메뉴 건너뛰기




Volumn 463, Issue 1, 2014, Pages 19-30

DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres

Author keywords

DNA dependent protein kinase catalytic subunit (DNA PKcs); DNA PKcs interacting protein (KIP); Shelterin; Telomere; Telomeric repeat binding factor 2 (TRF2)

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DNA; KIP PROTEIN; PROTEIN; SMALL INTERFERING RNA; TELOMERE BINDING PROTEIN; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; CIB1 PROTEIN, HUMAN; TELOMERASE; TERF2 PROTEIN, HUMAN;

EID: 84906987368     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131395     Document Type: Article
Times cited : (11)

References (53)
  • 1
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • CrossRef PubMed
    • Blackburn, E. H. (2001) Switching and signaling at the telomere. Cell 106, 661-673 CrossRef PubMed.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 2
    • 2042429168 scopus 로고    scopus 로고
    • Regulation of telomerase by telomeric proteins
    • CrossRef PubMed
    • Smogorzewska, A. and de Lange, T. (2004) Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 73, 177-208 CrossRef PubMed.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 177-208
    • Smogorzewska, A.1    De Lange, T.2
  • 3
    • 0024436330 scopus 로고
    • Conservation of the human telomere sequence (TTAGGG)n among vertebrates
    • CrossRef PubMed
    • Meyne, J., Ratliff, R. L. and Moyzis, R. K. (1989) Conservation of the human telomere sequence (TTAGGG)n among vertebrates. Proc. Natl. Acad. Sci. U.S.A. 86, 7049-7053 CrossRef PubMed.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 7049-7053
    • Meyne, J.1    Ratliff, R.L.2    Moyzis, R.K.3
  • 4
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long g-rich telomeric overhangs at one end
    • CrossRef PubMed
    • Wright, W. E., Tesmer, V. M., Huffman, K. E., Levene, S. D. and Shay, J. W. (1997) Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11, 2801-2809 CrossRef PubMed.
    • (1997) Genes Dev. , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 5
    • 0033553455 scopus 로고    scopus 로고
    • Telomeres do D-loop-t-loop
    • CrossRef PubMed
    • Greider, C. W. (1999) Telomeres do D-loop-T-loop. Cell 97, 419-422 CrossRef PubMed.
    • (1999) Cell , vol.97 , pp. 419-422
    • Greider, C.W.1
  • 7
    • 10944240539 scopus 로고    scopus 로고
    • Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
    • CrossRef PubMed
    • Liu, D., O'Connor, M. S., Qin, J. and Songyang, Z. (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279, 51338-51342 CrossRef PubMed.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51338-51342
    • Liu, D.1    O'Connor, M.S.2    Qin, J.3    Songyang, Z.4
  • 8
    • 46249125488 scopus 로고    scopus 로고
    • How shelterin protects mammalian telomeres
    • CrossRef PubMed
    • Palm, W. and de Lange, T. (2008) How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42, 301-334 CrossRef PubMed.
    • (2008) Annu. Rev. Genet. , vol.42 , pp. 301-334
    • Palm, W.1    De Lange, T.2
  • 9
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • CrossRef PubMed
    • van Steensel, B. and de Lange, T. (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385, 740-743 CrossRef PubMed.
    • (1997) Nature , vol.385 , pp. 740-743
    • Van Steensel, B.1    De Lange, T.2
  • 10
    • 84984775429 scopus 로고    scopus 로고
    • Human telomeres contain two distinct myb-related proteins, TRF1 and TRF2
    • CrossRef PubMed
    • Broccoli, D., Smogorzewska, A., Chong, L. and de Lange, T. (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 17, 231-235 CrossRef PubMed.
    • (1997) Nat. Genet. , vol.17 , pp. 231-235
    • Broccoli, D.1    Smogorzewska, A.2    Chong, L.3    De Lange, T.4
  • 11
    • 0035844082 scopus 로고    scopus 로고
    • Pot1, the putative telomere end-binding protein in fission yeast and humans
    • CrossRef PubMed
    • Baumann, P. and Cech, T. R. (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292, 1171-1175 CrossRef PubMed.
