메뉴 건너뛰기




Volumn 20, Issue 31, 2014, Pages 5010-5024

The metabolic syndrome and chronic liver disease

Author keywords

Cardiovascular risk; Hepatic steatosis; Hepatocellular carcinoma; Inflammasome; Metabolic syndrome

Indexed keywords

GLITAZONE DERIVATIVE; INSULIN SENSITIZING AGENT; LIPID; TRIACYLGLYCEROL;

EID: 84906267093     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612819666131206111352     Document Type: Article
Times cited : (39)

References (221)
  • 1
    • 84862850517 scopus 로고    scopus 로고
    • Metabolic syndrome: Its history, mechanisms, and limitations
    • Oda E. Metabolic syndrome: its history, mechanisms, and limitations. Acta Diabetol 2012; 49: 89-95.
    • (2012) Acta Diabetol , vol.49 , pp. 89-95
    • Oda, E.1
  • 3
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard JI, Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 2013; 339: 172-7.
    • (2013) Science , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 4
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010; 363: 1341-50.
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 5
    • 56649123256 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic Fatty liver disease: A global perspective
    • Lazo M, Clark JM. The epidemiology of nonalcoholic Fatty liver disease: a global perspective. Semin Liver Dis 2008; 28: 339-50.
    • (2008) Semin Liver Dis , vol.28 , pp. 339-350
    • Lazo, M.1    Clark, J.M.2
  • 6
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011; 140: 124-31.
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 7
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
    • Szczepaniak LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005; 288: E462-8.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3
  • 8
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004; 40: 1387-95.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 9
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003; 37: 917-23.
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 10
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005; 42: 987-1000.
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 11
    • 0033982172 scopus 로고    scopus 로고
    • Prevalence of and risk factors for hepatic steatosis in Northern Italy
    • Bellentani S, Saccoccio G, Masutti F, et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000; 132: 112-7.
    • (2000) Ann Intern Med , vol.132 , pp. 112-117
    • Bellentani, S.1    Saccoccio, G.2    Masutti, F.3
  • 12
    • 0038805259 scopus 로고    scopus 로고
    • The prevalence and etiology of elevated aminotransferase levels in the United States
    • Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastro-enterol 2003; 98: 960-7.
    • (2003) Am J Gastro-enterol , vol.98 , pp. 960-967
    • Clark, J.M.1    Brancati, F.L.2    Diehl, A.M.3
  • 13
    • 28044446543 scopus 로고    scopus 로고
    • The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    • Hamaguchi M, Kojima T, Takeda N, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005; 143: 722-8.
    • (2005) Ann Intern Med , vol.143 , pp. 722-728
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 14
    • 11244308124 scopus 로고    scopus 로고
    • Chronological development of elevated aminotransferases in a nonalcoholic population
    • Suzuki A, Angulo P, Lymp J, et al. Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatol-ogy 2005; 41: 64-71.
    • (2005) Hepatol-ogy , vol.41 , pp. 64-71
    • Suzuki, A.1    Angulo, P.2    Lymp, J.3
  • 15
    • 14844340783 scopus 로고    scopus 로고
    • Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: Results from the third National Health and Nutrition Survey (NHANES III)
    • Liangpunsakul S, Chalasani N. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III). Am J Med Sci 2005; 329: 111-6.
    • (2005) Am J Med Sci , vol.329 , pp. 111-116
    • Liangpunsakul, S.1    Chalasani, N.2
  • 18
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A feature of the metabolic syndrome
    • Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50: 1844-50.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 21
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44: 865-73.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 23
    • 79954526933 scopus 로고    scopus 로고
    • Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years
    • Roulot D, Costes JL, Buyck JF, et al. Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years. Gut 2011; 60:977-84.
    • (2011) Gut , vol.60 , pp. 977-984
    • Roulot, D.1    Costes, J.L.2    Buyck, J.F.3
  • 24
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-31.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 25
    • 0034843450 scopus 로고    scopus 로고
    • Cryptogenic cirrhosis and posttransplantation nonalcoholic fatty liver disease
    • Ong J, Younossi ZM, Reddy V, et al. Cryptogenic cirrhosis and posttransplantation nonalcoholic fatty liver disease. Liver Transpl 2001; 7: 797-801.
    • (2001) Liver Transpl , vol.7 , pp. 797-801
    • Ong, J.1    Younossi, Z.M.2    Reddy, V.3
  • 26
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990; 12: 1106-10.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 27
    • 84857933945 scopus 로고    scopus 로고
    • NAFLD in the absence of metabolic syndrome: Different epidemiology, pathogenetic mechanisms, risk factors for disease progression?
    • Yilmaz Y. NAFLD in the absence of metabolic syndrome: different epidemiology, pathogenetic mechanisms, risk factors for disease progression? Semin Liver Dis 2012; 32: 14-21.
    • (2012) Semin Liver Dis , vol.32 , pp. 14-21
    • Yilmaz, Y.1
  • 28
    • 79955663416 scopus 로고    scopus 로고
    • Genetics of alcoholic and nonalcoholic fatty liver disease
    • Anstee QM, Daly AK, Day CP. Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis 2011; 31: 128-46.
    • (2011) Semin Liver Dis , vol.31 , pp. 128-146
    • Anstee, Q.M.1    Daly, A.K.2    Day, C.P.3
  • 29
    • 51349083814 scopus 로고    scopus 로고
    • Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotrans-ferase levels: A role for insulin resistance and diabetes
    • Fracanzani AL, Valenti L, Bugianesi E, et al. Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotrans-ferase levels: a role for insulin resistance and diabetes. Hepatology 2008; 48: 792-8.
    • (2008) Hepatology , vol.48 , pp. 792-798
    • Fracanzani, A.L.1    Valenti, L.2    Bugianesi, E.3
  • 30
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • Fassio E, Alvarez E, Dominguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 2004; 40: 820-6.
    • (2004) Hepatology , vol.40 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 31
    • 77952556573 scopus 로고    scopus 로고
    • Systemic Symptoms in Non-Alcoholic Fatty Liver Disease
    • Newton JL. Systemic Symptoms in Non-Alcoholic Fatty Liver Disease. Digestive Diseases 2010; 28: 214-219.
    • (2010) Digestive Diseases , vol.28 , pp. 214-219
    • Newton, J.L.1
  • 32
    • 58649083017 scopus 로고    scopus 로고
    • Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population
    • Ruhl CE, Everhart JE. Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population. Gastroenterology 2009; 136: 477-85.
    • (2009) Gastroenterology , vol.136 , pp. 477-485
    • Ruhl, C.E.1    Everhart, J.E.2
  • 33
    • 68049120181 scopus 로고    scopus 로고
    • Non-invasive assessment and quantification of liver stea-tosis by ultrasound, computed tomography and magnetic resonance
    • Schwenzer NF, Springer F, Schraml C, Stefan N, Machann J, Schick F. Non-invasive assessment and quantification of liver stea-tosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 2009; 51: 433-45.
    • (2009) J Hepatol , vol.51 , pp. 433-445
    • Schwenzer, N.F.1    Springer, F.2    Schraml, C.3    Stefan, N.4    Machann, J.5    Schick, F.6
  • 34
    • 80052012241 scopus 로고    scopus 로고
    • Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis
    • Hernaez R, Lazo M, Bonekamp S, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 2011; 54: 1082-90.
    • (2011) Hepatology , vol.54 , pp. 1082-1090
    • Hernaez, R.1    Lazo, M.2    Bonekamp, S.3
  • 35
    • 0036729447 scopus 로고    scopus 로고
    • The utility of radiological imaging in nonalcoholic fatty liver disease
    • Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002; 123: 745-50.
    • (2002) Gastroenterology , vol.123 , pp. 745-750
    • Saadeh, S.1    Younossi, Z.M.2    Remer, E.M.3
  • 36
    • 36549056996 scopus 로고    scopus 로고
    • The severity of ultrasono-graphic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation
    • Hamaguchi M, Kojima T, Itoh Y, et al. The severity of ultrasono-graphic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroen-terol 2007; 102: 2708-15.
    • (2007) Am J Gastroen-terol , vol.102 , pp. 2708-2715
    • Hamaguchi, M.1    Kojima, T.2    Itoh, Y.3
  • 38
    • 84876464236 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver in nondiabetic patients with acute coronary syndromes
    • Boddi M, Tarquini R, Chiostri M, et al. Nonalcoholic fatty liver in nondiabetic patients with acute coronary syndromes. Eur J Clin Invest 2013.
