Non-homologous end joining plays a key role in transgene concatemer formation in transgenic zebrafish embryos

International Journal of Biological Sciences

Volumn 6, Issue 7, 2010, Pages 756-768

  Dai, Jun ^a,b   Cui, Xiaojuan ^a,b   Zhu, Zuoyan ^a   Hu, Wei ^a  

^a INSTITUTE OF HYDROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Concatemer; DSB (double strand breaks); NHEJ (non homologous end joining); Transgene; Zebrafish

Indexed keywords

CYTOMEGALOVIRUS; DANIO RERIO;

EID: 78650533817     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.6.756     Document Type: Article

References (40)

1. Zeng ZQ and Zhu ZY. The molecular polymorphism of transgenes in F4 generation red carp transfected with pMThGH gene. Chinese Sci Bulletin. 2000;45: 1957-1962.
2. Wu B, Sun YH, Wang Y W, Wang YP and Zhu ZY. Characterization of transgene integration pattern in F4 hGH-transgenic common carp (cyprinus carpio). Cell Res. 2005;15: 447-454.
3. Roth DB and Wilson JH. Non-homologous recombination in mammalian cells: role for short sequence homologies in the joining reaction. Mol Cell Biol. 1986; 6: 4295-4304.
4. Hamada T, Sasaki H, Seki R, Sakaki Y. Mechanism of chromosomal integration of transgenes in microinjected mouse eggs: sequence analysis of genome-transgene and transgene- transgene junctions at two loci. Gene. 1993; 128: 197-202.
5. Chan AWS, Homan EJ, Ballou LU, Burns JC and Bremel R. Transgenic cattle produced by reverse-transcribed gene transfer in oocyte. Proc Nat Acad Sci. 1998; 95: 14028-14033.
6. Bill CA and Summers J. Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc Nat Acad Sci. 2004;101: 11135-11140.
7. Houdebine LM and Chourrout D. Transgenesis in fish. Experientia. 1991;47(9):891-897
8. Bishop JO and Smith P. Mechanism of chromosomal integration of microinjected DNA. Mol Biol Med. 1989;6(4):283-298.
9. Folger KR, Wong EA, Wahl G and Capecchi MR. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Molecular and cellular biology. 1982;2(11):1372-1387.
10. Dellaire G, Yan J, Little KC, Drouin R and Chartrand P. Evidence that extrachromosomal double-strand break repair can be coupled to the repair of chromosomal double-strand breaks in mammalian cells. Chromosoma 2002;111(5): 304-312.
11. Roth DB, Wilson JH. Relative rates of homologous and nonhomologous recombination in transfected DNA. PNAS, 1985;82(10):3355-3359.
12. Penman DJ, Iyengar A, Beeching AJ, Rahman A, Sulaiman Z and MacLean N. Patterns of transgene inheritance in rainbow trout (oncorhynchus mykiss). Mol Reprod and Dev. 1991; 30: 201-206.
13. Hsiao CD, Hsieh FJ and Tsai HJ. Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafish. Dev Dyn. 2001;220: 323-36.
14. Jillian LY, O'neil NJ and Rose AM. Homologous recombination is required for genome stability in the absence of DOG-1in Caenorhabditis elegans. Genetics. 2006; 173: 697-708.
15. Siim P, Burkert JS, Martin J, et al. Alternative Induction of Meiotic Recombination From Single-Base Lesions of DNA deaminases. Genetics. 2009;182: 41-54.
16. Lieber RM. Immunoglobulin diversity: rearranging by cutting and repairing. Curr Biol. 1996;6: 134-136.
17. Vangent DC, Ramsden DA and Gellert M. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell. 1996;85: 107-113.
18. Ramsden DA, Van Gent DC and Gellert M. Specificity in V(D)J recombination: new lessons from biochemistry and genetics. Curr Opin Immunol. 1997; 8: 114-120.
