The application of induced pluripotent stem cells for bone regeneration: Current progress and prospects

Tissue Engineering - Part B: Reviews

Volumn 20, Issue 4, 2014, Pages 328-339

  Teng, Songsong ^a   Liu, Chaoxu ^b   Krettek, Christian ^a   Jagodzinski, Michael ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PATIENT TREATMENT; PHILOSOPHICAL ASPECTS; STEM CELLS;

BIOLOGICAL PROPERTIES; CLINICAL APPLICATION; EMBRYONIC STEM CELLS; INDUCED PLURIPOTENT STEM CELLS; MESENCHYMAL STEM CELL; OSTEOGENIC DIFFERENTIATION; PRIMARY TECHNOLOGIES; REGENERATIVE MEDICINE;

CELL CULTURE;

BONE MORPHOGENETIC PROTEIN 4; BONE SIALOPROTEIN; CALCIUM; DEXAMETHASONE; GLUTATHIONE; MANGANESE SUPEROXIDE DISMUTASE; MICRORNA 10B; MICRORNA 9; OSTEOCALCIN; OSTEOPONTIN; REACTIVE OXYGEN METABOLITE; RESVERATROL; RETINOIC ACID; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1;

ADIPOSE DERIVED STEM CELL; APOPTOSIS; BLOOD; BONE DEFECT; BONE DEVELOPMENT; BONE MARROW; BONE PROSTHESIS; BONE REGENERATION; BONE TISSUE; CARCINOGENICITY; CELL DIFFERENTIATION; DISEASE MODEL; DRUG SCREENING; ENGRAFTMENT; EXTRACELLULAR MATRIX; FIBROBLAST; GENOMIC INSTABILITY; GERIATRIC DISORDER; HEMATOPOIETIC CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; IRRADIATION; KERATINOCYTE; MARFAN SYNDROME; MELANOCYTE; MICROVASCULARIZATION; MUSCLE REGENERATION; NEURAL STEM CELL; NONHUMAN; NUCLEAR REPROGRAMMING; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; OSTEOGENESIS IMPERFECTA; PERICYTE; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; SOMATIC CELL; STEM CELL; STEM CELL TRANSPLANTATION; SUBSTITUTION THERAPY; TISSUE ENGINEERING; UMBILICAL CORD BLOOD; UPREGULATION; ADULT; BIOLOGICAL THERAPY; PROCEDURES;

ADULT; BONE REGENERATION; CELL- AND TISSUE-BASED THERAPY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; OSTEOGENESIS; STEM CELL TRANSPLANTATION;

EID: 84905591816     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2013.0301     Document Type: Review

References (111)

1. Dimitriou, R., Mataliotakis, G.I., Angoules, A.G., Kanakaris, N.K., and Giannoudis, P.V. Complications following autologous bone graft harvesting from the iliac crest and using the RIA: A systematic review. Injury 42, 3, 2011
2. Bauer, T.W., and Muschler, G.F. Bone graft materials. An overview of the basic science. Clin Orthop Relat Res 10, 2000
3. Jaiswal, N., Haynesworth, S.E., Caplan, A.I., and Bruder, S.P. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 64, 295, 1997
4. Colnot, C. Cell sources for bone tissue engineering: Insights from basic science. Tissue Eng Part B Rev 17, 449, 2011
5. Wang, C., Wang, Z., Li, A., Bai, F., Lu, J., Xu, S., and Li, D. Repair of segmental bone-defect of goat's tibia using a dynamic perfusion culture tissue engineering bone. J Biomed Mater Res A 92, 1145, 2010
6. An, S.H., Matsumoto, T., Miyajima, H., Nakahira, A., Kim, K.H., and Imazato, S. Porous zirconia/hydroxyapatite scaffolds for bone reconstruction. Dent Mater 28, 1221, 2012
7. Chen, K.Y., Dong, G.C., Hsu, C.Y., Chen, Y.S., and Yao, C.H. Autologous bone marrow stromal cells loaded onto porous gelatin scaffolds containing Drynaria fortunei extract for bone repair. J Biomed Mater Res A 101, 954, 2013
8. Stenderup, K., Justesen, J., Clausen, C., and Kassem, M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 33, 919, 2003
9. Kretlow, J.D., Jin, Y. Q., Liu, W., Zhang, W.J., Hong, T.H., Zhou, G., Baggett, L.S., Mikos, A.G., and Cao, Y. Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells. BMC Cell Biol 9, 60, 2008