    • (2013) Eur J Clin Invest
    • Boddi, M.1    Tarquini, R.2    Chiostri, M.3
  • 39
    • 80052996528 scopus 로고    scopus 로고
    • Quantitative assessment of liver fat with magnetic resonance imaging and spectros-copy
    • Reeder SB, Cruite I, Hamilton G, Sirlin CB. Quantitative assessment of liver fat with magnetic resonance imaging and spectros-copy. J Magn Reson Imaging 2011; 34: 729-49.
    • (2011) J Magn Reson Imaging , vol.34 , pp. 729-749
    • Reeder, S.B.1    Cruite, I.2    Hamilton, G.3    Sirlin, C.B.4
  • 40
    • 69249087403 scopus 로고    scopus 로고
    • Prediction of nonalcoholic fatty liver disease and liver fat using metabolic and genetic factors
    • Kotronen A, Peltonen M, Hakkarainen A, et al. Prediction of nonalcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 2009; 137: 865-72.
    • (2009) Gastroenterology , vol.137 , pp. 865-872
    • Kotronen, A.1    Peltonen, M.2    Hakkarainen, A.3
  • 41
    • 84857046691 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: A population study using proton-magnetic resonance spectroscopy and transient elastography
    • Wong VW, Chu WC, Wong GL, et al. Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut 2012; 61: 409-15.
    • (2012) Gut , vol.61 , pp. 409-415
    • Wong, V.W.1    Chu, W.C.2    Wong, G.L.3
  • 42
    • 77958154016 scopus 로고    scopus 로고
    • Controlled attenuation parameter (CAP): A novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: Preliminary study and validation in a cohort of patients with chronic liver disease from various causes
    • Sasso M, Beaugrand M, de Ledinghen V, et al. Controlled attenuation parameter (CAP): a novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes. Ultrasound Med Biol 2010; 36: 1825-35.
    • (2010) Ultrasound Med Biol , vol.36 , pp. 1825-1835
    • Sasso, M.1    Beaugrand, M.2    de Ledinghen, V.3
  • 43
    • 84861961483 scopus 로고    scopus 로고
    • Controlled Attenuation Parameter (CAP): A noninvasive method for the detection of hepatic steatosis based on transient elastography
    • Myers RP, Pollett A, Kirsch R, et al. Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography. Liver Int 2012; 32: 902-10.
    • (2012) Liver Int , vol.32 , pp. 902-910
    • Myers, R.P.1    Pollett, A.2    Kirsch, R.3
  • 44
    • 33751246499 scopus 로고    scopus 로고
    • The Fatty Liver Index: A simple and accurate predictor of hepatic steatosis in the general population
    • Bedogni G, Bellentani S, Miglioli L, et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006; 6: 33.
    • (2006) BMC Gastroenterol , vol.6 , pp. 33
    • Bedogni, G.1    Bellentani, S.2    Miglioli, L.3
  • 45
    • 66149119340 scopus 로고    scopus 로고
    • Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population
    • Gastaldelli A, Kozakova M, Hojlund K, et al. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. Hepatology 2009; 49: 1537-44.
    • (2009) Hepatology , vol.49 , pp. 1537-1544
    • Gastaldelli, A.1    Kozakova, M.2    Hojlund, K.3
  • 46
    • 79959541652 scopus 로고    scopus 로고
    • Fatty liver index and mortality: The Cremona study in the 15th year of follow-up
    • Calori G, Lattuada G, Ragogna F, et al. Fatty liver index and mortality: the Cremona study in the 15th year of follow-up. Hepatology 2011; 54: 145-52.
    • (2011) Hepatology , vol.54 , pp. 145-152
    • Calori, G.1    Lattuada, G.2    Ragogna, F.3
  • 47
    • 84882845563 scopus 로고    scopus 로고
    • External Validation of the Fatty Liver Index for Identifying Nonalcoholic Fatty Liver Disease in a Population-based Study
    • Koehler EM, Schouten JN, Hansen BE, Hofman A, Stricker BH, Janssen HL. External Validation of the Fatty Liver Index for Identifying Nonalcoholic Fatty Liver Disease in a Population-based Study. Clin Gastroenterol Hepatol 2013; 11:1201-4.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 1201-1204
    • Koehler, E.M.1    Schouten, J.N.2    Hansen, B.E.3    Hofman, A.4    Stricker, B.H.5    Janssen, H.L.6
  • 48
    • 0036829092 scopus 로고    scopus 로고
    • AGA technical review on nonalcoholic fatty liver disease
    • AGA technical review on nonalcoholic fatty liver disease. Gastro-enterology 2002; 123: 1705-25.
    • (2002) Gastro-enterology , vol.123 , pp. 1705-1725
  • 49
    • 77957330216 scopus 로고    scopus 로고
    • Reduced mortality rates following elective percutaneous liver biopsies
    • West J, Card TR. Reduced mortality rates following elective percutaneous liver biopsies. Gastroenterology 2010; 139: 1230-7.
    • (2010) Gastroenterology , vol.139 , pp. 1230-1237
    • West, J.1    Card, T.R.2
  • 50
    • 20444443042 scopus 로고    scopus 로고
    • Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    • Ratziu V, Charlotte F, Heurtier A, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128: 1898-906.
    • (2005) Gastroenterology , vol.128 , pp. 1898-1906
    • Ratziu, V.1    Charlotte, F.2    Heurtier, A.3
  • 51
    • 20444443042 scopus 로고    scopus 로고
    • Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    • Ratziu V, Charlotte F, Heurtier A, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128: 1898-906.
    • (2005) Gastroenterology , vol.128 , pp. 1898-1906
    • Ratziu, V.1    Charlotte, F.2    Heurtier, A.3
  • 52
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-21.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 54
    • 84868235041 scopus 로고    scopus 로고
    • Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
    • Bedossa P, Poitou C, Veyrie N, et al. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology 2012; 56: 1751-9.
    • (2012) Hepatology , vol.56 , pp. 1751-1759
    • Bedossa, P.1    Poitou, C.2    Veyrie, N.3
  • 55
    • 33845207096 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease
    • Poynard T, Ratziu V, Charlotte F, et al. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2006; 6: 34.
    • (2006) BMC Gastroenterol , vol.6 , pp. 34
    • Poynard, T.1    Ratziu, V.2    Charlotte, F.3
  • 56
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006; 44: 27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6
  • 57
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis: A Multicenter Validation Study
    • Feldstein AE, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis: A Multicenter Validation Study. Hepatology 2009; 50: 1072-8.
    • (2009) Hepatology , vol.50 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3    Liu, Y.C.4    Zein, N.N.5    McCullough, A.J.6
  • 58
    • 84862795311 scopus 로고    scopus 로고
    • Non-invasive diagnosis of nonalcoholic steatohepatitis by combined serum biomarkers
    • Shen J, Chan HL, Wong GL, et al. Non-invasive diagnosis of nonalcoholic steatohepatitis by combined serum biomarkers. J Hepatol 2012; 56: 1363-70.
    • (2012) J Hepatol , vol.56 , pp. 1363-1370
    • Shen, J.1    Chan, H.L.2    Wong, G.L.3
  • 59
    • 79956108335 scopus 로고    scopus 로고
    • An apoptosis panel for nonalcoholic steatohepatitis diagnosis
    • Tamimi TI, Elgouhari HM, Alkhouri N, et al. An apoptosis panel for nonalcoholic steatohepatitis diagnosis. J Hepatol 2011; 54: 1224-9.
    • (2011) J Hepatol , vol.54 , pp. 1224-1229
    • Tamimi, T.I.1    Elgouhari, H.M.2    Alkhouri, N.3
  • 60
    • 84856388968 scopus 로고    scopus 로고
    • Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis
    • Joka D, Wahl K, Moeller S, et al. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology 2012; 55: 455-64.
    • (2012) Hepatology , vol.55 , pp. 455-464
    • Joka, D.1    Wahl, K.2    Moeller, S.3
  • 61
    • 34447100647 scopus 로고    scopus 로고
    • Progressive fibrosis in nonalcoholic steatohepatitis: Association with altered regeneration and a ductular reaction
    • Richardson MM, Jonsson JR, Powell EE, et al. Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction. Gastroenterology 2007; 133: 80-90.
    • (2007) Gastroenterology , vol.133 , pp. 80-90
    • Richardson, M.M.1    Jonsson, J.R.2    Powell, E.E.3
  • 62
    • 24144444669 scopus 로고    scopus 로고
    • Histopathology of pediatric nonalcoholic fatty liver disease
    • Schwimmer JB, Behling C, Newbury R, et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 2005; 42: 641-9.