    • (2001) Science , vol.292 , pp. 1171-1175
    • Baumann, P.1    Cech, T.R.2
  • 12
    • 0034716904 scopus 로고    scopus 로고
    • Identification of human rap1: Implications for telomere evolution
    • CrossRef PubMed
    • Li, B., Oestreich, S. and de Lange, T. (2000) Identification of human Rap1: implications for telomere evolution. Cell 101, 471-483 CrossRef PubMed.
    • (2000) Cell , vol.101 , pp. 471-483
    • Li, B.1    Oestreich, S.2    De Lange, T.3
  • 13
    • 33747051742 scopus 로고    scopus 로고
    • A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
    • CrossRef PubMed
    • O'Connor, M. S., Safari, A., Xin, H., Liu, D. and Songyang, Z. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc. Natl. Acad. Sci. U.S.A. 103, 11874-11879 CrossRef PubMed.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 11874-11879
    • O'Connor, M.S.1    Safari, A.2    Xin, H.3    Liu, D.4    Songyang, Z.5
  • 14
    • 33846692105 scopus 로고    scopus 로고
    • TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase
    • CrossRef PubMed
    • Xin, H., Liu, D., Wan, M., Safari, A., Kim, H., Sun, W., O'Connor, M. S. and Songyang, Z. (2007) TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase. Nature 445, 559-562 CrossRef PubMed.
    • (2007) Nature , vol.445 , pp. 559-562
    • Xin, H.1    Liu, D.2    Wan, M.3    Safari, A.4    Kim, H.5    Sun, W.6    O'Connor, M.S.7    Songyang, Z.8
  • 16
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • CrossRef PubMed
    • Takai, H., Smogorzewska, A. and de Lange, T. (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 CrossRef PubMed.
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    De Lange, T.3
  • 17
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • CrossRef PubMed
    • de Lange, T. (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev. 19, 2100-2110 CrossRef PubMed.
    • (2005) Genes Dev. , vol.19 , pp. 2100-2110
    • De Lange, T.1
  • 19
    • 11144357186 scopus 로고    scopus 로고
    • Telomere maintenance requires the RAD51D recombination/repair protein
    • CrossRef PubMed
    • Tarsounas, M., Munoz, P., Claas, A., Smiraldo, P. G., Pittman, D. L., Blasco, M. A. and West, S. C. (2004) Telomere maintenance requires the RAD51D recombination/repair protein. Cell 117, 337-347 CrossRef PubMed.
    • (2004) Cell , vol.117 , pp. 337-347
    • Tarsounas, M.1    Munoz, P.2    Claas, A.3    Smiraldo, P.G.4    Pittman, D.L.5    Blasco, M.A.6    West, S.C.7
  • 20
    • 0347988045 scopus 로고    scopus 로고
    • Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
    • CrossRef PubMed
    • Garcia-Cao, M., O'Sullivan, R., Peters, A. H., Jenuwein, T. and Blasco, M. A. (2004) Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat. Genet. 36, 94-99 CrossRef PubMed.
    • (2004) Nat. Genet. , vol.36 , pp. 94-99
    • Garcia-Cao, M.1    O'Sullivan, R.2    Peters, A.H.3    Jenuwein, T.4    Blasco, M.A.5
  • 21
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • CrossRef PubMed
    • van Steensel, B., Smogorzewska, A. and de Lange, T. (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413 CrossRef PubMed.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 22
    • 0033605145 scopus 로고    scopus 로고
    • P53- And ATM -dependent apoptosis induced by telomeres lacking TRF2
    • CrossRef PubMed
    • Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. and de Lange, T. (1999) p53- And ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325 CrossRef PubMed.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 24
    • 36248952723 scopus 로고    scopus 로고
    • Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
    • CrossRef PubMed
    • Guo, X., Deng, Y., Lin, Y., Cosme-Blanco, W., Chan, S., He, H., Yuan, G., Brown, E. J. and Chang, S. (2007) Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J. 26, 4709-4719 CrossRef PubMed.
