메뉴 건너뛰기




Volumn 228, Issue , 2013, Pages 47-59

Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases

Author keywords

Cell therapy; Differentiation; Immunogenicity; Induced pluripotent stem cells; Neurodegerative diseases; Reprogramming factors

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA SYNUCLEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; DNA BINDING PROTEIN; HUNTINGTIN; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PRESENILIN 1; SURVIVAL MOTOR NEURON PROTEIN 1; SURVIVAL MOTOR NEURON PROTEIN 2; TAU PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LIN 28; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

EID: 84868594756     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.09.076     Document Type: Review
Times cited : (16)

References (101)
  • 2
    • 33745144314 scopus 로고    scopus 로고
    • Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector
    • Baughan T., Shababi M., Coady T.H., Dickson A.M., Tullis G.E., Lorson C.L. Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector. Mol Ther 2006, 14:54-62.
    • (2006) Mol Ther , vol.14 , pp. 54-62
    • Baughan, T.1    Shababi, M.2    Coady, T.H.3    Dickson, A.M.4    Tullis, G.E.5    Lorson, C.L.6
  • 3
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
    • Bensimon G., Lacomblez L., Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med 1994, 330:585-591.
    • (1994) N Engl J Med , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 5
    • 3543004099 scopus 로고    scopus 로고
    • Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury
    • Blesch A., Tuszynski M.H. Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J 2004, 45(Suppl):28-31.
    • (2004) Yonsei Med J , vol.45 , Issue.SUPPL. , pp. 28-31
    • Blesch, A.1    Tuszynski, M.H.2
  • 6
    • 77958610668 scopus 로고    scopus 로고
    • Analysis of human and mouse reprogramming of somatic cells to induced pluripotent stem cells. What is in the plate?
    • Boue S., Paramonov I., Barrero M.J., Izpisua Belmonte J.C. Analysis of human and mouse reprogramming of somatic cells to induced pluripotent stem cells. What is in the plate?. PLoS One 2010, 5.
    • (2010) PLoS One , vol.5
    • Boue, S.1    Paramonov, I.2    Barrero, M.J.3    Izpisua Belmonte, J.C.4
  • 7
    • 50649099903 scopus 로고    scopus 로고
    • Developmental biology. Neuron research leaps ahead
    • Brown R.H. Developmental biology. Neuron research leaps ahead. Science 2008, 321:1169-1170.
    • (2008) Science , vol.321 , pp. 1169-1170
    • Brown, R.H.1
  • 8
    • 77954932494 scopus 로고    scopus 로고
    • Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats
    • Cai J., Yang M., Poremsky E., Kidd S., Schneider J.S., Iacovitti L. Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev 2010, 19:1017-1023.
    • (2010) Stem Cells Dev , vol.19 , pp. 1017-1023
    • Cai, J.1    Yang, M.2    Poremsky, E.3    Kidd, S.4    Schneider, J.S.5    Iacovitti, L.6
  • 10
    • 77957916358 scopus 로고    scopus 로고
    • Reprogramming Huntington monkey skin cells into pluripotent stem cells
    • Chan A.W., Cheng P.H., Neumann A., Yang J.J. Reprogramming Huntington monkey skin cells into pluripotent stem cells. Cell Reprogram 2010, 12:509-517.
    • (2010) Cell Reprogram , vol.12 , pp. 509-517
    • Chan, A.W.1    Cheng, P.H.2    Neumann, A.3    Yang, J.J.4
  • 11
    • 80052819789 scopus 로고    scopus 로고
    • Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells
    • Chen T., Shen L., Yu J., Wan H., Guo A., Chen J., Long Y., Zhao J., Pei G. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell 2011, 10:908-911.