    • (2005) Hepatology , vol.42 , pp. 641-649
    • Schwimmer, J.B.1    Behling, C.2    Newbury, R.3
  • 63
    • 0034116558 scopus 로고    scopus 로고
    • Liver fibrosis in overweight patients
    • Ratziu V, Giral P, Charlotte F, et al. Liver fibrosis in overweight patients. Gastroenterology 2000; 118: 1117-23.
    • (2000) Gastroenterology , vol.118 , pp. 1117-1123
    • Ratziu, V.1    Giral, P.2    Charlotte, F.3
  • 64
    • 52649112178 scopus 로고    scopus 로고
    • Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease
    • Harrison SA, Oliver D, Arnold HL, Gogia S, Neuschwander-Tetri BA. Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease. Gut 2008; 57: 1441-7.
    • (2008) Gut , vol.57 , pp. 1441-1447
    • Harrison, S.A.1    Oliver, D.2    Arnold, H.L.3    Gogia, S.4    Neuschwander-Tetri, B.A.5
  • 65
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121: 91-100.
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 66
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepa-tology 1999; 30: 1356-62.
    • (1999) Hepa-tology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3    Lindor, K.D.4
  • 67
    • 34247384560 scopus 로고    scopus 로고
    • The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
    • Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007; 45: 846-54.
    • (2007) Hepatology , vol.45 , pp. 846-854
    • Angulo, P.1    Hui, J.M.2    Marchesini, G.3
  • 68
    • 84880432374 scopus 로고    scopus 로고
    • Non Invasive Indexes for the Assessment of Patients with Non-alcoholic Fatty Liver Disease
    • Petta S, Handberg A, Craxi A. Non Invasive Indexes for the Assessment of Patients with Non-alcoholic Fatty Liver Disease. Curr Pharm Des 2013;19:5193-218
    • (2013) Curr Pharm Des , vol.19 , pp. 5193-5218
    • Petta, S.1    Handberg, A.2    Craxi, A.3
  • 69
    • 77956119396 scopus 로고    scopus 로고
    • Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease
    • McPherson S, Stewart SF, Henderson E, Burt AD, Day CP. Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease. Gut 2010; 59: 1265-9.
    • (2010) Gut , vol.59 , pp. 1265-1269
    • McPherson, S.1    Stewart, S.F.2    Henderson, E.3    Burt, A.D.4    Day, C.P.5
  • 70
    • 9644279531 scopus 로고    scopus 로고
    • Serum markers detect the presence of liver fibrosis: A cohort study
    • Rosenberg WM, Voelker M, Thiel R, et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology 2004; 127: 1704-13.
    • (2004) Gastroenterology , vol.127 , pp. 1704-1713
    • Rosenberg, W.M.1    Voelker, M.2    Thiel, R.3
  • 71
    • 39549118158 scopus 로고    scopus 로고
    • Noninvasive markers of fi-brosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers
    • Guha IN, Parkes J, Roderick P, et al. Noninvasive markers of fi-brosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers. Hepatology 2008; 47: 455-60.
    • (2008) Hepatology , vol.47 , pp. 455-460
    • Guha, I.N.1    Parkes, J.2    Roderick, P.3
  • 72
    • 59849117801 scopus 로고    scopus 로고
    • Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease
    • Nobili V, Parkes J, Bottazzo G, et al. Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease. Gastroenterology 2009; 136: 160-7.
    • (2009) Gastroenterology , vol.136 , pp. 160-167
    • Nobili, V.1    Parkes, J.2    Bottazzo, G.3
  • 73
    • 33644607568 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    • Ratziu V, Massard J, Charlotte F, et al. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterology 2006; 6: 6.
    • (2006) BMC Gastroenterology , vol.6 , pp. 6
    • Ratziu, V.1    Massard, J.2    Charlotte, F.3
  • 74
    • 56949084285 scopus 로고    scopus 로고
    • Comparison of blood tests for liver fibrosis specific or not to NAFLD
    • Cales P, Laine F, Boursier J, et al. Comparison of blood tests for liver fibrosis specific or not to NAFLD. J Hepatol 2009; 50: 165-73.
    • (2009) J Hepatol , vol.50 , pp. 165-173
    • Cales, P.1    Laine, F.2    Boursier, J.3
  • 75
    • 58849116815 scopus 로고    scopus 로고
    • Elastography for the non-invasive assessment of liver disease: Limitations and future developments
    • Vizzutti F, Arena U, Marra F, Pinzani M. Elastography for the non-invasive assessment of liver disease: limitations and future developments. Gut 2009; 58: 157-60.
    • (2009) Gut , vol.58 , pp. 157-160
    • Vizzutti, F.1    Arena, U.2    Marra, F.3    Pinzani, M.4
  • 76
    • 49649105500 scopus 로고    scopus 로고
    • Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis
    • Nobili V, Vizzutti F, Arena U, et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 2008; 48: 442-8.
    • (2008) Hepatology , vol.48 , pp. 442-448
    • Nobili, V.1    Vizzutti, F.2    Arena, U.3
  • 77
    • 75449091784 scopus 로고    scopus 로고
    • Diagnosis of Fibrosis and Cirrhosis Using Liver Stiffness Measurement in Nonalcoholic Fatty Liver Disease
    • Wong VWS, Vergniol J, Wong GLH, et al. Diagnosis of Fibrosis and Cirrhosis Using Liver Stiffness Measurement in Nonalcoholic Fatty Liver Disease. Hepatology 2010; 51: 454-62.
    • (2010) Hepatology , vol.51 , pp. 454-462
    • Wong, V.W.S.1    Vergniol, J.2    Wong, G.L.H.3
  • 78
    • 78649630014 scopus 로고    scopus 로고
    • Reliability of transient elasto-graphy for the detection of fibrosis in non-alcoholic fatty liver disease and chronic viral hepatitis
    • Gaia S, Carenzi S, Barilli AL, et al. Reliability of transient elasto-graphy for the detection of fibrosis in non-alcoholic fatty liver disease and chronic viral hepatitis. J Hepatol 2011; 54: 64-71.
    • (2011) J Hepatol , vol.54 , pp. 64-71
    • Gaia, S.1    Carenzi, S.2    Barilli, A.L.3
  • 79
    • 34247631059 scopus 로고    scopus 로고
    • Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease
    • Fraquelli M, Rigamonti C, Casazza G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 2007; 56: 968-73.
    • (2007) Gut , vol.56 , pp. 968-973
    • Fraquelli, M.1    Rigamonti, C.2    Casazza, G.3
  • 80
    • 77956015752 scopus 로고    scopus 로고
    • Feasibility of liver transient elastography with Fi-broScan using a new probe for obese patients
    • de Ledinghen V, Vergniol J, Foucher J, El-Hajbi F, Merrouche W, Rigalleau V. Feasibility of liver transient elastography with Fi-broScan using a new probe for obese patients. Liver Int 2010; 30: 1043-8.
    • (2010) Liver Int , vol.30 , pp. 1043-1048
    • de Ledinghen, V.1    Vergniol, J.2    Foucher, J.3    El-Hajbi, F.4    Merrouche, W.5    Rigalleau, V.6
  • 81
    • 84857369747 scopus 로고    scopus 로고
    • Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe
    • Myers RP, Pomier-Layrargues G, Kirsch R, et al. Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe. J Hepatol 2012; 56: 564-70.
    • (2012) J Hepatol , vol.56 , pp. 564-570
    • Myers, R.P.1    Pomier-Layrargues, G.2    Kirsch, R.3
  • 82
    • 70249130127 scopus 로고    scopus 로고
    • Liver fibrosis in viral hepatitis: Noninvasive assessment with acoustic radiation force impulse imaging versus transient elastography
    • Friedrich-Rust M, Wunder K, Kriener S, et al. Liver fibrosis in viral hepatitis: noninvasive assessment with acoustic radiation force impulse imaging versus transient elastography. Radiology 2009; 252: 595-604.
    • (2009) Radiology , vol.252 , pp. 595-604
    • Friedrich-Rust, M.1    Wunder, K.2    Kriener, S.3
  • 83
    • 77955147344 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: US-based acoustic radiation force impulse elastography
    • Yoneda M, Suzuki K, Kato S, et al. Nonalcoholic fatty liver disease: US-based acoustic radiation force impulse elastography. Radiology 2010; 256: 640-7.