    • (2007) EMBO J. , vol.26 , pp. 4709-4719
    • Guo, X.1    Deng, Y.2    Lin, Y.3    Cosme-Blanco, W.4    Chan, S.5    He, H.6    Yuan, G.7    Brown, E.J.8    Chang, S.9
  • 25
    • 34548317418 scopus 로고    scopus 로고
    • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    • CrossRef PubMed
    • Denchi, E. L. and de Lange, T. (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448, 1068-1071 CrossRef PubMed.
    • (2007) Nature , vol.448 , pp. 1068-1071
    • Denchi, E.L.1    De Lange, T.2
  • 26
    • 33745651993 scopus 로고    scopus 로고
    • The apollo 5'exonuclease functions together with TRF2 to protect telomeres from DNA repair
    • CrossRef PubMed
    • Lenain, C., Bauwens, S., Amiard, S., Brunori, M., Giraud-Panis, M. J. and Gilson, E. (2006) The Apollo 5'exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr. Biol. 16, 1303-1310 CrossRef PubMed.
    • (2006) Curr. Biol. , vol.16 , pp. 1303-1310
    • Lenain, C.1    Bauwens, S.2    Amiard, S.3    Brunori, M.4    Giraud-Panis, M.J.5    Gilson, E.6
  • 27
    • 33745652501 scopus 로고    scopus 로고
    • Apollo, an artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase
    • CrossRef PubMed
    • van Overbeek, M. and de Lange, T. (2006) Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr. Biol. 16, 1295-1302 CrossRef PubMed.
    • (2006) Curr. Biol. , vol.16 , pp. 1295-1302
    • Van Overbeek, M.1    De Lange, T.2
  • 28
    • 64049099444 scopus 로고    scopus 로고
    • TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs
    • CrossRef PubMed
    • Kim, H., Lee, O. H., Xin, H., Chen, L. Y., Qin, J., Chae, H. K., Lin, S. Y., Safari, A., Liu, D. and Songyang, Z. (2009) TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat. Struct. Mol. Biol. 16, 372-379 CrossRef PubMed.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 372-379
    • Kim, H.1    Lee, O.H.2    Xin, H.3    Chen, L.Y.4    Qin, J.5    Chae, H.K.6    Lin, S.Y.7    Safari, A.8    Liu, D.9    Songyang, Z.10
  • 29
    • 79960329911 scopus 로고    scopus 로고
    • Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection
    • CrossRef PubMed
    • Yoo, H. H. and Chung, I. K. (2011) Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection. Aging Cell 10, 557-571 CrossRef PubMed.
    • (2011) Aging Cell , vol.10 , pp. 557-571
    • Yoo, H.H.1    Chung, I.K.2
  • 30
    • 27544471936 scopus 로고    scopus 로고
    • Ku: A multifunctional protein involved in telomere maintenance
    • CrossRef PubMed
    • Fisher, T. S. and Zakian, V. A. (2005) Ku: A multifunctional protein involved in telomere maintenance. DNA Repair 4, 1215-1226 CrossRef PubMed.
    • (2005) DNA Repair , vol.4 , pp. 1215-1226
    • Fisher, T.S.1    Zakian, V.A.2
  • 31
    • 33750033205 scopus 로고    scopus 로고
    • The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology
    • CrossRef PubMed
    • Riha, K., Heacock, M. L. and Shippen, D. E. (2006) The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology. Annu. Rev. Genet. 40, 237-277 CrossRef PubMed.
    • (2006) Annu. Rev. Genet. , vol.40 , pp. 237-277
    • Riha, K.1    Heacock, M.L.2    Shippen, D.E.3
  • 32
    • 33746644257 scopus 로고    scopus 로고
    • Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination
    • CrossRef PubMed
    • Celli, G. B., Denchi, E. L. and de Lange, T. (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nat. Cell Biol. 8, 885-890 CrossRef PubMed.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 885-890
    • Celli, G.B.1    Denchi, E.L.2    De Lange, T.3
  • 33
    • 77957002731 scopus 로고    scopus 로고
    • Ku80 facilitates chromatin binding of the telomere binding protein, TRF2
    • CrossRef PubMed
    • Fink, L. S., Lerner, C. A., Torres, P. F. and Sell, C. (2010) Ku80 facilitates chromatin binding of the telomere binding protein, TRF2. Cell Cycle 9, 3798-3806 CrossRef PubMed.
