Modeling stroke in mice - Middle cerebral artery occlusion with the filament model

Journal of Visualized Experiments

Volumn , Issue 47, 2010, Pages

  Engel, Odilo ^a   Kolodziej, Sabine ^a   Dirnagl, Ulrich ^a   Prinz, Vincent ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Animal model; Issue 47; MCAo; Medicine; Middle cerebral artery occlusion; Mouse; Stroke; Techniques

Indexed keywords

EID: 80053544728     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2423     Document Type: Article

References (41)

1. Dirnagl, U. & Members of the MCAO-SOP Group, Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse. Nature Precedings (Available online ) (2010).
2. Bederson, J.B. et al., Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 (3), 472-476 (1986).
3. Katchanov, J. et al., Selective neuronal vulnerability following mild focal brain ischemia in the mouse. Brain Pathol 13 (4), 452-464 (2003).
4. Dirnagl, U., Complexities, Confounders, and Challenges in Experimental Stroke Research: A checklist for researchers and reviewers in Rodent models of stroke, edited by U. Dirnagl (Springer, New York Dordrecht Heidelberg London, 2010), pp. 267.
5. Dirnagl, U., Kaplan, B., Jacewicz, M., & Pulsinelli, W., Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model. J Cereb Blood Flow Metab 9 (5), 589-596 (1989).
6. Wang, Y. et al., A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats. J Cereb Blood Flow Metab 28 (12), 1936-1950 (2008).
7. Lubjuhn, J. et al., Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery. J Neurosci Methods 184 (1), 95-103 (2009).
8. Jones, B.J. & Roberts, D.J., The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod. J Pharm Pharmacol 20 (4), 302-304 (1968).
9. Matsuura, K., Kabuto, H., Makino, H., & Ogawa, N., Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion. J Neurosci Methods 73 (1), 45-48 (1997).
10. Bouet, V. et al., Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Exp Neurol 203 (2), 555-567 (2007).
11. Freret, T. et al., Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat. Eur J Neurosci 23 (7), 1757-1765 (2006).
12. Modo, M. et al., Neurological sequelae and long-term behavioural assessment of rats with transient middle cerebral artery occlusion. J Neurosci Methods 104 (1), 99-109 (2000).
13. Montoya, C.P., Campbell-Hope, L.J., Pemberton, K.D., & Dunnett, S.B., The "staircase test": a measure of independent forelimb reaching and grasping abilities in rats. J Neurosci Methods 36 (2-3), 219-228 (1991).
14. Baird, A.L., Meldrum, A., & Dunnett, S.B., The staircase test of skilled reaching in mice. Brain Res Bull 54 (2), 243-250 (2001).
15. Metz, G.A. & Whishaw, I.Q., Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate foreand hindlimb stepping, placing, and co-ordination. J Neurosci Methods 115 (2), 169-179 (2002).
16. Farr, T.D., Liu, L., Colwell, K.L., Whishaw, I.Q., & Metz, G.A., Bilateral alteration in stepping pattern after unilateral motor cortex injury: a new test strategy for analysis of skilled limb movements in neurological mouse models. J Neurosci Methods 153 (1), 104-113 (2006).
17. Morris, R., Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11 (1), 47-60 (1984).
18. Koizumi, J., Yoshida, Y., Nakazawa, T., & Ooneda, G., Experimental studies of ischemic brain edema. I: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8, 1-8 (1986).
19. Longa, E.Z., Weinstein, P.R., Carlson, S., & Cummins, R., Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1), 84-91 (1989).
20. Endres, M. & Dirnagl, U., Neuroprotective Strategies in Animal and in vitro-Models of Neuronal Damage: Ischemia and Stroke in Molecular and Cellular Biology of Neuroprotection in the CNS, edited by Christian Alzheimer (Kluver Academic and Landes Bioscience, New York, 2003), Vol. 513, pp. 455-474.
21. Dirnagl, U., Iadecola, C., & Moskowitz, M.A., Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22 (9), 391-397 (1999).
22. Liu, S., Zhen, G., Meloni, B.P., Campbell, K., & Winn, H.R., Rodent Stroke Model Guidelines for Preclinical Stroke Trials (1st Edition). J Exp Stroke Transl Med 2 (2), 2-27 (2009).
23. Chen, Y., Ito, A., Takai, K., & Saito, N., Blocking pterygopalatine arterial blood flow decreases infarct volume variability in a mouse model of intraluminal suture middle cerebral artery occlusion. J Neurosci Methods 174 (1), 18-24 (2008).
24. Tsuchiya, D., Hong, S., Kayama, T., Panter, S.S., & Weinstein, P.R., Effect of suture size and carotid clip application upon blood flow and infarct volume after permanent and temporary middle cerebral artery occlusion in mice. Brain Res 970 (1-2), 131-139 (2003).
25. Beckmann, N., High resolution magnetic resonance angiography non-invasively reveals mouse strain differences in the cerebrovascular anatomy in vivo. Magn Reson Med 44 (2), 252-258 (2000).
26. Barone, F.C., Knudsen, D.J., Nelson, A.H., Feuerstein, G.Z., & Willette, R.N., Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J Cereb Blood Flow Metab 13 (4), 683-692 (1993).
27. Florian, B. et al., Long-term hypothermia reduces infarct volume in aged rats after focal ischemia. Neurosci Lett 438 (2), 180-185 (2008).
28. Noor, R., Wang, C.X., & Shuaib, A., Effects of hyperthermia on infarct volume in focal embolic model of cerebral ischemia in rats. Neurosci Lett 349 (2), 130-132 (2003).
29. Barber, P.A., Hoyte, L., Colbourne, F., & Buchan, A.M., Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomes. Stroke 35 (7), 1720-1725 (2004).
30. Shin, H.K. et al., Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia. Stroke 39 (5), 1548-1555 (2008).
31. Bottiger, B.W. et al., Global cerebral ischemia due to cardiocirculatory arrest in mice causes neuronal degeneration and early induction of transcription factor genes in the hippocampus. Brain Res Mol Brain Res 65 (2), 135-142 (1999).
32. Kapinya, K.J., Prass, K., & Dirnagl, U., Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism? Neuroreport 13 (11), 1431-1435 (2002).
33. Endres, M. et al., Mechanisms of stroke protection by physical activity. Ann Neurol 54 (5), 582-590 (2003).
34. Gertz, K. et al., Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res 99 (10), 1132-1140 (2006).
35. Richter, S.H., Garner, J.P., & Wurbel, H., Environmental standardization: cure or cause of poor reproducibility in animal experiments? Nat Methods 6 (4), 257-261 (2009).
36. Liesz, A. et al., The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation. Stroke 40 (8), 2849-2858 (2009).
37. Meisel, C., Schwab, J.M., Prass, K., Meisel, A., & Dirnagl, U., Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 6 (10), 775-786 (2005).
38. Engel, O. & Meisel, A., Models of Infection Before and After Stroke: Investigating New Targets. Infect Disord Drug Targets 9 (5) (2010).
39. Dirnagl, U., Bench to bedside: the quest for quality in experimental stroke research. J Cereb Blood Flow Metab 26 (12), 1465-1478 (2006).
40. Macleod, M.R. et al., Good laboratory practice: preventing introduction of bias at the bench. Stroke 40 (3), e50-52 (2009).
41. STAIR Group, Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30 (12), 2752-2758 (1999).