Induced pluripotent stem cells: It looks simple but can looks deceive?

Stem Cells

Volumn 28, Issue 5, 2010, Pages 845-850

  Lako, Majlinda ^a,b   Armstrong, Lyle ^a,b   Stojkovic, Miodrag ^a,c,d  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c Spebo Medical ^*  (Serbia)

^d Medical School   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; KRUPPEL LIKE FACTOR 4; LENTIVIRUS VECTOR; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

CELL CLONING; CELL DIFFERENTIATION; CELL FUNCTION; CELL STRUCTURE; CELL TRANSFER; COST EFFECTIVENESS ANALYSIS; DNA METHYLATION; DNA SEQUENCE; EDITORIAL; EMBRYONIC STEM CELL; EPIGENETICS; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME; HUMAN; MEDICAL ETHICS; MITOCHONDRION; NONHUMAN; PLURIPOTENT STEM CELL; SOMATIC CELL; STEM CELL TRANSPLANTATION; AGING; CELL NUCLEUS TRANSPLANTATION; CELL SURFACE; CELL TRANSDIFFERENTIATION; CELL TYPE; CLONING; DNA DAMAGE; FANCONI ANEMIA; GENE MUTATION; GENE VECTOR; HUMAN CELL; NERVE CELL; PHENOTYPE; TELOMERE; TRANSGENE;

ANIMALS; CELL DEDIFFERENTIATION; CELL LINEAGE; EMBRYONIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; NUCLEAR REPROGRAMMING; PHENOTYPE; STEM CELL TRANSPLANTATION; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 77952369617     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.411     Document Type: Editorial

References (40)

1. Gurdon JB, Melton DA. Nuclear reprogramming in cells. Science 2009;322:1811-1815.
2. Stojkovic M, Stojkovic P, Leary C et al. Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes. Reprod Biomed Online 2005;226-231. (Pubitemid 41086950)
3. Li J, Liu X, Wang H et al. Human embryos derived by somatic cell nuclear transfer using an alternative enucleation approach. Cloning Stem Cells 2009;11:39-50.
4. French AJ, Adams CA, Anderson LS et al. Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts. Stem Cells 2008;26:485-493.
5. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676. (Pubitemid 44233629)
6. Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872. (Pubitemid 350138099)
7. Yu J, Vodyanik MA, Smuga-Otto K et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-1920.
8. Chin MH, Mason MJ, Xie W et al. Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures. Cell Stem Cell 2009;5:111-123.
9. Ghosh Z, Wilson KD, Wu Y, Hu S et al. Persistent Donor Cell Gene Expression among Human Induced Pluripotent Stem Cells Contributes to Differences with Human Embryonic Stem Cells. Plos One YEAR 5:1-10.
10. Doi A, Park IH, Wen B et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genetics 2009;41:1350-1353.
11. Lee G, Papapetrou EP, Kim H et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature YEAR 461:402-406.
12. Dimos JT, Rodolfa KT, Niakan KK et al. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science 2009;321:1218-1221.
13. Choi KD, Yu J, Smuga-Ottok K et al. Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells 2009;27:559-567.
14. Schenke-Layland K, Rhodes KE, Angelis E et al. Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages. Stem Cells 2008;26:1537-1546.
15. Kazuki Y, Hiratsuka M, Takiguchi M et al. Complete Genetic Correction of iPS Cells from Duchenne Muscular Dystrophy. Molecular Therapy Mol Ther 2010;18:386-393.
16. Hanna J, Wernig M, Markoulaki S et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007;318:1879-1880.
17. Hu BY, Weick JP, Yu J et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. PNAS Proc Natl Acad Sci U S A. 2010 Feb 16;[Epub ahead of print].
18. Armstrong L, Tilgner K, Saretzki G et al. Human Induced Pluripotent Stem Cell Lines Show Similar Stress Defence Mechanisms and Mitochondrial Regulation to Human Embryonic Stem Cells. Stem Cells 2010;[Epub ahead of print].
19. Sommer CA, Sommer AG, Longmire TA et al. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells 2010;28:64-74.
20. Marion RM, Strati K, Li H et al. Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 2009;4:141-154.
21. Feng Q, Lu SJ, Klimanskaya I et al. Hemangioblastic derivatives from human induced pluripotent Stem cells exhibit limited expansión and early senescence. Stem Cells 2010 Feb 12;[Epub ahead of print].
22. Medawar, P.B. 1952. An Unsolved Problem of Biology. London: H.K. Lewis. http://www.telomere.org/Downloads/Medawar-UPB.pdf] Edney, E.B. and Gill, R.W. 1968.
23. Huangfu D, Osafune K, Maehr R et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology 2008;26:1269-1275.
24. Wernig M, Lengner CJ, Hanna J et al. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nature Biotechnology 2008;26:916-924.
25. Hyslop L, Stojkovic M, Armstrong L et al. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. Stem Cells 2005;23:1035-1043. (Pubitemid 41377718)
26. Bhutani N, Brady JJ, Damian M et al. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 2010;463:1042-1047.
27. Ichida JK, Blanchard J, Lam K et al. A small-molecule inhibitor of TGF-beta signaling replaces Sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009;5:491-503.
28. Priogione A, Fauler B, Lurz et al. The senescen-related mitocondrial/ oxidative stress pathway is repressed in human induced pluripotent Stem cells. Stem Cells 2010 Mar 3;[Epub ahead of print].
29. Aasen T, Raya A, Barrero MJ et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnol 2008;26:1276-1284.
30. Kim JB, Greber B, Araúzo-Bravo MJ et al. Direct reprogramming of human neural stem cells by OCT4. Nature 2009;461:649-653.
31. Utikal J, Maherali N, Kulalert W, Hochedlinger K. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci 2009;122:3502-3510.
32. Tsai SY, Clavel C, Kim S et al. Oct4 and Klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells 2010;28:221-228.
33. Haase A, Olmer R, Schwanke K et al. Generation of Induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell 2009;5:434-441
34. Balasubramanian S, Babai N, Chaudhuri A et al. Non cell-autonomous reprogramming of adult ocular progenitors: generation of pluripotent stem cells without exogenous transcription factors. Stem Cells 2009;27:3053-3062.
35. Ko K, Tapia N, Wu G et al. Induction of pluripotency in adult unipotent germline stem cells. Cell Stem Cell 2009;5:87-96.
36. Vierbuchen T, Ostermeier A, Pang ZO et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010 Feb 25;463(7284):1035-1041
37. Hakelien AM, Landsverk HB, Robl JM et al. Reprogramming fibroblasts to express T-cell functions using cell extracts. Nat Biotechnol 2002 May;20(5):460-466
38. Zhou Q, Brown J, Kanarek A et al. In Vivo Reprogramming Of Adult Pancreatic Exocrine Cells To beta-cells Nature 2008;455:627-632.
39. Goldberg AD, Allis CD, Bernstein E. Epigenetics: A landscape takes shape. Cell 2007;128:635-638.
40. Raya A, Rodríguez-Pizà I, Guenechea G et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 2009;460:53-59.