    • (2011) Aging Cell , vol.10 , pp. 908-911
    • Chen, T.1    Shen, L.2    Yu, J.3    Wan, H.4    Guo, A.5    Chen, J.6    Long, Y.7    Zhao, J.8    Pei, G.9
  • 12
    • 80054787664 scopus 로고    scopus 로고
    • What genetics tells us about the causes and mechanisms of Parkinson's disease
    • Corti O., Lesage S., Brice A. What genetics tells us about the causes and mechanisms of Parkinson's disease. Physiol Rev 2011, 91:1161-1218.
    • (2011) Physiol Rev , vol.91 , pp. 1161-1218
    • Corti, O.1    Lesage, S.2    Brice, A.3
  • 13
    • 0032816549 scopus 로고    scopus 로고
    • The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease
    • Damier P., Hirsch E.C., Agid Y., Graybiel A.M. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 1999, 122(Pt 8):1437-1448.
    • (1999) Brain , vol.122 , Issue.PART 8 , pp. 1437-1448
    • Damier, P.1    Hirsch, E.C.2    Agid, Y.3    Graybiel, A.M.4
  • 16
    • 26844489638 scopus 로고    scopus 로고
    • Potential of bone marrow stromal cells in applications for neuro-degenerative, neuro-traumatic and muscle degenerative diseases
    • Dezawa M., Ishikawa H., Hoshino M., Itokazu Y., Nabeshima Y. Potential of bone marrow stromal cells in applications for neuro-degenerative, neuro-traumatic and muscle degenerative diseases. Curr Neuropharmacol 2005, 3:257-266.
    • (2005) Curr Neuropharmacol , vol.3 , pp. 257-266
    • Dezawa, M.1    Ishikawa, H.2    Hoshino, M.3    Itokazu, Y.4    Nabeshima, Y.5
  • 18
    • 70350075024 scopus 로고    scopus 로고
    • Genetics of motor neuron disorders: new insights into pathogenic mechanisms
    • Dion P.A., Daoud H., Rouleau G.A. Genetics of motor neuron disorders: new insights into pathogenic mechanisms. Nat Rev Genet 2009, 10:769-782.
    • (2009) Nat Rev Genet , vol.10 , pp. 769-782
    • Dion, P.A.1    Daoud, H.2    Rouleau, G.A.3
  • 20
    • 77953623111 scopus 로고    scopus 로고
    • Stem cell model of spinal muscular atrophy
    • Ebert A.D., Svendsen C.N. Stem cell model of spinal muscular atrophy. Arch Neurol 2010, 67:665-669.
    • (2010) Arch Neurol , vol.67 , pp. 665-669
    • Ebert, A.D.1    Svendsen, C.N.2
  • 24
    • 62949220231 scopus 로고    scopus 로고
    • Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells
    • Feng B., Ng J.H., Heng J.C., Ng H.H. Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell 2009, 4:301-312.
    • (2009) Cell Stem Cell , vol.4 , pp. 301-312
    • Feng, B.1    Ng, J.H.2    Heng, J.C.3    Ng, H.H.4
  • 25
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 140:918-934.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 26
    • 79960035168 scopus 로고    scopus 로고
    • Single and local blockade of interleukin-6 signaling promotes neuronal differentiation from transplanted embryonic stem cell-derived neural precursor cells
    • Gomi M., Aoki T., Takagi Y., Nishimura M., Ohsugi Y., Mihara M., Nozaki K., Hashimoto N., Miyamoto S., Takahashi J. Single and local blockade of interleukin-6 signaling promotes neuronal differentiation from transplanted embryonic stem cell-derived neural precursor cells. J Neurosci Res 2011, 89:1388-1399.
    • (2011) J Neurosci Res , vol.89 , pp. 1388-1399
    • Gomi, M.1    Aoki, T.2    Takagi, Y.3    Nishimura, M.4    Ohsugi, Y.5    Mihara, M.6    Nozaki, K.7    Hashimoto, N.8    Miyamoto, S.9    Takahashi, J.10
  • 27
    • 78649816445 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: pathophysiology, diagnosis and management
    • Gordon P.H. Amyotrophic lateral sclerosis: pathophysiology, diagnosis and management. CNS Drugs 2011, 25:1-15.