    • (2010) Radiology , vol.256 , pp. 640-647
    • Yoneda, M.1    Suzuki, K.2    Kato, S.3
  • 84
    • 84860389114 scopus 로고    scopus 로고
    • Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease
    • Palmeri ML, Wang MH, Rouze NC, et al. Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease. J Hepatol 2011; 55: 666-72.
    • (2011) J Hepatol , vol.55 , pp. 666-672
    • Palmeri, M.L.1    Wang, M.H.2    Rouze, N.C.3
  • 85
    • 84880649809 scopus 로고    scopus 로고
    • Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: Noninvasive Assessment with MR Elastography
    • Kim D, Kim WR, Talwalkar JA, Kim HJ, Ehman RL. Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: Noninvasive Assessment with MR Elastography. Radiology 2013.
    • (2013) Radiology
    • Kim, D.1    Kim, W.R.2    Talwalkar, J.A.3    Kim, H.J.4    Ehman, R.L.5
  • 86
    • 46049100990 scopus 로고    scopus 로고
    • Magnetic resonance elasto-graphy for the noninvasive staging of liver fibrosis
    • Huwart L, Sempoux C, Vicaut E, et al. Magnetic resonance elasto-graphy for the noninvasive staging of liver fibrosis. Gastroenterol-ogy 2008; 135: 32-40.
    • (2008) Gastroenterol-ogy , vol.135 , pp. 32-40
    • Huwart, L.1    Sempoux, C.2    Vicaut, E.3
  • 87
    • 79956292596 scopus 로고    scopus 로고
    • Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography
    • Chen J, Talwalkar JA, Yin M, Glaser KJ, Sanderson SO, Ehman RL. Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology 2011; 259: 749-56.
    • (2011) Radiology , vol.259 , pp. 749-756
    • Chen, J.1    Talwalkar, J.A.2    Yin, M.3    Glaser, K.J.4    Sanderson, S.O.5    Ehman, R.L.6
  • 88
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study
    • Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995; 22: 1714-9.
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 89
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • Soderberg C, Stal P, Askling J, et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepa-tology 2010; 51: 595-602.
    • (2010) Hepa-tology , vol.51 , pp. 595-602
    • Soderberg, C.1    Stal, P.2    Askling, J.3
  • 90
    • 67649306197 scopus 로고    scopus 로고
    • Systematic review of risk factors for fibrosis progression in non-alcoholic stea-tohepatitis
    • Argo CK, Northup PG, Al-Osaimi AMS, Caldwell SH. Systematic review of risk factors for fibrosis progression in non-alcoholic stea-tohepatitis. Journal of Hepatology 2009; 51: 371-9.
    • (2009) Journal of Hepatology , vol.51 , pp. 371-379
    • Argo, C.K.1    Northup, P.G.2    Al-Osaimi, A.M.S.3    Caldwell, S.H.4
  • 91
    • 33748110788 scopus 로고    scopus 로고
    • Hepatic histology in obese patients undergoing bariatric surgery
    • Machado M, Marques-Vidal P, Cortez-Pinto H. Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol 2006; 45: 600-6.
    • (2006) J Hepatol , vol.45 , pp. 600-606
    • Machado, M.1    Marques-Vidal, P.2    Cortez-Pinto, H.3
  • 92
    • 77956127298 scopus 로고    scopus 로고
    • Cigarette smoking and chronic liver diseases
    • Altamirano J, Bataller R. Cigarette smoking and chronic liver diseases. Gut 2010; 59: 1159-62.
    • (2010) Gut , vol.59 , pp. 1159-1162
    • Altamirano, J.1    Bataller, R.2
  • 94
    • 77952563587 scopus 로고    scopus 로고
    • Genetic and Environmental Susceptibility to NonAlcoholic Fatty Liver Disease
    • Day CP. Genetic and Environmental Susceptibility to NonAlcoholic Fatty Liver Disease. Digestive Diseases 2010; 28: 255-60.
    • (2010) Digestive Diseases , vol.28 , pp. 255-260
    • Day, C.P.1
  • 95
    • 77950607738 scopus 로고    scopus 로고
    • Homozygosity for the pata-tin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L, Al-Serri A, Daly AK, et al. Homozygosity for the pata-tin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 2010; 51: 1209-17.
    • (2010) Hepatology , vol.51 , pp. 1209-1217
    • Valenti, L.1    Al-Serri, A.2    Daly, A.K.3
  • 96
    • 78049457761 scopus 로고    scopus 로고
    • Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease
    • Chalasani N, Guo X, Loomba R, et al. Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease. Gastroenterology; 139: 1567-1576.e6.
    • Gastroenterology , vol.139 , pp. 1567-1576
    • Chalasani, N.1    Guo, X.2    Loomba, R.3
  • 97
    • 84879602668 scopus 로고    scopus 로고
    • Maternal obesity programs offspring non-alcoholic fatty liver disease via innate immune dysfunction in mice
    • Mouralidarane A, Soeda J, Visconti-Pugmire C, et al. Maternal obesity programs offspring non-alcoholic fatty liver disease via innate immune dysfunction in mice. Hepatology 2013;58:128-38.
    • (2013) Hepatology , vol.58 , pp. 128-138
    • Mouralidarane, A.1    Soeda, J.2    Visconti-Pugmire, C.3
  • 98
    • 84868646303 scopus 로고    scopus 로고
    • Multigenerational epigenetic adaptation of the hepatic wound-healing response
    • Zeybel M, Hardy T, Wong YK, et al. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med 2012; 18: 1369-77.
    • (2012) Nat Med , vol.18 , pp. 1369-1377
    • Zeybel, M.1    Hardy, T.2    Wong, Y.K.3
  • 99
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • Sanyal AJ, Banas C, Sargeant C, et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 2006; 43: 682-9.
    • (2006) Hepatology , vol.43 , pp. 682-689
    • Sanyal, A.J.1    Banas, C.2    Sargeant, C.3
  • 100
    • 79960549297 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study
    • Bhala N, Angulo P, van der Poorten D, et al. The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology 2011; 54: 1208-16.
    • (2011) Hepatology , vol.54 , pp. 1208-1216
    • Bhala, N.1    Angulo, P.2    van der Poorten, D.3
  • 101
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • Adams LA, Lymp JF, St Sauver J, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005; 129: 113-21.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 102
    • 0043268063 scopus 로고    scopus 로고
    • Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    • Hui JM, Kench JG, Chitturi S, et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. He-patology 2003; 38: 420-7.
    • (2003) He-patology , vol.38 , pp. 420-427
    • Hui, J.M.1    Kench, J.G.2    Chitturi, S.3
  • 103
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-51.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 104
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    • Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 2008; 134: 424-31.
    • (2008) Gastroenterology , vol.134 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 105
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K, Yang L, McCall S, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepa-tology 2007; 45: 1366-74.
    • (2007) Hepa-tology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3
  • 106
    • 84859404868 scopus 로고    scopus 로고
    • Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: Pathophysiology and clinical implications
    • Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology 2012; 142: 711-25.
    • (2012) Gastroenterology , vol.142 , pp. 711-725
    • Cusi, K.1
  • 107
    • 84859942552 scopus 로고    scopus 로고
    • Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
    • Lomonaco R, Ortiz-Lopez C, Orsak B, et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepa-tology 2012; 55: 1389-97.
    • (2012) Hepa-tology , vol.55 , pp. 1389-1397
    • Lomonaco, R.1    Ortiz-Lopez, C.2    Orsak, B.3
  • 108
    • 77954944275 scopus 로고    scopus 로고
    • Triacylglycerol lipases and metabolic control: Implications for health and disease
    • Watt MJ, Spriet LL. Triacylglycerol lipases and metabolic control: implications for health and disease. Am J Physiol Endocrinol Me-tab 2010; 299: E162-8.
    • (2010) Am J Physiol Endocrinol Me-tab , vol.299
    • Watt, M.J.1    Spriet, L.L.2
  • 109
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-5.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 110
    • 77957936457 scopus 로고    scopus 로고
    • I148M patatin-like phosphol-ipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
    • Valenti L, Alisi A, Galmozzi E, et al. I148M patatin-like phosphol-ipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Hepatology 2010; 52: 1274-80.
    • (2010) Hepatology , vol.52 , pp. 1274-1280
    • Valenti, L.1    Alisi, A.2    Galmozzi, E.3
  • 111
    • 84860465005 scopus 로고    scopus 로고
    • Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase
    • Kumari M, Schoiswohl G, Chitraju C, et al. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab 2012; 15: 691-702.