    • (2010) Cell Cycle , vol.9 , pp. 3798-3806
    • Fink, L.S.1    Lerner, C.A.2    Torres, P.F.3    Sell, C.4
  • 34
    • 0033592950 scopus 로고    scopus 로고
    • DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
    • CrossRef PubMed
    • Bailey, S. M., Meyne, J., Chen, D. J., Kurimasa, A., Li, G. C., Lehnert, B. E. and Goodwin, E. H. (1999) DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc. Natl. Acad. Sci. U.S.A. 96, 14899-14904 CrossRef PubMed.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 14899-14904
    • Bailey, S.M.1    Meyne, J.2    Chen, D.J.3    Kurimasa, A.4    Li, G.C.5    Lehnert, B.E.6    Goodwin, E.H.7
  • 36
    • 0037112834 scopus 로고    scopus 로고
    • Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    • CrossRef PubMed
    • Espejel, S., Franco, S., Sgura, A., Gae, D., Bailey, S. M., Taccioli, G. E. and Blasco, M. A. (2002) Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J. 21, 6275-6287 CrossRef PubMed.
    • (2002) EMBO J. , vol.21 , pp. 6275-6287
    • Espejel, S.1    Franco, S.2    Sgura, A.3    Gae, D.4    Bailey, S.M.5    Taccioli, G.E.6    Blasco, M.A.7
  • 37
    • 4544379480 scopus 로고    scopus 로고
    • DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase
    • CrossRef PubMed
    • Lee, G. E., Yu, E. Y., Cho, C. H., Lee, J., Muller, M. T. and Chung, I. K. (2004) DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase. J. Biol. Chem. 279, 34750-34755 CrossRef PubMed.
    • (2004) J. Biol. Chem. , vol.279 , pp. 34750-34755
    • Lee, G.E.1    Yu, E.Y.2    Cho, C.H.3    Lee, J.4    Muller, M.T.5    Chung, I.K.6
  • 38
    • 84876396065 scopus 로고    scopus 로고
    • Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress
    • CrossRef PubMed
    • Choi, S. Y., Jang, H., Roe, J. S., Kim, S. T., Cho, E. J. and Youn, H. D. (2013) Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress. Nucleic Acids Res. 41, 2180-2190 CrossRef PubMed.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 2180-2190
    • Choi, S.Y.1    Jang, H.2    Roe, J.S.3    Kim, S.T.4    Cho, E.J.5    Youn, H.D.6
  • 39
    • 0038069024 scopus 로고    scopus 로고
    • Potent inhibition of human telomerase by nitrostyrene derivatives
    • CrossRef PubMed
    • Kim, J. H., Kim, J. H., Lee, G. E., Lee, J. E. and Chung, I. K. (2003) Potent inhibition of human telomerase by nitrostyrene derivatives. Mol. Pharmacol. 63, 1117-1124 CrossRef PubMed.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 1117-1124
    • Kim, J.H.1    Kim, J.H.2    Lee, G.E.3    Lee, J.E.4    Chung, I.K.5
  • 40
    • 0030743347 scopus 로고    scopus 로고
    • Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)
    • CrossRef PubMed
    • Kim, N. W. and Wu, F. (1997) Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res. 25, 2595-2597 CrossRef PubMed.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2595-2597
    • Kim, N.W.1    Wu, F.2
  • 41
    • 84864966476 scopus 로고    scopus 로고
    • Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation
    • CrossRef PubMed
    • Chung, J., Khadka, P. and Chung, I. K. (2012) Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. J. Cell Sci. 125, 2684-2697 CrossRef PubMed.
    • (2012) J. Cell Sci. , vol.125 , pp. 2684-2697
    • Chung, J.1    Khadka, P.2    Chung, I.K.3
  • 42
    • 0035798379 scopus 로고    scopus 로고
    • The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
    • CrossRef PubMed
    • Zhou, X. Z. and Lu, K. P. (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107, 347-359 CrossRef PubMed.
    • (2001) Cell , vol.107 , pp. 347-359
    • Zhou, X.Z.1    Lu, K.P.2
  • 43
    • 0030680162 scopus 로고    scopus 로고
    • Interaction between DNA-dependent protein kinase and a novel protein, KIP
    • CrossRef PubMed
    • Wu, X. and Lieber, M. R. (1997) Interaction between DNA-dependent protein kinase and a novel protein, KIP. Mutat. Res. 385, 13-20 CrossRef PubMed.