    • (2011) CNS Drugs , vol.25 , pp. 1-15
    • Gordon, P.H.1
  • 29
    • 0032491408 scopus 로고    scopus 로고
    • Genetic classification of primary neurodegenerative disease
    • Hardy J., Gwinn-Hardy K. Genetic classification of primary neurodegenerative disease. Science 1998, 282:1075-1079.
    • (1998) Science , vol.282 , pp. 1075-1079
    • Hardy, J.1    Gwinn-Hardy, K.2
  • 31
    • 0035865459 scopus 로고    scopus 로고
    • Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
    • Huang G., Shigesada K., Ito K., Wee H.J., Yokomizo T., Ito Y. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J 2001, 20:723-733.
    • (2001) EMBO J , vol.20 , pp. 723-733
    • Huang, G.1    Shigesada, K.2    Ito, K.3    Wee, H.J.4    Yokomizo, T.5    Ito, Y.6
  • 32
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • Huangfu D., Maehr R., Guo W., Eijkelenboom A., Snitow M., Chen A.E., Melton D.A. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008, 26:795-797.
    • (2008) Nat Biotechnol , vol.26 , pp. 795-797
    • Huangfu, D.1    Maehr, R.2    Guo, W.3    Eijkelenboom, A.4    Snitow, M.5    Chen, A.E.6    Melton, D.A.7
  • 33
    • 77955843524 scopus 로고    scopus 로고
    • Neurodegenerative disease-specific induced pluripotent stem cell research
    • Inoue H. Neurodegenerative disease-specific induced pluripotent stem cell research. Exp Cell Res 2010, 316:2560-2564.
    • (2010) Exp Cell Res , vol.316 , pp. 2560-2564
    • Inoue, H.1
  • 35
    • 79959827662 scopus 로고    scopus 로고
    • Cellular alchemy: induced pluripotent stem cells retain epigenetic memory
    • Jandial R., Levy M.L. Cellular alchemy: induced pluripotent stem cells retain epigenetic memory. World Neurosurg 2011, 75:5-6.
    • (2011) World Neurosurg , vol.75 , pp. 5-6
    • Jandial, R.1    Levy, M.L.2
  • 36
  • 37
    • 33744977254 scopus 로고    scopus 로고
    • The pathogenesis of cell death in Parkinson's disease
    • Jenner P., Olanow C.W. The pathogenesis of cell death in Parkinson's disease. Neurology 2006, 66:S24-36.
    • (2006) Neurology , vol.66
    • Jenner, P.1    Olanow, C.W.2
  • 38
    • 84861328547 scopus 로고    scopus 로고
    • Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model
    • Jensen M.B., Yan H., Krishnaney-Davison R., Al Sawaf A., Zhang S.C. Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model. J Stroke Cerebrovasc Dis 2011.
    • (2011) J Stroke Cerebrovasc Dis
    • Jensen, M.B.1    Yan, H.2    Krishnaney-Davison, R.3    Al Sawaf, A.4    Zhang, S.C.5
  • 40
    • 78649352832 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment of neurodegenerative disease
    • Joyce N., Annett G., Wirthlin L., Olson S., Bauer G., Nolta J.A. Mesenchymal stem cells for the treatment of neurodegenerative disease. Regen Med 2010, 5:933-946.
    • (2010) Regen Med , vol.5 , pp. 933-946
    • Joyce, N.1    Annett, G.2    Wirthlin, L.3    Olson, S.4    Bauer, G.5    Nolta, J.A.6
  • 41
    • 79959889155 scopus 로고    scopus 로고
    • Embryonic and induced pluripotent stem cell staining and sorting with the live-cell fluorescence imaging probe CDy1
    • Kang N.Y., Yun S.W., Ha H.H., Park S.J., Chang Y.T. Embryonic and induced pluripotent stem cell staining and sorting with the live-cell fluorescence imaging probe CDy1. Nat Protoc 2011, 6:1044-1052.
