Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 29, 2013, Pages

  McCormack, Ken ^a   Santos, Sonia ^a   Chapman, Mark L ^a   Krafte, Douglas S ^a   Marron, Brian E ^a   West, Christopher W ^a   Krambis, Michael J ^a   Antonio, Brett M ^a   Zellmer, Shannon G ^a   Printzenhoff, David ^a   Padilla, Karen M ^a   Lin, Zhixin ^a   Wagoner, P Kay ^a   Swain, Nigel A ^b   Stupple, Paul A ^b   De Groot, Marcel ^b   Butt, Richard P ^b   Castle, Neil A ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ICA 121431; LOCAL ANESTHETIC AGENT; PF 04856264; SODIUM; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.7; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHIMERA; CONTROLLED STUDY; HUMAN; IC 50; MOLECULAR INTERACTION; MOLECULAR SENSOR; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL;

ACETAMIDES; AMINO ACID MOTIFS; BINDING SITES; ELECTROPHYSIOLOGICAL PROCESSES; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; NAV1.3 VOLTAGE-GATED SODIUM CHANNEL; PATCH-CLAMP TECHNIQUES; SEQUENCE ALIGNMENT; THIAZOLES; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84880372282     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220844110     Document Type: Article

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