10. Waese, E.Y., Kandel, R.A., and Stanford, W.L. Application of stem cells in bone repair. Skeletal Radiol 37, 601, 2008
11. Mahmood, A., Napoli, C., and Aldahmash, A. In vitro differentiation and maturation of human embryonic stem cell into multipotent cells. Stem Cells Int 2011, 735420, 2011
12. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., and Jones, J.M. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145, 1998
13. Gamie, Z., Tran, G.T., Vyzas, G., Korres, N., Heliotis, M., Mantalaris, A., and Tsiridis, E. Stem cells combined with bone graft substitutes in skeletal tissue engineering. Expert Opin Biol Ther 12, 713, 2012
14. Chen, W., Zhou, H., Weir, M.D., Tang, M., Bao, C., and Xu, H.H. Human embryonic stem cell-derived mesenchymal stem cell seeding on calcium phosphate cement-chitosan-RGD scaffold for bone repair. Tissue Eng Part A 19, 915, 2013
15. Chen, C., and Xiao, S.F. Induced pluripotent stem cells and neurodegenerative diseases. Neurosci Bull 27, 107, 2011
16. Takahashi, K., and Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663, 2006
17. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861, 2007
18. Liu, S.P., Fu, R.H., Huang, Y.C., Chen, S.Y., Chien, Y.J., Hsu, C.Y., Tsai, C.H., Shyu, W.C., and Lin, S.Z. Induced pluripotent stem (iPS) cell research overview. Cell Transplant 20, 15, 2011
19. Li, W., and Xiang, A.P. Safeguarding clinical translation of pluripotent stem cells with suicide genes. Organogenesis 9, 2013
20. Cheng, F., Ke, Q., Chen, F., Cai, B., Gao, Y., Ye, C., Wang, D., Zhang, L., Lahn, B.T., Li, W., and Xiang, A.P. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials 33, 3195, 2012
21. Chen, F., Cai, B., Gao, Y., Yuan, X., Cheng, F., Wang, T., Jiang, M., Zhou, Y., Lahn, B.T., Li, W., and Xiang, A.P. Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells. Biomaterials 34, 1701, 2013
22. Kim, D., Kim, C.H., Moon, J.I., Chung, Y.G., Chang, M.Y., Han, B.S., Ko, S., Yang, E., Cha, K.Y., Lanza, R., and Kim, K.S. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 4, 472, 2009
23. Warren, L., Manos, P.D., Ahfeldt, T., Loh, Y.H., Li, H., Lau, F., Ebina, W., Mandal, P.K., Smith, Z.D., Meissner, A., Daley, G.Q., Brack, A.S., Collins, J.J., Cowan, C., Schlaeger, T.M., and Rossi, D.J. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618, 2010
24. Park, H.Y., Noh, E.H., Chung, H.M., Kang, M.J., Kim, E.Y., and Park, S.P. Efficient generation of virus-free iPS cells using liposomal magnetofection. PLoS One 7, e45812, 2012
25. Zhao, X.Y., Li, W., Lv, Z., Liu, L., Tong, M., Hai, T., Hao, J., Guo, C.L., Wang, X., Wang, L., Zeng, F., and Zhou, Q. Efficient and rapid generation of induced pluripotent stem cells using an alternative culture medium. Cell Res 20, 383, 2010
26. Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A.E., and Melton, D.A. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 26, 795, 2008
27. Shi, Y., Do, J.T., Desponts, C., Hahm, H.S., Scholer, H.R., and Ding, S. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2, 525, 2008
28. Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., Lin, X., Hahm, H.S., Hao, E., Hayek, A., and Ding, S. A chemical platform for improved induction of human iPSCs. Nat Methods 6, 805, 2009
29. Trokovic, R., Weltner, J., Manninen, T., Mikkola, M., Lundin, K., Hamalainen, R., Suomalainen, A., and Otonkoski, T. Small molecule inhibitors promote efficient generation of induced pluripotent stem cells from human skeletal myoblasts. Stem Cells Dev 22, 114, 2013