    • (2011) Nat Protoc , vol.6 , pp. 1044-1052
    • Kang, N.Y.1    Yun, S.W.2    Ha, H.H.3    Park, S.J.4    Chang, Y.T.5
  • 43
    • 37549055802 scopus 로고    scopus 로고
    • Stem cell-based cell therapy for Huntington disease: a review
    • Kim M., Lee S.T., Chu K., Kim S.U. Stem cell-based cell therapy for Huntington disease: a review. Neuropathology 2008, 28:1-9.
    • (2008) Neuropathology , vol.28 , pp. 1-9
    • Kim, M.1    Lee, S.T.2    Chu, K.3    Kim, S.U.4
  • 45
    • 79956037142 scopus 로고    scopus 로고
    • Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease
    • Klinge P.M., Harmening K., Miller M.C., Heile A., Wallrapp C., Geigle P., Brinker T. Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease. Neurosci Lett 2011, 497:6-10.
    • (2011) Neurosci Lett , vol.497 , pp. 6-10
    • Klinge, P.M.1    Harmening, K.2    Miller, M.C.3    Heile, A.4    Wallrapp, C.5    Geigle, P.6    Brinker, T.7
  • 48
    • 66949152096 scopus 로고    scopus 로고
    • Parkinson's disease
    • Lees A.J., Hardy J., Revesz T. Parkinson's disease. Lancet 2009, 373:2055-2066.
    • (2009) Lancet , vol.373 , pp. 2055-2066
    • Lees, A.J.1    Hardy, J.2    Revesz, T.3
  • 53
    • 0033033434 scopus 로고    scopus 로고
    • A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy
    • Lorson C.L., Hahnen E., Androphy E.J., Wirth B. A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. Proc Natl Acad Sci U S A 1999, 96:6307-6311.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6307-6311
    • Lorson, C.L.1    Hahnen, E.2    Androphy, E.J.3    Wirth, B.4
  • 55
    • 0030273702 scopus 로고    scopus 로고
    • Huntington's disease: translating a CAG repeat into a pathogenic mechanism
    • MacDonald M.E., Gusella J.F. Huntington's disease: translating a CAG repeat into a pathogenic mechanism. Curr Opin Neurobiol 1996, 6:638-643.
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 638-643
    • MacDonald, M.E.1    Gusella, J.F.2
  • 59
    • 0042536471 scopus 로고    scopus 로고
    • Neuronal and glial calcium signaling in Alzheimer's disease
    • Mattson M.P., Chan S.L. Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium 2003, 34:385-397.
    • (2003) Cell Calcium , vol.34 , pp. 385-397
    • Mattson, M.P.1    Chan, S.L.2
  • 60
    • 0036304650 scopus 로고    scopus 로고
    • Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior
    • Mattson M.P., Chan S.L., Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev 2002, 82:637-672.
    • (2002) Physiol Rev , vol.82 , pp. 637-672
    • Mattson, M.P.1    Chan, S.L.2    Duan, W.3
  • 63
    • 77956638256 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells from liver progenitor cells by only small molecules
    • author reply 1169-1170
    • Moriguchi H., Chung R.T., Mihara M., Sato C. Generation of human induced pluripotent stem cells from liver progenitor cells by only small molecules. Hepatology 2010, 52:1169. author reply 1169-1170.
    • (2010) Hepatology , vol.52 , pp. 1169
    • Moriguchi, H.1    Chung, R.T.2    Mihara, M.3    Sato, C.4
  • 65
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse induced pluripotent stem cells without viral vectors
    • Okita K., Nakagawa M., Hyenjong H., Ichisaka T., Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008, 322:949-953.
    • (2008) Science , vol.322 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3    Ichisaka, T.4    Yamanaka, S.5
  • 66
    • 80053005674 scopus 로고    scopus 로고
    • Immunogenicity of induced pluripotent stem cells
    • Okita K., Nagata N., Yamanaka S. Immunogenicity of induced pluripotent stem cells. Circ Res 2011, 109:720-721.
