Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

Peptides

Volumn 44, Issue , 2013, Pages 40-46

  Revell, Jefferson D ^a   Lund, Per Eric ^b   Linley, John E ^a   Metcalfe, Jacky ^a   Burmeister, Nicole ^a   Sridharan, Sudharsan ^a   Jones, Clare ^a   Jermutus, Lutz ^a   Bednarek, Maria A ^a  

^a MEDIMMUNE   (United States)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Huwentoxin IV; Nav1.7; Neuropathic; Nociceptive; Spider toxin; Synthetic peptide; Voltage gated sodium channel

Indexed keywords

GLUTAMIC ACID; GLYCINE; HUWENTOXIN IV; NEUROTOXIN; PEPTIDE; PHENYLALANINE; SODIUM CHANNEL; SODIUM CHANNEL NAV 1.7; SPIDER VENOM; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG POTENCY; ELECTROPHYSIOLOGY; HAPLOPELMA; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN FOLDING; SELENOCOSMIA HUWENA; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPIDER VENOMS; SPIDERS; STRUCTURE-ACTIVITY RELATIONSHIP; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

ARANEAE; AVES; ORNITHOCTONUS HUWENA;

EID: 84875982442     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2013.03.011     Document Type: Article

References (20)

1. I. Alicino, M. Giglio, F. Manca, F. Bruno, and F. Puntillo Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choice Pain 153 2012 245 249
2. I.P. Chessell, A. Dudley, and A. Billinton Biologics: the next generation of analgesic drugs? Drug Discov Today 17 15/16 2012 875 879
3. Y.P. Goldberg, N. Price, R. Namdari, C.J. Cohen, M.H. Lamers, and C. Winters Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker Pain 154 2012 80 85
4. M.L. Haanpää, M.D. Backonja, M.I. Bennett, D. Bouhassira, G. Cruccu, and P.T. Hansson Assessment of neuropathic pain in primary care Am J Med 122 2009 S13 S21
5. R.J. Lewis, S. Dutertre, I. Vetter, and M.J. Christie Conus venom peptide pharmacology Pharmacol Rev 64 2 2012 259 298
6. D. Li, Y. Xiao, X. Xu, X. Xiong, S. Lu, and Z. Liu Structure-activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers J Biol Chem 279 36 2004 37734 37740 (Pubitemid 39195487)
7. Y. Liu, D. Li, Z. Wu, J. Li, D. Nie, and Y. Xiang A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels J Pept Sci 18 2012 643 649
8. S. Liang An overview of peptide toxins from the venom of the Chinese bird spider selenocosmia huwena wang [= ornithoctonus huwena (Wang)] Toxicon 43 2004 575 585 (Pubitemid 38520197)
9. H. Kolmar Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins Curr Opin Pharmacol 9 2009 608 614
10. J.H. Park, K.P. Carlin, G. Wu, V.I. Ilyin, and D. Kyle Cysteine racemization during the fmoc solid phase peptide synthesis of the Nav1.7-selective peptide - Protoxin-II J Pept Sci 18 2012 442 448
11. K. Peng, Q. Shu, Z. Liu, and S. Liang Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider selenocosmia huwena J Biol Chem 277 49 2002 47564 47571 (Pubitemid 36159276)
12. N.J. Saez, S. Senff, J.E. Jensen, S.Y. Er, V. Herzig, and L.D. Rash Spider-venom peptides as therapeutics Toxins 2 2010 2851 2871
13. W.A. Schmalhofer, J. Calhoun, R. Burrows, T. Bailey, M.G. Kohler, and A.B. Weinglass ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors Mol Pharmacol 74 5 2008 1476 1484
14. A. Schmidtko, J. Lotsch, R. Freynhagen, and G. Geisslinger Ziconotide for the treatment of severe pain Lancet 375 2010 1569 1577
15. K. Schroeder, B. Neagle, D.J. Trezise, and J. Worley IonWorks™ HT A new high-throughput electrophysiology measurement platform J Biomol Screen 8 1 2003 50 64
16. A.M. Steiner, and G. Bulaj Optimization of oxidative folding methods for cysteine-rich peptides: a study of conotoxins containing three disulfide bridges J Pept Sci 17 2011 1 7
17. Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, and X. Zeng Synthesis and characterisation of Huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels Toxicon 51 2008 230 239
18. Y. Xiao, J.P. Bingham, W. Zhu, E. Moczydlowski, S. Liang, and T.R. Cummins Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration J Biol Chem 283 40 2008 27300 27313
19. Y. Xiao, K. Blumenthal, J.O. Jackson, S. Liang, and T.R. Cummins The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation Mol Pharmacol 78 6 2010 1124 1134
20. Y. Xiao, J.O. Jackson, S. Liang, and T.R. Cummins Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV J Biol Chem 286 31 2011 27301 27310