-
1
-
-
42249103062
-
Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease
-
Public Policy Committee of the American Association for the Study of Liver Disease
-
Kim W R., Flamm S L., Di Bisceglie A M., Bodenheimer H C., Public Policy Committee of the American Association for the Study of Liver Disease. Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology 2008 47 (4) 1363-1370
-
(2008)
Hepatology
, vol.47
, Issue.4
, pp. 1363-1370
-
-
Kim, W.R.1
Flamm, S.L.2
Di Bisceglie, A.M.3
Bodenheimer, H.C.4
-
2
-
-
0034060334
-
Apoptosis and liver disease
-
Rust C, Gores G J. Apoptosis and liver disease. Am J Med 2000 108 (7) 567-574
-
(2000)
Am J Med
, vol.108
, Issue.7
, pp. 567-574
-
-
Rust, C.1
Gores, G.J.2
-
3
-
-
1242336980
-
Apoptosis: The nexus of liver injury and fibrosis
-
Canbay A, Friedman S, Gores G J. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004 39 (2) 273-278
-
(2004)
Hepatology
, vol.39
, Issue.2
, pp. 273-278
-
-
Canbay, A.1
Friedman, S.2
Gores, G.J.3
-
4
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr J F., Wyllie A H., Currie A R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972 26 (4) 239-257
-
(1972)
Br J Cancer
, vol.26
, Issue.4
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
5
-
-
9144247682
-
Detection of the M30 neoepitope as a new tool to quantify liver apoptosis: Timing and patterns of positivity on frozen and paraffin-embedded sections
-
Grassi A, Susca M, Ferri S et al. Detection of the M30 neoepitope as a new tool to quantify liver apoptosis: timing and patterns of positivity on frozen and paraffin-embedded sections. Am J Clin Pathol 2004 121 (2) 211-219
-
(2004)
Am J Clin Pathol
, vol.121
, Issue.2
, pp. 211-219
-
-
Grassi, A.1
Susca, M.2
Ferri, S.3
-
6
-
-
69249100500
-
Human caspases: Activation, specificity, and regulation
-
Pop C, Salvesen G S. Human caspases: activation, specificity, and regulation. J Biol Chem 2009 284 (33) 21777-21781
-
(2009)
J Biol Chem
, vol.284
, Issue.33
, pp. 21777-21781
-
-
Pop, C.1
Salvesen, G.S.2
-
7
-
-
77952784381
-
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation
-
Oberst A, Pop C, Tremblay A G. et al. Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem 2010 285 (22) 16632-16642
-
(2010)
J Biol Chem
, vol.285
, Issue.22
, pp. 16632-16642
-
-
Oberst, A.1
Pop, C.2
Tremblay, A.G.3
-
8
-
-
1342329725
-
The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse
-
Canbay A, Feldstein A, Baskin-Bey E, Bronk S F., Gores G J. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther 2004 308 (3) 1191-1196
-
(2004)
J Pharmacol Exp Ther
, vol.308
, Issue.3
, pp. 1191-1196
-
-
Canbay, A.1
Feldstein, A.2
Baskin-Bey, E.3
Bronk, S.F.4
Gores, G.J.5
-
9
-
-
33745904468
-
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
-
Wieckowska A, Zein N N., Yerian L M., Lopez A R., McCullough A J., Feldstein A E. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006 44 (1) 27-33
-
(2006)
Hepatology
, vol.44
, Issue.1
, pp. 27-33
-
-
Wieckowska, A.1
Zein, N.N.2
Yerian, L.M.3
Lopez, A.R.4
McCullough, A.J.5
Feldstein, A.E.6
-
10
-
-
39749182234
-
Apoptosis: Controlled demolition at the cellular level
-
Taylor R C., Cullen S P., Martin S J. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008 9 (3) 231-241
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, Issue.3
, pp. 231-241
-
-
Taylor, R.C.1
Cullen, S.P.2
Martin, S.J.3
-
11
-
-
77955591462
-
Hepatocyte death: A clear and present danger
-
Malhi H, Guicciardi M E., Gores G J. Hepatocyte death: a clear and present danger. Physiol Rev 2010 90 (3) 1165-1194
-
(2010)
Physiol Rev
, vol.90
, Issue.3
, pp. 1165-1194
-
-
Malhi, H.1
Guicciardi, M.E.2
Gores, G.J.3
-
12
-
-
42949086433
-
Cellular and molecular mechanisms of liver injury
-
Malhi H, Gores G J. Cellular and molecular mechanisms of liver injury. Gastroenterology 2008 134 (6) 1641-1654
-
(2008)
Gastroenterology
, vol.134
, Issue.6
, pp. 1641-1654
-
-
Malhi, H.1
Gores, G.J.2
-
13
