NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway

Cellular Physiology and Biochemistry

Volumn 27, Issue 6, 2011, Pages 681-690

  Zhuo, Li ^a   Fu, Bo ^a   Bai, Xueyuan ^a   Zhang, Bin ^a   Wu, Lingling ^a   Cui, Jing ^a   Cui, Shaoyuan ^a   Wei, Ribao ^a   Chen, Xiangmei ^a   Cai, Guangyan ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

AMPK; Mesangial hypertrophy; mTOR; NAD; Sirtuins

Indexed keywords

GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SIRTUIN; SIRTUIN 1; SIRTUIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; IN VITRO STUDY; KIDNEY HYPERTROPHY; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

RATTUS;

EID: 79959391159     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000330077     Document Type: Article

References (50)

1. Lehmann R, Schleicher ED: Molecular mechanism of diabetic nephropathy. Clin Chim Acta 2000;297:135-144. (Pubitemid 30332284)
2. Mason RM, Wahab NA: Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol 2003;14:1358-1373. (Pubitemid 36519197)
3. Wolf G, Ziyadeh FN: Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 1999;56:393-405. (Pubitemid 29353136)
4. Pillai JB, Isbatan A, Imai S, Gupta MP: Poly(adp-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by nad+ depletion and reduced sir2alpha deacetylase activity. J Biol Chem 2005;280:43121-43130. (Pubitemid 43049278)
5. Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J: Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 2007;100:1512-1521. (Pubitemid 46834764)
6. Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, Sueyasu K, Washida N, Tokuyama H, Tzukerman M, Skorecki K, Hayashi K, Itoh H: Kidney-specific overexpression of sirt1 protects against acute kidney injury by retaining peroxisome function. J Biol Chem 2010;285:13045-13056.
7. Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isono M, Isshiki K, Uzu T, Kashiwagi A, Koya D: Silent information regulator 2 (sirt1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radic Biol Med 2006;40:2175-2182. (Pubitemid 43903102)
8. Bao J, Lu Z, Joseph JJ, Carabenciov D, Dimond CC, Pang L, Samsel L, McCoy JP Jr, Leclerc J, Nguyen P, Gius D, Sack MN: Characterization of the murine sirt3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short sirt3 isoforms. J Cell Biochem 2010;110:238-247.
9. Shi T, Wang F, Stieren E, Tong Q: Sirt3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem 2005;280:13560-13567. (Pubitemid 40517248)
10. Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP: Sirt3 blocks the cardiac hypertrophic response by augmenting foxo3adependent antioxidant defense mechanisms in mice. J Clin Invest 2009;119:2758-2771.
11. Lin SJ, Ford E, Haigis M, Liszt G, Guarente L: Calorie restriction extends yeast life span by lowering the level of nadh. Genes Dev 2004;18:12-16. (Pubitemid 38090683)
12. Ying W, Wei G, Wang D, Wang Q, Tang X, Shi J, Zhang P, Lu H: Intranasal administration with nad+ profoundly decreases brain injury in a rat model of transient focal ischemia. Front Biosci 2007;12:2728-2734.
13. Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS, Huber LJ: Inhibition of sirt1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 2006;26:28-38.
14. Yitzhaki S, Barnea A, Keysary A, Zahavy E: New approach for serological testing for leptospirosis by using detection of leptospira agglutination by flow cytometry light scatter analysis. J Clin Microbiol 2004;42:1680-1685. (Pubitemid 38500816)
15. Nagai K, Matsubara T, Mima A, Sumi E, Kanamori H, Iehara N, Fukatsu A, Yanagita M, Nakano T, Ishimoto Y, Kita T, Doi T, Arai H: Gas6 induces akt/mtormediated mesangial hypertrophy in diabetic nephropathy. Kidney Int 2005;68:552-561. (Pubitemid 43323110)
16. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using realtime quantitative pcr and the 2(-delta delta c(t)) method. Methods 2001;25:402-408. (Pubitemid 34164012)
17. Ohtake K, Ishiyama Y, Uchida H, Muraki E, Kobayashi J: Dietary nitrite inhibits early glomerular injury in streptozotocin-induced diabetic nephropathy in rats. Nitric Oxide 2007;17:75-81. (Pubitemid 47259730)
18. Jaimes EA, Tian RX, Pearse D, Raij L: Up-regulation of glomerular cox-2 by angiotensin ii: Role of reactive oxygen species. Kidney Int 2005;68:2143-2153. (Pubitemid 43117788)
19. Shankland SJ, Wolf G: Cell cycle regulatory proteins in renal disease: Role in hypertrophy, proliferation, and apoptosis. Am J Physiol Renal Physiol 2000;278:F515-529. (Pubitemid 30215229)
20. Franch HA: Pathways of proteolysis affecting renal cell growth. Curr Opin Nephrol Hypertens 2002;11:445-450. (Pubitemid 34734625)
21. Wolf G, Sharma K, Chen Y, Ericksen M, Ziyadeh FN: High glucose-induced proliferation in mesangial cells is reversed by autocrine tgf-beta. Kidney Int 1992;42:647-656.
22. Young BA, Johnson RJ, Alpers CE, Eng E, Gordon K, Floege J, Couser WG, Seidel K: Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 1995;47:935-944.
23. Mahimainathan L, Das F, Venkatesan B, Choudhury GG: Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor pten. Diabetes 2006;55:2115-2125. (Pubitemid 44509987)
