메뉴 건너뛰기




Volumn 49, Issue 6, 2010, Pages 311-314

Roles of PE_PGRS family in mycobacterium tuberculosis pathogenesis and novel measures against tuberculosis

Author keywords

Antigenic variation; Mycobacterium tuberculosis; PE_PGRS; Persistence; Reactivation

Indexed keywords

BACTERIAL PROTEIN; BCG VACCINE; INTERLEUKIN 10; INTERLEUKIN 12; MYCOBACTERIUM ANTIGEN; NITRIC OXIDE; PE PGRS PROTEIN; PE PGRS62 PROTEIN; RV1759C PROTEIN; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 77957800836     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2010.07.004     Document Type: Review
Times cited : (47)

References (41)
  • 1
    • 0028889845 scopus 로고
    • Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic
    • Raviglione M.C., Snider D.E., Kochi A. Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic. JAMA 1995, 273(3):220-226.
    • (1995) JAMA , vol.273 , Issue.3 , pp. 220-226
    • Raviglione, M.C.1    Snider, D.E.2    Kochi, A.3
  • 2
    • 0034677007 scopus 로고    scopus 로고
    • Inhibition of Ca(2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages
    • Malik Z.A., Denning G.M., Kusner D.J. Inhibition of Ca(2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages. J Exp Med 2000, 191(2):287-302.
    • (2000) J Exp Med , vol.191 , Issue.2 , pp. 287-302
    • Malik, Z.A.1    Denning, G.M.2    Kusner, D.J.3
  • 3
    • 57349134450 scopus 로고    scopus 로고
    • A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins
    • Singh P.P., Parra M., Cadieux N., Brennan M.J. A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins. Microbiology 2008, 154(Pt. 11):3469-3479.
    • (2008) Microbiology , vol.154 , Issue.PART. 11 , pp. 3469-3479
    • Singh, P.P.1    Parra, M.2    Cadieux, N.3    Brennan, M.J.4
  • 4
    • 0036568632 scopus 로고    scopus 로고
    • The PE multigene family: a 'molecular mantra' for mycobacteria
    • Brennan M.J., Delogu G. The PE multigene family: a 'molecular mantra' for mycobacteria. Trends Microbiol 2002, 10(5):246-249.
    • (2002) Trends Microbiol , vol.10 , Issue.5 , pp. 246-249
    • Brennan, M.J.1    Delogu, G.2
  • 5
    • 67651207964 scopus 로고    scopus 로고
    • Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families
    • Bottai D., Brosch R. Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families. Mol Microbiol 2009, 73(3):325-328.
    • (2009) Mol Microbiol , vol.73 , Issue.3 , pp. 325-328
    • Bottai, D.1    Brosch, R.2
  • 6
    • 38949193910 scopus 로고    scopus 로고
    • Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds
    • Bachhawat N., Singh B. Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds. Genomics Proteomics Bioinformatics 2007, 5(3-4):236-241.
    • (2007) Genomics Proteomics Bioinformatics , vol.5 , Issue.3-4 , pp. 236-241
    • Bachhawat, N.1    Singh, B.2
  • 8
    • 0033396817 scopus 로고    scopus 로고
    • The PE-PGRS glycine-rich proteins of Mycobacterium tuberculosis: a new family of fibronectin-binding proteins?
    • Espitia C., Laclette J.P., Mondragon-Palomino M., Amador A., Campuzano J., Martens A., et al. The PE-PGRS glycine-rich proteins of Mycobacterium tuberculosis: a new family of fibronectin-binding proteins?. Microbiology 1999, 145(Pt 12):3487-3495.
    • (1999) Microbiology , vol.145 , Issue.PART 12 , pp. 3487-3495
    • Espitia, C.1    Laclette, J.P.2    Mondragon-Palomino, M.3    Amador, A.4    Campuzano, J.5    Martens, A.6
  • 9
    • 0035177858 scopus 로고    scopus 로고
    • Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells
    • Brennan M.J., Delogu G., Chen Y., Bardarov S., Kriakov J., Alavi M., et al. Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infect Immun 2001, 69(12):7326-7333.
