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Volumn 33, Issue 17, 2014, Pages 1960-1976

Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation

Author keywords

apoptosis; mitochondria; mitosis; mitotic slippage; the spindle checkpoint

Indexed keywords

CELL CYCLE PROTEIN 20; CYCLIN B1; DRP1 PROTEIN; MITOCHONDRIAL PROTEIN; PACLITAXEL; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN NOXA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84906834987     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201487826     Document Type: Article
Times cited : (35)

References (61)
  • 1
    • 28444487509 scopus 로고    scopus 로고
    • Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death
    • Arnoult D, Rismanchi N, Grodet A, Roberts RG, Seeburg DP, Estaquier J, Sheng M, Blackstone C, (2005) Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr Biol 15: 2112-2118
    • (2005) Curr Biol , vol.15 , pp. 2112-2118
    • Arnoult, D.1    Rismanchi, N.2    Grodet, A.3    Roberts, R.G.4    Seeburg, D.P.5    Estaquier, J.6    Sheng, M.7    Blackstone, C.8
  • 2
    • 33744996707 scopus 로고    scopus 로고
    • Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint
    • Brito DA, Rieder CL, (2006) Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol 16: 1194-1200
    • (2006) Curr Biol , vol.16 , pp. 1194-1200
    • Brito, D.A.1    Rieder, C.L.2
  • 3
    • 67749147567 scopus 로고    scopus 로고
    • The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells
    • Brito DA, Rieder CL, (2009) The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells. Cell Motil Cytoskeleton 66: 437-447
    • (2009) Cell Motil Cytoskeleton , vol.66 , pp. 437-447
    • Brito, D.A.1    Rieder, C.L.2
  • 7
    • 58149288060 scopus 로고    scopus 로고
    • Bim is reversibly phosphorylated but plays a limited role in paclitaxel cytotoxicity of breast cancer cell lines
    • Czernick M, Rieger A, Goping IS, (2009) Bim is reversibly phosphorylated but plays a limited role in paclitaxel cytotoxicity of breast cancer cell lines. Biochem Biophys Res Commun 379: 145-150
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 145-150
    • Czernick, M.1    Rieger, A.2    Goping, I.S.3
  • 8
    • 0036199862 scopus 로고    scopus 로고
    • Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex
    • Fang G, (2002) Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol Biol Cell 13: 755-766
    • (2002) Mol Biol Cell , vol.13 , pp. 755-766
    • Fang, G.1
  • 9
    • 0032525783 scopus 로고    scopus 로고
    • The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
    • Fang G, Yu H, Kirschner MW, (1998) The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev 12: 1871-1883
    • (1998) Genes Dev , vol.12 , pp. 1871-1883
    • Fang, G.1    Yu, H.2    Kirschner, M.W.3
  • 10
    • 84871530214 scopus 로고    scopus 로고
    • Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
    • Foley EA, Kapoor TM, (2013) Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore. Nat Rev Mol Cell Biol 14: 25-37
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 25-37
    • Foley, E.A.1    Kapoor, T.M.2
  • 11
    • 48449098623 scopus 로고    scopus 로고
    • Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
    • Gascoigne KE, Taylor SS, (2008) Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 14: 111-122
    • (2008) Cancer Cell , vol.14 , pp. 111-122
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 12
    • 69549120405 scopus 로고    scopus 로고
    • How do anti-mitotic drugs kill cancer cells?
    • Gascoigne KE, Taylor SS, (2009) How do anti-mitotic drugs kill cancer cells? J Cell Sci 122: 2579-2585
    • (2009) J Cell Sci , vol.122 , pp. 2579-2585
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 13
    • 0037011119 scopus 로고    scopus 로고
    • Identification of a MAD2-binding protein, CMT2, and its role in mitosis
    • Habu T, Kim SH, Weinstein J, Matsumoto T, (2002) Identification of a MAD2-binding protein, CMT2, and its role in mitosis. EMBO J 21: 6419-6428