19. Yoshida K, Kondoh G, Matsuda Y, Habu T, Nishimune Y and Morita T. The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol Cell. 1998; 1: 707-718.
20. Couteau F, Belzile F, Horlow C, Grandjean O, Vezon D and Doutriaux MP. Random chromosome segregation without meiotic arrest in both male and female meiocytes of a Dmc1 mutant of Arabidopsis. Plant Cell. 1999;11: 1623-1634.
21. Kenichiro M, Shinohara A and Shinohara M. Forkhead- associated domain of yeast Xrs2, a homolog of human Nbs1, promotes non-homologous end joining through interaction with a ligase IV partner protein, Lif1. Genetics. 2008;179:213-25.
22. Kegel A, Martinez P, Carter SD and Åström SU. Genome wide distribution of illegitimate recombination events in Kluyveromyces lactis. Nucleic Acids Res. 2006; 34: 1633-1645.
23. Jin L, Wen TJ and Schnable PS. Role of RAD51 in the repair of MuDR-induced double-strand breaks in Maize (zea mays L.). Genetics.2007; 178: 57-66.
24. Mansour WY, Schumacher S, Rosskopf R et al. Hierarchy of non-homologous end joining, single-strand annealing and gene converse at site-directed DNA double-strand breaks. Nucleic Acids Res. 2008; 36: 4088-4098.
25. Pastwa E and Blasiak J. Non-homologous DNA end joining. Acta Biochimica Polonica. 2003;50: 891-908.
26. Xin Y and Abram G. Ku-dependent and Ku-independent end joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae. Genetics. 2003;163: 843-856.
27. Kanaar R, Hoeijmakers J and Van Gent DC. Molecular mechanisms of DNA double-strand break repair. Trends in Cell Biol. 1998;8: 483-489.
28. Liang F, Han M, Romanienko MP and Jasin M. Homology- directed repair is major double-strand break repair pathway in mammalian cells. Proc Nat Acad Sci. 1998; 95: 5172-5177.
29. Mia RL, Meier B, Lee TW, Hall J and Ahmed S. End joining at Caenorhabditis elegans telomeres. Genetics. 2008;180: 741-754.
30. Lees-Miller SP, Godbout R, Chan D et al. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science. 1995;5201: 1183-1185.
31. Haber JE, Leung WY. Lack of chromosome territoriality in yeast: promiscuous rejoining of broken chromosome ends. Proc Nat Acad Sci.1996; 93: 13949-54.
32. Lieber MR, Ma Y, Pannicke U and Schwarz K. Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol. 2003;4: 712-720.
33. Jason AS, Waldman BC and Waldman AS. A Role for DNA mismatch repair protein Msh2 in error-prone double-strand-break repair in mammalian chromosomes. Genetics. 2005;170: 355-363.
34. Wyman C, Kanaar R. DNA double-strand break repair: all's well that ends well. Annu Rev. of Genet. 2006; 40: 363-383.
35. Catherine L, Bladen WKL, Dynan WS and Kozlowski DJ. DNA damage response and Ku80 function in the vertebrate embryo. Nucleic Acids Res. 2005; 9: 3002-3010.
36. Li Z and Chang Y. V(D)J recombination in zebrafish: Normal joining products with accumulation of unresolved coding ends and deleted signal ends. Mol Immunol. 2007; 44: 1793-1802.
37. Zhong H, Li Z, Lin S and Chang Y. Initiation of V(D)J recombination in zebrafish (danio rerio) ovaries. Mol Immunol. 2007;44: 1784-1792.
38. Westerfield M. The zebrafish book:a guide for the laboratory use of zebrafish danio (brachydanio) rerio. Eugene: University of Oregon Press, 2000.
39. Kornberg A. DNA replication. San Francisco: WH Freeman & Co, 1980.
40. Hu W, Li SF, Tang B, Wang YP, Lin HR, Liu XC, Zou J and Zhu ZY. Antisense for gonadotropin-releasing hormone reduces gonadotrop in synthesis and gonadal development in transgenic common carp (cyprinus carpio). Aquaculture. 2007; 271: 498-506.