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Volumn 220, Issue , 2014, Pages 497-512

Modulation of neurotrophin signaling by monoclonal antibodies

Author keywords

Arthritis pain; Bone pain; Chronic low back pain; Interstitial cystitis; NGF antagonists; Pain; Tanezumab

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN 4; PROTEIN TYROSINE KINASE A; TANEZUMAB;

EID: 84906568452     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-45106-5_19     Document Type: Article
Times cited : (12)

References (133)
  • 1
    • 0026579864 scopus 로고
    • Nerve growth factor in the synovial fluid of patients with chronic arthritis
    • Aloe L, Tuveri MA, Carcassi U, Levi-Montalcini R (1992a) Nerve growth factor in the synovial fluid of patients with chronic arthritis. Arthritis Rheum 35:351-355
    • (1992) Arthritis Rheum , vol.35 , pp. 351-355
    • Aloe, L.1    Tuveri, M.A.2    Carcassi, U.3    Levi-Montalcini, R.4
  • 2
    • 0026824480 scopus 로고
    • Nerve growth factor and distribution of mast cells in the synovium of adult rats
    • Aloe L, Tuveri MA, Levi-Montalcini R (1992b) Nerve growth factor and distribution of mast cells in the synovium of adult rats. Clin Exp Rheumatol 10:203-204
    • (1992) Clin Exp Rheumatol , vol.10 , pp. 203-204
    • Aloe, L.1    Tuveri, M.A.2    Levi-Montalcini, R.3
  • 3
    • 0027074150 scopus 로고
    • Studies on carrageenan-induced arthritis in adult rats: Presence of nerve growth factor and role of sympathetic innervation
    • Aloe L, Tuveri MA, Levi-Montalcini R (1992c) Studies on carrageenan-induced arthritis in adult rats: presence of nerve growth factor and role of sympathetic innervation. Rheumatol Int 12:213-216
    • (1992) Rheumatol Int , vol.12 , pp. 213-216
    • Aloe, L.1    Tuveri, M.A.2    Levi-Montalcini, R.3
  • 4
    • 0027227942 scopus 로고
    • The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor
    • Aloe L, Probert L, Kollias G, Bracci-Laudiero L, Spillantini MG, Levi-Montalcini R (1993) The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor. Growth Factors 9:149-155
    • (1993) Growth Factors , vol.9 , pp. 149-155
    • Aloe, L.1    Probert, L.2    Kollias, G.3    Bracci-Laudiero, L.4    Spillantini, M.G.5    Levi-Montalcini, R.6
  • 5
    • 0028863291 scopus 로고
    • The pharmacokinetics of subcutaneaously administered recombinant human ciliary neurotrophic factor (RHCNTF) in patients with amyotrophic lateral sclerosis: Relation to parameters of the acute-phase response
    • ALS CNTF Treatment Study (ACTS) Phase I-II Study Group (1995) The pharmacokinetics of subcutaneaously administered recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis: relation to parameters of the acute-phase response. Clin Neuropharmacol 18:500-514
    • (1995) Clin Neuropharmacol , vol.18 , pp. 500-514
  • 6
    • 28844508273 scopus 로고    scopus 로고
    • Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia
    • Banik RK, Subieta AR, Wu C, Brennan TJ (2005) Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia. Pain 117:68-76
    • (2005) Pain , vol.117 , pp. 68-76
    • Banik, R.K.1    Subieta, A.R.2    Wu, C.3    Brennan, T.J.4
  • 7
    • 0028090302 scopus 로고
    • The Trk family of neurotrophin receptors
    • Barbacid M (1994) The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403
    • (1994) J Neurobiol , vol.25 , pp. 1386-1403
    • Barbacid, M.1
  • 8
    • 0020338405 scopus 로고
    • Purification of a new neurotrophic factor from mammalian brain
    • Barde YA, Edgar D, Thoenen H (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J 1:549-553
    • (1982) EMBO J , vol.1 , pp. 549-553
    • Barde, Y.A.1    Edgar, D.2    Thoenen, H.3
  • 10
    • 66649122305 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control
    • Bariohay B, Roux J, Tardivel C, Trouslard J, Jean A, Lebrun B (2009) Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control. Endocrinology 150:2646-2653
    • (2009) Endocrinology , vol.150 , pp. 2646-2653
    • Bariohay, B.1    Roux, J.2    Tardivel, C.3    Trouslard, J.4    Jean, A.5    Lebrun, B.6
  • 11
    • 79851511400 scopus 로고    scopus 로고
    • Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration
    • Baydyuk M, Nguyen MT, Xu B (2011) Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration. Exp Neurol 228:118-125
    • (2011) Exp Neurol , vol.228 , pp. 118-125
    • Baydyuk, M.1    Nguyen, M.T.2    Xu, B.3
  • 15
    • 77952329581 scopus 로고    scopus 로고
    • Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse
    • Boado RJ, Hui EK, Lu JZ, Pardridge WM (2010) Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse. J Pharmacol Exp Ther 333:961-969
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 961-969
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Pardridge, W.M.4
  • 17
    • 31444434393 scopus 로고    scopus 로고
    • The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression
    • Chang Q, Khare G, Dani V, Nelson S, Jaenisch R (2006) The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49:341-348
    • (2006) Neuron , vol.49 , pp. 341-348
    • Chang, Q.1    Khare, G.2    Dani, V.3    Nelson, S.4    Jaenisch, R.5
  • 18
    • 0027942459 scopus 로고
    • The p75 neurotrophin receptor
    • Chao MV (1994) The p75 neurotrophin receptor. J Neurobiol 25:1373-1385
    • (1994) J Neurobiol , vol.25 , pp. 1373-1385
    • Chao, M.V.1
  • 19
    • 32644451922 scopus 로고    scopus 로고
    • Neurotrophin signalling in health and disease
    • Chao MV, Rajagopal R, Lee FS (2006) Neurotrophin signalling in health and disease. Clin Sci (Lond) 110:167-173
    • (2006) Clin Sci (Lond) , vol.110 , pp. 167-173
    • Chao, M.V.1    Rajagopal, R.2    Lee, F.S.3
  • 20
    • 28344437369 scopus 로고    scopus 로고
    • Autoimmune thrombocytopenia
    • Chong BH, Ho SJ (2005) Autoimmune thrombocytopenia. J Thromb Haemost 3:1763-1772
    • (2005) J Thromb Haemost , vol.3 , pp. 1763-1772
    • Chong, B.H.1    Ho, S.J.2
  • 21