    • (2002) EMBO J , vol.21 , pp. 6419-6428
    • Habu, T.1    Kim, S.H.2    Weinstein, J.3    Matsumoto, T.4
  • 15
    • 84891719259 scopus 로고    scopus 로고
    • Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20
    • Han JS, Holland AJ, Fachinetti D, Kulukian A, Cetin B, Cleveland DW, (2013) Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell 51: 92-104
    • (2013) Mol Cell , vol.51 , pp. 92-104
    • Han, J.S.1    Holland, A.J.2    Fachinetti, D.3    Kulukian, A.4    Cetin, B.5    Cleveland, D.W.6
  • 16
    • 77954884045 scopus 로고    scopus 로고
    • Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
    • Harley ME, Allan LA, Sanderson HS, Clarke PR, (2010) Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J 29: 2407-2420
    • (2010) EMBO J , vol.29 , pp. 2407-2420
    • Harley, M.E.1    Allan, L.A.2    Sanderson, H.S.3    Clarke, P.R.4
  • 17
    • 78650992174 scopus 로고    scopus 로고
    • Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest
    • Huang HC, Mitchison TJ, Shi J, (2010) Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest. PLoS ONE 5: e15724
    • (2010) PLoS ONE , vol.5
    • Huang, H.C.1    Mitchison, T.J.2    Shi, J.3
  • 18
    • 70349452101 scopus 로고    scopus 로고
    • Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly
    • Huang HC, Shi J, Orth JD, Mitchison TJ, (2009) Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell 16: 347-358
    • (2009) Cancer Cell , vol.16 , pp. 347-358
    • Huang, H.C.1    Shi, J.2    Orth, J.D.3    Mitchison, T.J.4
  • 19
    • 77950679687 scopus 로고    scopus 로고
    • Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs
    • Hubner NC, Wang LH, Kaulich M, Descombes P, Poser I, Nigg EA, (2010) Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs. Chromosoma 119: 149-165
    • (2010) Chromosoma , vol.119 , pp. 149-165
    • Hubner, N.C.1    Wang, L.H.2    Kaulich, M.3    Descombes, P.4    Poser, I.5    Nigg, E.A.6
  • 20
    • 36348971785 scopus 로고    scopus 로고
    • Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment
    • Janssen K, Pohlmann S, Janicke RU, Schulze-Osthoff K, Fischer U, (2007) Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood 110: 3662-3672
    • (2007) Blood , vol.110 , pp. 3662-3672
    • Janssen, K.1    Pohlmann, S.2    Janicke, R.U.3    Schulze-Osthoff, K.4    Fischer, U.5
  • 21
    • 84878156617 scopus 로고    scopus 로고
    • Tracking spindle checkpoint signals from kinetochores to APC/C
    • Jia L, Kim S, Yu H, (2013) Tracking spindle checkpoint signals from kinetochores to APC/C. Trends Biochem Sci 38: 302-311
    • (2013) Trends Biochem Sci , vol.38 , pp. 302-311
    • Jia, L.1    Kim, S.2    Yu, H.3
  • 23
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome C-mediated apoptosis
    • Jiang X, Wang X, (2004) Cytochrome C-mediated apoptosis. Annu Rev Biochem 73: 87-106
    • (2004) Annu Rev Biochem , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 24
    • 33747873322 scopus 로고    scopus 로고
    • A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
    • Jin J, Arias EE, Chen J, Harper JW, Walter JC, (2006) A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell 23: 709-721
    • (2006) Mol Cell , vol.23 , pp. 709-721
    • Jin, J.1    Arias, E.E.2    Chen, J.3    Harper, J.W.4    Walter, J.C.5
  • 25
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan MA, Wilson L, (2004) Microtubules as a target for anticancer drugs. Nat Rev Cancer 4: 253-265
    • (2004) Nat Rev Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 26
    • 77649191871 scopus 로고    scopus 로고
    • Microtubules and resistance to tubulin-binding agents
    • Kavallaris M, (2010) Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer 10: 194-204
    • (2010) Nat Rev Cancer , vol.10 , pp. 194-204
    • Kavallaris, M.1
  • 27
    • 80155198836 scopus 로고    scopus 로고
    • PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution
    • Ke Y, Huh JW, Warrington R, Li B, Wu N, Leng M, Zhang J, Ball HL, Li B, Yu H, (2011) PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution. EMBO J 30: 3309-3321
    • (2011) EMBO J , vol.30 , pp. 3309-3321
    • Ke, Y.1    Huh, J.W.2    Warrington, R.3    Li, B.4    Wu, N.5    Leng, M.6    Zhang, J.7    Ball, H.L.8    Li, B.9    Yu, H.10
  • 28
    • 58149466576 scopus 로고    scopus 로고
    • Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding
    • Kulukian A, Han JS, Cleveland DW, (2009) Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell 16: 105-117
    • (2009) Dev Cell , vol.16 , pp. 105-117
    • Kulukian, A.1    Han, J.S.2    Cleveland, D.W.3
  • 29
    • 54249093808 scopus 로고    scopus 로고
    • Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737
    • Kutuk O, Letai A, (2008) Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737. Cancer Res 68: 7985-7994
    • (2008) Cancer Res , vol.68 , pp. 7985-7994
    • Kutuk, O.1    Letai, A.2
  • 30
    • 77956710766 scopus 로고    scopus 로고
    • Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells
    • Kutuk O, Letai A, (2010) Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells. Cell Death Differ 17: 1624-1635
    • (2010) Cell Death Differ , vol.17 , pp. 1624-1635
    • Kutuk, O.1    Letai, A.2
  • 31
    • 84856905741 scopus 로고    scopus 로고
    • BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner
    • Lara-Gonzalez P, Scott MI, Diez M, Sen O, Taylor SS, (2011) BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. J Cell Sci 124: 4332-4345
    • (2011) J Cell Sci , vol.124 , pp. 4332-4345
    • Lara-Gonzalez, P.1    Scott, M.I.2    Diez, M.3    Sen, O.4    Taylor, S.S.5
  • 33
    • 0036731485 scopus 로고    scopus 로고
    • STATs: Transcriptional control and biological impact
    • Levy DE, Darnell JE Jr, (2002) STATs: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3: 651-662
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, Jr.J.E.2
  • 34
    • 14944349359 scopus 로고    scopus 로고
    • Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim
    • Li R, Moudgil T, Ross HJ, Hu HM, (2005) Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim. Cell Death Differ 12: 292-303
    • (2005) Cell Death Differ , vol.12 , pp. 292-303
    • Li, R.1    Moudgil, T.2    Ross, H.J.3    Hu, H.M.4
  • 35
    • 0036161468 scopus 로고    scopus 로고
    • The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20
    • Luo X, Tang Z, Rizo J, Yu H, (2002) The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell 9: 59-71
    • (2002) Mol Cell , vol.9 , pp. 59-71
    • Luo, X.1    Tang, Z.2    Rizo, J.3    Yu, H.4
  • 36
    • 55249120526 scopus 로고    scopus 로고
    • Protein metamorphosis: The two-state behavior of Mad2
    • Luo X, Yu H, (2008) Protein metamorphosis: the two-state behavior of Mad2. Structure 16: 1616-1625
    • (2008) Structure , vol.16 , pp. 1616-1625
    • Luo, X.1    Yu, H.2
  • 39
    • 36549050792 scopus 로고    scopus 로고
    • MAD contortions: Conformational dimerization boosts spindle checkpoint signaling
    • Mapelli M, Musacchio A, (2007) MAD contortions: conformational dimerization boosts spindle checkpoint signaling. Curr Opin Struct Biol 17: 716-725
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 716-725
    • Mapelli, M.1    Musacchio, A.2
  • 40
    • 77958569157 scopus 로고    scopus 로고
    • Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1
    • Mena AL, Lam EW, Chatterjee S, (2010) Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1. PLoS ONE 5: e13037
    • (2010) PLoS ONE , vol.5
    • Mena, A.L.1    Lam, E.W.2    Chatterjee, S.3
  • 41
    • 67749089562 scopus 로고    scopus 로고
    • A hyperfused mitochondrial state achieved at G1-S regulates cyclin e buildup and entry into S phase
    • Mitra K, Wunder C, Roysam B, Lin G, Lippincott-Schwartz J, (2009) A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase. Proc Natl Acad Sci USA 106: 11960-11965
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11960-11965