    • (2001) Infect Immun , vol.69 , Issue.12 , pp. 7326-7333
    • Brennan, M.J.1    Delogu, G.2    Chen, Y.3    Bardarov, S.4    Kriakov, J.5    Alavi, M.6
  • 10
    • 67651233950 scopus 로고    scopus 로고
    • PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5
    • Abdallah A.M., Verboom T., Weerdenburg E.M., Gey van Pittius N.C., Mahasha P.W., Jimenez C., et al. PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5. Mol Microbiol 2009, 73(3):329-340.
    • (2009) Mol Microbiol , vol.73 , Issue.3 , pp. 329-340
    • Abdallah, A.M.1    Verboom, T.2    Weerdenburg, E.M.3    Gey van Pittius, N.C.4    Mahasha, P.W.5    Jimenez, C.6
  • 11
    • 0242268398 scopus 로고    scopus 로고
    • Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
    • Stanley S.A., Raghavan S., Hwang W.W., Cox J.S. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc Natl Acad Sci U S A 2003, 100(22):13001-13006.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.22 , pp. 13001-13006
    • Stanley, S.A.1    Raghavan, S.2    Hwang, W.W.3    Cox, J.S.4
  • 12
    • 4644320227 scopus 로고    scopus 로고
    • A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion
    • Gao L.Y., Guo S., McLaughlin B., Morisaki H., Engel J.N., Brown E.J. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol 2004, 53(6):1677-1693.
    • (2004) Mol Microbiol , vol.53 , Issue.6 , pp. 1677-1693
    • Gao, L.Y.1    Guo, S.2    McLaughlin, B.3    Morisaki, H.4    Engel, J.N.5    Brown, E.J.6
  • 13
    • 0942290453 scopus 로고    scopus 로고
    • Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis
    • Guinn K.M., Hickey M.J., Mathur S.K., Zakel K.L., Grotzke J.E., Lewinsohn D.M., et al. Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol Microbiol 2004, 51(2):359-370.
    • (2004) Mol Microbiol , vol.51 , Issue.2 , pp. 359-370
    • Guinn, K.M.1    Hickey, M.J.2    Mathur, S.K.3    Zakel, K.L.4    Grotzke, J.E.5    Lewinsohn, D.M.6
  • 14
    • 14544279302 scopus 로고    scopus 로고
    • A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis
    • Converse S.E., Cox J.S. A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis. J Bacteriol 2005, 187(4):1238-1245.
    • (2005) J Bacteriol , vol.187 , Issue.4 , pp. 1238-1245
    • Converse, S.E.1    Cox, J.S.2
  • 15
    • 33749997722 scopus 로고    scopus 로고
    • A specific secretion system mediates PPE41 transport in pathogenic mycobacteria
    • Abdallah A.M., Verboom T., Hannes F., Safi M., Strong M., Eisenberg D., et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol Microbiol 2006, 62(3):667-679.
    • (2006) Mol Microbiol , vol.62 , Issue.3 , pp. 667-679
    • Abdallah, A.M.1    Verboom, T.2    Hannes, F.3    Safi, M.4    Strong, M.5    Eisenberg, D.6
  • 16
    • 0038751936 scopus 로고    scopus 로고
    • Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
    • Pym A.S., Brodin P., Majlessi L., Brosch R., Demangel C., Williams A., et al. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat Med 2003, 9(5):533-539.
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 533-539
    • Pym, A.S.1    Brodin, P.2    Majlessi, L.3    Brosch, R.4    Demangel, C.5    Williams, A.6
  • 18
    • 25144441735 scopus 로고    scopus 로고
    • A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis
    • MacGurn J.A., Raghavan S., Stanley S.A., Cox J.S. A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis. Mol Microbiol 2005, 57(6):1653-1663.
