-
1
-
-
82755165443
-
Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche
-
Blagoev KB. Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche. Proc. Natl. Acad. Sci. USA 2011; 108: 1921 6-21.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, Issue.19
-
-
Blagoev, K.B.1
-
2
-
-
84655165043
-
Senescence: Tumorigenesis under surveillance
-
Burgess DJ. Senescence: Tumorigenesis under surveillance. Nat. Rev. Cancer 2011; 12: 6-7.
-
(2011)
Nat. Rev. Cancer
, vol.12
, pp. 6-7
-
-
Burgess, D.J.1
-
3
-
-
80053349458
-
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks
-
Wang M, Morsbach F, Sander D et al. EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks. Cancer Res. 2011; 71: 6261-9.
-
(2011)
Cancer Res.
, vol.71
, pp. 6261-6269
-
-
Wang, M.1
Morsbach, F.2
Sander, D.3
-
4
-
-
80054121212
-
Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence
-
Hovest MG, Krieg T, Herrmann G. Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence. Exp. Dermatol. 2011; 20: 883-9.
-
(2011)
Exp. Dermatol.
, vol.20
, pp. 883-889
-
-
Hovest, M.G.1
Krieg, T.2
Herrmann, G.3
-
5
-
-
77951157657
-
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
-
Kume S, Uzu T, Horiike K et al. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J. Clin. Invest. 2010; 120: 1043-55.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 1043-1055
-
-
Kume, S.1
Uzu, T.2
Horiike, K.3
-
6
-
-
81255201280
-
Glyoxalase I retards renal senescence
-
Ikeda Y, Inagi R, Miyata T et al. Glyoxalase I retards renal senescence. Am. J. Pathol. 2011; 179: 2810-21.
-
(2011)
Am. J. Pathol.
, vol.179
, pp. 2810-2821
-
-
Ikeda, Y.1
Inagi, R.2
Miyata, T.3
-
7
-
-
79954419399
-
Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals
-
Erol A. Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals. Cell Signal. 2011; 23: 1076-81.
-
(2011)
Cell Signal.
, vol.23
, pp. 1076-1081
-
-
Erol, A.1
-
8
-
-
80855138775
-
Clearance of p16 (Ink4a)-positive senescent cells delays ageing-associated disorders
-
Baker DJ, Wijshake T, Tchkonia T et al. Clearance of p16 (Ink4a)-positive senescent cells delays ageing-associated disorders. Nature 2011; 479: 232-6.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
-
9
-
-
80052410357
-
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
-
Villeda SA, Luo J, Mosher KI et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011; 477: 90-4.
-
(2011)
Nature
, vol.477
, pp. 90-94
-
-
Villeda, S.A.1
Luo, J.2
Mosher, K.I.3
-
11
-
-
79151486799
-
Renal epidermal growth factor receptor: Its role in sodium and water homeostasis in diabetic nephropathy
-
Panchapakesan U, Pollock C, Saad S. Renal epidermal growth factor receptor: Its role in sodium and water homeostasis in diabetic nephropathy. Clin. Exp. Pharmacol. Physiol. 2011; 38: 84-8.
-
(2011)
Clin. Exp. Pharmacol. Physiol.
, vol.38
, pp. 84-88
-
-
Panchapakesan, U.1
Pollock, C.2
Saad, S.3
-
12
-
-
0242542479
-
Regulation of renal proximal and distal tubule transport Sodium, chloride and organic anions
-
Dantzler WH. Regulation of renal proximal and distal tubule transport Sodium, chloride and organic anions. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2003; 136: 453-78.
-
(2003)
Comp. Biochem. Physiol. A Mol. Integr. Physiol.
, vol.136
, pp. 453-478
-
-
Dantzler, W.H.1
-
13
-
-
78651406659
-
SGLT 2 mediates glucose reabsorption in the early proximal tubule
-
Vallon V, Platt KA, Cunard R et al. SGLT 2 mediates glucose reabsorption in the early proximal tubule. J. Am. Soc. Nephrol. 2011; 22: 104-12.
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 104-112
-
-
Vallon, V.1
Platt, K.A.2
Cunard, R.3
-
16
-
-
34248148043
-
Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
-
Cunningham R, Brazie M, Kanumuru S et al. Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J. Am. Soc. Nephrol. 2007; 18: 1419-25.
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 1419-1425
-
-
Cunningham, R.1
Brazie, M.2
Kanumuru, S.3
-
17
-
-
78149299782
-
Cubilin is essential for albumin reabsorption in the renal proximal tubule
-
Amsellem S, Gburek J, Hamard G et al. Cubilin is essential for albumin reabsorption in the renal proximal tubule. J. Am. Soc. Nephrol. 2010; 21: 1859-67.