    • 0001716873 scopus 로고
    • A nerve growth-stimulating factor isolated from snake venom
    • Cohen S, Levi-Montalcini R (1956) A nerve growth-stimulating factor isolated from snake venom. Proc Natl Acad Sci U S A 42:571-574
    • (1956) Proc Natl Acad Sci U S A , vol.42 , pp. 571-574
    • Cohen, S.1    Levi-Montalcini, R.2
  • 22
    • 0000050472 scopus 로고
    • A nerve growth-stimulating factor isolated from sarcom as 37 and 180
    • Cohen S, Levi-Montalcini R, Hamburger V (1954) A nerve growth-stimulating factor isolated from sarcom as 37 and 180. Proc Natl Acad Sci U S A 40:1014-1018
    • (1954) Proc Natl Acad Sci U S A , vol.40 , pp. 1014-1018
    • Cohen, S.1    Levi-Montalcini, R.2    Hamburger, V.3
  • 23
    • 0030759543 scopus 로고    scopus 로고
    • Neurotrophin regulation of the developing nervous system: Analyses of knockout mice
    • Conover JC, Yancopoulos GD (1997) Neurotrophin regulation of the developing nervous system: analyses of knockout mice. Rev Neurosci 8:13-27
    • (1997) Rev Neurosci , vol.8 , pp. 13-27
    • Conover, J.C.1    Yancopoulos, G.D.2
  • 24
    • 0029017970 scopus 로고
    • Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4
    • Conover JC, Erickson JT, Katz DM, Bianchi LM, Poueymirou WT et al (1995) Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature 375:235-238
    • (1995) Nature , vol.375 , pp. 235-238
    • Conover, J.C.1    Erickson, J.T.2    Katz, D.M.3    Bianchi, L.M.4    Poueymirou, W.T.5
  • 25
    • 77249134520 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system
    • Cordeira JW, Frank L, Sena-Esteves M, Pothos EN, Rios M (2010) Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system. J Neurosci 30:2533-2541
    • (2010) J Neurosci , vol.30 , pp. 2533-2541
    • Cordeira, J.W.1    Frank, L.2    Sena-Esteves, M.3    Pothos, E.N.4    Rios, M.5
  • 26
    • 0025768037 scopus 로고
    • The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
    • Cordon-Cardo C, Tapley P, Jing SQ, Nanduri V, O’Rourke E et al (1991) The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 66:173-183
    • (1991) Cell , vol.66 , pp. 173-183
    • Cordon-Cardo, C.1    Tapley, P.2    Jing, S.Q.3    Nanduri, V.4    O’rourke, E.5
  • 27
    • 0037044576 scopus 로고    scopus 로고
    • The neurotrophin receptor p75NTR as a positive modulator of myelination
    • Cosgaya JM, Chan JR, Shooter EM (2002) The neurotrophin receptor p75NTR as a positive modulator of myelination. Science 298:1245-1248
    • (2002) Science , vol.298 , pp. 1245-1248
    • Cosgaya, J.M.1    Chan, J.R.2    Shooter, E.M.3
  • 28
    • 0028297308 scopus 로고
    • Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
    • Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S et al (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1011
    • (1994) Cell , vol.76 , pp. 1001-1011
    • Crowley, C.1    Spencer, S.D.2    Nishimura, M.C.3    Chen, K.S.4    Pitts-Meek, S.5
  • 29
    • 0022508030 scopus 로고
    • The response of chick sensory neurons to brain-derived neurotrophic factor
    • Davies AM, Thoenen H, Barde YA (1986) The response of chick sensory neurons to brain-derived neurotrophic factor. J Neurosci 6:1897-1904
    • (1986) J Neurosci , vol.6 , pp. 1897-1904
    • Davies, A.M.1    Thoenen, H.2    Barde, Y.A.3
  • 30
    • 0027374072 scopus 로고
    • Neurotrophin-4/ 5 is a mammalian-specific survival factor for distinct populations of sensory neurons
    • Davies AM, Horton A, Burton LE, Schmelzer C, Vandlen R, Rosenthal A (1993) Neurotrophin-4/ 5 is a mammalian-specific survival factor for distinct populations of sensory neurons. J Neurosci 13:4961-4967
    • (1993) J Neurosci , vol.13 , pp. 4961-4967
    • Davies, A.M.1    Horton, A.2    Burton, L.E.3    Schmelzer, C.4    Vandlen, R.5    Rosenthal, A.6
  • 31
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A 98:8850-8855
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8850-8855
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 32
    • 0031562358 scopus 로고    scopus 로고
    • The role of nerve growth factor in a model of visceral inflammation
    • Dmitrieva N, Shelton D, Rice AS, McMahon SB (1997) The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78:449-459
    • (1997) Neuroscience , vol.78 , pp. 449-459
    • Dmitrieva, N.1    Shelton, D.2    Rice, A.S.3    McMahon, S.B.4
  • 33
    • 0037562083 scopus 로고    scopus 로고
    • Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brainderived neurotrophic factor
    • Duan W, Guo Z, Jiang H, Ware M, Mattson MP (2003) Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brainderived neurotrophic factor. Endocrinology 144:2446-2453
    • (2003) Endocrinology , vol.144 , pp. 2446-2453
    • Duan, W.1    Guo, Z.2    Jiang, H.3    Ware, M.4    Mattson, M.P.5
  • 34
    • 0031020724 scopus 로고    scopus 로고
    • Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans
    • Dyck PJ, Peroutka S, Rask C, Burton E, Baker MK et al (1997) Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans. Neurology 48:501-505
    • (1997) Neurology , vol.48 , pp. 501-505
    • Dyck, P.J.1    Peroutka, S.2    Rask, C.3    Burton, E.4    Baker, M.K.5
  • 35
    • 0029827692 scopus 로고    scopus 로고
    • Mice lacking brainderived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing
    • Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M et al (1996) Mice lacking brainderived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. J Neurosci 16:5361-5371
    • (1996) J Neurosci , vol.16 , pp. 5361-5371
    • Erickson, J.T.1    Conover, J.C.2    Borday, V.3    Champagnat, J.4    Barbacid, M.5
  • 36
    • 0030831604 scopus 로고    scopus 로고
    • Identification of genes differentially expressed by nerve growth factor- and neurotrophin-3-dependent sensory neurons
    • Friedel RH, Schnurch H, Stubbusch J, Barde YA (1997) Identification of genes differentially expressed by nerve growth factor- and neurotrophin-3-dependent sensory neurons. Proc Natl Acad Sci U S A 94:12670-12675
