69, 241-248.
26. Lee, J.H., Zhou, H.Y., Cho, S.Y., Kim, Y.S., Lee, Y.S., Jeong, C.S. Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. Arch. Pharm. Res. 2007, 30, 1318-1327.
27. Cohn, L., Tepper, J.S., Bottomly, K. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J. Immunol. 1998, 161, 3813-3816.
28. Murphy, C.A., Langrish, C.L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R.A., Sedgwick, J.D., Cua, D.J. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 2003, 198, 1951-1957.
29. Yen, D., Cheung, J., Scheerens, H., Poulet, F., McClanahan, T., McKenzie, B., Kleinschek, M.A., Owyang, A., Mattson, J., Blumenschein, W., Murphy, E., Sathe, M., Cua, D.J., Kastelein, R.A., Rennick, D. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 2006, 116, 1310-1316.
30. Zheng, Y., Danilenko, D.M., Valdez, P., Kasman, I., Eastham- Anderson, J., Wu, J., Ouyang, W. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature. 2007, 445, 648-651.
31. Wakashin, H., Hirose, K., Maezawa, Y., Kagami, S., Suto, A., Watanabe, N., Saito, Y., Hatano, M., Tokuhisa, T., Iwakura, Y., Puccetti, P., Iwamoto, I., Nakajima, H. IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am. J. Respir. Crit. Care Med. 2008, 178, 1023-1032.
32. McKinley, L., Alcorn, J.F., Peterson, A., Dupont, R.B., Kapadia, S., Logar, A., Henry, A., Irvin, C.G., Piganelli, J.D., Ray, A., Kolls, J.K. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 2008, 181, 4089-4097.
33. Kearley, J., Barker, J.E., Robinson, D.S., Lloyd, C.M. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J. Exp. Med. 2005, 202, 1539-1547.
34. Kearley, J., Robinson, D.S., Lloyd, C.M. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J. Allergy. Clin. Immunol. 2008, 122, 617-624 e6.