    • (2005) Mol Microbiol , vol.57 , Issue.6 , pp. 1653-1663
    • MacGurn, J.A.1    Raghavan, S.2    Stanley, S.A.3    Cox, J.S.4
  • 19
    • 34548411365 scopus 로고    scopus 로고
    • A mycobacterium ESX-1-secreted virulence factor with unique requirements for export
    • McLaughlin B., Chon J.S., MacGurn J.A., Carlsson F., Cheng T.L., Cox J.S., et al. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog 2007, 3(8):e105.
    • (2007) PLoS Pathog , vol.3 , Issue.8
    • McLaughlin, B.1    Chon, J.S.2    MacGurn, J.A.3    Carlsson, F.4    Cheng, T.L.5    Cox, J.S.6
  • 21
    • 60049091769 scopus 로고    scopus 로고
    • ESX/type VII secretion systems and their role in host-pathogen interaction
    • Simeone R., Bottai D., Brosch R. ESX/type VII secretion systems and their role in host-pathogen interaction. Curr Opin Microbiol 2009, 12(1):4-10.
    • (2009) Curr Opin Microbiol , vol.12 , Issue.1 , pp. 4-10
    • Simeone, R.1    Bottai, D.2    Brosch, R.3
  • 22
    • 77954050777 scopus 로고    scopus 로고
    • Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection
    • Carlsson F., Kim J., Dumitru C., Barck K.H., Carano R.A., Sun M., et al. Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. PLoS Pathog 2010, 6(5):e1000895.
    • (2010) PLoS Pathog , vol.6 , Issue.5
    • Carlsson, F.1    Kim, J.2    Dumitru, C.3    Barck, K.H.4    Carano, R.A.5    Sun, M.6
  • 23
    • 33751323180 scopus 로고    scopus 로고
    • Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
    • Gey van Pittius N.C., Sampson S.L., Lee H., Kim Y., van Helden P.D., Warren R.M. Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evol Biol 2006, 695.
    • (2006) BMC Evol Biol , pp. 695
    • Gey van Pittius, N.C.1    Sampson, S.L.2    Lee, H.3    Kim, Y.4    van Helden, P.D.5    Warren, R.M.6
  • 24
    • 33646586667 scopus 로고    scopus 로고
    • Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo
    • Dheenadhayalan V., Delogu G., Sanguinetti M., Fadda G., Brennan M.J. Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo. J Bacteriol 2006, 188(10):3721-3725.
    • (2006) J Bacteriol , vol.188 , Issue.10 , pp. 3721-3725
    • Dheenadhayalan, V.1    Delogu, G.2    Sanguinetti, M.3    Fadda, G.4    Brennan, M.J.5
  • 25
    • 2442515282 scopus 로고    scopus 로고
    • Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure
    • Delogu G., Pusceddu C., Bua A., Fadda G., Brennan M.J., Zanetti S. Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure. Mol Microbiol 2004, 52(3):725-733.
    • (2004) Mol Microbiol , vol.52 , Issue.3 , pp. 725-733
    • Delogu, G.1    Pusceddu, C.2    Bua, A.3    Fadda, G.4    Brennan, M.J.5    Zanetti, S.6
  • 26
    • 34250649240 scopus 로고    scopus 로고
    • Association of Mycobacterium tuberculosis PE PGRS33 polymorphism with clinical and epidemiological characteristics
    • Talarico S., Cave M.D., Foxman B., Marrs C.F., Zhang L., Bates J.H., et al. Association of Mycobacterium tuberculosis PE PGRS33 polymorphism with clinical and epidemiological characteristics. Tuberculosis (Edinb) 2007, 87(4):338-346.
