Caspase-3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: Relevance to oxidative stress in dopaminergic degeneration

European Journal of Neuroscience

Volumn 18, Issue 6, 2003, Pages 1387-1401

  Kaul, Siddharth ^a   Kanthasamy, Arthi ^a   Kitazawa, Masashi ^a   Anantharam, Vellareddy ^a   Kanthasamy, Anumantha G ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Environmental factors; Feedback regulation; MPTP; Parkinson's disease; Phosphorylation

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN CHLORIDE; PORPHYRIN DERIVATIVE; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; ROTTLERIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN SLICE; CELL DEATH; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME RELEASE; MESENCEPHALON; NERVE CELL DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; APOPTOSIS; BENZIMIDAZOLES; CASPASE 3; CASPASE 9; CASPASES; CELL LINE; COUMARINS; CYTOCHROMES C; DNA FRAGMENTATION; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HERBICIDES; MANGANESE COMPOUNDS; MESENCEPHALON; METALLOPORPHYRINS; NERVE DEGENERATION; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; PRECIPITIN TESTS; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RATS; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRANSFECTION;

EID: 0141705340     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02864.x     Document Type: Article

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