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 12670-12675
    • Friedel, R.H.1    Schnurch, H.2    Stubbusch, J.3    Barde, Y.A.4
  • 37
    • 19244385562 scopus 로고    scopus 로고
    • Nerve growth factor and its highaffinity receptor in chronic pancreatitis
    • Friess H, Zhu ZW, di Mola FF, Kulli C, Graber HU et al (1999) Nerve growth factor and its highaffinity receptor in chronic pancreatitis. Ann Surg 230:615-624
    • (1999) Ann Surg , vol.230 , pp. 615-624
    • Friess, H.1    Zhu, Z.W.2    Di Mola, F.F.3    Kulli, C.4    Graber, H.U.5
  • 38
    • 1942457251 scopus 로고    scopus 로고
    • Erythropoietin gene therapy leads to autoimmune anemia in macaques
    • Gao G, Lebherz C, Weiner DJ, Grant R, Calcedo R et al (2004) Erythropoietin gene therapy leads to autoimmune anemia in macaques. Blood 103:3300-3302
    • (2004) Blood , vol.103 , pp. 3300-3302
    • Gao, G.1    Lebherz, C.2    Weiner, D.J.3    Grant, R.4    Calcedo, R.5
  • 39
    • 79960081481 scopus 로고    scopus 로고
    • Fate of novel painkiller mAbs hangs in balance
    • Garber K (2011) Fate of novel painkiller mAbs hangs in balance. Nat Biotechnol 29:173-174
    • (2011) Nat Biotechnol , vol.29 , pp. 173-174
    • Garber, K.1
  • 40
    • 78649756871 scopus 로고    scopus 로고
    • Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain
    • Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP et al (2010) Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. Mol Pain 6:87
    • (2010) Mol Pain , vol.6
    • Ghilardi, J.R.1    Freeman, K.T.2    Jimenez-Andrade, J.M.3    Mantyh, W.G.4    Bloom, A.P.5
  • 41
    • 78650983503 scopus 로고    scopus 로고
    • Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers
    • Ghilardi JR, Freeman KT, Jimenez-Andrade JM, Mantyh WG, Bloom AP et al (2011) Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers. Bone 48(2):389-398
    • (2011) Bone , vol.48 , Issue.2 , pp. 389-398
    • Ghilardi, J.R.1    Freeman, K.T.2    Jimenez-Andrade, J.M.3    Mantyh, W.G.4    Bloom, A.P.5
  • 42
    • 0018951680 scopus 로고
    • Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: An experimental autoimmune approach
    • Gorin PD, Johnson EM Jr (1980) Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: an experimental autoimmune approach. Brain Res 198:27-42
    • (1980) Brain Res , vol.198 , pp. 27-42
    • Gorin, P.D.1    Johnson, E.M.2
  • 43
    • 33846613209 scopus 로고    scopus 로고
    • Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity
    • Gray J, Yeo G, Hung C, Keogh J, Clayton P et al (2007) Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. Int J Obes (Lond) 31:359-364
    • (2007) Int J Obes (Lond) , vol.31 , pp. 359-364
    • Gray, J.1    Yeo, G.2    Hung, C.3    Keogh, J.4    Clayton, P.5
  • 44
    • 27144433512 scopus 로고    scopus 로고
    • A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone
    • Halvorson KG, Kubota K, Sevcik MA, Lindsay TH, Sotillo JE et al (2005) A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone. Cancer Res 65:9426-9435
    • (2005) Cancer Res , vol.65 , pp. 9426-9435
    • Halvorson, K.G.1    Kubota, K.2    Sevcik, M.A.3    Lindsay, T.H.4    Sotillo, J.E.5
  • 45
    • 50449091665 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and obesity in the WAGR syndrome
    • Han JC, Liu QR, Jones M, Levinn RL, Menzie CM et al (2008) Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med 359:918-927
    • (2008) N Engl J Med , vol.359 , pp. 918-927
    • Han, J.C.1    Liu, Q.R.2    Jones, M.3    Levinn, R.L.4    Menzie, C.M.5
  • 46
    • 77954947327 scopus 로고    scopus 로고
    • Lower brain-derived neurotrophic factor in patients with Prader-Willi syndrome compared to obese and lean control subjects
    • Han JC, Muehlbauer MJ, Cui HN, Newgard CB, Haqq AM (2010) Lower brain-derived neurotrophic factor in patients with Prader-Willi syndrome compared to obese and lean control subjects. J Clin Endocrinol Metab 95:3532-3536
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3532-3536
    • Han, J.C.1    Muehlbauer, M.J.2    Cui, H.N.3    Newgard, C.B.4    Haqq, A.M.5
  • 47
    • 0037243828 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor modulates glucagon secretion from pancreatic alpha cells: Its contribution to glucose metabolism
    • Hanyu O, Yamatani K, Ikarashi T, Soda S, Maruyama S et al (2003) Brain-derived neurotrophic factor modulates glucagon secretion from pancreatic alpha cells: its contribution to glucose metabolism. Diabetes Obes Metab 5:27-37
    • (2003) Diabetes Obes Metab , vol.5 , pp. 27-37
    • Hanyu, O.1    Yamatani, K.2    Ikarashi, T.3    Soda, S.4    Maruyama, S.5
  • 48
    • 0027318116 scopus 로고
    • Neurotrophins promote motor neuron survival and are present in embryonic limb bud
    • Henderson CE, Camu W, Mettling C, Gouin A, Poulsen K et al (1993) Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363:266-270
    • (1993) Nature , vol.363 , pp. 266-270
    • Henderson, C.E.1    Camu, W.2    Mettling, C.3    Gouin, A.4    Poulsen, K.5
  • 49
    • 0025317838 scopus 로고
    • Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
    • Hohn A, Leibrock J, Bailey K, Barde YA (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344:339-341
    • (1990) Nature , vol.344 , pp. 339-341
    • Hohn, A.1    Leibrock, J.2    Bailey, K.3    Barde, Y.A.4
  • 50
    • 37549031788 scopus 로고    scopus 로고
    • Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (R-metHuGDNF) in rhesus monkeys
    • Hovland DN Jr, Boyd RB, Butt MT, Engelhardt JA, Moxness MS et al (2007) Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) in rhesus monkeys. Toxicol Pathol 35:676-692
    • (2007) Toxicol Pathol , vol.35 , pp. 676-692
    • Hovland, D.N.1    Boyd, R.B.2    Butt, M.T.3    Engelhardt, J.A.4    Moxness, M.S.5
  • 51
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: Roles in neuronal development and function
    • Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 52
    • 0025876757 scopus 로고
    • BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
    • Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD et al (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350:230-232
    • (1991) Nature , vol.350 , pp. 230-232
    • Hyman, C.1    Hofer, M.2    Barde, Y.A.3    Juhasz, M.4    Yancopoulos, G.D.5
  • 53
    • 0028127755 scopus 로고
    • Neurotrophin- 4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures
    • Hynes MA, Poulsen K, Armanini M, Berkemeier L, Phillips H, Rosenthal A (1994) Neurotrophin- 4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. J Neurosci Res 37:144-154
    • (1994) J Neurosci Res , vol.37 , pp. 144-154
    • Hynes, M.A.1    Poulsen, K.2    Armanini, M.3    Berkemeier, L.4    Phillips, H.5    Rosenthal, A.6
  • 54
    • 0027189812 scopus 로고
    • Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion
    • Ibanez CF, Ernfors P, Timmusk T, Ip NY, Arenas E et al (1993) Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion. Development 117:1345-1353
    • (1993) Development , vol.117 , pp. 1345-1353
    • Ibanez, C.F.1    Ernfors, P.2    Timmusk, T.3    Ip, N.Y.4    Arenas, E.5
  • 55
    • 0027528768 scopus 로고
    • Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells
    • Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ et al (1993) Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10:137-149
    • (1993) Neuron , vol.10 , pp. 137-149
    • Ip, N.Y.1    Stitt, T.N.2    Tapley, P.3    Klein, R.4    Glass, D.J.5
  • 56
    • 36248975322 scopus 로고    scopus 로고
    • Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture
    • Jimenez-Andrade JM, Martin CD, Koewler NJ, Freeman KT, Sullivan LJ et al (2007) Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture. Pain 133:183-196
    • (2007) Pain , vol.133 , pp. 183-196
    • Jimenez-Andrade, J.M.1    Martin, C.D.2    Koewler, N.J.3    Freeman, K.T.4    Sullivan, L.J.5
  • 57
    • 78049509543 scopus 로고    scopus 로고
    • Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain
    • Jimenez-Andrade JM, Bloom AP, Stake JI, Mantyh WG, Taylor RN et al (2010) Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. J Neurosci 30:14649-14656
    • (2010) J Neurosci , vol.30 , pp. 14649-14656
    • Jimenez-Andrade, J.M.1    Bloom, A.P.2    Stake, J.I.3    Mantyh, W.G.4    Taylor, R.N.5
  • 58
    • 0021883927 scopus 로고
    • Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival
    • Johnson EM Jr, Yip HK (1985) Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival. Nature 314:751-752
    • (1985) Nature , vol.314 , pp. 751-752
    • Johnson, E.M.1    Yip, H.K.2
  • 59
    • 0019161427 scopus 로고
    • Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor
    • Johnson EM Jr, Gorin PD, Brandeis LD, Pearson J (1980) Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor. Science 210:916-918
    • (1980) Science , vol.210 , pp. 916-918
    • Johnson, E.M.1    Gorin, P.D.2    Brandeis, L.D.3    Pearson, J.4
  • 60
    • 0023428978 scopus 로고
    • In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells
    • Kalcheim C, Barde YA, Thoenen H, Le Douarin NM (1987) In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells. EMBO J 6:2871-2873
    • (1987) EMBO J , vol.6 , pp. 2871-2873
    • Kalcheim, C.1    Barde, Y.A.2    Thoenen, H.3    Le Douarin, N.M.4
  • 61
    • 0026570535 scopus 로고
    • Neurotrophin 3 is a mitogen for cultured neural crest cells
    • Kalcheim C, Carmeli C, Rosenthal A (1992) Neurotrophin 3 is a mitogen for cultured neural crest cells. Proc Natl Acad Sci U S A 89:1661-1665
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1661-1665
    • Kalcheim, C.1    Carmeli, C.2    Rosenthal, A.3
  • 62
    • 2442702838 scopus 로고    scopus 로고
    • AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease
    • Kells AP, Fong DM, Dragunow M, During MJ, Young D, Connor B (2004) AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease. Mol Ther 9:682-688
    • (2004) Mol Ther , vol.9 , pp. 682-688
    • Kells, A.P.1    Fong, D.M.2    Dragunow, M.3    During, M.J.4    Young, D.5    Connor, B.6
  • 63
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie SG, Liebl DJ, Parada LF (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19:1290-1300
    • (2000) EMBO J , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 64
    • 0025857391 scopus 로고
    • The trk proto-oncogene encodes a receptor for nerve growth factor
    • Klein R, Jing SQ, Nanduri V, O’Rourke E, Barbacid M (1991a) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189-197
    • (1991) Cell , vol.65 , pp. 189-197
    • Klein, R.1    Jing, S.Q.2    Nanduri, V.3    O’rourke, E.4    Barbacid, M.5
  • 65
    • 0025873435 scopus 로고
    • The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
    • Klein R, Nanduri V, Jing SA, Lamballe F, Tapley P et al (1991b) The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66:395-403
    • (1991) Cell , vol.66 , pp. 395-403
    • Klein, R.1    Nanduri, V.2    Jing, S.A.3    Lamballe, F.4    Tapley, P.5
  • 66
    • 0026703471 scopus 로고
    • The trkB tyrosine protein kinase is a receptor for neurotrophin-4
    • Klein R, Lamballe F, Bryant S, Barbacid M (1992) The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 8:947-956
    • (1992) Neuron , vol.8 , pp. 947-956
    • Klein, R.1    Lamballe, F.2    Bryant, S.3    Barbacid, M.4
  • 67
    • 77951014800 scopus 로고    scopus 로고
    • Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice
    • Kline DD, Ogier M, Kunze DL, Katz DM (2010) Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice. J Neurosci 30:5303-5310
    • (2010) J Neurosci , vol.30 , pp. 5303-5310
    • Kline, D.D.1    Ogier, M.2    Kunze, D.L.3    Katz, D.M.4
  • 68
    • 0026574673 scopus 로고
    • Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