    • (2012) Cell Metab , vol.15 , pp. 691-702
    • Kumari, M.1    Schoiswohl, G.2    Chitraju, C.3
  • 112
    • 84864118287 scopus 로고    scopus 로고
    • Immunological complications of obesity
    • Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol 2012; 13: 707-12.
    • (2012) Nat Immunol , vol.13 , pp. 707-712
    • Kanneganti, T.D.1    Dixit, V.D.2
  • 113
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011; 121: 2111-7.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 114
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008; 118: 829-38.
    • (2008) J Clin Invest , vol.118 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 115
    • 49649096375 scopus 로고    scopus 로고
    • Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
    • van der Poorten D, Milner KL, Hui J, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008; 48: 449-57.
    • (2008) Hepatology , vol.48 , pp. 449-457
    • van der Poorten, D.1    Milner, K.L.2    Hui, J.3
  • 116
    • 83855161551 scopus 로고    scopus 로고
    • Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease
    • Petta S, Amato MC, Di Marco V, Camma C, Pizzolanti G, Barcel-lona MR, et al. Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2012; 35: 238-47.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 238-247
    • Petta, S.1    Amato, M.C.2    Di Marco, V.3    Camma, C.4    Pizzolanti, G.5    Barcel-Lona, M.R.6
  • 117
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • Marra F, Bertolani C. Adipokines in liver diseases. Hepatology 2009; 50: 957-69.
    • (2009) Hepatology , vol.50 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 118
    • 67650963803 scopus 로고    scopus 로고
    • Kupffer cells mediate leptin-induced liver fibrosis
    • Wang J, Leclercq I, Brymora JM, et al. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology 2009; 137: 713-23.
    • (2009) Gastroenterology , vol.137 , pp. 713-723
    • Wang, J.1    Leclercq, I.2    Brymora, J.M.3
  • 119
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772-83.
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 120
    • 79954558287 scopus 로고    scopus 로고
    • Adipokines and Redox Signaling: Impact on Fatty Liver Disease
    • in press
    • Parola M, Marra F. Adipokines and Redox Signaling: Impact on Fatty Liver Disease. Antioxidant & Redox Signaling 2011; in press.
    • (2011) Antioxidant & Redox Signaling
    • Parola, M.1    Marra, F.2
  • 121
    • 79953863868 scopus 로고    scopus 로고
    • Molecular mechanism for adiponectin-dependent M2 macrophage polarization: Link between the metabolic and innate immune activity of full-length adiponectin
    • Mandal P, Pratt BT, Barnes M, McMullen MR, Nagy LE. Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin. J Biol Chem 2011; 286: 13460-9.
    • (2011) J Biol Chem , vol.286 , pp. 13460-13469
    • Mandal, P.1    Pratt, B.T.2    Barnes, M.3    McMullen, M.R.4    Nagy, L.E.5
  • 122
    • 68049110522 scopus 로고    scopus 로고
    • The metabolic syndrome: How it may influence hepatic stellate cell activation and hepatic fi-brosis
    • Lanthier N, Horsmans Y, Leclercq IA. The metabolic syndrome: how it may influence hepatic stellate cell activation and hepatic fi-brosis. Curr Opin Clin Nutr Metab Care 2009; 12: 404-11.
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 404-411
    • Lanthier, N.1    Horsmans, Y.2    Leclercq, I.A.3
  • 123
    • 62949144844 scopus 로고    scopus 로고
    • The adipose renin-angiotensin system: Role in cardiovascular disease
    • Thatcher S, Yiannikouris F, Gupte M, Cassis L. The adipose renin-angiotensin system: role in cardiovascular disease. Mol Cell Endo-crinol 2009; 302: 111-7.
    • (2009) Mol Cell Endo-crinol , vol.302 , pp. 111-117
    • Thatcher, S.1    Yiannikouris, F.2    Gupte, M.3    Cassis, L.4
  • 125
    • 84862017188 scopus 로고    scopus 로고
    • Gut microbiota and nonalcoholic fatty liver disease
    • Machado MV, Cortez-Pinto H. Gut microbiota and nonalcoholic fatty liver disease. Ann Hepatol 2012; 11: 440-9.
    • (2012) Ann Hepatol , vol.11 , pp. 440-449
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 126
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J, Elinav E, Jin C, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482: 179-85.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 127
    • 84857668720 scopus 로고    scopus 로고
    • The role of diet and nutrient composition in nonalcoholic Fatty liver disease
    • McCarthy EM, Rinella ME. The role of diet and nutrient composition in nonalcoholic Fatty liver disease. J Acad Nutr Diet 2012; 112: 401-9.
    • (2012) J Acad Nutr Diet , vol.112 , pp. 401-409
    • McCarthy, E.M.1    Rinella, M.E.2
  • 128
    • 84858703583 scopus 로고    scopus 로고
    • Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • Parker HM, Johnson NA, Burdon CA, Cohn JS, O'Connor HT, George J. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 2012; 56: 944-51.
    • (2012) J Hepatol , vol.56 , pp. 944-951
    • Parker, H.M.1    Johnson, N.A.2    Burdon, C.A.3    Cohn, J.S.4    O'Connor, H.T.5    George, J.6
  • 129
    • 33747626511 scopus 로고    scopus 로고
    • Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
    • Mari M, Caballero F, Colell A, et al. Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab 2006; 4: 185-98.
    • (2006) Cell Metab , vol.4 , pp. 185-198
    • Mari, M.1    Caballero, F.2    Colell, A.3
  • 130
    • 84859898706 scopus 로고    scopus 로고
    • Review article: Fructose in non-alcoholic fatty liver disease
    • Yilmaz Y. Review article: fructose in non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2012; 35: 1135-44.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 1135-1144
    • Yilmaz, Y.1
  • 131
    • 84856381801 scopus 로고    scopus 로고
    • Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis
    • Molloy JW, Calcagno CJ, Williams CD, Jones FJ, Torres DM, Harrison SA. Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. Hepatology 2012; 55: 429-36.
    • (2012) Hepatology , vol.55 , pp. 429-436
    • Molloy, J.W.1    Calcagno, C.J.2    Williams, C.D.3    Jones, F.J.4    Torres, D.M.5    Harrison, S.A.6
  • 132
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepati-tis
    • Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepati-tis. J Hepatol 2007; 47: 571-9.
    • (2007) J Hepatol , vol.47 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3    Tagalicud, A.4    Allman, M.5    Wallace, M.6
  • 133
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012; 122: 787-95.
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 134
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W, Metlakunta A, Dedousis N, et al. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 2010; 59: 347-57.
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3
  • 136
    • 84864017250 scopus 로고    scopus 로고
    • Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis
    • Galastri S, Zamara E, Milani S, et al. Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis. Clin Sci (Lond) 2012; 123: 459-71.
    • (2012) Clin Sci (Lond) , vol.123 , pp. 459-471
    • Galastri, S.1    Zamara, E.2    Milani, S.3
  • 137
    • 78049492110 scopus 로고    scopus 로고
    • The frac-talkine receptor CXCR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes
    • Karlmark KR, Zimmermann HW, Roderburg C, et al. The frac-talkine receptor CXCR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology 2010; 52: 1769-82.
    • (2010) Hepatology , vol.52 , pp. 1769-1782
    • Karlmark, K.R.1    Zimmermann, H.W.2    Roderburg, C.3
  • 138
    • 66349110620 scopus 로고    scopus 로고
    • Toll-like receptors as targets in chronic liver diseases
    • Mencin A, Kluwe J, Schwabe RF. Toll-like receptors as targets in chronic liver diseases. Gut 2009; 58: 704-20.
    • (2009) Gut , vol.58 , pp. 704-720
    • Mencin, A.1    Kluwe, J.2    Schwabe, R.F.3
  • 139
    • 84870986481 scopus 로고    scopus 로고
    • Toll-like receptors in liver disease
    • Petrasek J, Csak T, Szabo G. Toll-like receptors in liver disease. Adv Clin Chem 2013; 59: 155-201.
    • (2013) Adv Clin Chem , vol.59 , pp. 155-201
    • Petrasek, J.1    Csak, T.2    Szabo, G.3
  • 140
    • 79959573042 scopus 로고    scopus 로고
    • Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
    • Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G. Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology 2011; 54: 133-44.
    • (2011) Hepatology , vol.54 , pp. 133-144
    • Csak, T.1    Ganz, M.2    Pespisa, J.3    Kodys, K.4    Dolganiuc, A.5    Szabo, G.6
  • 141
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 in-flammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 in-flammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011; 17: 179-88.
