High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Mortuza, Rokhsana ^a   Chen, Shali ^a   Feng, Biao ^a   Sen, Subhrojit ^a   Chakrabarti, Subrata ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DNA; E1A ASSOCIATED P300 PROTEIN; GLUCOSE; LACTATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL DIVISION; CELL STRUCTURE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DNA BINDING; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; GLOMERULUS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY BLOOD VESSEL; MALE; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PROTEIN EXPRESSION; TISSUE INJURY;

CELL AGING; ENDOTHELIAL CELLS; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; P300-CBP TRANSCRIPTION FACTORS; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUINS;

ANIMALIA;

EID: 84872448285     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054514     Document Type: Article

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