    • Knusel B, Beck KD, Winslow JW, Rosenthal A, Burton LE et al (1992) Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J Neurosci 12:4391-4402
    • (1992) J Neurosci , vol.12 , pp. 4391-4402
    • Knusel, B.1    Beck, K.D.2    Winslow, J.W.3    Rosenthal, A.4    Burton, L.E.5
  • 69
    • 38449103747 scopus 로고    scopus 로고
    • Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur
    • Koewler NJ, Freeman KT, Buus RJ, Herrera MB, Jimenez-Andrade JM et al (2007) Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur. J Bone Miner Res 22:1732-1742
    • (2007) J Bone Miner Res , vol.22 , pp. 1732-1742
    • Koewler, N.J.1    Freeman, K.T.2    Buus, R.J.3    Herrera, M.B.4    Jimenez-Andrade, J.M.5
  • 71
    • 0025944524 scopus 로고
    • TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
    • Lamballe F, Klein R, Barbacid M (1991) trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66:967-979
    • (1991) Cell , vol.66 , pp. 967-979
    • Lamballe, F.1    Klein, R.2    Barbacid, M.3
  • 73
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    • Lang AE, Gill S, Patel NK, Lozano A, Nutt JG et al (2006) Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol 59:459-466
    • (2006) Ann Neurol , vol.59 , pp. 459-466
    • Lang, A.E.1    Gill, S.2    Patel, N.K.3    Lozano, A.4    Nutt, J.G.5
  • 74
    • 0001564728 scopus 로고
    • Growth control of nerve cells by a protein factor and its antiserum: Discovery of this factor may provide new leads to understanding of some neurogenetic processes
    • Levi-Montalcini R (1964) Growth control of nerve cells by a protein factor and its antiserum: discovery of this factor may provide new leads to understanding of some neurogenetic processes. Science 143:105-110
    • (1964) Science , vol.143 , pp. 105-110
    • Levi-Montalcini, R.1
  • 75
    • 0010537251 scopus 로고
    • Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles
    • Levi-Montalcini R, Aloe L (1985) Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles. Proc Natl Acad Sci U S A 82:7111-7115
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 7111-7115
    • Levi-Montalcini, R.1    Aloe, L.2
  • 76
    • 76549235314 scopus 로고
    • Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo
    • Levi-Montalcini R, Hamburger V (1951) Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp Zool 116:321-361
    • (1951) J Exp Zool , vol.116 , pp. 321-361
    • Levi-Montalcini, R.1    Hamburger, V.2
  • 77
    • 0027184399 scopus 로고
    • Nerve growth factor and nociception
    • Lewin GR, Mendell LM (1993) Nerve growth factor and nociception. Trends Neurosci 16:353-359
    • (1993) Trends Neurosci , vol.16 , pp. 353-359
    • Lewin, G.R.1    Mendell, L.M.2
  • 78
    • 0027406813 scopus 로고
    • Nerve growth factor-induced hyperalgesia in the neonatal and adult rat
    • Lewin GR, Ritter AM, Mendell LM (1993) Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci 13:2136-2148
    • (1993) J Neurosci , vol.13 , pp. 2136-2148
    • Lewin, G.R.1    Ritter, A.M.2    Mendell, L.M.3
  • 79
    • 44849115778 scopus 로고    scopus 로고
    • Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates
    • Lin JC, Tsao D, Barras P, Bastarrachea RA, Boyd B et al (2008) Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates. PLoS One 3:e1900
    • (2008) Plos One , vol.3
    • Lin, J.C.1    Tsao, D.2    Barras, P.3    Bastarrachea, R.A.4    Boyd, B.5
  • 80
    • 0024503489 scopus 로고
    • Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons
    • Lindsay RM, Harmar AJ (1989) Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 337:362-364
    • (1989) Nature , vol.337 , pp. 362-364
    • Lindsay, R.M.1    Harmar, A.J.2
  • 81
    • 0022404075 scopus 로고
    • Differences and similarities in the neurotrophic growth factor requirements of sensory neurons derived from neural crest and neural placode
    • Lindsay RM, Barde YA, Davies AM, Rohrer H (1985) Differences and similarities in the neurotrophic growth factor requirements of sensory neurons derived from neural crest and neural placode. J Cell Sci Suppl 3:115-129
    • (1985) J Cell Sci , vol.3 , pp. 115-129
    • Lindsay, R.M.1    Barde, Y.A.2    Davies, A.M.3    Rohrer, H.4
  • 82
    • 0029014099 scopus 로고
    • Sensory but not motor neuron deficits in mice lacking NT4 and BDNF
    • Liu X, Ernfors P, Wu H, Jaenisch R (1995) Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 375:238-241
    • (1995) Nature , vol.375 , pp. 238-241
    • Liu, X.1    Ernfors, P.2    Wu, H.3    Jaenisch, R.4
  • 83
    • 0031397783 scopus 로고    scopus 로고
    • Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis
    • Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV, Osborne JL (1997) Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. Br J Urol 79:572-577
    • (1997) Br J Urol , vol.79 , pp. 572-577
    • Lowe, E.M.1    Anand, P.2    Terenghi, G.3    Williams-Chestnut, R.E.4    Sinicropi, D.V.5    Osborne, J.L.6
  • 84
    • 65649134290 scopus 로고    scopus 로고
    • P75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents
    • Luther JA, Birren SJ (2009) p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents. J Neurosci 29:5411-5424
    • (2009) J Neurosci , vol.29 , pp. 5411-5424
    • Luther, J.A.1    Birren, S.J.2
  • 85
    • 0033592920 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    • Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW et al (1999) Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A 96:15239-15244
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 15239-15244
    • Lyons, W.E.1    Mamounas, L.A.2    Ricaurte, G.A.3    Coppola, V.4    Reid, S.W.5
  • 87
    • 78149280765 scopus 로고    scopus 로고
    • Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain
    • Mantyh WG, Jimenez-Andrade JM, Stake JI, Bloom AP, Kaczmarska MJ et al (2010) Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain. Neuroscience 171:588-598
    • (2010) Neuroscience , vol.171 , pp. 588-598