    • (2007) Tuberculosis (Edinb) , vol.87 , Issue.4 , pp. 338-346
    • Talarico, S.1    Cave, M.D.2    Foxman, B.3    Marrs, C.F.4    Zhang, L.5    Bates, J.H.6
  • 27
    • 33645236362 scopus 로고    scopus 로고
    • A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis
    • Deb C., Daniel J., Sirakova T.D., Abomoelak B., Dubey V.S., Kolattukudy P.E. A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis. J Biol Chem 2006, 281(7):3866-3875.
    • (2006) J Biol Chem , vol.281 , Issue.7 , pp. 3866-3875
    • Deb, C.1    Daniel, J.2    Sirakova, T.D.3    Abomoelak, B.4    Dubey, V.S.5    Kolattukudy, P.E.6
  • 28
    • 45849108709 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis PE_PGRS16 and PE_PGRS26 genetic polymorphism among clinical isolates
    • Talarico S., Zhang L., Marrs C.F., Foxman B., Cave M.D., Brennan M.J., et al. Mycobacterium tuberculosis PE_PGRS16 and PE_PGRS26 genetic polymorphism among clinical isolates. Tuberculosis (Edinb) 2008, 88(4):283-294.
    • (2008) Tuberculosis (Edinb) , vol.88 , Issue.4 , pp. 283-294
    • Talarico, S.1    Zhang, L.2    Marrs, C.F.3    Foxman, B.4    Cave, M.D.5    Brennan, M.J.6
  • 29
  • 30
    • 0032615249 scopus 로고    scopus 로고
    • DNA microsatellites: agents of evolution?
    • Moxon E.R., Wills C. DNA microsatellites: agents of evolution?. Sci Am 1999, 280(1):94-99.
    • (1999) Sci Am , vol.280 , Issue.1 , pp. 94-99
    • Moxon, E.R.1    Wills, C.2
  • 31
    • 0033613335 scopus 로고    scopus 로고
    • Enzymes of evolutionary change
    • 869
    • Radman M. Enzymes of evolutionary change. Nature 1999, 401(6756):866-867. 869.
    • (1999) Nature , vol.401 , Issue.6756 , pp. 866-867
    • Radman, M.1
  • 32
    • 0035013083 scopus 로고    scopus 로고
    • Antigens of Mycobacterium tuberculosis expressed during preclinical tuberculosis: serological immunodominance of proteins with repetitive amino acid sequences
    • Singh K.K., Zhang X., Patibandla A.S., Chien P., Laal S. Antigens of Mycobacterium tuberculosis expressed during preclinical tuberculosis: serological immunodominance of proteins with repetitive amino acid sequences. Infect Immun 2001, 69(6):4185-4191.
    • (2001) Infect Immun , vol.69 , Issue.6 , pp. 4185-4191
    • Singh, K.K.1    Zhang, X.2    Patibandla, A.S.3    Chien, P.4    Laal, S.5
  • 33
    • 0034717008 scopus 로고    scopus 로고
    • Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family
    • Ramakrishnan L., Federspiel N.A., Falkow S. Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Science 2000, 288(5470):1436-1439.
    • (2000) Science , vol.288 , Issue.5470 , pp. 1436-1439
    • Ramakrishnan, L.1    Federspiel, N.A.2    Falkow, S.3
  • 34
    • 33847342563 scopus 로고    scopus 로고
    • Apoptosis triggered by Rv1818c, a PE family gene from Mycobacterium tuberculosis is regulated by mitochondrial intermediates in T cells
    • Balaji K.N., Goyal G., Narayana Y., Srinivas M., Chaturvedi R., Mohammad S. Apoptosis triggered by Rv1818c, a PE family gene from Mycobacterium tuberculosis is regulated by mitochondrial intermediates in T cells. Microbes Infect 2007, 9(3):271-281.