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3
  • 142
    • 84860280502 scopus 로고    scopus 로고
    • Caspase-1-mediated regulation of fibrogenesis in diet-induced stea-tohepatitis
    • Dixon LJ, Berk M, Thapaliya S, Papouchado BG, Feldstein AE. Caspase-1-mediated regulation of fibrogenesis in diet-induced stea-tohepatitis. Lab Invest 2012; 92: 713-23.
    • (2012) Lab Invest , vol.92 , pp. 713-723
    • Dixon, L.J.1    Berk, M.2    Thapaliya, S.3    Papouchado, B.G.4    Feldstein, A.E.5
  • 143
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005; 11: 183-90.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3
  • 144
    • 33644813043 scopus 로고    scopus 로고
    • JNK1 but not JNK2 promotes the development of steatohepatitis in mice
    • Schattenberg JM, Singh R, Wang Y, et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 2006; 43: 163-72.
    • (2006) Hepatology , vol.43 , pp. 163-172
    • Schattenberg, J.M.1    Singh, R.2    Wang, Y.3
  • 145
    • 79960297797 scopus 로고    scopus 로고
    • The endocannabinoid system as a key mediator during liver diseases: New insights and therapeutic openings
    • Mallat A, Teixeira-Clerc F, Deveaux V, Manin S, Lotersztajn S. The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings. Br J Pharmacol 2011 163: 1432-40.
    • (2011) Br J Pharmacol , vol.163 , pp. 1432-1440
    • Mallat, A.1    Teixeira-Clerc, F.2    Deveaux, V.3    Manin, S.4    Lotersztajn, S.5
  • 146
    • 51349153318 scopus 로고    scopus 로고
    • Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
    • Osei-Hyiaman D, Liu J, Zhou L, et al. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest 2008; 118: 3160-9.
    • (2008) J Clin Invest , vol.118 , pp. 3160-3169
    • Osei-Hyiaman, D.1    Liu, J.2    Zhou, L.3
  • 147
    • 77951184370 scopus 로고    scopus 로고
    • CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice
    • Jourdan T, Djaouti L, Demizieux L, Gresti J, Verges B, Degrace P. CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice. Diabetes 2010; 59: 926-34.
    • (2010) Diabetes , vol.59 , pp. 926-934
    • Jourdan, T.1    Djaouti, L.2    Demizieux, L.3    Gresti, J.4    Verges, B.5    Degrace, P.6
  • 148
    • 34547423962 scopus 로고    scopus 로고
    • Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    • Gary-Bobo M, Elachouri G, Gallas JF, et al. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology 2007; 46: 122-9.
    • (2007) Hepatology , vol.46 , pp. 122-129
    • Gary-Bobo, M.1    Elachouri, G.2    Gallas, J.F.3
  • 149
    • 84864696439 scopus 로고    scopus 로고
    • Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance
    • Tam J, Cinar R, Liu J, et al. Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. Cell Metab 2012; 16: 167-79.
    • (2012) Cell Metab , vol.16 , pp. 167-179
    • Tam, J.1    Cinar, R.2    Liu, J.3
  • 150
    • 33745003240 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibro-sis
    • Teixeira-Clerc F, Julien B, Grenard P, et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibro-sis. Nat Med 2006; 12: 671-6.
    • (2006) Nat Med , vol.12 , pp. 671-676
    • Teixeira-Clerc, F.1    Julien, B.2    Grenard, P.3
  • 151
    • 77955286305 scopus 로고    scopus 로고
    • Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
    • Tam J, Vemuri VK, Liu J, et al. Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest 2010; 120: 2953-66.
    • (2010) J Clin Invest , vol.120 , pp. 2953-2966
    • Tam, J.1    Vemuri, V.K.2    Liu, J.3
  • 152
    • 67649159879 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis
    • Deveaux V, Cadoudal T, Ichigotani Y, et al. Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS One 2009; 4: e5844.
    • (2009) PLoS One , vol.4
    • Deveaux, V.1    Cadoudal, T.2    Ichigotani, Y.3
  • 153
    • 80053314254 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
    • Louvet A, Teixeira-Clerc F, Chobert MN, et al. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology 2011; 54: 1217-26.
    • (2011) Hepatology , vol.54 , pp. 1217-1226
    • Louvet, A.1    Teixeira-Clerc, F.2    Chobert, M.N.3
  • 154
    • 15744388722 scopus 로고    scopus 로고
    • Antifibrogenic role of the cannabinoid receptor CB2 in the liver
    • Julien B, Grenard P, Teixeira-Clerc F, et al. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology 2005; 128: 742-55.
    • (2005) Gastroenterology , vol.128 , pp. 742-755
    • Julien, B.1    Grenard, P.2    Teixeira-Clerc, F.3
  • 155
    • 77958166518 scopus 로고    scopus 로고
    • Apoptosis as a mechanism for liver disease progression
    • Guicciardi ME, Gores GJ. Apoptosis as a mechanism for liver disease progression. Semin Liver Dis 2010; 30: 402-10.
    • (2010) Semin Liver Dis , vol.30 , pp. 402-410
    • Guicciardi, M.E.1    Gores, G.J.2
  • 156
    • 84864269699 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in nonalcoholic fatty liver disease
    • Pagliassotti MJ. Endoplasmic reticulum stress in nonalcoholic fatty liver disease. Annu Rev Nutr 2012; 32: 17-33.
    • (2012) Annu Rev Nutr , vol.32 , pp. 17-33
    • Pagliassotti, M.J.1
  • 157
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature 2009; 458: 1131-5.
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 158
    • 84859444880 scopus 로고    scopus 로고
    • Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
    • Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 2012; 142: 938-46.
    • (2012) Gastroenterology , vol.142 , pp. 938-946
    • Hernandez-Gea, V.1    Ghiassi-Nejad, Z.2    Rozenfeld, R.3
  • 159
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two hits?
    • Day C, James O. Steatohepatitis: a tale of two hits? Gastroen-terology 1998; 114: 842-5.
    • (1998) Gastroen-terology , vol.114 , pp. 842-845
    • Day, C.1    James, O.2
  • 160
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    • Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med 2012; 52: 59-69.
    • (2012) Free Radic Biol Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 161
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000; 105: 1067-75.
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 162
    • 79960797578 scopus 로고    scopus 로고
    • Redox balance in the patho-genesis of nonalcoholic fatty liver disease: Mechanisms and therapeutic opportunities
    • Gambino R, Musso G, Cassader M. Redox balance in the patho-genesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities. Antioxid Redox Signal 2011; 15: 1325-65.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1325-1365
    • Gambino, R.1    Musso, G.2    Cassader, M.3
  • 163
    • 80052940689 scopus 로고    scopus 로고
    • Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target
    • Dongiovanni P, Fracanzani AL, Fargion S, Valenti L. Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J Hepatol 2011; 55: 920-32.
    • (2011) J Hepatol , vol.55 , pp. 920-932
    • Dongiovanni, P.1    Fracanzani, A.L.2    Fargion, S.3    Valenti, L.4
  • 164
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. Journal of Hepatology 2001; 35: 297-306.
    • (2001) Journal of Hepatology , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 165
    • 79960742122 scopus 로고    scopus 로고
    • Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis
    • Berzigotti A, Garcia-Tsao G, Bosch J, et al. Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis. Hepatology 2011; 54: 555-61.
    • (2011) Hepatology , vol.54 , pp. 555-561
    • Berzigotti, A.1    Garcia-Tsao, G.2    Bosch, J.3
  • 166
    • 67651095837 scopus 로고    scopus 로고
    • Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial
    • Everhart JE, Lok AS, Kim HY, et al. Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial. Gastroenterology 2009; 137: 549-57.
    • (2009) Gastroenterology , vol.137 , pp. 549-557
    • Everhart, J.E.1    Lok, A.S.2    Kim, H.Y.3
  • 167
    • 18544365700 scopus 로고    scopus 로고
    • Survival, liver failure, and hepatocellular carcinoma in obesity- related cryptogenic cirrhosis
    • Ratziu V, Bonyhay L, Di Martino V, et al. Survival, liver failure, and hepatocellular carcinoma in obesity- related cryptogenic cirrhosis. Hepatology 2002; 35: 1485-93.
    • (2002) Hepatology , vol.35 , pp. 1485-1493
    • Ratziu, V.1    Bonyhay, L.2    Di Martino, V.3
  • 168
    • 84856474979 scopus 로고    scopus 로고
    • The interaction of metabolic factors with HCV infection: Does it matter?