    • Mantyh, W.G.1    Jimenez-Andrade, J.M.2    Stake, J.I.3    Bloom, A.P.4    Kaczmarska, M.J.5
  • 88
    • 77951855933 scopus 로고    scopus 로고
    • Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
    • Massa SM, Yang T, Xie Y, Shi J, Bilgen M et al (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest 120:1774-1785
    • (2010) J Clin Invest , vol.120 , pp. 1774-1785
    • Massa, S.M.1    Yang, T.2    Xie, Y.3    Shi, J.4    Bilgen, M.5
  • 89
    • 0029085192 scopus 로고
    • The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
    • McMahon SB, Bennett DL, Priestley JV, Shelton DL (1995) The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule. Nat Med 1:774-780
    • (1995) Nat Med , vol.1 , pp. 774-780
    • McMahon, S.B.1    Bennett, D.L.2    Priestley, J.V.3    Shelton, D.L.4
  • 90
    • 33644850095 scopus 로고    scopus 로고
    • Adenoviral gene transfer of BDNF and GDNF synergistically prevent motoneuron loss in the nucleus ambiguus
    • Moro K, Shiotani A, Watabe K, Takeda Y, Saito K et al (2006) Adenoviral gene transfer of BDNF and GDNF synergistically prevent motoneuron loss in the nucleus ambiguus. Brain Res 1076:1-8
    • (2006) Brain Res , vol.1076 , pp. 1-8
    • Moro, K.1    Shiotani, A.2    Watabe, K.3    Takeda, Y.4    Saito, K.5
  • 91
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer’s disease
    • Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE et al (2009) Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer’s disease. Nat Med 15:331-337
    • (2009) Nat Med , vol.15 , pp. 331-337
    • Nagahara, A.H.1    Merrill, D.A.2    Coppola, G.3    Tsukada, S.4    Schroeder, B.E.5
  • 92
    • 18144435678 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice
    • Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M et al (2000) Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 49:436-444
    • (2000) Diabetes , vol.49 , pp. 436-444
    • Nakagawa, T.1    Tsuchida, A.2    Itakura, Y.3    Nonomura, T.4    Ono, M.5
  • 93
    • 77952746932 scopus 로고    scopus 로고
    • Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/ FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    • Ng MC, Tam CH, So WY, Ho JS, Chan AW et al (2010) Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/ FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 95:2418-2425
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2418-2425
    • Ng, M.C.1    Tam, C.H.2    So, W.Y.3    Ho, J.S.4    Chan, A.W.5
  • 94
    • 0034008090 scopus 로고    scopus 로고
    • Tissue disposition and pharmacokinetics of recombinant human nerve growth factor after acute and chronic subcutaneous administration in monkeys
    • Nguyen CB, Harris L, Szonyi E, Baughman SA, Hale VG et al (2000) Tissue disposition and pharmacokinetics of recombinant human nerve growth factor after acute and chronic subcutaneous administration in monkeys. Drug Metab Dispos 28:598-607
    • (2000) Drug Metab Dispos , vol.28 , pp. 598-607
    • Nguyen, C.B.1    Harris, L.2    Szonyi, E.3    Baughman, S.A.4    Hale, V.G.5
  • 95
    • 36248944567 scopus 로고    scopus 로고
    • Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function
    • Nicholson JR, Peter JC, Lecourt AC, Barde YA, Hofbauer KG (2007) Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function. J Neuroendocrinol 19:974-982
    • (2007) J Neuroendocrinol , vol.19 , pp. 974-982
    • Nicholson, J.R.1    Peter, J.C.2    Lecourt, A.C.3    Barde, Y.A.4    Hofbauer, K.G.5
  • 96
    • 0031577526 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice
    • Ono M, Ichihara J, Nonomura T, Itakura Y, Taiji M et al (1997) Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238:633-637
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 633-637
    • Ono, M.1    Ichihara, J.2    Nonomura, T.3    Itakura, Y.4    Taiji, M.5
  • 97
    • 0033963228 scopus 로고    scopus 로고
    • Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice
    • Ono M, Itakura Y, Nonomura T, Nakagawa T, Nakayama C et al (2000) Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice. Metabolism 49:129-133
    • (2000) Metabolism , vol.49 , pp. 129-133
    • Ono, M.1    Itakura, Y.2    Nonomura, T.3    Nakagawa, T.4    Nakayama, C.5
  • 98
    • 0035369840 scopus 로고    scopus 로고
    • Trk receptors: Mediators of neurotrophin action
    • Patapoutian A, Reichardt LF (2001) Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11:272-280
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 272-280
    • Patapoutian, A.1    Reichardt, L.F.2
  • 99
    • 0027427443 scopus 로고
    • Neurotrophin-3 affects proliferation and differentiation of distinct neural crest cells and is present in the early neural tube of avian embryos
    • Pinco O, Carmeli C, Rosenthal A, Kalcheim C (1993) Neurotrophin-3 affects proliferation and differentiation of distinct neural crest cells and is present in the early neural tube of avian embryos. J Neurobiol 24:1626-1641
    • (1993) J Neurobiol , vol.24 , pp. 1626-1641
    • Pinco, O.1    Carmeli, C.2    Rosenthal, A.3    Kalcheim, C.4
  • 100
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    • Rios M, Fan G, Fekete C, Kelly J, Bates B et al (2001) Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15:1748-1757
    • (2001) Mol Endocrinol , vol.15 , pp. 1748-1757
    • Rios, M.1    Fan, G.2    Fekete, C.3    Kelly, J.4    Bates, B.5
  • 101
    • 0033047028 scopus 로고    scopus 로고
    • Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve
    • Ro LS, Chen ST, Tang LM, Jacobs JM (1999) Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve. Pain 79:265-274
    • (1999) Pain , vol.79 , pp. 265-274
    • Ro, L.S.1    Chen, S.T.2    Tang, L.M.3    Jacobs, J.M.4
  • 102
    • 0025348686 scopus 로고
    • Primary structure and biological activity of a novel human neurotrophic factor
    • Rosenthal A, Goeddel DV, Nguyen T, Lewis M, Shih A et al (1990) Primary structure and biological activity of a novel human neurotrophic factor. Neuron 4:767-773