    • (2007) Microbes Infect , vol.9 , Issue.3 , pp. 271-281
    • Balaji, K.N.1    Goyal, G.2    Narayana, Y.3    Srinivas, M.4    Chaturvedi, R.5    Mohammad, S.6
  • 35
    • 31344463710 scopus 로고    scopus 로고
    • Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival
    • Dheenadhayalan V., Delogu G., Brennan M.J. Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival. Microbes Infect 2006, 8(1):262-272.
    • (2006) Microbes Infect , vol.8 , Issue.1 , pp. 262-272
    • Dheenadhayalan, V.1    Delogu, G.2    Brennan, M.J.3
  • 36
    • 34147108365 scopus 로고    scopus 로고
    • The PGRS domain of Mycobacterium tuberculosis PE_PGRS Rv1759c antigen is an efficient subunit vaccine to prevent reactivation in a murine model of chronic tuberculosis
    • Campuzano J., Aguilar D., Arriaga K., Leon J.C., Salas-Rangel L.P., Gonzalez-y-Merchand J., et al. The PGRS domain of Mycobacterium tuberculosis PE_PGRS Rv1759c antigen is an efficient subunit vaccine to prevent reactivation in a murine model of chronic tuberculosis. Vaccine 2007, 25(18):3722-3729.
    • (2007) Vaccine , vol.25 , Issue.18 , pp. 3722-3729
    • Campuzano, J.1    Aguilar, D.2    Arriaga, K.3    Leon, J.C.4    Salas-Rangel, L.P.5    Gonzalez-y-Merchand, J.6
  • 37
    • 77954423625 scopus 로고    scopus 로고
    • Expression of PE_PGRS 62 protein in Mycobacterium smegmatis decrease mRNA expression of proinflammatory cytokines IL-1beta, IL-6 in macrophages
    • Huang Y., Wang Y., Bai Y., Wang Z.G., Yang L., Zhao D. Expression of PE_PGRS 62 protein in Mycobacterium smegmatis decrease mRNA expression of proinflammatory cytokines IL-1beta, IL-6 in macrophages. Mol Cell Biochem 2010.
    • (2010) Mol Cell Biochem
    • Huang, Y.1    Wang, Y.2    Bai, Y.3    Wang, Z.G.4    Yang, L.5    Zhao, D.6
  • 38
    • 0033846833 scopus 로고    scopus 로고
    • Restraining mycobacteria: role of granulomas in mycobacterial infections
    • Saunders B.M., Cooper A.M. Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol Cell Biol 2000, 78(4):334-341.
    • (2000) Immunol Cell Biol , vol.78 , Issue.4 , pp. 334-341
    • Saunders, B.M.1    Cooper, A.M.2
  • 39
    • 0001004486 scopus 로고
    • Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2)
    • Hirano T., Taga T., Nakano N., Yasukawa K., Kashiwamura S., Shimizu K., et al. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A 1985, 82(16):5490-5494.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , Issue.16 , pp. 5490-5494
    • Hirano, T.1    Taga, T.2    Nakano, N.3    Yasukawa, K.4    Kashiwamura, S.5    Shimizu, K.6
  • 40
    • 0021288903 scopus 로고
    • The synergism of accessory cells and of soluble alpha-factors derived from them in the activation of B cells to proliferation
    • Corbel C., Melchers F. The synergism of accessory cells and of soluble alpha-factors derived from them in the activation of B cells to proliferation. Immunol Rev 1984, 7851-7874.
    • (1984) Immunol Rev , pp. 7851-7874
    • Corbel, C.1    Melchers, F.2
  • 41
    • 0019128380 scopus 로고
    • Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies
    • Weissenbach J., Chernajovsky Y., Zeevi M., Shulman L., Soreq H., Nir U., et al. Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies. Proc Natl Acad Sci U S A 1980, 77(12):7152-7156.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , Issue.12 , pp. 7152-7156
    • Weissenbach, J.1    Chernajovsky, Y.2    Zeevi, M.3    Shulman, L.4    Soreq, H.5    Nir, U.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.