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 1859-1867
-
-
Amsellem, S.1
Gburek, J.2
Hamard, G.3
-
18
-
-
79958084119
-
Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2
-
Desmond MJ, Lee D, Fraser SA et al. Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2. Am. J. Physiol. Renal Physiol. 2011; 300: F1437-47.
-
(2011)
Am. J. Physiol. Renal Physiol.
, vol.300
-
-
Desmond, M.J.1
Lee, D.2
Fraser, S.A.3
-
19
-
-
79951587283
-
Aldosterone/mineralocorticoid receptor stimulation induces cellular senescence in the kidney
-
Fan YY, Kohno M, Hitomi H et al. Aldosterone/mineralocorticoid receptor stimulation induces cellular senescence in the kidney. Endocrinology 2011; 152: 680-8.
-
(2011)
Endocrinology
, vol.152
, pp. 680-688
-
-
Fan, Y.Y.1
Kohno, M.2
Hitomi, H.3
-
20
-
-
19944363481
-
Cardiac oxidative stress in acute and chronic isoproterenol-infused rats
-
Zhang GX, Kimura S, Nishiyama A et al. Cardiac oxidative stress in acute and chronic isoproterenol-infused rats. Cardiovasc. Res. 2005; 65: 230-8.
-
(2005)
Cardiovasc. Res.
, vol.65
, pp. 230-238
-
-
Zhang, G.X.1
Kimura, S.2
Nishiyama, A.3
-
21
-
-
78649951030
-
Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters
-
Maeda Y, Inoguchi T, Takei R et al. Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters. Am. J. Physiol. Renal Physiol. 2010; 299: F1328-38.
-
(2010)
Am. J. Physiol. Renal Physiol.
, vol.299
-
-
Maeda, Y.1
Inoguchi, T.2
Takei, R.3
-
22
-
-
84856371433
-
Collective and single cell behavior in epithelial contact inhibition
-
Puliafito A, Hufnagel L, Neveu P et al. Collective and single cell behavior in epithelial contact inhibition. Proc. Natl. Acad. Sci. USA 2012; 109: 739-44.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 739-744
-
-
Puliafito, A.1
Hufnagel, L.2
Neveu, P.3
-
23
-
-
79958847483
-
NF-kappaB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells
-
Crescenzi E, Pacifico F, Lavorgna A et al. NF-kappaB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells. Oncogene 2011; 30: 2707-17.
-
(2011)
Oncogene
, vol.30
, pp. 2707-2717
-
-
Crescenzi, E.1
Pacifico, F.2
Lavorgna, A.3
-
24
-
-
0033517302
-
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
-
Pitt B, Zannad F, Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N. Engl. J. Med. 1999; 341: 709-17.
-
(1999)
N. Engl. J. Med
, vol.341
, pp. 709-717
-
-
Pitt, B.1
Zannad, F.2
Remme, W.J.3
-
25
-
-
0037417252
-
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
-
Pitt B, Remme W, Zannad F et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N. Engl. J. Med. 2003; 348: 1309-21.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1309-1321
-
-
Pitt, B.1
Remme, W.2
Zannad, F.3
-
26
-
-
12144286297
-
Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats
-
Nishiyama A, Yao L, Nagai Y et al. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 2004; 43: 841-8.
-
(2004)
Hypertension
, vol.43
, pp. 841-848
-
-
Nishiyama, A.1
Yao, L.2
Nagai, Y.3
-
27
-
-
33646075100
-
Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesartan
-
Fan YY, Baba R, Nagai Y et al. Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesartan. Hypertens. Res. 2006; 29: 169-78.
-
(2006)
Hypertens. Res.
, vol.29
, pp. 169-178
-
-
Fan, Y.Y.1
Baba, R.2
Nagai, Y.3
-
28
-
-
0032875388
-
The lack of a functional p21 (WAF1/CIP1) gene ameliorates progression to chronic renal failure
-
Megyesi J, Price PM, Tamayo E, Safirstein RL. The lack of a functional p21 (WAF1/CIP1) gene ameliorates progression to chronic renal failure. Proc. Natl. Acad. Sci. USA 1999; 96: 10 830-5.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.10
, pp. 830-835
-
-
Megyesi, J.1
Price, P.M.2
Tamayo, E.3
Safirstein, R.L.4
-
29
-
-
0346786308
-
Living forever and dying in the attempt
-
Hayflick L. Living forever and dying in the attempt. Exp. Gerontol. 2003; 38: 1231-41.
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 1231-1241
-
-
Hayflick, L.1
-
30
-
-
54849382700
-
Vascular aging: Insights from studies on cellular senescence, stem cell aging, and progeroid syndromes
-
Minamino T, Komuro I. Vascular aging: Insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat. Clin. Pract. Cardiovasc. Med. 2008; 5: 637-48.