    • (1990) Neuron , vol.4 , pp. 767-773
    • Rosenthal, A.1    Goeddel, D.V.2    Nguyen, T.3    Lewis, M.4    Shih, A.5
  • 103
    • 0026058675 scopus 로고
    • Primary structure and biological activity of human brain-derived neurotrophic factor
    • Rosenthal A, Goeddel DV, Nguyen T, Martin E, Burton LE et al (1991) Primary structure and biological activity of human brain-derived neurotrophic factor. Endocrinology 129:1289-1294
    • (1991) Endocrinology , vol.129 , pp. 1289-1294
    • Rosenthal, A.1    Goeddel, D.V.2    Nguyen, T.3    Martin, E.4    Burton, L.E.5
  • 104
    • 24644446342 scopus 로고    scopus 로고
    • NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients
    • Sahenk Z, Nagaraja HN, McCracken BS, King WM, Freimer ML et al (2005) NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients. Neurology 65:681-689
    • (2005) Neurology , vol.65 , pp. 681-689
    • Sahenk, Z.1    Nagaraja, H.N.2    McCracken, B.S.3    King, W.M.4    Freimer, M.L.5
  • 105
    • 77954659607 scopus 로고    scopus 로고
    • TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler
    • Sahenk Z, Galloway G, Edwards C, Malik V, Kaspar BK et al (2010) TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Exp Neurol 224:495-506
    • (2010) J Mice. Exp Neurol , vol.224 , pp. 495-506
    • Sahenk, Z.1    Galloway, G.2    Edwards, C.3    Malik, V.4    Kaspar, B.K.5
  • 106
    • 77949721758 scopus 로고    scopus 로고
    • Neurotrophin receptors: Old friends with new partners
    • Schecterson LC, Bothwell M (2010) Neurotrophin receptors: old friends with new partners. Dev Neurobiol 70:332-338
    • (2010) Dev Neurobiol , vol.70 , pp. 332-338
    • Schecterson, L.C.1    Bothwell, M.2
  • 107
    • 0027070473 scopus 로고
    • Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section
    • Sendtner M, Holtmann B, Kolbeck R, Thoenen H, Barde YA (1992) Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature 360:757-759
    • (1992) Nature , vol.360 , pp. 757-759
    • Sendtner, M.1    Holtmann, B.2    Kolbeck, R.3    Thoenen, H.4    Barde, Y.A.5
  • 108
    • 20144388553 scopus 로고    scopus 로고
    • Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization
    • Sevcik MA, Ghilardi JR, Peters CM, Lindsay TH, Halvorson KG et al (2005) Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain 115:128-141
    • (2005) Pain , vol.115 , pp. 128-141
    • Sevcik, M.A.1    Ghilardi, J.R.2    Peters, C.M.3    Lindsay, T.H.4    Halvorson, K.G.5
  • 110
    • 20444498114 scopus 로고    scopus 로고
    • Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis
    • Shelton DL, Zeller J, Ho WH, Pons J, Rosenthal A (2005) Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis. Pain 116:8-16
    • (2005) Pain , vol.116 , pp. 8-16
    • Shelton, D.L.1    Zeller, J.2    Ho, W.H.3    Pons, J.4    Rosenthal, A.5
  • 111
    • 0028331599 scopus 로고
    • Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
    • Smeyne RJ, Klein R, Schnapp A, Long LK, Bryant S et al (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368:246-249
    • (1994) Nature , vol.368 , pp. 246-249
    • Smeyne, R.J.1    Klein, R.2    Schnapp, A.3    Long, L.K.4    Bryant, S.5
  • 112
    • 23644437308 scopus 로고    scopus 로고
    • Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson’s disease
    • Sun M, Kong L, Wang X, Lu XG, Gao Q, Geller AI (2005) Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson’s disease. Brain Res 1052:119-129
    • (2005) Brain Res , vol.1052 , pp. 119-129
    • Sun, M.1    Kong, L.2    Wang, X.3    Lu, X.G.4    Gao, Q.5    Geller, A.I.6
  • 113
    • 0037823440 scopus 로고    scopus 로고
    • Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia
    • Svensson P, Cairns BE, Wang K, Arendt-Nielsen L (2003) Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia. Pain 104:241-247
    • (2003) Pain , vol.104 , pp. 241-247
    • Svensson, P.1    Cairns, B.E.2    Wang, K.3    Arendt-Nielsen, L.4
  • 114
    • 77949508276 scopus 로고    scopus 로고
    • Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARalpha and FGF21 in mice with hepatic ablation of brainderived neurotropic factor
    • Teillon S, Calderon GA, Rios M (2010) Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARalpha and FGF21 in mice with hepatic ablation of brainderived neurotropic factor. J Endocrinol 205:37-47
    • (2010) J Endocrinol , vol.205 , pp. 37-47
    • Teillon, S.1    Calderon, G.A.2    Rios, M.3
  • 115
    • 58149163141 scopus 로고    scopus 로고
    • Genomewide association yields new sequence variants at seven loci that associate with measures of obesity
    • Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P et al (2009) Genomewide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41:18-24
    • (2009) Nat Genet , vol.41 , pp. 18-24
    • Thorleifsson, G.1    Walters, G.B.2    Gudbjartsson, D.F.3    Steinthorsdottir, V.4    Sulem, P.5
  • 116
    • 0034324018 scopus 로고    scopus 로고
    • Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis
    • Toma H, Winston J, Micci MA, Shenoy M, Pasricha PJ (2000) Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis. Gastroenterology 119:1373-1381
    • (2000) Gastroenterology , vol.119 , pp. 1373-1381
    • Toma, H.1    Winston, J.2    Micci, M.A.3    Shenoy, M.4    Pasricha, P.J.5
  • 117
    • 0033005143 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(Db)/ lepr(db) mice
    • Tonra JR, Ono M, Liu X, Garcia K, Jackson C et al (1999) Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/ lepr(db) mice. Diabetes 48:588-594
    • (1999) Diabetes , vol.48 , pp. 588-594
    • Tonra, J.R.1    Ono, M.2    Liu, X.3    Garcia, K.4    Jackson, C.5
  • 118
    • 40849136303 scopus 로고    scopus 로고
    • TrkB agonists ameliorate obesity and associated metabolic conditions in mice
    • Tsao D, Thomsen HK, Chou J, Stratton J, Hagen M et al (2008) TrkB agonists ameliorate obesity and associated metabolic conditions in mice. Endocrinology 149:1038-1048
