Editorial: Renaissance of ion channel research and drug discovery by patch clamp automation

Future Medicinal Chemistry

Volumn 2, Issue 5, 2010, Pages 691-695

  Fertig, Niels ^a   Farre, Cecilia ^a  

^a NANION TECHNOLOGIES GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; VERAPAMIL;

CELL COMMUNICATION; COST BENEFIT ANALYSIS; DRUG INDUSTRY; DRUG RESEARCH; EDITORIAL; FLUORESCENCE ANALYSIS; LABORATORY AUTOMATION; PATCH CLAMP; PRIORITY JOURNAL; ANIMAL; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; METHODOLOGY; NOTE;

ANIMALS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ION CHANNELS; PATCH-CLAMP TECHNIQUES;

EID: 77953367280     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.10.183     Document Type: Editorial

References (17)

1. Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat. Rev. Drug Discov. 5, 993-996 (2006).
2. Gonzalez JE, Oades K, Leychkis Y et al. Cell-based assays and instrumentation for screening ion channel targets. Drug Discov. Today. 4, 431-439 (1999).
3. Terstappen GC, Roncarati R, Dunlop J et al. Screening technologies for ion channel drug discovery. Future Med. Chem. 2 (5), 715-730 (2010).
4. Hamill OP, Marty A, Neher E et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391 (2) 85-100 (1981).
5. Dunlop J, Bowlby M, Peri R et al. Highthroughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nature Rev. Drug Disc. 7, 358-368 (2008).
6. Mathes C. QPatch: the past, present and future of automated patch clamp. Expert Opin. Ther. Targets 10, 319-327 (2006).
7. Farre C, Stoelze S, Haarmann C et al. Automated ion channel screening: patch clamping made easy. Expert Opin. Ther. Targets. 11, 557-565 (2007).
8. Farre C, Haythornthwaite A, Haarmann C et al. Port-a-Patch and Patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology. Comb. Chem. HTS 12 (1), 24-37 (2009).
9. Behrends JC, Fertig N. Planar patch clamping. In: Neuromethods Patch Clamp Analysis - Advanced Techniques (Volume 38). Walz W (Ed.). Humana Press, Totowa, Canada, 411-433 (2007).
10. Kiss L, Bennett PB, Uebele VN et al. High-throughput ion-channel pharmacology: planar-array-based voltage clamp. Assay Drug Dev. Technol. 1, 127-135 (2003).
11. Schroeder K, Neagle B, Trezise DJ et al. Ionworks HT: a new high-throughput electrophysiology measurement platform. J. Biomol. Screen. 8, 1-14 (2003).
12. Finkel A, Wittel A, Yang N et al. Population patch clamp improves data consistency and success rates in the measurement of ionic currents. J. Biomol. Screen. 11, 488-496 (2006).
13. Xu SZ, Sukumar P, Zeng F et al. TRPC channel activation by extracellular thioredoxin. Nature 451 (7174), 69-72 (2008).
14. Milligan CJ, Li J, Sukumar P et al. Robotic multiwall planar patch-clamp for native and primary mammalian cells. Nature Protocols 4 (2), 244-255 (2009).
15. Kahlig KM, Saridey SK, Kaja A et al. Multiplexed transposon-mediated stable gene transfer in human cells. Proc. Natl Acad. Sci. USA 107 (4), 1343-1348 (2010).
16. Kreir M, Farre C, Beckler M et al. Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes. Lab-on-a-Chip. 4, 587-595 (2008).
17. Fenichel RR, Malik M, Antzelevitch C et al. Drug induced torsade de pointes and implications for drug development. J. Cardiovasc. Electrophysiol. 15 (4), 475-495 (2004).