Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice

Hepatology

Volumn 58, Issue 1, 2013, Pages 128-138

  Mouralidarane, Angelina ^a,b   Soeda, Junpei ^a   Visconti Pugmire, Clara ^a,b   Samuelsson, Anne Maj ^b   Pombo, Joaquim ^b   Maragkoudaki, Xanthi ^b   Butt, Adil ^a   Saraswati, Ruma ^a   Novelli, Marco ^a   Fusai, Guiseppe ^a   Poston, Lucilla ^b   Taylor, Paul D ^b   Oben, Jude A ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CELL COUNT; CELL FUNCTION; CONTROLLED STUDY; DIET; FATTY LIVER; FEMALE; INNATE IMMUNITY; KUPFFER CELL; LACTATION; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MATERNAL OBESITY; NATURAL KILLER T CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PUERPERIUM; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIETARY FATS; FATTY LIVER; FEMALE; IMMUNITY, INNATE; LIVER; LIVER DISEASES; MICE; MICE, INBRED C57BL; OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84879602668     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26248     Document Type: Article

References (34)

1. Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, Zenari L, et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 2007; 30: 1212-1218.
2. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
3. Oben JA, Mouralidarane A, Samuelsson AM, Matthews PJ, Morgan ML, McKee C, et al. Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol 2010; 52: 913-920.
4. Bayol SA, Simbi BH, Fowkes RC, Stickland NC. A maternal "junk food" diet in pregnancy and lactation promotes nonalcoholic fatty liver disease in rat offspring. Endocrinology 2010; 151: 1451-1461.
5. Bruce KD, Cagampang FR, Argenton M, Zhang J, Ethirajan PL, Burdge GC, et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology 2009; 50: 1796-1808.
6. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012; 307: 491-497.
7. Barker DJ. The fetal and infant origins of disease. Eur J Clin Invest 1995; 25: 457-463.
8. Poston L. Maternal obesity, gestational weight gain and diets as determinants of offspring long term health. Best Pract Res Clin Endocrinol Metab 2012; 26: 627-639.
9. Rooney K, Ozanne SE. Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions. Int J Obes (Lond) 2011; 35: 883-890.
10. Catalano PM, Farrell K, Thomas A, Huston-Presley L, Mencin P, de Mouzon SH, et al. Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr 2009; 90: 1303-1313.
11. Day CP, Saksena S. Non-alcoholic steatohepatitis: definitions and pathogenesis. J Gastroenterol Hepatol 2002; 17( Suppl 3): S377-S384.
12. Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol 2007; 47: 571-579.
13. Zhan YT, An W. Roles of liver innate immune cells in nonalcoholic fatty liver disease. World J Gastroenterol 2010; 16: 4652-4660.
14. Guebre-Xabier M, Yang S, Lin HZ, Schwenk R, Krzych U, Diehl AM. Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. Hepatology 2000; 31: 633-640.
15. Matthews PA, Samuelsson AM, Seed P, Pombo J, Oben JA, Poston L, et al. Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood. J Physiol 2011; 589( Pt 16): 3969-3981.
16. Samuelsson AM, Matthews PA, Argenton M, Christie MR, McConnell JM, Jansen EH, et al. Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension 2008; 51: 383-392.
17. Pot GK, Prynne CJ, Roberts C, Olson A, Nicholson SK, Whitton C, et al. National Diet and Nutrition Survey: fat and fatty acid intake from the first year of the rolling programme and comparison with previous surveys. Br J Nutr 2012; 107: 405-415.
18. Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T, et al. Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. Gut 2010; 59: 258-266.
19. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226: 497-509.
20. Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-845.
21. Wheeler MD. Endotoxin and Kupffer cell activation in alcoholic liver disease. Alcohol Res Health 2003; 27: 300-306.
22. Baffy G. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol 2009; 51: 212-223.
23. Doherty DG, O'Farrelly C. Innate and adaptive lymphoid cells in the human liver. Immunol Rev 2000; 174: 5-20.
24. Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 2002; 283: G256-G265.
25. Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37: 343-350.
26. Mouralidarane A, Suleyman N, Soeda J, Oben JA. Practical management of the increasing burden of non-alcoholic fatty liver disease. Frontline Gastroenterol 2010; 1: 149-155.
27. Maemura K, Zheng Q, Wada T, Ozaki M, Takao S, Aikou T, et al. Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells. Immunol Cell Biol 2005; 83: 336-343.
28. Wei Y, Clark SE, Morris EM, Thyfault JP, Uptergrove GM, Whaley-Connell AT, et al. Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. J Hepatol 2008; 49: 417-428.
29. Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T, et al. Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. Gut 2010; 59: 258-266.
30. Neyrinck AM, Cani PD, Dewulf EM, De BF, Bindels LB, Delzenne NM. Critical role of Kupffer cells in the management of diet-induced diabetes and obesity. Biochem Biophys Res Commun 2009; 385: 351-356.
31. Li Z, Soloski MJ, Diehl AM. Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 2005; 42: 880-885.
32. Kremer M, Thomas E, Milton RJ, Perry AW, van Rooijen N, Wheeler MD, et al. Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. Hepatology 2010; 51: 130-141.
33. Elinav E, Abd-Elnabi A, Pappo O, Bernstein I, Klein A, Engelhardt D, et al. Suppression of hepatocellular carcinoma growth in mice via leptin, is associated with inhibition of tumor cell growth and natural killer cell activation. J Hepatol 2006; 44: 529-536.
34. Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 2011; 121: 2126-2132.