30. Liu, S.P., Harn, H.J., Chien, Y.J., Chang, C.H., Hsu, C.Y., Fu, R.H., Huang, Y.C., Chen, S.Y., Shyu, W.C., and Lin, S.Z. n-Butylidenephthalide (BP) maintains stem cell pluripotency by activating Jak2/Stat3 pathway and increases the efficiency of iPS cells generation. PLoS One 7, e44024, 2012
31. Esteban, M.A., Wang, T., Qin, B., Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., Chen, K., Li, Y., Liu, X., Xu, J., Zhang, S., Li, F., He, W., Labuda, K., Song, Y., Peterbauer, A., Wolbank, S., Redl, H., Zhong, M., Cai, D., Zeng, L., and Pei, D. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71, 2010
32. Jiao, J., Dang, Y., Yang, Y., Gao, R., Zhang, Y., Kou, Z., Sun, X.F., and Gao, S. Promoting reprogramming by FGF2 reveals that the extracellular matrix is a barrier for reprogramming fibroblasts to pluripotency. Stem Cells 31, 729, 2012
33. Xu, Y., Wei, X., Wang, M., Zhang, R., Fu, Y., Xing, M., Hua, Q., and Xie, X. Proliferation rate of somatic cells affects reprogramming efficiency. J Biol Chem 288, 9767, 2013
34. Sun, N., Longaker, M.T., and Wu, J.C. Human iPS cellbased therapy: Considerations before clinical applications. Cell Cycle 9, 880, 2010
35. Miura, K., Okada, Y., Aoi, T., Okada, A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., Ogawa, D., Ikeda, E., Okano, H., and Yamanaka, S. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol 27, 743, 2009
36. Niibe, K., Kawamura, Y., Araki, D., Morikawa, S., Miura, K., Suzuki, S., Shimmura, S., Sunabori, T., Mabuchi, Y., Nagai, Y., Nakagawa, T., Okano, H., and Matsuzaki, Y. Purified mesenchymal stem cells are an efficient source for iPS cell induction. PLoS One 6, e17610, 2011
37. Polo, J.M., Liu, S., Figueroa, M.E., Kulalert, W., Eminli, S., Tan, K.Y., Apostolou, E., Stadtfeld, M., Li, Y., Shioda, T., Natesan, S., Wagers, A.J., Melnick, A., Evans, T., and Hochedlinger, K. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol 28, 848, 2010
38. Chun, Y.S., Byun, K., and Lee, B. Induced pluripotent stem cells and personalized medicine: Current progress and future perspectives. Anat Cell Biol 44, 245, 2011
39. Zhou, T., Benda, C., Duzinger, S., Huang, Y., Li, X., Li, Y., Guo, X., Cao, G., Chen, S., Hao, L., Chan, Y.C., Ng, K.M., Ho, J.C., Wieser, M., Wu, J., Redl, H., Tse, H.F., Grillari, J., Grillari-Voglauer, R., Pei, D., and Esteban, M.A. Generation of induced pluripotent stem cells from urine. J Am Soc Nephrol 22, 1221, 2011
40. Zhou, T., Benda, C., Dunzinger, S., Huang, Y., Ho, J.C., Yang, J., Wang, Y., Zhang, Y., Zhuang, Q., Li, Y., Bao, X., Tse, H.F., Grillari, J., Grillari-Voglauer, R., Pei, D., and Esteban, M.A. Generation of human induced pluripotent stem cells from urine samples. Nat Protoc 7, 2080, 2012
41. van Laake, L.W., Qian, L., Cheng, P., Huang, Y., Hsiao, E.C., Conklin, B.R., and Srivastava, D. Reporter-based isolation of induced pluripotent stem cell-And embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circ Res 107, 340, 2010
42. Fujimoto, Y., Abematsu, M., Falk, A., Tsujimura, K., Sanosaka, T., Juliandi, B., Semi, K., Namihira, M., Komiya, S., Smith, A., and Nakashima, K. Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-Term selfrenewing neuroepithelial-like stem cells. Stem Cells 30, 1163, 2012
43. Woods, N.B., Parker, A.S., Moraghebi, R., Lutz, M.K., Firth, A.L., Brennand, K.J., Berggren, W.T., Raya, A., Izpisua Belmonte, J.C., Gage, F.H., and Verma, I.M. Brief report: Efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells 29, 1158, 2011
44. Tashiro, K., Inamura, M., Kawabata, K., Sakurai, F., Yamanishi, K., Hayakawa, T., and Mizuguchi, H. Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction. Stem Cells 27, 1802, 2009
