Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats

Transgenic Research

Volumn 21, Issue 4, 2012, Pages 743-755

  Yamamoto, Satoshi ^a   Nakata, Mitsugu ^a   Sasada, Reiko ^a   Ooshima, Yuki ^a   Yano, Takashi ^a   Shinozawa, Tadahiro ^a   Tsukimi, Yasuhiro ^a   Takeyama, Michiyasu ^a   Matsumoto, Yoshio ^a   Hashimoto, Tadatoshi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Embryonic stem cells; Gene targeting; Knockout; PAR 2; Rat

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2;

ANIMAL; ARTICLE; BLASTOCYST; CULTURE TECHNIQUE; CYTOLOGY; EMBRYONIC STEM CELL; GENE INACTIVATION; GENE TARGETING; GENETICS; HEART MUSCLE CELL; HOMOLOGOUS RECOMBINATION; RAT; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLASTOCYST; CELL CULTURE TECHNIQUES; EMBRYONIC STEM CELLS; GENE KNOCKOUT TECHNIQUES; GENE TARGETING; HOMOLOGOUS RECOMBINATION; MYOCYTES, CARDIAC; RATS; RECEPTOR, PAR-2;

AGOUTI; MUS; RATTUS;

EID: 84864033715     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-011-9564-0     Document Type: Article

References (34)