    • Bugianesi E, Salamone F, Negro F. The interaction of metabolic factors with HCV infection: does it matter? J Hepatol 2012; 56 Suppl 1: S56-65.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 1
    • Bugianesi, E.1    Salamone, F.2    Negro, F.3
  • 169
    • 34547097746 scopus 로고    scopus 로고
    • Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • Waris G, Felmlee DJ, Negro F, Siddiqui A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol 2007; 81: 8122-30.
    • (2007) J Virol , vol.81 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.J.2    Negro, F.3    Siddiqui, A.4
  • 170
    • 33646382082 scopus 로고    scopus 로고
    • Liver microsomal transfer protein is involved in hepatitics C related liver steatosis
    • Mirandola S, Realdon S, Iqbal J, et al. Liver microsomal transfer protein is involved in hepatitics C related liver steatosis. Gastroen-terology 2006; 130: 1661-9.
    • (2006) Gastroen-terology , vol.130 , pp. 1661-1669
    • Mirandola, S.1    Realdon, S.2    Iqbal, J.3
  • 171
    • 14044265120 scopus 로고    scopus 로고
    • Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids
    • Kapadia SB, Chisari FV. Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. Proc Natl Acad Sci USA 2005; 102: 2561-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2561-2566
    • Kapadia, S.B.1    Chisari, F.V.2
  • 172
    • 0033779703 scopus 로고    scopus 로고
    • Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States
    • Mehta SH, Brancati FL, Sulkowski MS, Strathdee SA, Szklo M, Thomas DL. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 2000; 133: 592-9.
    • (2000) Ann Intern Med , vol.133 , pp. 592-599
    • Mehta, S.H.1    Brancati, F.L.2    Sulkowski, M.S.3    Strathdee, S.A.4    Szklo, M.5    Thomas, D.L.6
  • 173
    • 79960807577 scopus 로고    scopus 로고
    • Current understanding of insulin resistance in hepatitis C
    • Kaddai V, Negro F. Current understanding of insulin resistance in hepatitis C. Expert Rev Gastroenterol Hepatol 2011; 5: 503-16.
    • (2011) Expert Rev Gastroenterol Hepatol , vol.5 , pp. 503-516
    • Kaddai, V.1    Negro, F.2
  • 174
    • 70349247875 scopus 로고    scopus 로고
    • Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C
    • Vanni E, Abate ML, Gentilcore E, et al. Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C. Hepatology 2009; 50: 697-706.
    • (2009) Hepatology , vol.50 , pp. 697-706
    • Vanni, E.1    Abate, M.L.2    Gentilcore, E.3
  • 175
    • 78349285127 scopus 로고    scopus 로고
    • Hepatitis C: Viral and host factors associated with non-response to pegylated interferon plus ribavirin
    • Asselah T, Estrabaud E, Bieche I, et al. Hepatitis C: viral and host factors associated with non-response to pegylated interferon plus ribavirin. Liver Int 2010; 30: 1259-69.
    • (2010) Liver Int , vol.30 , pp. 1259-1269
    • Asselah, T.1    Estrabaud, E.2    Bieche, I.3
  • 176
    • 55649094639 scopus 로고    scopus 로고
    • Interaction of metabolic syndrome, nonalcoholic fatty liver disease and chronic hepatitis C
    • Rafiq N, Younossi ZM. Interaction of metabolic syndrome, nonalcoholic fatty liver disease and chronic hepatitis C. Expert Rev Gas-troenterol Hepatol 2008; 2: 207-15.
    • (2008) Expert Rev Gas-troenterol Hepatol , vol.2 , pp. 207-215
    • Rafiq, N.1    Younossi, Z.M.2
  • 177
    • 0043037223 scopus 로고    scopus 로고
    • High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    • Bressler BL, Guindi M, Tomlinson G, Heathcote J. High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Hepatology 2003; 38: 639-44.
    • (2003) Hepatology , vol.38 , pp. 639-644
    • Bressler, B.L.1    Guindi, M.2    Tomlinson, G.3    Heathcote, J.4
  • 178
    • 33745580391 scopus 로고    scopus 로고
    • Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway
    • Di Bona D, Cippitelli M, Fionda C, et al. Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway. J Hepatol 2006; 45: 271-9.
    • (2006) J Hepatol , vol.45 , pp. 271-279
    • Di Bona, D.1    Cippitelli, M.2    Fionda, C.3
  • 179
    • 33745560465 scopus 로고    scopus 로고
    • Impact of obesity on treatment of chronic hepatitis C
    • Charlton MR, Pockros PJ, Harrison SA. Impact of obesity on treatment of chronic hepatitis C. Hepatology 2006; 43: 1177-86.
    • (2006) Hepatology , vol.43 , pp. 1177-1186
    • Charlton, M.R.1    Pockros, P.J.2    Harrison, S.A.3
  • 180
    • 79960824576 scopus 로고    scopus 로고
    • Impact of insulin resistance on sustained response in HCV patients treated with pegylated interferon and ribavirin: A meta-analysis
    • Deltenre P, Louvet A, Lemoine M, et al. Impact of insulin resistance on sustained response in HCV patients treated with pegylated interferon and ribavirin: a meta-analysis. J Hepatol 2011; 55: 1187-94.
    • (2011) J Hepatol , vol.55 , pp. 1187-1194
    • Deltenre, P.1    Louvet, A.2    Lemoine, M.3
  • 181
    • 72549104493 scopus 로고    scopus 로고
    • Treatment of insulin resistance with metformin in naive genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin
    • Romero-Gomez M, Diago M, Andrade RJ, et al. Treatment of insulin resistance with metformin in naive genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin. Hepatology 2009; 50: 1702-8.
    • (2009) Hepatology , vol.50 , pp. 1702-1708
    • Romero-Gomez, M.1    Diago, M.2    Andrade, R.J.3
  • 183
    • 0036185832 scopus 로고    scopus 로고
    • Risk factors of fibrosis in alcohol-induced liver disease
    • Raynard B, Balian A, Fallik D, et al. Risk factors of fibrosis in alcohol-induced liver disease. Hepatology 2002; 35: 635-8.
    • (2002) Hepatology , vol.35 , pp. 635-638
    • Raynard, B.1    Balian, A.2    Fallik, D.3
  • 184
    • 84860389258 scopus 로고    scopus 로고
    • Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
    • Xu J, Lai KK, Verlinsky A, et al. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol 2011; 55: 673-82.
    • (2011) J Hepatol , vol.55 , pp. 673-682
    • Xu, J.1    Lai, K.K.2    Verlinsky, A.3
  • 185
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet 2012; 379: 1245-55.
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 186
    • 84862660912 scopus 로고    scopus 로고
    • Are common factors involved in the patho-genesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma
    • Palmer WC, Patel T. Are common factors involved in the patho-genesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma. J Hepatol 2012; 57: 69-76.
    • (2012) J Hepatol , vol.57 , pp. 69-76
    • Palmer, W.C.1    Patel, T.2
  • 187
    • 84872613896 scopus 로고    scopus 로고
    • Metabolic syndrome and hepatocellular carcinoma risk
    • Turati F, Talamini R, Pelucchi C, et al. Metabolic syndrome and hepatocellular carcinoma risk. Br J Cancer 2013; 108: 222-8.
    • (2013) Br J Cancer , vol.108 , pp. 222-228
    • Turati, F.1    Talamini, R.2    Pelucchi, C.3
  • 188
    • 79953185045 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis
    • Ertle J, Dechene A, Sowa JP, et al. Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis. Int J Cancer 2011; 128: 2436-43.
    • (2011) Int J Cancer , vol.128 , pp. 2436-2443
    • Ertle, J.1    Dechene, A.2    Sowa, J.P.3
  • 189
    • 79955033727 scopus 로고    scopus 로고
    • Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellu-lar carcinoma
    • quiz e50
    • Yasui K, Hashimoto E, Komorizono Y, et al. Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellu-lar carcinoma. Clin Gastroenterol Hepatol 2011; 9: 428-433; quiz e50.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 428-433
    • Yasui, K.1    Hashimoto, E.2    Komorizono, Y.3
  • 190
    • 63349085247 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis
    • Paradis V, Zalinski S, Chelbi E, et al. Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis. Hepatology 2009; 49: 851-9.
    • (2009) Hepatology , vol.49 , pp. 851-859
    • Paradis, V.1    Zalinski, S.2    Chelbi, E.3
  • 191
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 1625-38.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 192
    • 79961218135 scopus 로고    scopus 로고
    • Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: A systematic review and meta-analysis of cohort studies
    • Wang C, Wang X, Gong G, et al. Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies. Int J Cancer 2012; 130: 1639-48.