45. Gao, A., Peng, Y., Deng, Y., and Qing, H. Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases. Neuroscience 228, 47, 2013
46. Nasu, A., Ikeya, M., Yamamoto, T., Watanabe, A., Jin, Y., Matsumoto, Y., Hayakawa, K., Amano, N., Sato, S., Osafune, K., Aoyama, T., Nakamura, T., Kato, T., and Toguchida, J. Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation Differs with clones, not cell type of origin. PLoS One 8, e53771, 2013
47. Kang, L., Wang, J., Zhang, Y., Kou, Z., and Gao, S. iPS cells can support full-Term development of tetraploid blastocystcomplemented embryos. Cell Stem Cell 5, 135, 2009
48. Sottile, V., Thomson, A., and McWhir, J. In vitro osteogenic differentiation of human ES cells. Cloning Stem Cells 5, 149, 2003
49. Karp, J.M., Ferreira, L.S., Khademhosseini, A., Kwon, A.H., Yeh, J., and Langer, R.S. Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro. Stem Cells 24, 835, 2006
50. Marolt, D., Campos, I.M., Bhumiratana, S., Koren, A., Petridis, P., Zhang, G., Spitalnik, P.F., Grayson, W.L., and Vunjak-Novakovic, G. Engineering bone tissue from human embryonic stem cells. Proc Natl Acad Sci U S A 109, 8705, 2012
51. Grayson, W.L., Marolt, D., Bhumiratana, S., Frohlich, M., Guo, X.E., and Vunjak-Novakovic, G. Optimizing the medium perfusion rate in bone tissue engineering bioreactors. Biotechnol Bioeng 108, 1159, 2011
52. Kao, C.L., Tai, L.K., Chiou, S.H., Chen, Y.J., Lee, K.H., Chou, S.J., Chang, Y.L., Chang, C.M., Chen, S.J., Ku, H.H., and Li, H.Y. Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells. Stem Cells Dev 19, 247, 2010
53. Hayashi, T., Misawa, H., Nakahara, H., Noguchi, H., Yoshida, A., Kobayashi, N., Tanaka, M., and Ozaki, T. Transplantation of osteogenically differentiated mouse iPS cells for bone repair. Cell Transplant 21, 591, 2012
54. Jin, G.Z., Kim, T.H., Kim, J.H., Won, J.E., Yoo, S.Y., Choi, S.J., Hyun, J.K., and Kim, H.W. Bone tissue engineering of induced pluripotent stem cells cultured with macrochanneled polymer scaffold. J Biomed Mater Res A 101, 1283, 2013
55. Bilousova, G., Jun Du, H., King, K.B., De Langhe, S., Chick, W.S., Torchia, E.C., Chow, K.S., Klemm, D.J., Roop, D.R., and Majka, S.M. Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo. Stem Cells 29, 206, 2011
56. Ye, J.H., Xu, Y.J., Gao, J., Yan, S.G., Zhao, J., Tu, Q., Zhang, J., Duan, X.J., Sommer, C.A., Mostoslavsky, G., Kaplan, D.L., Wu, Y.N., Zhang, C.P., Wang, L., and Chen, J. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials 32, 5065, 2011
57. Duan, X., Tu, Q., Zhang, J., Ye, J., Sommer, C., Mostoslavsky, G., Kaplan, D., Yang, P., and Chen, J. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. J Cell Physiol 226, 150, 2011
58. Okamoto, H., Matsumi, Y., Hoshikawa, Y., Takubo, K., Ryoke, K., and Shiota, G. Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. PLoS One 7, e43800, 2012
59. Moore, K.A., and Lemischka, I.R. Stem cells and their niches. Science 311, 1880, 2006
60. Levi, B., Hyun, J.S., Montoro, D.T., Lo, D.D., Chan, C.K., Hu, S., Sun, N., Lee, M., Grova, M., Connolly, A.J., Wu, J.C., Gurtner, G.C., Weissman, I.L., Wan, D.C., and Longaker, M.T. In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc Natl Acad Sci U S A 109, 20379, 2012
61. Gruenloh, W., Kambal, A., Sondergaard, C., McGee, J., Nacey, C., Kalomoiris, S., Pepper, K., Olson, S., Fierro, F., and Nolta, J.A. Characterization and in vivo testing of mesenchymal stem cells derived from human embryonic stem cells. Tissue Eng Part A 17, 1517, 2011