24. Viollet B, Andreelli F, Jorgensen SB, Perrin C, Flamez D, Mu J, Wojtaszewski JF, Schuit FC, Birnbaum M, Richter E, Burcelin R, Vaulont S: Physiological role of amp-activated protein kinase (ampk): Insights from knockout mouse models. Biochem Soc Trans 2003;31:216-219. (Pubitemid 36241431)
25. Hardie DG: The amp-activated protein kinase pathway-new players upstream and downstream. J Cell Sci 2004;117:5479-5487. (Pubitemid 40012195)
26. Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G: Mammalian tor: A homeostatic atp sensor. Science 2001;294:1102-1105. (Pubitemid 33041865)
27. Inoki K, Zhu T, Guan KL: Tsc2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-590. (Pubitemid 37506046)
28. Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR: Resveratrol inhibits cardiac hypertrophy via amp-activated protein kinase and akt. J Biol Chem 2008;283:24194-24201.
29. Cheng SW, Fryer LG, Carling D, Shepherd PR: Thr2446 is a novel mammalian target of rapamycin (mtor) phosphorylation site regulated by nutrient status. J Biol Chem 2004;279:15719-15722. (Pubitemid 38509255)
30. Pillai VB, Sundaresan NR, Kim G, Gupta M, Rajamohan SB, Pillai JB, Samant S, Ravindra PV, Isbatan A, Gupta MP: Exogenous nad blocks cardiac hypertrophic response via activation of the sirt3-lkb1-amp-activated kinase pathway. J Biol Chem 2010;285:3133-3144.
31. Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J: Ampk regulates energy expenditure by modulating nad+ metabolism and sirt1 activity. Nature 2009;458:1056-1060.
32. Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA: Nutrientsensitive mitochondrial nad+ levels dictate cell survival. Cell 2007;130:1095-1107. (Pubitemid 47410271)
33. Lan F, Cacicedo JM, Ruderman N, Ido Y: Sirt1 modulation of the acetylation status, cytosolic localization, and activity of lkb1. Possible role in amp-activated protein kinase activation. J Biol Chem 2008;283:27628-27635.
34. Lin JN, Lin VC, Rau KM, Shieh PC, Kuo DH, Shieh JC, Chen WJ, Tsai SC, Way TD: Resveratrol modulates tumor cell proliferation and protein translation via sirt1-dependent ampk activation. J Agric Food Chem 2010;58:1584-1592.
35. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M: Sirt1 regulates hepatocyte lipid metabolism through activating ampactivated protein kinase. J Biol Chem 2008;283:20015-20026.
36. Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V: Glucose restriction inhibits skeletal myoblast differentiation by activating sirt1 through ampk-mediated regulation of nampt. Dev Cell 2008;14:661-673. (Pubitemid 351622608)
37. Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y: Ampk and sirt1: A long-standing partnership? Am J Physiol Endocrinol Metab 2010;298:E751-760.
38. Carling D: The amp-activated protein kinase cascade-a unifying system for energy control. Trends Biochem Sci 2004;29:18-24. (Pubitemid 38068476)
39. Fraser S, Mount P, Hill R, Levidiotis V, Katsis F, Stapleton D, Kemp BE, Power DA: Regulation of the energy sensor amp-activated protein kinase in the kidney by dietary salt intake and osmolality. Am J Physiol Renal Physiol 2005;288:F578-586. (Pubitemid 40279465)
40. Hardie DG, Carling D, Carlson M: The amp-activated/snf1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu Rev Biochem 1998;67:821-855. (Pubitemid 28411146)
41. Merrill GF, Kurth EJ, Hardie DG, Winder WW: Aica riboside increases ampactivated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 1997;273:E1107-1112.
42. Zheng D, MacLean PS, Pohnert SC, Knight JB, Olson AL, Winder WW, Dohm GL: Regulation of muscle glut-4 transcription by amp-activated protein kinase. J Appl Physiol 2001;91:1073-1083. (Pubitemid 32803899)
43. Zhou M, Lin BZ, Coughlin S, Vallega G, Pilch PF: Ucp-3 expression in skeletal muscle: Effects of exercise, hypoxia, and amp-activated protein kinase. Am J Physiol Endocrinol Metab 2000;279:E622-629.
44. Bergeron R, Ren JM, Cadman KS, Moore IK, Perret P, Pypaert M, Young LH, Semenkovich CF, Shulman GI: Chronic activation of amp kinase results in nrf-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab 2001;281:E1340-1346.
45. Wullschleger S, Loewith R, Hall MN: Tor signaling in growth and metabolism. Cell 2006;124:471-484. (Pubitemid 43199434)
46. Zhuo L, Cai G, Liu F, Fu B, Liu W, Hong Q, Ma Q, Peng Y, Wang J, Chen X: Expression and mechanism of mammalian target of rapamycin in agerelated renal cell senescence and organ aging. Mech Ageing Dev 2009;130:700-708.
47. Bolster DR, Crozier SJ, Kimball SR, Jefferson LS: Amp-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mtor) signaling. J Biol Chem 2002;277:23977-23980. (Pubitemid 34951907)
48. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL: Tsc2 integrates wnt and energy signals via a coordinated phosphorylation by ampk and gsk3 to regulate cell growth. Cell 2006;126:955-968. (Pubitemid 44310775)
49. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ: Ampk phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008;30:214-226. (Pubitemid 351626684)
50. Lee MJ, Feliers D, Mariappan MM, Sataranatarajan K, Mahimainathan L, Musi N, Foretz M, Viollet B, Weinberg JM, Choudhury GG, Kasinath BS: A role for amp-activated protein kinase in diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol 2007;292:F617-627. (Pubitemid 46220529)