    • Mitra, K.1    Wunder, C.2    Roysam, B.3    Lin, G.4    Lippincott-Schwartz, J.5
  • 42
    • 84883781728 scopus 로고    scopus 로고
    • BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βtrCP1
    • Moustafa-Kamal M, Gamache I, Lu Y, Li S, Teodoro JG, (2013) BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1. Cell Death Differ 20: 1393-1403
    • (2013) Cell Death Differ , vol.20 , pp. 1393-1403
    • Moustafa-Kamal, M.1    Gamache, I.2    Lu, Y.3    Li, S.4    Teodoro, J.G.5
  • 43
    • 79959905130 scopus 로고    scopus 로고
    • Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics
    • Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ, (2011) Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res 71: 4608-4616
    • (2011) Cancer Res , vol.71 , pp. 4608-4616
    • Orth, J.D.1    Kohler, R.H.2    Foijer, F.3    Sorger, P.K.4    Weissleder, R.5    Mitchison, T.J.6
  • 44
    • 68149153007 scopus 로고    scopus 로고
    • Noxa: At the tip of the balance between life and death
    • Ploner C, Kofler R, Villunger A, (2008) Noxa: at the tip of the balance between life and death. Oncogene 27 (Suppl 1): S84-S92
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Ploner, C.1    Kofler, R.2    Villunger, A.3
  • 45
    • 84874694989 scopus 로고    scopus 로고
    • Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress
    • Qian W, Choi S, Gibson GA, Watkins SC, Bakkenist CJ, Van Houten B, (2012) Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress. J Cell Sci 125: 5745-5757
    • (2012) J Cell Sci , vol.125 , pp. 5745-5757
    • Qian, W.1    Choi, S.2    Gibson, G.A.3    Watkins, S.C.4    Bakkenist, C.J.5    Van Houten, B.6
  • 46
    • 34247355517 scopus 로고    scopus 로고
    • Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
    • Reddy SK, Rape M, Margansky WA, Kirschner MW, (2007) Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446: 921-925
    • (2007) Nature , vol.446 , pp. 921-925
    • Reddy, S.K.1    Rape, M.2    Margansky, W.A.3    Kirschner, M.W.4
  • 48
    • 0035802122 scopus 로고    scopus 로고
    • Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
    • Sudakin V, Chan GK, Yen TJ, (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol 154: 925-936
    • (2001) J Cell Biol , vol.154 , pp. 925-936
    • Sudakin, V.1    Chan, G.K.2    Yen, T.J.3
  • 49
    • 34249689057 scopus 로고    scopus 로고
    • Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
    • Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K, (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282: 11521-11529
    • (2007) J Biol Chem , vol.282 , pp. 11521-11529
    • Taguchi, N.1    Ishihara, N.2    Jofuku, A.3    Oka, T.4    Mihara, K.5
  • 53
    • 34248182897 scopus 로고    scopus 로고
    • Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
    • Wasiak S, Zunino R, McBride HM, (2007) Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol 177: 439-450
    • (2007) J Cell Biol , vol.177 , pp. 439-450
    • Wasiak, S.1    Zunino, R.2    McBride, H.M.3
  • 57
    • 84897976388 scopus 로고    scopus 로고
    • Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death
    • Westrate LM, Sayfie AD, Burgenske DM, MacKeigan JP, (2014) Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death. PLoS ONE 9: e91911
    • (2014) PLoS ONE , vol.9
    • Westrate, L.M.1    Sayfie, A.D.2    Burgenske, D.M.3    MacKeigan, J.P.4
  • 61
    • 77954378366 scopus 로고    scopus 로고
    • MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression
    • Zhou M, Liu Z, Zhao Y, Ding Y, Liu H, Xi Y, Xiong W, Li G, Lu J, Fodstad O, Riker AI, Tan M, (2010) MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem 285: 21496-21507
    • (2010) J Biol Chem , vol.285 , pp. 21496-21507
    • Zhou, M.1    Liu, Z.2    Zhao, Y.3    Ding, Y.4    Liu, H.5    Xi, Y.6    Xiong, W.7    Li, G.8    Lu, J.9    Fodstad, O.10    Riker, A.I.11    Tan, M.12


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