62. Li, F., Bronson, S., and Niyibizi, C. Derivation of murine induced pluripotent stem cells (iPS) and assessment of their differentiation toward osteogenic lineage. J Cell Biochem 109, 643, 2010
63. Li, F., and Niyibizi, C. Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo. BMC Cell Biol 13, 35, 2012
64. Liu, Y., Goldberg, A.J., Dennis, J.E., Gronowicz, G.A., and Kuhn, L.T. One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating. PLoS One 7, e33225, 2012
65. Lian, Q., Zhang, Y., Zhang, J., Zhang, H.K., Wu, X., Zhang, Y., Lam, F.F., Kang, S., Xia, J.C., Lai, W.H., Au, K.W., Chow, Y.Y., Siu, C.W., Lee, C.N., and Tse, H.F. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation 121, 1113, 2010
66. Guzzo, R.M., Gibson, J., Xu, R.H., Lee, F.Y., and Drissi, H. Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells. J Cell Biochem 114, 480, 2013
67. Kim, J., and Ma, T. Perfusion regulation of hMSC microenvironment and osteogenic differentiation in 3D scaffold. Biotechnol Bioeng 109, 252, 2012
68. Haasper, C., Jagodzinski, M., Drescher, M., Meller, R., Wehmeier, M., Krettek, C., and Hesse, E. Cyclic strain induces FosB and initiates osteogenic differentiation of mesenchymal cells. Exp Toxicol Pathol 59, 355, 2008
69. Huang, C.H., Chen, M.H., Young, T.H., Jeng, J.H., and Chen, Y.J. Interactive effects of mechanical stretching and extracellular matrix proteins on initiating osteogenic differentiation of human mesenchymal stem cells. J Cell Biochem 108, 1263, 2009
70. Jagodzinski, M., Breitbart, A., Wehmeier, M., Hesse, E., Haasper, C., Krettek, C., Zeichen, J., and Hankemeier, S. Influence of perfusion and cyclic compression on proliferation and differentiation of bone marrow stromal cells in 3-dimensional culture. J Biomech 41, 1885, 2008
71. de Peppo, G.M., Marcos-Campos, I., Kahler, D.J., Alsalman, D., Shang, L., Vunjak-Novakovic, G., and Marolt, D. Engineering bone tissue substitutes from human induced pluripotent stem cells. Proc Natl Acad Sci U S A 110, 8680, 2013
72. Crisan, M., Yap, S., Casteilla, L., Chen, C.W., Corselli, M., Park, T.S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., Norotte, C., Teng, P.N., Traas, J., Schugar, R., Deasy, B.M., Badylak, S., Buhring, H.J., Giacobino, J.P., Lazzari, L., Huard, J., and Peault, B. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3, 301, 2008
73. Crisan, M., Chen, C.W., Corselli, M., Andriolo, G., Lazzari, L., and Peault, B. Perivascular multipotent progenitor cells in human organs. Ann N Y Acad Sci 1176, 118, 2009
74. Corselli, M., Chen, C.W., Sun, B., Yap, S., Rubin, J.P., and Peault, B. The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells. Stem Cells Dev 21, 1299, 2012
75. James, A.W., Zara, J.N., Corselli, M., Askarinam, A., Zhou, A.M., Hourfar, A., Nguyen, A., Megerdichian, S., Asatrian, G., Pang, S., Stoker, D., Zhang, X., Wu, B., Ting, K., Peault, B., and Soo, C. An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Transl Med 1, 673, 2012
76. James, A.W., Zara, J.N., Zhang, X., Askarinam, A., Goyal, R., Chiang, M., Yuan, W., Chang, L., Corselli, M., Shen, J., Pang, S., Stoker, D., Wu, B., Ting, K., Peault, B., and Soo, C. Perivascular stem cells: A prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Transl Med 1, 510, 2012
77. Horwitz, E.M., Gordon, P.L., Koo, W.K., Marx, J.C., Neel, M.D., McNall, R.Y., Muul, L., and Hofmann, T. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci U S A 99, 8932, 2002
78. Deyle, D.R., Khan, I.F., Ren, G., Wang, P.R., Kho, J., Schwarze, U., and Russell, D.W. Normal collagen and bone production by gene-Targeted human osteogenesis imperfecta iPSCs. Mol Ther 20, 204, 2012