    • (2012) Int J Cancer , vol.130 , pp. 1639-1648
    • Wang, C.1    Wang, X.2    Gong, G.3
  • 193
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocel-lular carcinoma cells
    • Saxena NK, Sharma D, Ding X, et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocel-lular carcinoma cells. Cancer Res 2007; 67: 2497-507.
    • (2007) Cancer Res , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3
  • 194
    • 73149120271 scopus 로고    scopus 로고
    • Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link
    • Siegel AB, Zhu AX. Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer 2009; 115: 5651-61.
    • (2009) Cancer , vol.115 , pp. 5651-5661
    • Siegel, A.B.1    Zhu, A.X.2
  • 195
    • 48149091097 scopus 로고    scopus 로고
    • Epidemic inflammation: Pondering obesity
    • Nathan C. Epidemic inflammation: pondering obesity. Mol Med 2008; 14: 485-92.
    • (2008) Mol Med , vol.14 , pp. 485-492
    • Nathan, C.1
  • 196
    • 79960517989 scopus 로고    scopus 로고
    • Patients with NASH and cryptogenic cirrhosis are less likely than those with hepatitis C to receive liver transplants
    • O'Leary JG, Landaverde C, Jennings L, Goldstein RM, Davis GL. Patients with NASH and cryptogenic cirrhosis are less likely than those with hepatitis C to receive liver transplants. Clin Gastroente-rol Hepatol 2011; 9: 700-704.e1.
    • (2011) Clin Gastroente-rol Hepatol , vol.9 , pp. 700-704
    • O'Leary, J.G.1    Landaverde, C.2    Jennings, L.3    Goldstein, R.M.4    Davis, G.L.5
  • 197
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepa-tology 2010; 51: 1820-32.
    • (2010) Hepa-tology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 198
    • 84858658381 scopus 로고    scopus 로고
    • EASL-EORTC clinical practice guidelines: Management of hepato-cellular carcinoma
    • EASL-EORTC clinical practice guidelines: management of hepato-cellular carcinoma. J Hepatol 2012; 56: 908-943.
    • (2012) J Hepatol , vol.56 , pp. 908-943
  • 199
    • 84876494014 scopus 로고    scopus 로고
    • Hepatocellular benign tumors-from molecular classification to personalized clinical care
    • Nault JC, Bioulac-Sage P, Zucman-Rossi J. Hepatocellular benign tumors-from molecular classification to personalized clinical care. Gastroenterology 2013; 144: 888-902.
    • (2013) Gastroenterology , vol.144 , pp. 888-902
    • Nault, J.C.1    Bioulac-Sage, P.2    Zucman-Rossi, J.3
  • 200
    • 79955804203 scopus 로고    scopus 로고
    • High prevalence of colo-rectal neoplasm in patients with non-alcoholic steatohepatitis
    • Wong VW, Wong GL, Tsang SW, et al. High prevalence of colo-rectal neoplasm in patients with non-alcoholic steatohepatitis. Gut 2011; 60: 829-36.
    • (2011) Gut , vol.60 , pp. 829-836
    • Wong, V.W.1    Wong, G.L.2    Tsang, S.W.3
  • 201
    • 84872150627 scopus 로고    scopus 로고
    • The relationship between nonalcoholic fatty liver disease and colorectal cancer: The future challenges and outcomes of the metabolic syndrome
    • Muhidin SO, Magan AA, Osman KA, Syed S, Ahmed MH. The relationship between nonalcoholic fatty liver disease and colorectal cancer: the future challenges and outcomes of the metabolic syndrome. J Obes 2012; 2012: 637538.
    • (2012) J Obes , vol.2012 , pp. 637538
    • Muhidin, S.O.1    Magan, A.A.2    Osman, K.A.3    Syed, S.4    Ahmed, M.H.5
  • 202
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
    • Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123: 134-40.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 203
    • 77957375969 scopus 로고    scopus 로고
    • Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
    • Targher G, Day CP, Bonora E. Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease. New England Journal of Medicine 2010; 363: 1341-1350.
    • (2010) New England Journal of Medicine , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 204
    • 84864110034 scopus 로고    scopus 로고
    • Management of nonalcoholic steatohepati-tis: An evidence-based approach
    • Mahady SE, George J. Management of nonalcoholic steatohepati-tis: an evidence-based approach. Clin Liver Dis 2012; 16: 631-45.
    • (2012) Clin Liver Dis , vol.16 , pp. 631-645
    • Mahady, S.E.1    George, J.2
  • 205
    • 84864081494 scopus 로고    scopus 로고
    • Features, diagnosis, and treatment of nonalcoholic fatty liver disease
    • Torres DM, Williams CD, Harrison SA. Features, diagnosis, and treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2012; 10: 837-58.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 837-858
    • Torres, D.M.1    Williams, C.D.2    Harrison, S.A.3
  • 206
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroen-terological Association
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroen-terological Association. Hepatology 2012; 55: 2005-23.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 207
    • 84881320210 scopus 로고    scopus 로고
    • Pathophysiology of NASH: Perspectives for A Targeted Treatment
    • Marra F, Lotersztajn S. Pathophysiology of NASH: Perspectives for A Targeted Treatment. Curr Pharm Des 2013;19:5250-69.
    • (2013) Curr Pharm Des , vol.19 , pp. 5250-5269
    • Marra, F.1    Lotersztajn, S.2
  • 208
    • 19144372447 scopus 로고    scopus 로고
    • One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: A pilot study
    • Huang MA, Greenson JK, Chao C, et al. One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroen-terol 2005; 100: 1072-81.
    • (2005) Am J Gastroen-terol , vol.100 , pp. 1072-1081
    • Huang, M.A.1    Greenson, J.K.2    Chao, C.3
  • 209
    • 27744490794 scopus 로고    scopus 로고
    • Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease
    • Suzuki A, Lindor K, St Sauver J, et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005; 43: 1060-6.
    • (2005) J Hepatol , vol.43 , pp. 1060-1066
    • Suzuki, A.1    Lindor, K.2    St Sauver, J.3
  • 210
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic stea-tohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic stea-tohepatitis. Hepatology 2010; 51: 121-9.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 211
    • 70350072281 scopus 로고    scopus 로고
    • Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss
    • Johnson NA, Sachinwalla T, Walton DW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 2009; 50: 1105-12.
    • (2009) Hepatology , vol.50 , pp. 1105-1112
    • Johnson, N.A.1    Sachinwalla, T.2    Walton, D.W.3
  • 212
    • 84861573124 scopus 로고    scopus 로고
    • Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
    • Sullivan S, Kirk EP, Mittendorfer B, Patterson BW, Klein S. Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology 2012; 55: 1738-45.
    • (2012) Hepatology , vol.55 , pp. 1738-1745
    • Sullivan, S.1    Kirk, E.P.2    Mittendorfer, B.3    Patterson, B.W.4    Klein, S.5
  • 214
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E, Gentilcore E, Manini R, et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005; 100: 1082-90.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3
  • 215
    • 70350662659 scopus 로고    scopus 로고
    • Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial
    • Haukeland JW, Konopski Z, Eggesbo HB, et al. Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial. Scand J Gastroenterol 2009; 44: 853-60.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 853-860
    • Haukeland, J.W.1    Konopski, Z.2    Eggesbo, H.B.3
  • 216
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274-85.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 217
    • 57549107354 scopus 로고    scopus 로고
    • Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design
    • Chalasani NP, Sanyal AJ, Kowdley KV, et al. Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. Contemp Clin Trials 2009; 30: 88-96.
    • (2009) Contemp Clin Trials , vol.30 , pp. 88-96
    • Chalasani, N.P.1    Sanyal, A.J.2    Kowdley, K.V.3
  • 218
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006; 355: 2297-307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 219
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oliver D, Bacon BR. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003; 38: 1008-17.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 220
    • 75449116707 scopus 로고    scopus 로고
    • Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
    • Ratziu V, Charlotte F, Bernhardt C, et al. Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial. Hepatology 2010; 51: 445-53.
    • (2010) Hepatology , vol.51 , pp. 445-453
    • Ratziu, V.1    Charlotte, F.2    Bernhardt, C.3
  • 221
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal GP, Thomas JA, Kaye PV, et al. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 2008; 135: 1176-84.
    • (2008) Gastroenterology , vol.135 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.