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei M C., Zong W X., Cheng E H. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001 292 (5517) 727-730
-
(2001)
Science
, vol.292
, Issue.5517
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
-
14
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
Youle R J., Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008 9 (1) 47-59
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, Issue.1
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
15
-
-
0034616945
-
SMAC, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
-
Du C, Fang M, Li Y, Li L, Wang X. SMAC, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000 102 (1) 33-42
-
(2000)
Cell
, vol.102
, Issue.1
, pp. 33-42
-
-
Du, C.1
Fang, M.2
Li, Y.3
Li, L.4
Wang, X.5
-
16
-
-
67649386107
-
Life and death by death receptors
-
Guicciardi M E., Gores G J. Life and death by death receptors. FASEB J 2009 23 (6) 1625-1637
-
(2009)
FASEB J
, vol.23
, Issue.6
, pp. 1625-1637
-
-
Guicciardi, M.E.1
Gores, G.J.2
-
17
-
-
0032899887
-
Death receptors in liver biology and pathobiology
-
Faubion W A., Gores G J. Death receptors in liver biology and pathobiology. Hepatology 1999 29 (1) 1-4
-
(1999)
Hepatology
, vol.29
, Issue.1
, pp. 1-4
-
-
Faubion, W.A.1
Gores, G.J.2
-
18
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998 94 (4) 481-490
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
19
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H, Zhu H, Xu C J., Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998 94 (4) 491-501
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
20
-
-
35948933964
-
Death receptor-mediated liver injury
-
Akazawa Y, Gores G J. Death receptor-mediated liver injury. Semin Liver Dis 2007 27 (4) 327-338
-
(2007)
Semin Liver Dis
, vol.27
, Issue.4
, pp. 327-338
-
-
Akazawa, Y.1
Gores, G.J.2
-
21
-
-
0030892283
-
Cytotoxic T cells and viral hepatitis
-
Chisari F V. Cytotoxic T cells and viral hepatitis. J Clin Invest 1997 99 (7) 1472-1477
-
(1997)
J Clin Invest
, vol.99
, Issue.7
, pp. 1472-1477
-
-
Chisari, F.V.1
-
22
-
-
0033936183
-
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas
-
Sodeman T, Bronk S F., Roberts P J., Miyoshi H, Gores G J. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas. Am J Physiol Gastrointest Liver Physiol 2000 278 (6) G992-G999
-
(2000)
Am J Physiol Gastrointest Liver Physiol
, vol.278
, Issue.6
-
-
Sodeman, T.1
Bronk, S.F.2
Roberts, P.J.3
Miyoshi, H.4
Gores, G.J.5
-
23
-
-
0032919402
-
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
-
Faubion W A., Guicciardi M E., Miyoshi H et al. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest 1999 103 (1) 137-145
-
(1999)
J Clin Invest
, vol.103
, Issue.1
, pp. 137-145
-
-
Faubion, W.A.1
Guicciardi, M.E.2
Miyoshi, H.3
-
24
-
-
0036827808
-
Cholestasis increases tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-R2/DR5 expression and sensitizes the liver to TRAIL-mediated cytotoxicity
-
Higuchi H, Bronk S F., Taniai M, Canbay A, Gores G J. Cholestasis increases tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-R2/DR5 expression and sensitizes the liver to TRAIL-mediated cytotoxicity. J Pharmacol Exp Ther 2002 303 (2) 461-467
-
(2002)
J Pharmacol Exp Ther
, vol.303
, Issue.2
, pp. 461-467
-
-
Higuchi, H.1
Bronk, S.F.2
Taniai, M.3
Canbay, A.4
Gores, G.J.5
-
25
-
-
0035111054
-
Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis
-
Natori S, Rust C, Stadheim L M., Srinivasan A, Burgart L J., Gores G J. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001 34 (2) 248-253
-
(2001)
J Hepatol
, vol.34
, Issue.2
, pp. 248-253
-
-
Natori, S.1
Rust, C.2
Stadheim, L.M.3
Srinivasan, A.4
Burgart, L.J.5
Gores, G.J.6
-
26
-
-
0035665313
-
Increased severity of alcoholic liver injury in female rats: Role of oxidative stress, endotoxin, and chemokines
-
Nanji A A., Jokelainen K, Fotouhinia M et al. Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines. Am J Physiol Gastrointest Liver Physiol 2001 281 (6) G1348-G1356