    • (2011) Circ Res , vol.109 , pp. 720-721
    • Okita, K.1    Nagata, N.2    Yamanaka, S.3
  • 72
    • 0037194897 scopus 로고    scopus 로고
    • Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders
    • Ross C.A. Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders. Neuron 2002, 35:819-822.
    • (2002) Neuron , vol.35 , pp. 819-822
    • Ross, C.A.1
  • 73
    • 37849050242 scopus 로고    scopus 로고
    • Neurotrophic factors in Alzheimer's disease: role of axonal transport
    • Schindowski K., Belarbi K., Buee L. Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behav 2008, 7(Suppl 1):43-56.
    • (2008) Genes Brain Behav , vol.7 , Issue.SUPPL. 1 , pp. 43-56
    • Schindowski, K.1    Belarbi, K.2    Buee, L.3
  • 74
    • 77955118962 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors
    • Si-Tayeb K., Noto F.K., Sepac A., Sedlic F., Bosnjak Z.J., Lough J.W., Duncan S.A. Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. BMC Dev Biol 2010, 10:81.
    • (2010) BMC Dev Biol , vol.10 , pp. 81
    • Si-Tayeb, K.1    Noto, F.K.2    Sepac, A.3    Sedlic, F.4    Bosnjak, Z.J.5    Lough, J.W.6    Duncan, S.A.7
  • 77
    • 55849115999 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated without viral integration
    • Stadtfeld M., Nagaya M., Utikal J., Weir G., Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008, 322:945-949.
    • (2008) Science , vol.322 , pp. 945-949
    • Stadtfeld, M.1    Nagaya, M.2    Utikal, J.3    Weir, G.4    Hochedlinger, K.5
  • 78
    • 33646135323 scopus 로고    scopus 로고
    • Therapeutics development for spinal muscular atrophy
    • Sumner C.J. Therapeutics development for spinal muscular atrophy. NeuroRx 2006, 3:235-245.
    • (2006) NeuroRx , vol.3 , pp. 235-245
    • Sumner, C.J.1
  • 79
    • 78149302874 scopus 로고    scopus 로고
    • Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions
    • Swistowski A., Peng J., Liu Q., Mali P., Rao M.S., Cheng L., Zeng X. Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem cells 2010, 28:1893-1904.
    • (2010) Stem cells , vol.28 , pp. 1893-1904
    • Swistowski, A.1    Peng, J.2    Liu, Q.3    Mali, P.4    Rao, M.S.5    Cheng, L.6    Zeng, X.7
  • 80
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 81
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 82
    • 34848904785 scopus 로고    scopus 로고
    • Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates
    • Teuling E., Ahmed S., Haasdijk E., Demmers J., Steinmetz M.O., Akhmanova A., Jaarsma D., Hoogenraad C.C. Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates. J Neurosci 2007, 27:9801-9815.
    • (2007) J Neurosci , vol.27 , pp. 9801-9815
    • Teuling, E.1    Ahmed, S.2    Haasdijk, E.3    Demmers, J.4    Steinmetz, M.O.5    Akhmanova, A.6    Jaarsma, D.7    Hoogenraad, C.C.8
  • 83
    • 79551512488 scopus 로고    scopus 로고
    • Research advances in amyotrophic lateral sclerosis, 2009 to 2010
    • Traub R., Mitsumoto H., Rowland L.P. Research advances in amyotrophic lateral sclerosis, 2009 to 2010. Curr Neurol Neurosci Rep 2011, 11:67-77.
    • (2011) Curr Neurol Neurosci Rep , vol.11 , pp. 67-77
    • Traub, R.1    Mitsumoto, H.2    Rowland, L.P.3
  • 89
    • 79952579942 scopus 로고    scopus 로고
    • Neurodegenerative disease and adult neurogenesis
    • Winner B., Kohl Z., Gage F.H. Neurodegenerative disease and adult neurogenesis. Eur J Neurosci 2011, 33:1139-1151.