79. Gioia, R., Panaroni, C., Besio, R., Palladini, G., Merlini, G., Giansanti, V., Scovassi, I.A., Villani, S., Villa, I., Villa, A., Vezzoni, P., Tenni, R., Rossi, A., Marini, J.C., and Forlino, A. Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: A new target for osteogenesis imperfecta pharmacological therapy. Stem Cells 30, 1465, 2012
80. Quarto, N., Leonard, B., Li, S., Marchand, M., Anderson, E., Behr, B., Francke, U., Reijo-Pera, R., Chiao, E., and Longaker, M.T. Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patientspecific induced-pluripotent stem cells. Proc Natl Acad Sci U S A 109, 215, 2012
81. Quarto, N., Li, S., Renda, A., and Longaker, M.T. Exogenous activation of BMP-2 signaling overcomes TGFbetamediated inhibition of osteogenesis in Marfan embryonic stem cells and Marfan patient-specific induced pluripotent stem cells. Stem Cells 30, 2709, 2012
82. Bilic, J., and Izpisua Belmonte, J.C. Concise review: Induced pluripotent stem cells versus embryonic stem cells: Close enough or yet too far apart?. Stem Cells 30, 33, 2012
83. Chin, M.H., Mason, M.J., Xie, W., Volinia, S., Singer, M., Peterson, C., Ambartsumyan, G., Aimiuwu, O., Richter, L., Zhang, J., Khvorostov, I., Ott, V., Grunstein, M., Lavon, N., Benvenisty, N., Croce, C.M., Clark, A.T., Baxter, T., Pyle, A.D., Teitell, M.A., Pelegrini, M., Plath, K., and Lowry, W.E. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 5, 111, 2009
84. Ghosh, Z., Wilson, K.D., Wu, Y., Hu, S., Quertermous, T., and Wu, J.C. Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One 5, e8975, 2010
85. Doi, A., Park, I.H., Wen, B., Murakami, P., Aryee, M.J., Irizarry, R., Herb, B., Ladd-Acosta, C., Rho, J., Loewer, S., Miller, J., Schlaeger, T., Daley, G.Q., and Feinberg, A.P. Differential methylation of tissue-And cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 41, 1350, 2009
86. Meissen, J.K., Yuen, B.T., Kind, T., Riggs, J.W., Barupal, D.K., Knoepfler, P.S., and Fiehn, O. Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PLoS One 7, e46770, 2012
87. Hu, B.Y., Weick, J.P., Yu, J., Ma, L.X., Zhang, X.Q., Thomson, J.A., and Zhang, S.C. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A 107, 4335, 2010
88. Qi, S.D., Smith, P.D., and Choong, P.F. Nuclear reprogramming and induced pluripotent stem cells: A review for surgeons. ANZ J Surg 2012. [Epub ahead of print]; DOI: 10.1111/j.1445-2197.2012.06282.x.
89. Liu, Y., Cheng, D., Li, Z., Gao, X., and Wang, H. The gene expression profiles of induced pluripotent stem cells (iPSCs) generated by a non-integrating method are more similar to embryonic stem cells than those of iPSCs generated by an integrating method. Genet Mol Biol 35, 693, 2012
90. Ramos-Mejia, V., Munoz-Lopez, M., Garcia-Perez, J.L., and Menendez, P. iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability. Cell Res 20, 1092, 2010
91. Ben-David, U., Benvenisty, N., and Mayshar, Y. Genetic instability in human induced pluripotent stem cells: Classification of causes and possible safeguards. Cell Cycle 9, 4603, 2010
92. Schnabel, L.V., Abratte, C.M., Schimenti, J.C., Southard, T.L., and Fortier, L.A. Genetic background affects induced pluripotent stem cell generation. Stem Cell Res Ther 3, 30, 2012
93. Guo, C.W., Kawakatsu, M., Idemitsu, M., Urata, Y., Goto, S., Ono, Y., Hamano, K., and Li, T.S. Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells. J Cell Physiol 228, 2159, 2013
