Mycobacterium tuberculosis DinG is a structure-specific helicase that unwinds G4 DNA: Implications for targeting G4 DNA as a novel therapeutic approach

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25112-25136

  Thakur, Roshan Singh ^a   Desingu, Ambika ^a   Basavaraju, Shivakumar ^a   Subramanya, Shreelakshmi ^a   Rao, Desirazu N ^a   Nagaraju, Ganesh ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; GENE EXPRESSION; MODEL STRUCTURES; REPAIR;

DNA REPLICATIONS; HOLLIDAY JUNCTIONS; M. TUBERCULOSIS; MULTI-FUNCTIONAL STRUCTURES; MYCOBACTERIUM TUBERCULOSIS; PROMOTER SEQUENCES; REPLICATION FORK; THERAPEUTIC STRATEGY;

DNA;

DEOXYRIBONUCLEASE; DING PROTEIN; DNA HELICASE; GUANINE QUADRUPLEX; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CRUCIFORM DNA; DEOXYRIBONUCLEASE I; DING PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ENZYME INHIBITOR; PROTEIN BINDING; SINGLE STRANDED DNA;

ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIUM IDENTIFICATION; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DNA BINDING; DNA DENATURATION; DNA FOOTPRINTING; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; IN VIVO STUDY; MCE1R GENE; MOEB1 GENE; MOLECULAR CLONING; MOLECULAR DYNAMICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROMOTER REGION; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BIOCATALYSIS; BIOLOGICAL MODEL; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; PROCEDURES; SEQUENCE HOMOLOGY; TUBERCULOSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIOCATALYSIS; CIRCULAR DICHROISM; DEOXYRIBONUCLEASE I; DNA FOOTPRINTING; DNA HELICASES; DNA, CRUCIFORM; DNA, SINGLE-STRANDED; ENZYME INHIBITORS; G-QUADRUPLEXES; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID CONFORMATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TUBERCULOSIS;

EID: 84906968831     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.563569     Document Type: Article

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