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.281
, Issue.6
-
-
Nanji, A.A.1
Jokelainen, K.2
Fotouhinia, M.3
-
27
-
-
0042165989
-
Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
-
Feldstein A E., Canbay A, Angulo P et al. Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003 125 (2) 437-443
-
(2003)
Gastroenterology
, vol.125
, Issue.2
, pp. 437-443
-
-
Feldstein, A.E.1
Canbay, A.2
Angulo, P.3
-
28
-
-
34848861130
-
Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis
-
Barreyro F J., Kobayashi S, Bronk S F., Werneburg N W., Malhi H, Gores G J. Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem 2007 282 (37) 27141-27154
-
(2007)
J Biol Chem
, vol.282
, Issue.37
, pp. 27141-27154
-
-
Barreyro, F.J.1
Kobayashi, S.2
Bronk, S.F.3
Werneburg, N.W.4
Malhi, H.5
Gores, G.J.6
-
29
-
-
70350418854
-
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
-
Cazanave S C., Mott J L., Elmi N A. et al. JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem 2009 284 (39) 26591-26602
-
(2009)
J Biol Chem
, vol.284
, Issue.39
, pp. 26591-26602
-
-
Cazanave, S.C.1
Mott, J.L.2
Elmi, N.A.3
-
30
-
-
33744948514
-
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
-
Malhi H, Bronk S F., Werneburg N W., Gores G J. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 2006 281 (17) 12093-12101
-
(2006)
J Biol Chem
, vol.281
, Issue.17
, pp. 12093-12101
-
-
Malhi, H.1
Bronk, S.F.2
Werneburg, N.W.3
Gores, G.J.4
-
31
-
-
33646891970
-
Bax inhibition protects against free fatty acid-induced lysosomal permeabilization
-
Feldstein A E., Werneburg N W., Li Z, Bronk S F., Gores G J. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol 2006 290 (6) G1339-G1346
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
, Issue.6
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Li, Z.3
Bronk, S.F.4
Gores, G.J.5
-
32
-
-
34547193134
-
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
-
Malhi H, Barreyro F J., Isomoto H, Bronk S F., Gores G J. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 2007 56 (8) 1124-1131
-
(2007)
Gut
, vol.56
, Issue.8
, pp. 1124-1131
-
-
Malhi, H.1
Barreyro, F.J.2
Isomoto, H.3
Bronk, S.F.4
Gores, G.J.5
-
33
-
-
77349114276
-
Histologic predictors of fibrosis progression in liver allografts in patients with hepatitis C virus infection
-
Meriden Z, Forde K A., Pasha T L. et al. Histologic predictors of fibrosis progression in liver allografts in patients with hepatitis C virus infection. Clin Gastroenterol Hepatol 2010 8 (3) 289-296, 296, e1e8
-
(2010)
Clin Gastroenterol Hepatol
, vol.8
, Issue.3
, pp. 289-296
-
-
Meriden, Z.1
Forde, K.A.2
Pasha, T.L.3
-
34
-
-
0036788277
-
Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
-
Canbay A, Higuchi H, Bronk S F., Taniai M, Sebo T J., Gores G J. Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Gastroenterology 2002 123 (4) 1323-1330
-
(2002)
Gastroenterology
, vol.123
, Issue.4
, pp. 1323-1330
-
-
Canbay, A.1
Higuchi, H.2
Bronk, S.F.3
Taniai, M.4
Sebo, T.J.5
Gores, G.J.6
-
35
-
-
0036548118
-
Inflammation in response to hepatocellular apoptosis
-
Jaeschke H. Inflammation in response to hepatocellular apoptosis. Hepatology 2002 35 (4) 964-966
-
(2002)
Hepatology
, vol.35
, Issue.4
, pp. 964-966
-
-
Jaeschke, H.1
-
36
-
-
0035966059
-
Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway
-
Faouzi S, Burckhardt B E., Hanson J C. et al. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J Biol Chem 2001 276 (52) 49077-49082
-
(2001)
J Biol Chem
, vol.276
, Issue.52
, pp. 49077-49082
-
-
Faouzi, S.1
Burckhardt, B.E.2
Hanson, J.C.3
-
37
-
-
75949105922
-
The BCL-2 family reunion
-
Chipuk J E., Moldoveanu T, Llambi F, Parsons M J., Green D R. The BCL-2 family reunion. Mol Cell 2010 37 (3) 299-310
-
(2010)
Mol Cell
, vol.37
, Issue.3
, pp. 299-310
-
-
Chipuk, J.E.1
Moldoveanu, T.2
Llambi, F.3
Parsons, M.J.4
Green, D.R.5
-
38
-
-
70350048553
-
