Tissue disposition and pharmacokinetics of recombinant human nerve growth factor after acute and chronic subcutaneous administration in monkeys

Drug Metabolism and Disposition

Volumn 28, Issue 5, 2000, Pages 598-607

  Nguyen, Cindy B ^a   Harris, Louise ^a   Szönyi, Éva ^a   Baughman, Sharon A ^a   Hale, Victoria G ^a   Dybdal, Noël O ^a   Sadick, Michael D ^a   Escandón, Enrique ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE; NEUROTROPHIN; RECOMBINANT NERVE GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; DRUG DISPOSITION; DRUG EXCRETION; DRUG METABOLISM; DRUG TISSUE LEVEL; EMULSION; ENZYME LINKED IMMUNOSORBENT ASSAY; MONKEY; NEURAL CREST; NEUROPATHY; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SPINAL GANGLION; SYMPATHETIC GANGLION; TARGET ORGAN;

ANIMALS; AREA UNDER CURVE; AUTORADIOGRAPHY; CHO CELLS; CRICETINAE; DIABETIC NEPHROPATHIES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FECES; HALF-LIFE; HUMANS; INJECTIONS, SUBCUTANEOUS; IODINE RADIOISOTOPES; MACACA FASCICULARIS; MALE; NERVE GROWTH FACTORS; PRECIPITIN TESTS; RECOMBINANT PROTEINS; TISSUE DISTRIBUTION;

ANIMALIA; MACACA FASCICULARIS;