    • (2008) Endocrinology , vol.149 , pp. 1038-1048
    • Tsao, D.1    Thomsen, H.K.2    Chou, J.3    Stratton, J.4    Hagen, M.5
  • 119
    • 0035025080 scopus 로고    scopus 로고
    • The effects of brain-derived neurotrophic factor on insulin signal transduction in the liver of diabetic mice
    • Tsuchida A, Nakagawa T, Itakura Y, Ichihara J, Ogawa W et al (2001) The effects of brain-derived neurotrophic factor on insulin signal transduction in the liver of diabetic mice. Diabetologia 44:555-566
    • (2001) Diabetologia , vol.44 , pp. 555-566
    • Tsuchida, A.1    Nakagawa, T.2    Itakura, Y.3    Ichihara, J.4    Ogawa, W.5
  • 120
    • 37549055474 scopus 로고    scopus 로고
    • Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
    • Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M (2007) Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27:14265-14274
    • (2007) J Neurosci , vol.27 , pp. 14265-14274
    • Unger, T.J.1    Calderon, G.A.2    Bradley, L.C.3    Sena-Esteves, M.4    Rios, M.5
  • 121
    • 34250779953 scopus 로고    scopus 로고
    • Antibodies to nerve growth factor reverse established tactile allodynia in rodent models of neuropathic pain without tolerance
    • Wild KD, Bian D, Zhu D, Davis J, Bannon AW et al (2007) Antibodies to nerve growth factor reverse established tactile allodynia in rodent models of neuropathic pain without tolerance. J Pharmacol Exp Ther 322:282-287
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 282-287
    • Wild, K.D.1    Bian, D.2    Zhu, D.3    Davis, J.4    Bannon, A.W.5
  • 122
    • 0035125534 scopus 로고    scopus 로고
    • Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons
    • Winston J, Toma H, Shenoy M, Pasricha PJ (2001) Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons. Pain 89:181-186
    • (2001) Pain , vol.89 , pp. 181-186
    • Winston, J.1    Toma, H.2    Shenoy, M.3    Pasricha, P.J.4
  • 123
    • 77957963249 scopus 로고    scopus 로고
    • Nerve growth factor and pain
    • Wood JN (2010) Nerve growth factor and pain. N Engl J Med 363:1572-1573
    • (2010) N Engl J Med , vol.363 , pp. 1572-1573
    • Wood, J.N.1
  • 124
    • 58749092895 scopus 로고    scopus 로고
    • Expression profile of nerve growth factor after muscle incision in the rat
    • Wu C, Erickson MA, Xu J, Wild KD, Brennan TJ (2009) Expression profile of nerve growth factor after muscle incision in the rat. Anesthesiology 110:140-149
    • (2009) Anesthesiology , vol.110 , pp. 140-149
    • Wu, C.1    Erickson, M.A.2    Xu, J.3    Wild, K.D.4    Brennan, T.J.5
  • 125
    • 78049525220 scopus 로고    scopus 로고
    • BDNF overexpression in the forebrain rescues Huntington’s disease phenotypes in YAC128 mice
    • Xie Y, Hayden MR, Xu B (2010) BDNF overexpression in the forebrain rescues Huntington’s disease phenotypes in YAC128 mice. J Neurosci 30:14708-14718
    • (2010) J Neurosci , vol.30 , pp. 14708-14718
    • Xie, Y.1    Hayden, M.R.2    Xu, B.3
  • 126
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • Xu B, Goulding EH, Zang K, Cepoi D, Cone RD et al (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6:736-742
    • (2003) Nat Neurosci , vol.6 , pp. 736-742
    • Xu, B.1    Goulding, E.H.2    Zang, K.3    Cepoi, D.4    Cone, R.D.5
  • 127
    • 7044262828 scopus 로고    scopus 로고
    • A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
    • Yeo GS, Connie Hung CC, Rochford J, Keogh J, Gray J et al (2004) A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 7:1187-1189
    • (2004) Nat Neurosci , vol.7 , pp. 1187-1189
    • Yeo, G.S.1    Connie Hung, C.C.2    Rochford, J.3    Keogh, J.4    Gray, J.5
  • 128
    • 0021745840 scopus 로고
    • The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia
    • Yip HK, Rich KM, Lampe PA, Johnson EM Jr (1984) The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia. J Neurosci 4:2986-2992
    • (1984) J Neurosci , vol.4 , pp. 2986-2992
    • Yip, H.K.1    Rich, K.M.2    Lampe, P.A.3    Johnson, E.M.4
  • 129
    • 3042780039 scopus 로고    scopus 로고
    • Effect of blockade of nerve growth factor and tumor necrosis factor on pain behaviors after plantar incision
    • Zahn PK, Subieta A, Park SS, Brennan TJ (2004) Effect of blockade of nerve growth factor and tumor necrosis factor on pain behaviors after plantar incision. J Pain 5:157-163
    • (2004) J Pain , vol.5 , pp. 157-163
    • Zahn, P.K.1    Subieta, A.2    Park, S.S.3    Brennan, T.J.4
  • 130
    • 29244484493 scopus 로고    scopus 로고
    • NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    • Zhang X, Huang J, McNaughton PA (2005) NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J 24:4211-4223
    • (2005) EMBO J , vol.24 , pp. 4211-4223
    • Zhang, X.1    Huang, J.2    McNaughton, P.A.3
  • 131
    • 79952932382 scopus 로고    scopus 로고
    • Receptor-mediated abeta amyloid antibody targeting to Alzheimer’s disease mouse brain
    • Zhou QH, Fu A, Boado RJ, Hui EK, Lu JZ, Pardridge WM (2011) Receptor-mediated abeta amyloid antibody targeting to Alzheimer’s disease mouse brain. Mol Pharm 8:280-285
    • (2011) Mol Pharm , vol.8 , pp. 280-285
    • Zhou, Q.H.1    Fu, A.2    Boado, R.J.3    Hui, E.K.4    Lu, J.Z.5    Pardridge, W.M.6
  • 132
    • 0032792960 scopus 로고    scopus 로고
    • Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer
    • Zhu Z, Friess H, diMola FF, Zimmermann A, Graber HU et al (1999) Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer. J Clin Oncol 17:2419-2428
    • (1999) J Clin Oncol , vol.17 , pp. 2419-2428
    • Zhu, Z.1    Friess, H.2    Dimola, F.F.3    Zimmermann, A.4    Graber, H.U.5
  • 133
    • 68849083063 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neurodegenerative diseases
    • Zuccato C, Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5:311-322
    • (2009) Nat Rev Neurol , vol.5 , pp. 311-322
    • Zuccato, C.1    Cattaneo, E.2


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