A critical role for interferon regulatory factor 9 in cerebral Ischemic Stroke

Journal of Neuroscience

Volumn 34, Issue 36, 2014, Pages 11897-11912

  Chen, Hou Zao ^a   Guo, Sen ^b,c   Li, Zuo Zhi ^a   Lu, Yanyun ^b,c   Jiang, Ding Sheng ^b,c   Zhang, Ran ^a   Lei, Hao ^d   Gao, Lu ^e   Zhang, Xiaofei ^c   Zhang, Yan ^b,c   Wang, Lang ^b,c   Zhu, Li Hua ^b,c   Xiang, Mei ^b,c   Zhou, Yan ^c   Wan, Qi ^f   Dong, Hailong ^g   Liu, De Pei ^a   Li, Hongliang ^b,c  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

^d Wuhan National Laboratory for Optoelectronics   (China)

^e HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^f WUHAN UNIVERSITY   (China)

^g FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

IRF9; Neuroapoptosis; p53; Sirt1; Stroke

Indexed keywords

IRF9; NEUROAPOPTOSIS; P53; SIRT1; STROKE;

ACETYLATION; ANIMALS; APOPTOSIS; CELLS, CULTURED; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; NEURONS; SIRTUIN 1; STROKE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84906898008     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1545-14.2014     Document Type: Article

References (55)