EID: 0034008090     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Angeletti PU and Levi-Montalcini R (1970) Sympathetic nerve cell destruction in newborn mammals by 6-hydroxydopamine. Proc Natl Acad Sci USA 65:114-121.
2. Apfel SC, Kessler JA, Adornato BT, Litchy WJ, Sanders C and Rask CA (1998) Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. Neurology 51:695-702.
3. Barbacid M (1994) The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
4. Barde YA (1989) Trophic factors and neuronal survival. Neuron 2:1525-1534.
5. Bennett GL, Burton LE, Chan W-P and Wong WLT (1990) Sensitive enzyme immunoassay for recombinant human NGF. J Cell Biochem 14:F87.
6. Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV and Rosenthal A (1991) Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB. Neuron 7:857-866.
7. Campenot RB (1982) Development of sympathetic neurons in compartmentalized cultures. II. Local control of neurite growth by nerve growth factor. Dev Biol 93:1-12.
8. Chao MV (1992) Neurotrophin receptors: A window into neuronal differentiation. Neuron 9:583-593.
9. Davies AM (1994) The role of neurotrophins in the developing nervous system. J Neurobiol 25:1334-1348.
10. Dechant G, Rodriguez-Tebar A and Barde YA (1994) Neurotrophin receptors. Prog Neurobiol 42:347-352.
11. Diamond J, Coughlin M, Macintyre L, Holmes M and Visheau B (1987) Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats. Proc Natl Acad Sci USA 84:6596-6600.
12. Escandon E, Burton LE, Szonyi E and Nikolics K (1993) Characterization of neurotrophin receptors by affinity crosslinking. J Neurosci Res 34:601-613.
13. Escandon E, Soppet D, Rosenthal A, Mendoza-Ramirez JL, Szonyi E, Burton LE, Henderson CE, Parada LF and Nikolics K (1994) Regulation of neurotrophin receptor expression during embryonic and postnatal development. J Neurosci 14:2054-2068.
14. Henderson CE, Camu W, Mettling C, Gouin A, Poulsen K, Karihaloo M, Rullamas J, Evans T, McMahon SB, Armanini MP, Berkemeier L, Phillips HS and Rosenthal A (1993) Neurotro phins promote motor neuron survival and are present in embryonic limb bud. Nature (Lond) 363:266-270.
15. Hohn A, Leibrock J, Bailey K and Barde YA (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature (Lond) 344:339-341.
16. Hoyle GW, Mercer EH, Palmiter RD and Brinster RL (1993) Expression of NGF in sympathetic neurons leads to excessive axon outgrowth from ganglia but decreased terminal innervation within tissues. Neuron 10:1019-1034.
17. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV and Parada LF (1991) The trk proto-oncogene product: A signal transducing receptor for nerve growth factor. Science (Wash DC) 252:554-558.
18. Kessler JA and Black IB (1980a) The effects of nerve growth factor (NGF) and antiserum to NGF on the development of embryonic sympathetic neurons in vivo. Brain Res 189:157-168.
19. Kessler JA and Black IB (1980b) Nerve growth factor stimulates the development of substance P in sensory ganglia. Proc Natl Acad Sci USA 77:649-652.
20. Levi-Montalcini R (1983) The nerve growth factor-target cells interaction: A model system for the study of directed axonal growth and regeneration. Birth Def 19:3-22.
21. Levi-Montalcini R (1987) The nerve growth factor 35 years later. Science (Wash DC) 237: 1154-1162.
22. McDonald NQ and Chao MV (1995) Structural determinants of neurotrophin action. J Biol Chem 270:19669-19672.
23. McMahon SB, Armanini MP, Ling LH and Phillips HS (1994) Expression and co-expression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron 12:1161-1171.
24. Otten U, Schwab M, Gagnon C and Thoenen H (1977) Selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase by nerve growth factor: Comparison between adrenal medulla and sympathetic ganglia of adult and newborn rats. Brain Res 133:291-303.
25. Pradier P, Jalenques I, Dalle M, Reuling R, Despres G and Romand R (1994) Distribution and metabolism patterns of plasma 7S- and beta-NGF in the adult male rat. J Physiol (Paris) 88:273-277.
26. Purves D and Lichtman JW (1985) Principles of Neural Development. Sinauer Associates, Sunderland, MA.
27. Raffioni S, Bradshaw RA and Buxser SE (1993) The receptors for nerve growth factor and other neurotrophins. Ann Rev Biochem 62:823-850.
28. Rodriguez-Tebar A, Dechant G and Barde YA (1990) Binding of brain-derived neurotropic factor to the nerve growth factor receptor. Neuron 4:487-492.
29. Rodriguez-Tebar A, Dechant G, Gotz R and Barde YA (1992) Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor. EMBO J 11:917-922.
30. Rush RA, Mayo R and Zettler C (1995) The regulation of nerve growth factor synthesis and delivery to peripheral neurons. Pharmacol Ther 65:93-123.
31. Sadick MD, Galloway A, Shelton D, Hale V, Week S, Anicetti V and Wong WL (1997) Analysis of neurotrophin/receptor interactions with a gD-flag-modified quantitative kinase receptor activation (gD.KIRA) enzyme-linked immunosorbent assay. Exp Cell Res 234:354-361.
32. Shelton DL, Sutherland J, Gripp J, Camerato T, Armanini MP, Phillips HS, Carroll K, Spencer SD and Levinson AD (1995) Human trks: Molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J Neurosci 15:477-491.
33. Snider WD (1988) Nerve growth factor enhances dendritic arborization of sympathetic ganglion cells in developing mammals. J Neurosci 8:2628-2634.
34. Sutter A, Riopelle RJ, Harris-Warrick RM and Shooter EM (1979) Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem 254:5972-5982.
35. Thoenen H and Barde YA (1980) Physiology of nerve growth factor. Physiol Rev 60:1284-1335.
36. Tria MA, Fusco M, Vantini G and Mariot R (1994) Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats. Exp Neurol 127:178-183.
37. Verge VM, Merlio JP, Grondin J, Ernfors P, Persson H, Riopelle RJ, Hokfelt T and Richardson PM (1992) Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF. J Neurosci 12:4011-4022.
38. Wetmore C and Olson L (1995) Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions. J Comp Neurol 353:143-159.
39. Wright DE and Snider WD (1995) Neurotrophin receptor mRNA expression defines distinct populations of neurons in rat dorsal root ganglia. J Comp Neurol 351:329-338.