The liver's dance with death: Two Bcl-2 guardian proteins from the abyss
-
Cazanave S C., Gores G J. The liver's dance with death: two Bcl-2 guardian proteins from the abyss. Hepatology 2009 50 (4) 1009-1013
-
(2009)
Hepatology
, vol.50
, Issue.4
, pp. 1009-1013
-
-
Cazanave, S.C.1
Gores, G.J.2
-
39
-
-
5144232785
-
Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses
-
Takehara T, Tatsumi T, Suzuki T et al. Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. Gastroenterology 2004 127 (4) 1189-1197
-
(2004)
Gastroenterology
, vol.127
, Issue.4
, pp. 1189-1197
-
-
Takehara, T.1
Tatsumi, T.2
Suzuki, T.3
-
40
-
-
70350070333
-
Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver
-
Hikita H, Takehara T, Shimizu S et al. Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver. Hepatology 2009 50 (4) 1217-1226
-
(2009)
Hepatology
, vol.50
, Issue.4
, pp. 1217-1226
-
-
Hikita, H.1
Takehara, T.2
Shimizu, S.3
-
41
-
-
77649152255
-
Autoimmunity and the clearance of dead cells
-
Nagata S, Hanayama R, Kawane K. Autoimmunity and the clearance of dead cells. Cell 2010 140 (5) 619-630
-
(2010)
Cell
, vol.140
, Issue.5
, pp. 619-630
-
-
Nagata, S.1
Hanayama, R.2
Kawane, K.3
-
42
-
-
0030892234
-
Apoptosis by death factor
-
Nagata S. Apoptosis by death factor. Cell 1997 88 (3) 355-365
-
(1997)
Cell
, vol.88
, Issue.3
, pp. 355-365
-
-
Nagata, S.1
-
43
-
-
0142151769
-
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
-
Canbay A, Feldstein A E., Higuchi H et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology 2003 38 (5) 1188-1198
-
(2003)
Hepatology
, vol.38
, Issue.5
, pp. 1188-1198
-
-
Canbay, A.1
Feldstein, A.E.2
Higuchi, H.3
-
44
-
-
0038476330
-
Apoptotic body engulfment by a human stellate cell line is profibrogenic
-
Canbay A, Taimr P, Torok N, Higuchi H, Friedman S, Gores G J. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab Invest 2003 83 (5) 655-663
-
(2003)
Lab Invest
, vol.83
, Issue.5
, pp. 655-663
-
-
Canbay, A.1
Taimr, P.2
Torok, N.3
Higuchi, H.4
Friedman, S.5
Gores, G.J.6
-
45
-
-
67349172516
-
Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways
-
Jiang J X., Mikami K, Venugopal S, Li Y, Török N J. Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. J Hepatol 2009 51 (1) 139-148
-
(2009)
J Hepatol
, vol.51
, Issue.1
, pp. 139-148
-
-
Jiang, J.X.1
Mikami, K.2
Venugopal, S.3
Li, Y.4
Török, N.J.5
-
46
-
-
70249090374
-
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
-
Elliott M R., Chekeni F B., Trampont P C. et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 2009 461 (7261) 282-286
-
(2009)
Nature
, vol.461
, Issue.7261
, pp. 282-286
-
-
Elliott, M.R.1
Chekeni, F.B.2
Trampont, P.C.3
-
47
-
-
70249103104
-
Cell biology: Sent by the scent of death
-
Gregory C. Cell biology: Sent by the scent of death. Nature 2009 461 (7261) 181-182
-
(2009)
Nature
, vol.461
, Issue.7261
, pp. 181-182
-
-
Gregory, C.1
-
48
-
-
3242673389
-
Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells
-
Dranoff J A., Ogawa M, Kruglov E A. et al. Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2004 287 (2) G417-G424
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
, Issue.2
-
-
Dranoff, J.A.1
Ogawa, M.2
Kruglov, E.A.3
-
49
-
-
77954990550
-
Cell death and fibrogenesis
-
Mehal W, Imaeda A. Cell death and fibrogenesis. Semin Liver Dis 2010 30 (3) 226-231
-
(2010)
Semin Liver Dis
, vol.30
, Issue.3
, pp. 226-231
-
-
Mehal, W.1
Imaeda, A.2
-
50
-
-
70349305527
-
CX3CL1/fractalkine shedding by human hepatic stellate cells: Contribution to chronic inflammation in the liver
-
Bourd-Boittin K, Basset L, Bonnier D, L'helgoualc'h A, Samson M, Théret N. CX3CL1/fractalkine shedding by human hepatic stellate cells: contribution to chronic inflammation in the liver. J Cell Mol Med 2009 13 (8A, 8A) 1526-1535
-
(2009)
J Cell Mol Med
, vol.13
, Issue.8 A
, pp. 1526-1535
-
-
Bourd-Boittin, K.1
Basset, L.2
Bonnier, D.3
L'Helgoualc'H, A.4
Samson, M.5
Théret, N.6
-
51
-
-
