Generation of reactive oxygen species, release of L-glutamate and activation of caspases are required for oxygen-induced apoptosis of embryonic hippocampal neurons in culture

Brain Research

Volumn 824, Issue 1, 1999, Pages 71-80

  Ishikawa, Yasuyuki ^a   Satoh, Takumi ^a,b   Enokido, Yasushi ^a   Nishio, Chika ^a   Ikeuchi, Toshihiko ^a   Hatanaka, Hiroshi ^a  

^a BIOMOL ENG RESEARCH INSTITUTE   (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

Apoptosis; Caspase; Glutamate; Nitric oxide; PARP; Reactive oxygen species

Indexed keywords

AMPA RECEPTOR ANTAGONIST; CASPASE; CASPASE INHIBITOR; CATALASE; DEFEROXAMINE; GLUTAMIC ACID; HYDROGEN PEROXIDE; HYDROXYL RADICAL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGEN; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HIPPOCAMPUS; IN VITRO STUDY; MODEL; NERVE CELL CULTURE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CASPASES; CYCLIC AMP; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GLUTAMIC ACID; HIPPOCAMPUS; MALE; NEURONS; NITRIC OXIDE; OXYGEN; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUTAMATE;

EID: 0033119182     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01108-7     Document Type: Article

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