-
(2008)
Nat. Clin. Pract. Cardiovasc. Med.
, vol.5
, pp. 637-648
-
-
Minamino, T.1
Komuro, I.2
-
31
-
-
35348903872
-
Aldosterone promotes proximal tubular cell apoptosis: Role of oxidative stress
-
Patni H, Mathew JT, Luan L, Franki N, Chander PN, Singhal PC. Aldosterone promotes proximal tubular cell apoptosis: Role of oxidative stress. Am. J. Physiol. Renal. Physiol. 2007; 293: F1065-71.
-
(2007)
Am. J. Physiol. Renal. Physiol.
, vol.293
-
-
Patni, H.1
Mathew, J.T.2
Luan, L.3
Franki, N.4
Chander, P.N.5
Singhal, P.C.6
-
32
-
-
32944475760
-
Plasma osteopontin levels are higher in patients with primary aldosteronism than in patients with essential hypertension
-
Irita J, Okura T, Manabe S et al. Plasma osteopontin levels are higher in patients with primary aldosteronism than in patients with essential hypertension. Am. J. Hypertens. 2006; 19: 293-7.
-
(2006)
Am. J. Hypertens.
, vol.19
, pp. 293-297
-
-
Irita, J.1
Okura, T.2
Manabe, S.3
-
33
-
-
74949136547
-
Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha
-
Carvajal CA, Herrada AA, Castillo CR et al. Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha. J. Endocrinol. Invest. 2009; 32: 759-65.
-
(2009)
J. Endocrinol. Invest.
, vol.32
, pp. 759-765
-
-
Carvajal, C.A.1
Herrada, A.A.2
Castillo, C.R.3
-
34
-
-
63849327602
-
Outcome of renal transplantation from very old donors
-
Rigotti P, Ekser B, Furian L et al. Outcome of renal transplantation from very old donors. N. Engl. J. Med. 2009; 360: 1464-5.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1464-1465
-
-
Rigotti, P.1
Ekser, B.2
Furian, L.3
-
35
-
-
58049202919
-
Effects of donor age and cell senescence on kidney allograft survival
-
Melk A, Schmidt BM, Braun H et al. Effects of donor age and cell senescence on kidney allograft survival. Am. J. Transplant. 2009; 9: 114-23.
-
(2009)
Am. J. Transplant.
, vol.9
, pp. 114-123
-
-
Melk, A.1
Schmidt, B.M.2
Braun, H.3
-
36
-
-
84866000795
-
Cellular senescence limits regenerative capacity and allograft survival
-
Epub 12 July 2012; doi:10.1681/ASN.2011100967
-
Braun H, Schmidt BM, Raiss M et al. Cellular senescence limits regenerative capacity and allograft survival. J. Am. Soc. Nephrol. 2012; Epub 12 July 2012; doi:10.1681/ASN.2011100967
-
(2012)
J. Am. Soc. Nephrol.
-
-
Braun, H.1
Schmidt, B.M.2
Raiss, M.3
-
37
-
-
0037340592
-
Increased expression of P21 (WAF1/CIP1) CDKI gene in chronic allograft nephropathy correlating with the number of acute rejection episodes
-
Chkhotua AB, Altimari A, Gabusi E et al. Increased expression of P21 (WAF1/CIP1) CDKI gene in chronic allograft nephropathy correlating with the number of acute rejection episodes. Transplant. Proc. 2003; 35: 655-8.
-
(2003)
Transplant. Proc.
, vol.35
, pp. 655-658
-
-
Chkhotua, A.B.1
Altimari, A.2
Gabusi, E.3
-
38
-
-
0033104495
-
Apoptosis inhibitory activity of cytoplasmic p21 (Cip1/WAF1) in monocytic differentiation
-
Asada M, Yamada T, Ichijo H et al. Apoptosis inhibitory activity of cytoplasmic p21 (Cip1/WAF1) in monocytic differentiation. EMBO J. 1999; 18: 1223-34.
-
(1999)
EMBO J.
, vol.18
, pp. 1223-1234
-
-
Asada, M.1
Yamada, T.2
Ichijo, H.3
-
39
-
-
78649440078
-
Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival
-
Witko-Sarsat V, Mocek J, Bouayad D et al. Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. J. Exp. Med. 2010; 207: 2631-45.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2631-2645
-
-
Witko-Sarsat, V.1
Mocek, J.2
Bouayad, D.3
-
40
-
-
77957832584
-
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer
-
Koster R, di Pietro A, Timmer-Bosscha H et al. Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer. J. Clin. Invest. 2010; 120: 3594-605.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3594-3605
-
-
Koster, R.1
di, P.A.2
Timmer-Bosscha, H.3
|