    • (1997) Mutat. Res. , vol.385 , pp. 13-20
    • Wu, X.1    Lieber, M.R.2
  • 44
    • 0031046185 scopus 로고    scopus 로고
    • Identification of a novel calcium-binding protein that interacts with the integrin αiib cytoplasmic domain
    • CrossRef PubMed
    • Naik, U. P., Patel, P. M. and Parise, L. V. (1997) Identification of a novel calcium-binding protein that interacts with the integrin αIIb cytoplasmic domain. J. Biol. Chem. 272, 4651-4654 CrossRef PubMed.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4651-4654
    • Naik, U.P.1    Patel, P.M.2    Parise, L.V.3
  • 46
    • 67650096772 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair
    • CrossRef PubMed
    • Huda, N., Tanaka, H., Mendonca, M. S. and Gilley, D. (2009) DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair. Mol. Cell. Biol. 29, 3597-3604 CrossRef PubMed.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3597-3604
    • Huda, N.1    Tanaka, H.2    Mendonca, M.S.3    Gilley, D.4
  • 47
    • 0037472924 scopus 로고    scopus 로고
    • Dna damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • CrossRef PubMed
    • Bakkenist, C. J. and Kastan, M. B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 CrossRef PubMed.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 48
    • 33747614605 scopus 로고    scopus 로고
    • Involvement of novel autophosphorylation sites in ATM activation
    • CrossRef PubMed
    • Kozlov, S. V., Graham, M. E., Peng, C., Chen, P., Robinson, P. J. and Lavin, M. F. (2006) Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 25, 3504-3514 CrossRef PubMed.
    • (2006) EMBO J. , vol.25 , pp. 3504-3514
    • Kozlov, S.V.1    Graham, M.E.2    Peng, C.3    Chen, P.4    Robinson, P.J.5    Lavin, M.F.6
  • 49
    • 67649424560 scopus 로고    scopus 로고
    • P21 in cancer: Intricate networks and multiple activities
    • CrossRef PubMed
    • Abbas, T. and Dutta, A. (2009) p21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer 9, 400-414 CrossRef PubMed.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 400-414
    • Abbas, T.1    Dutta, A.2
  • 50
    • 84883145808 scopus 로고    scopus 로고
    • CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling
    • CrossRef PubMed
    • Leisner, T. M., Moran, C., Holly, S. P. and Parise, L. V. (2013) CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling. Oncogene 32, 4017-4027 CrossRef PubMed.
    • (2013) Oncogene , vol.32 , pp. 4017-4027
    • Leisner, T.M.1    Moran, C.2    Holly, S.P.3    Parise, L.V.4
  • 51
    • 0035476710 scopus 로고    scopus 로고
    • T-loop assembly in vitro involves binding of TRF2 near the 3'telomeric overhang
    • CrossRef PubMed
    • Stansel, R. M., de Lange, T. and Griffith, J. D. (2001) T-loop assembly in vitro involves binding of TRF2 near the 3'telomeric overhang. EMBO J. 20, 5532-5540 CrossRef PubMed.
    • (2001) EMBO J. , vol.20 , pp. 5532-5540
    • Stansel, R.M.1    De Lange, T.2    Griffith, J.D.3
  • 52
    • 34250841785 scopus 로고    scopus 로고
    • Replication and protection of telomeres
    • CrossRef PubMed
    • Verdun, R. E. and Karlseder, J. (2007) Replication and protection of telomeres. Nature 447, 924-931 CrossRef PubMed.
    • (2007) Nature , vol.447 , pp. 924-931
    • Verdun, R.E.1    Karlseder, J.2
  • 53
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53 and p21CIP1, but not p16INK4a
    • CrossRef PubMed
    • Herbig, U., Jobling, W. A., Chen, B. P., Chen, D. J. and Sedivy, J. M. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53 and p21CIP1, but not p16INK4a. Mol. Cell 14, 501-513 CrossRef PubMed.
    • (2004) Mol. Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.