Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus

American Journal of Physiology - Renal Physiology

Volumn 304, Issue 2, 2013, Pages

  Vallon, Volker ^a,b,c   Rose, Michael ^c   Gerasimova, Maria ^c   Satriano, Joseph ^a,c   Platt, Kenneth A ^d   Koepsell, Hermann ^e   Cunard, Robyn ^a,c   Sharma, Kumar ^a,c   Thomson, Scott C ^a,c   Rieg, Timo ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b San Diego   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d LEXICON PHARMACEUTICALS INC   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Diabetes; Diabetic nephropathy; Fibrosis; Glomerular hyperfiltration; Inflammation; Proximal tubule; Renal growth

Indexed keywords

COLLAGEN; CYCLINE; FIBRONECTIN; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; HEME OXYGENASE 1; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTEIN P27; PROTEIN P62; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SODIUM GLUCOSE COTRANSPORTER 2; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; FIBROSIS; GENE INACTIVATION; GENOTYPE; GLOMERULAR HYPERFILTRATION; GLOMERULUS FILTRATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HYPERGLYCEMIA; INFLAMMATION; KIDNEY DEVELOPMENT; KIDNEY INJURY; KIDNEY MASS; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES;

EID: 84872400230     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00409.2012     Document Type: Article

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