37848999947
-
The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection
-
Wasmuth H E., Zaldivar M M., Berres M L. et al. The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection. J Hepatol 2008 48 (2) 208-215
-
(2008)
J Hepatol
, vol.48
, Issue.2
, pp. 208-215
-
-
Wasmuth, H.E.1
Zaldivar, M.M.2
Berres, M.L.3
-
52
-
-
70350451432
-
Cell death
-
Hotchkiss R S., Strasser A, McDunn J E., Swanson P E. Cell death. N Engl J Med 2009 361 (16) 1570-1583
-
(2009)
N Engl J Med
, vol.361
, Issue.16
, pp. 1570-1583
-
-
Hotchkiss, R.S.1
Strasser, A.2
McDunn, J.E.3
Swanson, P.E.4
-
53
-
-
35948954244
-
Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
-
Friedman S L. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008 88 (1) 125-172
-
(2008)
Physiol Rev
, vol.88
, Issue.1
, pp. 125-172
-
-
Friedman, S.L.1
-
54
-
-
0030896618
-
Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages
-
Kiener P A., Davis P M., Starling G C. et al. Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages. J Exp Med 1997 185 (8) 1511-1516
-
(1997)
J Exp Med
, vol.185
, Issue.8
, pp. 1511-1516
-
-
Kiener, P.A.1
Davis, P.M.2
Starling, G.C.3
-
55
-
-
0032573581
-
Regulation of the proinflammatory effects of Fas ligand (CD95L)
-
Chen J J., Sun Y, Nabel G J. Regulation of the proinflammatory effects of Fas ligand (CD95L). Science 1998 282 (5394) 1714-1717
-
(1998)
Science
, vol.282
, Issue.5394
, pp. 1714-1717
-
-
Chen, J.J.1
Sun, Y.2
Nabel, G.J.3
-
56
-
-
77950611682
-
Portal fibroblasts: Underappreciated mediators of biliary fibrosis
-
Dranoff J A., Wells R G. Portal fibroblasts: Underappreciated mediators of biliary fibrosis. Hepatology 2010 51 (4) 1438-1444
-
(2010)
Hepatology
, vol.51
, Issue.4
, pp. 1438-1444
-
-
Dranoff, J.A.1
Wells, R.G.2
-
57
-
-
42949163491
-
Mechanisms of hepatic fibrogenesis
-
Friedman S L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008 134 (6) 1655-1669
-
(2008)
Gastroenterology
, vol.134
, Issue.6
, pp. 1655-1669
-
-
Friedman, S.L.1
-
58
-
-
56149119778
-
Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism
-
Jiang J X., Mikami K, Shah V H., Torok N J. Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism. Hepatology 2008 48 (5) 1497-1505
-
(2008)
Hepatology
, vol.48
, Issue.5
, pp. 1497-1505
-
-
Jiang, J.X.1
Mikami, K.2
Shah, V.H.3
Torok, N.J.4
-
59
-
-
33645243410
-
Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
-
Zhan S S., Jiang J X., Wu J et al. Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology 2006 43 (3) 435-443
-
(2006)
Hepatology
, vol.43
, Issue.3
, pp. 435-443
-
-
Zhan, S.S.1
Jiang, J.X.2
Wu, J.3
-
60
-
-
36348997503
-
Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
-
Watanabe A, Hashmi A, Gomes D A. et al. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology 2007 46 (5) 1509-1518
-
(2007)
Hepatology
, vol.46
, Issue.5
, pp. 1509-1518
-
-
Watanabe, A.1
Hashmi, A.2
Gomes, D.A.3
-
61
-
-
61749099391
-
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
-
Imaeda A B., Watanabe A, Sohail M A. et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest 2009 119 (2) 305-314
-
(2009)
J Clin Invest
, vol.119
, Issue.2
, pp. 305-314
-
-
Imaeda, A.B.1
Watanabe, A.2
Sohail, M.A.3
-
62
-
-
52949125148
-
Role of TLR9 in hepatic stellate cells and experimental liver fibrosis
-
Gäbele E, Mühlbauer M, Dorn C et al. Role of TLR9 in hepatic stellate cells and experimental liver fibrosis. Biochem Biophys Res Commun 2008 376 (2) 271-276
-
(2008)
Biochem Biophys Res Commun
, vol.376
, Issue.2
, pp. 271-276
-
-
Gäbele, E.1
Mühlbauer, M.2
Dorn, C.3
-
63
-
-
36348931523
-
Apoptotic cell death takes its toll
-
Torok N J. Apoptotic cell death takes its toll. Hepatology 2007 46 (5) 1323-1325
-
(2007)
Hepatology
, vol.46
, Issue.5
, pp. 1323-1325
-
-
Torok, N.J.1
-
64
-
-
72949123737
-
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
-
Witek R P., Stone W C., Karaca F G. et al. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology 2009 50 (5) 1421-1430