1. Andrabi SA, Kang HC, Haince JF, Lee YI, Zhang J, Chi Z, West AB, Koehler RC, Poirier GG, Dawson TM, Dawson VL (2011) Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. Nat Med 17:692-699. CrossRef Medline
2. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973. CrossRef Medline
3. Broughton BR, Reutens DC, Sobey CG (2009) Apoptotic mechanisms after cerebral ischemia. Stroke 40:e331-e339. CrossRef Medline
4. Chamorro Á, Meisel A, Planas AM, Urra X, van de Beek D, Veltkamp R (2012) The immunology of acute stroke. Nat Rev Neurol 8:401-410. CrossRef Medline
5. Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L (2008) Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 22: 1753-1757. CrossRef Medline
6. Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNAdamage responses. Cell 123:437-448. CrossRef Medline
7. Darnell JE Jr, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421. CrossRef Medline
8. Donmez G (2012) The neurobiology of sirtuins and their role in neurodegeneration. Trends Pharmacol Sci 33:494-501. CrossRef Medline
9. Engel O, Kolodziej S, Dirnagl U, Prinz V (2011) Modeling stroke in mice: middle cerebral artery occlusion with the filament model. J Vis Exp 47: 2423. CrossRef Medline
10. Han L, Zhou R, Niu J, McNutt MA, Wang P, Tong T (2010) SIRT1 is regulated by a PPAR_-SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res 38:7458-7471. CrossRef Medline
11. Hasegawa K, Yoshikawa K (2008) Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci 28:8772-8784. CrossRef Medline
12. Hernández-Jiménez M, Hurtado O, Cuartero MI, Ballesteros I, Moraga A, Pradillo JM, McBurney MW, Lizasoain I, Moro MA (2013) Silent information regulator 1 protects the brain against cerebral ischemic damage. Stroke 44:2333-2337. CrossRef Medline
13. Hofer MJ, Li W, Lim SL, Campbell IL (2010) The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. J Neurosci 30:1149-1157. CrossRef Medline
14. Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795-800. CrossRef Medline
15. Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR 3rd, Bordone L, Guarente L, Krainc D (2012) Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med 18:159-165. CrossRef Medline
16. Jiang DS, Luo YX, Zhang R, Zhang XD, Chen HZ, Zhang Y, Chen K, Zhang SM, Fan GC, Liu PP, Liu DP, Li H (2014) Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin. Hypertension 63:119-127. CrossRef Medline
17. Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, Zhang J, Mori S, Yang XW, Tamashiro KL, Aja S, et al. (2012) Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med 18:153-158. CrossRef Medline
18. Khorooshi R, Owens T (2010) Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. J Immunol 185: 1258-1264. CrossRef Medline
19. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J 26: 3169-3179. CrossRef Medline
20. Labiche LA, Grotta JC (2004) Clinical trials for cytoprotection in stroke. NeuroRx 1:46-70. CrossRef Medline
21. Li L, Zhang HN, Chen HZ, Gao P, Zhu LH, Li HL, Lv X, Zhang QJ, Zhang R, Wang Z, She ZG, Zhang R, Wei YS, Du GH, Liu DP, Liang CC (2011) SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res 108:1180-1189. CrossRef Medline
22. Liu D, Gharavi R, Pitta M, Gleichmann M, Mattson MP (2009) Nicotinamide prevents NAD depletion and protects neurons against excitotoxicity and cerebral ischemia:NAD consumption by SIRT1 may endanger energetically compromised neurons. Neuromol Med 11:28-42. CrossRef Medline
23. Lo EH (2008) A new penumbra: transitioning from injury into repair after stroke. Nat Med 14:497-500. CrossRef Medline
24. Lo EH, Dalkara T, Moskowitz MA (2003) Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4:399-415. CrossRef Medline
25. Lu YY, Li ZZ, Jiang DS, Wang L, Zhang Y, Chen K, Zhang XF, Liu Y, Fan GC, Chen Y, Yang Q, Zhou Y, Zhang XD, Liu DP, Li H (2013) TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death. Nat Commun 4:2852. CrossRef Medline
26. Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107:137-148. CrossRef Medline
27. Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: mechanisms in search of treatments. Neuron 67:181-198. CrossRef Medline
28. Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García- Sastre A, Lee SW, Aaronson SA (2008) Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med 205:1929-1938. CrossRef Medline
29. Noriega LG, Feige JN, Canto C, Yamamoto H, Yu J, Herman MA, Mataki C, Kahn BB, Auwerx J (2011) CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep 12:1069-1076. CrossRef Medline
30. Ousman SS, Wang J, Campbell IL (2005) Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. J Virol 79:7514-7527. CrossRef Medline
31. Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317:516-519. CrossRef Medline
32. Paraíso AF, Mendes KL, Santos SH (2013) Brain activation of SIRT1: role in neuropathology. Mol Neurobiol 48:681-689. CrossRef Medline
33. Paun A, Pitha PM (2007) The IRF family, revisited. Biochimie 89:744-753. CrossRef Medline
34. Raz L, Zhang QG, Han D, Dong Y, De Sevilla L, Brann DW (2011) Acetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogen. PLoS One 6:e27039. CrossRef Medline
35. Savitz SI, Schäbitz WR (2008) A critique of SAINT II: wishful thinking, dashed hopes, and the future of neuroprotection for acute stroke. Stroke 39:1389-1391. CrossRef Medline
36. Schmued LC, Hopkins KJ (2000) Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874:123-130. CrossRef Medline
37. Takaoka A, Hayakawa S, Yanai H, Stoiber D, Negishi H, Kikuchi H, Sasaki S, Imai K, Shibue T, Honda K, Taniguchi T (2003) Integration of interferon- alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 424:516-523. CrossRef Medline
38. Tamura T, Yanai H, Savitsky D, Taniguchi T (2008) The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26: 535-584. CrossRef Medline
39. Taniguchi T, Takaoka A (2002) The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol 14:111-116. CrossRef Medline
40. Tsuno T, Mejido J, Zhao T, Schmeisser H, Morrow A, Zoon KC (2009) IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha. J Immunother 32:803-816. CrossRef Medline
41. Tymianski M (2011) Emerging mechanisms of disrupted cellular signaling in brain ischemia. Nat Neurosci 14:1369-1373. CrossRef Medline
42. Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM (2012) p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149:1536-1548. CrossRef Medline
43. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149-159. CrossRef Medline
44. Vosler PS, Chen J (2009) Potential molecular targets for translational stroke research. Stroke 40:S119-S120. CrossRef Medline
45. Wang L, Deng S, Lu Y, Zhang Y, Yang L, Guan Y, Jiang H, Li H (2012a) Increased inflammation and brain injury after transient focal cerebral ischemia in activating transcription factor 3 knockout mice. Neuroscience 220:100-108. CrossRef Medline
46. Wang L, Lu Y, Deng S, Zhang Y, Yang L, Guan Y, Matozaki T, Ohnishi H, Jiang H, Li H (2012b) SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress. J Neurochem 122:834-843. CrossRef Medline
47. Wang L, Lu Y, Guan H, Jiang D, Guan Y, Zhang X, Nakano H, Zhou Y, Zhang Y, Yang L, Li H (2013a) Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction. J Neurochem 126:400-414. CrossRef Medline
48. Wang L, Lu Y, Zhang X, Zhang Y, Jiang D, Dong X, Deng S, Yang L, Guan Y, Zhu L, Zhou Y, Zhang X, Li H (2013b) Mindin is a critical mediator of ischemic brain injury in an experimental stroke model. Exp Neurol 247: 506-516. CrossRef Medline
49. Wang P, Xu TY, Guan YF, Tian WW, Viollet B, Rui YC, Zhai QW, Su DF, Miao CY (2011) Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 69:360-374. CrossRef Medline
50. Wang XA, Zhang R, Jiang D, Deng W, Zhang S, Deng S, Zhong J, Wang T, Zhu LH, Yang L, Hong S, Guo S, Chen K, Zhang XF, She Z, Chen Y, Yang Q, Zhang XD, Li H (2013) Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice. Hepatology 58:603-616. CrossRef Medline
51. Xia CF, Smith RS Jr, Shen B, Yang ZR, Borlongan CV, Chao L, Chao J (2006) Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension 47:752-761. CrossRef Medline
52. Yanai H, Negishi H, Taniguchi T (2012) The IRF family of transcription factors: inception, impact and implications in oncogenesis. Oncoimmunology 1:1376-1386. CrossRef Medline
53. Yenari MA, Han HS (2012) Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci 13:267-278. CrossRef Medline
54. Zhou S, Chen HZ, Wan YZ, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC (2011) Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res 109:639-648. CrossRef Medline
55. Zhu HR, Wang ZY, Zhu XL, Wu XX, Li EG, Xu Y (2010) Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology 59:70-76. CrossRef Medline