1. Buehr M, Meek S, Blair K, Yang J, Ure J, Silva J, McLay R, Hall J, Ying QL, Smith A (2008) Capture of authentic embryonic stem cells from rat blastocysts. Cell 135: 1287-1298.
2. Capecchi MR (2005) Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 6: 507-512.
3. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, Moffatt JD (1999) A protective role for protease-activated receptors in the airways. Nature 398: 156-160.
4. Consortium International Mouse Knockout, Collins FS, Rossant J, Wurst W (2007) A mouse for all reasons. Cell 128: 9-13.
5. Consortium STAR, Saar K, Beck A, Bihoreau MT, Birney E, Brocklebank D, Chen Y, Cuppen E, Demonchy S, Dopazo J, Flicek P, Foglio M, Fujiyama A, Gut IG, Gauguier D, Guigo R, Guryev V, Heinig M, Hummel O, Jahn N, Klages S, Kren V, Kube M, Kuhl H, Kuramoto T, Kuroki Y, Lechner D, Lee YA, Lopez-Bigas N, Lathrop GM, Mashimo T, Medina I, Mott R, Patone G, Perrier-Cornet JA, Platzer M, Pravenec M, Reinhardt R, Sakaki Y, Schilhabel M, Schulz H, Serikawa T, Shikhagaie M, Tatsumoto S, Taudien S, Toyoda A, Voigt B, Zelenika D, Zimdahl H, Hubner N (2008) SNP and haplotype mapping for genetic analysis in the rat. Nat Genet 40: 560-566.
6. Cui X, Ji D, Fisher DA, Wu Y, Briner DM, Weinstein EJ (2011) Targeted integration in rat and mouse embryos with zinc-finger nucleases. Nat Biotechnol 29: 64-67.
7. Damiano BP, Cheung WM, Santulli RJ, Fung-Leung WP, Ngo K, Ye RD, Darrow AL, Derian CK, de Garavilla L, Andrade-Gordon P (1999) Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J Pharmacol Exp Ther 288: 671-678.
8. Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292: 154-156.
9. Feero WG, Guttmacher AE, Collins FS (2010) Genomic medicine-an updated primer. N Engl J Med 362: 2001-2011.
10. Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R (2009) Knockout rats via embryo microinjection of zinc-finger nucleases. Science 325: 433.
11. Hirabayashi M, Kato M, Kobayashi T, Sanbo M, Yagi T, Hochi S, Nakauchi H (2010) Establishment of rat embryonic stem cell lines that can participate in germline chimerae at high efficiency. Mol Reprod Dev 77: 94.
12. Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R (2009) Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol 27: 851-857.
13. Izsvák Z, Fröhlich J, Grabundzija I, Shirley JR, Powell HM, Chapman KM, Ivics Z, Hamra FK (2010) Generating knockout rats by transposon mutagenesis in spermatogonial stem cells. Nat Methods 7: 443-445.
14. Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM (2010) Gene targeting in the rat: advances and opportunities. Trends Genet 26: 510-518.
15. Katada H, Chen HJ, Shigi N, Komiyama M (2009) Homologous recombination in human cells using artificial restriction DNA cutter. Chem Commun (Camb) (43): 6545-6547.
16. Kawabata A (2003) Gastrointestinal functions of proteinase-activated receptors. Life Sci 74: 247-254.
17. Kawabata A, Kubo S, Nakaya Y, Ishiki T, Kuroda R, Sekiguchi F, Kawao N, Nishikawa H (2004) Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery. Cardiovasc Res 61: 683-692.
18. Kawagoe J, Takizawa T, Matsumoto J, Tamiya M, Meek SE, Smith AJ, Hunter GD, Plevin R, Saito N, Kanke T, Fujii M, Wada Y (2002) Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear. Jpn J Pharmacol 88: 77-84.
19. Kawamata M, Ochiya T (2010) Generation of genetically modified rats from embryonic stem cells. Proc Natl Acad Sci USA 107: 14223-14228.
20. Kitada K, Ishishita S, Tosaka K, Takahashi R, Ueda M, Keng VW, Horie K, Takeda J (2007) Transposon-tagged mutagenesis in the rat. Nat Methods 4: 131-133.
21. Li P, Tong C, Mehrian-Shai R, Jia L, Wu N, Yan Y, Maxson RE, Schulze EN, Song H, Hsieh CL, Pera MF, Ying QL (2008) Germline competent embryonic stem cells derived from rat blastocysts. Cell 135: 1299-1310.
22. Lindner JR, Kahn ML, Coughlin SR, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K (2000) Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol 165: 6504-6510.
23. Martin GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78: 7634-7638.
24. McNeish J (2004) Embryonic stem cells in drug discovery. Nat Rev Drug Discov 3: 70-80.
25. Nagy A, Gócza E, Diaz EM, Prideaux VR, Iványi E, Markkula M, Rossant J (1990) Embryonic stem cells alone are able to support fetal development in the mouse. Development. 110: 815-821.
26. Nichols J, Ying QL (2006) Derivation and propagation of embryonic stem cells in serum- and feeder-free culture. Methods Mol Biol 329: 91-98.
27. Shinozawa T, Tsuji A, Imahashi K, Nakashima K, Sawada H, Toyoshiba H, Yamamoto S, Takami K, Imai R (2009) Gene expression profiling of functional murine embryonic stem cell-derived cardiomyocytes and comparison with adult heart: profiling of murine ESC-derived cardiomyocytes. J Biomol Screen 14: 239-245.
28. Tong C, Li P, Wu NL, Yan Y, Ying QL (2010) Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature 467: 211-213.
29. Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD (2003) High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21: 652-659.
30. Ying QL, Smith AG (2003) Defined conditions for neural commitment and differentiation. Methods Enzymol 365: 327-341.
31. Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J, Cohen P, Smith A (2008) The ground state of embryonic stem cell self-renewal. Nature 453: 519-523.
32. Zambrowicz BP, Sands AT (2003) Knockouts model the 100 best-selling drugs-will they model the next 100? Nat Rev Drug Discov 2: 38-51.
33. Zan Y, Haag JD, Chen KS, Shepel LA, Wigington D, Wang YR, Hu R, Lopez-Guajardo CC, Brose HL, Porter KI, Leonard RA, Hitt AA, Schommer SL, Elegbede AF, Gould MN (2003) Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Nat Biotechnol 21: 645-651.
34. Zhou Q, Renard JP, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J (2003) Generation of fertile cloned rats by regulating oocyte activation. Science 302: 1179.