-
(2009)
Hepatology
, vol.50
, Issue.5
, pp. 1421-1430
-
-
Witek, R.P.1
Stone, W.C.2
Karaca, F.G.3
-
65
-
-
67650552582
-
Caspase inhibitors for the treatment of hepatitis C
-
Masuoka H C., Guicciardi M E., Gores G J. Caspase inhibitors for the treatment of hepatitis C. Clin Liver Dis 2009 13 (3) 467-475
-
(2009)
Clin Liver Dis
, vol.13
, Issue.3
, pp. 467-475
-
-
Masuoka, H.C.1
Guicciardi, M.E.2
Gores, G.J.3
-
66
-
-
34548336791
-
Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C
-
Pockros P J., Schiff E R., Shiffman M L. et al. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology 2007 46 (2) 324-329
-
(2007)
Hepatology
, vol.46
, Issue.2
, pp. 324-329
-
-
Pockros, P.J.1
Schiff, E.R.2
Shiffman, M.L.3
-
67
-
-
33947399867
-
A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia
-
Hoglen N C., Anselmo D M., Katori M et al. A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia. Liver Transpl 2007 13 (3) 361-366
-
(2007)
Liver Transpl
, vol.13
, Issue.3
, pp. 361-366
-
-
Hoglen, N.C.1
Anselmo, D.M.2
Katori, M.3
-
68
-
-
33845654847
-
Clinical trial of the Pan-Caspase inhibitor, IDN-6556, in human liver preservation injury
-
Baskin-Bey E S., Washburn K, Feng S et al. Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury. Am J Transplant 2007 7 (1) 218-225
-
(2007)
Am J Transplant
, vol.7
, Issue.1
, pp. 218-225
-
-
Baskin-Bey, E.S.1
Washburn, K.2
Feng, S.3
-
69
-
-
3042687605
-
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
-
Ekert P G., Read S H., Silke J et al. Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol 2004 165 (6) 835-842
-
(2004)
J Cell Biol
, vol.165
, Issue.6
, pp. 835-842
-
-
Ekert, P.G.1
Read, S.H.2
Silke, J.3
-
70
-
-
77952909686
-
Resistance to caspase-independent cell death requires persistence of intact mitochondria
-
Tait S W., Parsons M J., Llambi F et al. Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell 2010 18 (5) 802-813
-
(2010)
Dev Cell
, vol.18
, Issue.5
, pp. 802-813
-
-
Tait, S.W.1
Parsons, M.J.2
Llambi, F.3
-
71
-
-
0036463405
-
A matter of life and death
-
Green D R., Evan G I. A matter of life and death. Cancer Cell 2002 1 (1) 19-30
-
(2002)
Cancer Cell
, vol.1
, Issue.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
72
-
-
58149262908
-
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
-
Kaufmann T, Jost P J., Pellegrini M et al. Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity 2009 30 (1) 56-66
-
(2009)
Immunity
, vol.30
, Issue.1
, pp. 56-66
-
-
Kaufmann, T.1
Jost, P.J.2
Pellegrini, M.3
-
73
-
-
0038610713
-
Caspase 8 small interfering RNA prevents acute liver failure in mice
-
Zender L, Hutker S, Liedtke C et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci U S A 2003 100 (13) 7797-7802
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.13
, pp. 7797-7802
-
-
Zender, L.1
Hutker, S.2
Liedtke, C.3
-
74
-
-
0036708291
-
Death receptor-mediated apoptosis and the liver
-
Yoon J H., Gores G J. Death receptor-mediated apoptosis and the liver. J Hepatol 2002 37 (3) 400-410
-
(2002)
J Hepatol
, vol.37
, Issue.3
, pp. 400-410
-
-
Yoon, J.H.1
Gores, G.J.2
-
75
-
-
77953532645
-
Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9
-
Lenert P S. Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9. Mediators Inflamm 2010 2010 986596
-
(2010)
Mediators Inflamm
, vol.2010
, pp. 986596
-
-
Lenert, P.S.1
-
76
-
-
71649101226
-
Emerging roles of TLR7 and TLR9 in murine SLE
-
Santiago-Raber M L., Baudino L, Izui S. Emerging roles of TLR7 and TLR9 in murine SLE. J Autoimmun 2009 33 (3-4) 231-238
-
(2009)
J Autoimmun
, vol.33
, Issue.34
, pp. 231-238
-
-
Santiago-Raber, M.L.1
Baudino, L.2
Izui, S.3
-
77
-
-
0032618720
-
Liver tissue expression of CD80 and CD95 antigens in chronic hepatitis C: Relationship with biological and histological disease activities
-
Fiore G, Piazzolla G, Galetta V, Caccetta L, Schiraldi O, Antonaci S. Liver tissue expression of CD80 and CD95 antigens in chronic hepatitis C: relationship with biological and histological disease activities. Microbios 1999 97 (386) 29-38
