Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Hermann, Mario ^a,d   Maeder, Morgan L ^b   Rector, Kyle ^c   Ruiz, Joseph ^c   Becher, Burkhard ^a   Bürki, Kurt ^a   Khayter, Cyd ^b   Aguzzi, Adriano ^d   Joung, J Keith ^b,e   Buch, Thorsten ^a,f   Pelczar, Pawel ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Transposagen Biopharmaceuticals Inc   (United States)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e HARVARD MEDICAL SCHOOL   (United States)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC FINGER NUCLEASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYONAL TISSUE; EXPRESSION VECTOR; GENE; GENE DISRUPTION; GENE EXPRESSION; GENE LOCUS; GENE REARRANGEMENT; GENE TARGETING; GENE TECHNOLOGY; GENOME ANALYSIS; HOMOLOGOUS RECOMBINATION; MOUSE; MUTAGENESIS; NONHUMAN; OLIGOMERIZED POOL ENGINEERING TECHNOLOGY; ROSA26 GENE; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION; ZYGOTE;

ANIMALS; DNA END-JOINING REPAIR; EMBRYO, MAMMALIAN; ENDONUCLEASES; FEMALE; GENE TARGETING; GENETIC LOCI; HOMOLOGOUS RECOMBINATION; MALE; MICE; MICROINJECTIONS; PROTEINS; ZINC FINGERS; ZYGOTE;

EID: 84866133669     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041796     Document Type: Article

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