    • (2011) Eur J Neurosci , vol.33 , pp. 1139-1151
    • Winner, B.1    Kohl, Z.2    Gage, F.H.3
  • 90
    • 33749264614 scopus 로고    scopus 로고
    • Spinal muscular atrophy: from gene to therapy
    • Wirth B., Brichta L., Hahnen E. Spinal muscular atrophy: from gene to therapy. Semin Pediatr Neurol 2006, 13:121-131.
    • (2006) Semin Pediatr Neurol , vol.13 , pp. 121-131
    • Wirth, B.1    Brichta, L.2    Hahnen, E.3
  • 92
    • 79955572417 scopus 로고    scopus 로고
    • Harnessing the potential of induced pluripotent stem cells for regenerative medicine
    • Wu S.M., Hochedlinger K. Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol 2011, 13:497-505.
    • (2011) Nat Cell Biol , vol.13 , pp. 497-505
    • Wu, S.M.1    Hochedlinger, K.2
  • 93
    • 77955851538 scopus 로고    scopus 로고
    • The iPS technique provides hope for Parkinson's disease treatment
    • Xu L., Tan Y.Y., Ding J.Q., Chen S.D. The iPS technique provides hope for Parkinson's disease treatment. Stem Cell Rev 2010, 6:398-404.
    • (2010) Stem Cell Rev , vol.6 , pp. 398-404
    • Xu, L.1    Tan, Y.Y.2    Ding, J.Q.3    Chen, S.D.4
  • 94
    • 58149330092 scopus 로고    scopus 로고
    • Effects of engrafted neural stem cells in Alzheimer's disease rats
    • Xuan A.G., Luo M., Ji W.D., Long D.H. Effects of engrafted neural stem cells in Alzheimer's disease rats. Neurosci Lett 2009, 450:167-171.
    • (2009) Neurosci Lett , vol.450 , pp. 167-171
    • Xuan, A.G.1    Luo, M.2    Ji, W.D.3    Long, D.H.4
  • 95
    • 77953466536 scopus 로고    scopus 로고
    • Nuclear reprogramming to a pluripotent state by three approaches
    • Yamanaka S., Blau H.M. Nuclear reprogramming to a pluripotent state by three approaches. Nature 2010, 465:704-712.
    • (2010) Nature , vol.465 , pp. 704-712
    • Yamanaka, S.1    Blau, H.M.2
  • 97
    • 0030976172 scopus 로고    scopus 로고
    • Spinal muscular atrophy-clinical and genetic correlations
    • Zerres K., Wirth B., Rudnik-Schoneborn S. Spinal muscular atrophy-clinical and genetic correlations. Neuromuscul Disord 1997, 7:202-207.
    • (1997) Neuromuscul Disord , vol.7 , pp. 202-207
    • Zerres, K.1    Wirth, B.2    Rudnik-Schoneborn, S.3
  • 100
    • 79957807595 scopus 로고    scopus 로고
    • Immunogenicity of induced pluripotent stem cells
    • Zhao T., Zhang Z.N., Rong Z., Xu Y. Immunogenicity of induced pluripotent stem cells. Nature 2011, 474:212-215.
    • (2011) Nature , vol.474 , pp. 212-215
    • Zhao, T.1    Zhang, Z.N.2    Rong, Z.3    Xu, Y.4
  • 101
    • 80052496433 scopus 로고    scopus 로고
    • Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau
    • Zilka N., Zilkova M., Kazmerova Z., Sarissky M., Cigankova V., Novak M. Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau. Neuroscience 2011, 193:330-337.
    • (2011) Neuroscience , vol.193 , pp. 330-337
    • Zilka, N.1    Zilkova, M.2    Kazmerova, Z.3    Sarissky, M.4    Cigankova, V.5    Novak, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.