-
(1999)
Microbios
, vol.97
, Issue.386
, pp. 29-38
-
-
Fiore, G.1
Piazzolla, G.2
Galetta, V.3
Caccetta, L.4
Schiraldi, O.5
Antonaci, S.6
-
78
-
-
0033782754
-
Expression of perforin and Fas ligand mRNA in the liver of viral hepatitis
-
Tagashira M, Yamamoto K, Fujio K et al. Expression of perforin and Fas ligand mRNA in the liver of viral hepatitis. J Clin Immunol 2000 20 (5) 347-353
-
(2000)
J Clin Immunol
, vol.20
, Issue.5
, pp. 347-353
-
-
Tagashira, M.1
Yamamoto, K.2
Fujio, K.3
-
79
-
-
0035990942
-
In situ expression of granzyme B and Fas-ligand in the liver of viral hepatitis
-
Ibuki N, Yamamoto K, Yabushita K et al. In situ expression of granzyme B and Fas-ligand in the liver of viral hepatitis. Liver 2002 22 (3) 198-204
-
(2002)
Liver
, vol.22
, Issue.3
, pp. 198-204
-
-
Ibuki, N.1
Yamamoto, K.2
Yabushita, K.3
-
80
-
-
84905529077
-
Apoptosis-related proteins, BCL-2, BAX, FAS, FAS-L and PCNA in liver biopsies of patients with chronic hepatitis B virus infection
-
Ehrmann J Jr, Galuszková D, Ehrmann J et al. Apoptosis-related proteins, BCL-2, BAX, FAS, FAS-L and PCNA in liver biopsies of patients with chronic hepatitis B virus infection. Pathol Oncol Res 2000 6 (2) 130-135
-
(2000)
Pathol Oncol Res
, vol.6
, Issue.2
, pp. 130-135
-
-
Ehrmann, Jr.J.1
Galuszková, D.2
Ehrmann, J.3
-
81
-
-
0035552883
-
Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: Mechanisms of liver cell injury in chronic hepatitis C virus infection
-
Pianko S, Patella S, Ostapowicz G, Desmond P, Sievert W. Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection. J Viral Hepat 2001 8 (6) 406-413
-
(2001)
J Viral Hepat
, vol.8
, Issue.6
, pp. 406-413
-
-
Pianko, S.1
Patella, S.2
Ostapowicz, G.3
Desmond, P.4
Sievert, W.5
-
82
-
-
0038053181
-
The role of intrahepatic immune effector cells in inflammatory liver injury and viral control during chronic hepatitis B infection
-
Tang T J., Kwekkeboom J, Laman J D. et al. The role of intrahepatic immune effector cells in inflammatory liver injury and viral control during chronic hepatitis B infection. J Viral Hepat 2003 10 (3) 159-167
-
(2003)
J Viral Hepat
, vol.10
, Issue.3
, pp. 159-167
-
-
Tang, T.J.1
Kwekkeboom, J.2
Laman, J.D.3
-
83
-
-
0036904115
-
Apoptosis mediated by the Fas system in the fulminant hepatitis by hepatitis B virus
-
Rivero M, Crespo J, Fábrega E et al. Apoptosis mediated by the Fas system in the fulminant hepatitis by hepatitis B virus. J Viral Hepat 2002 9 (2) 107-113
-
(2002)
J Viral Hepat
, vol.9
, Issue.2
, pp. 107-113
-
-
Rivero, M.1
Crespo, J.2
Fábrega, E.3
-
84
-
-
0038577625
-
Increased serum soluble Fas in patients with acute liver failure due to paracetamol overdose
-
Tagami A, Ohnishi H, Hughes R D. Increased serum soluble Fas in patients with acute liver failure due to paracetamol overdose. Hepatogastroenterology 2003 50 (51) 742-745
-
(2003)
Hepatogastroenterology
, vol.50
, Issue.51
, pp. 742-745
-
-
Tagami, A.1
Ohnishi, H.2
Hughes, R.D.3
-
85
-
-
0033869445
-
Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure
-
Ryo K, Kamogawa Y, Ikeda I et al. Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure. Am J Gastroenterol 2000 95 (8) 2047-2055
-
(2000)
Am J Gastroenterol
, vol.95
, Issue.8
, pp. 2047-2055
-
-
Ryo, K.1
Kamogawa, Y.2
Ikeda, I.3
-
86
-
-
0037352240
-
Fas-mediated apoptosis in acute alcoholic hepatitis
-
Tagami A, Ohnishi H, Moriwaki H, Phillips M, Hughes R D. Fas-mediated apoptosis in acute alcoholic hepatitis. Hepatogastroenterology 2003 50 (50) 443-448
-
(2003)
Hepatogastroenterology
, vol.50
, Issue.50
, pp. 443-448
-
-
Tagami, A.1
Ohnishi, H.2
Moriwaki, H.3
Phillips, M.4
Hughes, R.D.5
-
87
-
-
4544335155
-
Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
-
Ribeiro P S., Cortez-Pinto H, Solá S et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004 99 (9) 1708-1717
-
(2004)