94. Lohle, M., Hermann, A., Glass, H., Kempe, A., Schwarz, S.C., Kim, J.B., Poulet, C., Ravens, U., Schwarz, J., Scholer, H.R., and Storch, A. Differentiation efficiency of induced pluripotent stem cells depends on the number of reprogramming factors. Stem Cells 30, 570, 2012
95. Anokye-Danso, F., Trivedi, C.M., Juhr, D., Gupta, M., Cui, Z., Tian, Y., Zhang, Y., Yang, W., Gruber, P.J., Epstein, J.A., and Morrisey, E.E. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8, 376, 2011
96. Li, P., Hu, H., Yang, S., Tian, R., Zhang, Z., Zhang, W., Ma, M., Zhu, Y., Guo, X., Huang, Y., He, Z., and Li, Z. Differentiation of induced pluripotent stem cells into male germ cells in vitro through embryoid body formation and retinoic acid or testosterone induction. Biomed Res Int 2013, 608728, 2013
97. Cai, H., Xia, X., Wang, L., Liu, Y., He, Z., Guo, Q., and Xu, C. In vitro and in vivo differentiation of induced pluripotent stem cells into male germ cells. Biochem Biophys Res Commun 433, 286, 2013
98. Lako, M., Armstrong, L., and Stojkovic, M. Induced pluripotent stem cells: It looks simple but can looks deceive?. Stem Cells 28, 845, 2010
99. Nakatsuji, N., Nakajima, F., and Tokunaga, K. HLAhaplotype banking and iPS cells. Nat Biotechnol 26, 739, 2008
100. Tamaoki, N., Takahashi, K., Tanaka, T., Ichisaka, T., Aoki, H., Takeda-Kawaguchi, T., Iida, K., Kunisada, T., Shibata, T., Yamanaka, S., and Tezuka, K. Dental pulp cells for induced pluripotent stem cell banking. J Dent Res 89, 773, 2010
101. Taylor, C.J., Peacock, S., Chaudhry, A.N., Bradley, J.A., and Bolton, E.M. Generating an iPSC bank for HLA-matched tissue transplantation based on known Donor and recipient HLA types. Cell Stem Cell 11, 147, 2012
102. Sun, X., Tan, G., and Liew, R. Future challenges for patientspecific induced pluripotent stem cells in cardiovascular medicine. Expert Rev Cardiovasc Ther 10, 943, 2012
103. Xing, Z., Xue, Y., Danmark, S., Schander, K., Ostvold, S., Arvidson, K., Hellem, S., Finne-Wistrand, A., Albertsson, A.C., and Mustafa, K. Effect of endothelial cells on bone regeneration using poly(L-lactide-co-1,5-dioxepan-2- one) scaffolds. J Biomed Mater Res A 96, 349, 2011
104. Stiehler, M., Bunger, C., Baatrup, A., Lind, M., Kassem, M., and Mygind, T. Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A 89, 96, 2009
105. Kim, J., and Ma, T. Bioreactor strategy in bone tissue engineering: Pre-culture and osteogenic differentiation under two flow configurations. Tissue Eng Part A 18, 2354, 2012
106. Lian, Q., Chow, Y., Esteban, M.A., Pei, D., and Tse, H.F. Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human Diseases. Thromb Haemost 104, 39, 2010
107. Wang, Z., Goh, J., Das De, S., Ge, Z., Ouyang, H., Chong, J.S., Low, S.L., and Lee, E.H. Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model. Tissue Eng 12, 1753, 2006
108. Ocarino Nde, M., Boeloni, J.N., Jorgetti, V., Gomes, D.A., Goes, A.M., and Serakides, R. Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats. Connect Tissue Res 51, 426, 2010
109. Hsiao, F.S., Cheng, C.C., Peng, S.Y., Huang, H.Y., Lian, W.S., Jan, M.L., Fang, Y.T., Cheng, E.C., Lee, K.H., Cheng, W.T., Lin, S.P., and Wu, S.C. Isolation of therapeutically functional mouse bone marrow mesenchymal stem cells within 3 h by an effective single-step plastic-Adherent method. Cell Prolif 43, 235, 2010
110. Liu, Y., Wu, J., Zhu, Y., and Han, J. Therapeutic application of mesenchymal stem cells in bone and joint diseases. Clin Exp Med 2012
111. Liu, J., Chen, W., Zhao, Z., and Xu, H.H. Reprogramming of mesenchymal stem cells derived from iPSCs seeded on biofunctionalized calcium phosphate scaffold for bone engineering. Biomaterials 34, 7862, 2013