The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signaling

Biochemical Journal

Volumn 463, Issue 1, 2014, Pages 41-52

  Vauzour, David ^c   Pinto, John T ^b   Cooper, Arthur J L ^b   Spencer, Jeremy P E ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

5 s cysteinyldopamine (CysDA); Mitogen activated protein kinase (MAPK); Neurotoxicity; Parkinson's disease (PD); Primary neuron

Indexed keywords

5 CYSTEINYLDOPAMINE; APOPTOSIS SIGNAL REGULATING KINASE 1; BETA ACTIN; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; GLUTATHIONE; GLUTATHIONE DISULFIDE; JANUS KINASE 1; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROTOXIN; PROTEINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; 5 (S CYSTEAMINYL)DOPAMINE; 5-S-CYSTEAMINYLDOPAMINE; CASPASE; DOPAMINE; DRUG DERIVATIVE; MAP3K5 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE 9; NERVE PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOBLOTTING; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; METABOLISM; NERVE CELL; PARKINSON DISEASE; PATHOLOGY;

ANIMALS; APOPTOSIS; CASPASES; CELLS, CULTURED; CYTOCHROMES C; DOPAMINE; ELECTRON TRANSPORT COMPLEX I; MAP KINASE KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NERVE TISSUE PROTEINS; NEURONS; PARKINSON DISEASE;

EID: 84906979540     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131519     Document Type: Article

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