Am J Gastroenterol
, vol.99
, Issue.9
, pp. 1708-1717
-
-
Ribeiro, P.S.1
Cortez-Pinto, H.2
Solá, S.3
-
88
-
-
0034919633
-
Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis
-
Fox C K., Furtwaengler A, Nepomuceno R R., Martinez O M., Krams S M. Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis. Liver 2001 21 (4) 272-279
-
(2001)
Liver
, vol.21
, Issue.4
, pp. 272-279
-
-
Fox, C.K.1
Furtwaengler, A.2
Nepomuceno, R.R.3
Martinez, O.M.4
Krams, S.M.5
-
89
-
-
0035990949
-
Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
-
Tinmouth J, Lee M, Wanless I R., Tsui F W., Inman R, Heathcote E J. Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. Liver 2002 22 (3) 228-234
-
(2002)
Liver
, vol.22
, Issue.3
, pp. 228-234
-
-
Tinmouth, J.1
Lee, M.2
Wanless, I.R.3
Tsui, F.W.4
Inman, R.5
Heathcote, E.J.6
-
90
-
-
17344387813
-
Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis
-
Strand S, Hofmann W J., Grambihler A et al. Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis. Nat Med 1998 4 (5) 588-593
-
(1998)
Nat Med
, vol.4
, Issue.5
, pp. 588-593
-
-
Strand, S.1
Hofmann, W.J.2
Grambihler, A.3
-
91
-
-
0033561109
-
Apoptosis and the expression of Fas and Fas ligand (FasL) antigen in rejection and reinfection in liver allograft specimens
-
Tannapfel A, Kohlhaw K, Ebelt J et al. Apoptosis and the expression of Fas and Fas ligand (FasL) antigen in rejection and reinfection in liver allograft specimens. Transplantation 1999 67 (7) 1079-1083
-
(1999)
Transplantation
, vol.67
, Issue.7
, pp. 1079-1083
-
-
Tannapfel, A.1
Kohlhaw, K.2
Ebelt, J.3
-
92
-
-
16144363507
-
Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cellsa mechanism of immune evasion?
-
Strand S, Hofmann W J., Hug H et al. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cellsa mechanism of immune evasion? Nat Med 1996 2 (12) 1361-1366
-
(1996)
Nat Med
, vol.2
, Issue.12
, pp. 1361-1366
-
-
Strand, S.1
Hofmann, W.J.2
Hug, H.3
-
93
-
-
0032783244
-
The alteration of Fas receptor and ligand system in hepatocellular carcinomas: How do hepatoma cells escape from the host immune surveillance in vivo?
-
Nagao M, Nakajima Y, Hisanaga M et al. The alteration of Fas receptor and ligand system in hepatocellular carcinomas: how do hepatoma cells escape from the host immune surveillance in vivo? Hepatology 1999 30 (2) 413-421
-
(1999)
Hepatology
, vol.30
, Issue.2
, pp. 413-421
-
-
Nagao, M.1
Nakajima, Y.2
Hisanaga, M.3
-
94
-
-
0034098493
-
The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma
-
Ito Y, Monden M, Takeda T et al. The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma. Br J Cancer 2000 82 (6) 1211-1217
-
(2000)
Br J Cancer
, vol.82
, Issue.6
, pp. 1211-1217
-
-
Ito, Y.1
Monden, M.2
Takeda, T.3
-
95
-
-
0031985504
-
Fas antigen expression in hepatocellular carcinoma tissues
-
Ito Y, Takeda T, Umeshita K et al. Fas antigen expression in hepatocellular carcinoma tissues. Oncol Rep 1998 5 (1) 41-44
-
(1998)
Oncol Rep
, vol.5
, Issue.1
, pp. 41-44
-
-
Ito, Y.1
Takeda, T.2
Umeshita, K.3
-
96
-
-
0035079863
-
Expression of Fas and Fas-related molecules in human hepatocellular carcinoma
-
Lee S H., Shin M S., Lee H S. et al. Expression of Fas and Fas-related molecules in human hepatocellular carcinoma. Hum Pathol 2001 32 (3) 250-256
-
(2001)
Hum Pathol
, vol.32
, Issue.3
, pp. 250-256
-
-
Lee, S.H.1
Shin, M.S.2
Lee, H.S.3
-
97
-
-
0042809497
-
Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma
-
Okano H, Shiraki K, Inoue H et al. Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma. Lab Invest 2003 83 (7) 1033-1043
-
(2003)
Lab Invest
, vol.83
, Issue.7
, pp. 1033-1043
-
-
Okano, H.1
Shiraki, K.2
Inoue, H.3
-
98
-
-
77953891627
-
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
-
Miura K, Kodama Y, Inokuchi S et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010 139 (1) 323-334, e7
-
(2010)
Gastroenterology
, vol.139
, Issue.1
, pp. 323-334
-
-
Miura, K.1
Kodama, Y.2
Inokuchi, S.3
|