Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo

International Immunopharmacology

Volumn 22, Issue 2, 2014, Pages 332-340

  Park, Eun Jung ^a   Park, Sang Won ^a   Kim, Hye Jung ^a   Kwak, Jong Hwan ^b   Lee, Dong Ung ^c   Chang, Ki Churl ^a  

^a Gyeongsang National University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Dongguk University   (South Korea)

Author keywords

Dehydrocostuslactone; Heme oxygenase; Inflammation; Mice; Sepsis

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOOXYGENASE 2; DEHYDROCOSTUS LACTONE; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; PROTOPORPHYRIN ZINC; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; HMOX1 PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTONE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; SESQUITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG INHIBITION; ENZYME INDUCTION; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEPSIS; SURVIVAL; ANIMAL; CECUM; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INJURIES; LIGATION; LIVER; LUNG; METABOLISM; PATHOLOGY; SURGERY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CECUM; CELL LINE; CELL SURVIVAL; DINOPROSTONE; GENE SILENCING; HEME OXYGENASE-1; LACTONES; LIGATION; LIPOPOLYSACCHARIDES; LIVER; LUNG; MACROPHAGES; MEMBRANE PROTEINS; MICE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SEPSIS; SESQUITERPENES;

EID: 84905458989     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.07.012     Document Type: Article

References (33)

1. L.E. Otterbein, P.J. Lee, B.Y. Chin, I. Petrache, S.L. Camhi, and J. Alam et al. Protective effects of heme oxygenase-1 in acute lung injury Chest 116 1999 61S 63S (Pubitemid 29340213)
2. C.A. Dinarello, and R.C. Thompson Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro Immunol Today 12 1991 404 410
3. F.P. Heinzel The role of IFN-gamma in the pathology of experimental endotoxemia J Immunol 145 1990 2920 2924 (Pubitemid 20382561)
4. M.R. Dinapoli, C.L. Calderon, and D.M. Lopez The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene J Exp Med 183 1996 1323 1329
5. R.S. Hotchkiss, and I.E. Karl The pathophysiology and treatment of sepsis N Engl J Med 348 2003 138 150 (Pubitemid 36056721)
6. F. Venet, C.S. Chung, G. Monneret, X. Huang, B. Horner, and M. Garber et al. Regulatory T cell populations in sepsis and trauma J Leukoc Biol 83 2008 523 535 (Pubitemid 351966861)
7. A.L. Taylor, and M.J. Llewelyn Superantigen-induced proliferation of human CD4 + CD25-T cells is followed by a switch to a functional regulatory phenotype J Immunol 185 2010 6591 6598
8. F. Hein, F. Massin, A. Cravoisy-Popovic, D. Barraud, B. Levy, and P.E. Bollaert et al. The relationship between CD4 + CD25 + CD127-regulatory T cells and inflammatory response and outcome during shock states Crit Care 14 2010 R19
9. F. Venet, C.S. Chung, H. Kherouf, A. Geeraert, C. Malcus, and F. Poitevin et al. Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients Intensive Care Med 35 2009 678 686
10. K.J. Hartemink, and A.B. Groeneveld The hemodynamics of human septic shock relate to circulating innate immunity factors Immunol Invest 39 2010 849 862
11. J. Monserrat, R. de Pablo, E. Reyes, D. Diaz, H. Barcenilla, and M.R. Zapata et al. Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients Crit Care 13 2009 R26
12. E. Maury, H.S. Blanchard, P. Chauvin, J. Guglielminotti, M. Alzieu, and B. Guidet et al. Circulating endotoxin and antiendotoxin antibodies during severe sepsis and septic shock J Crit Care 18 2003 115 120 (Pubitemid 36759163)
13. D.E. Fry Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues Am Surg 78 2012 1 8
14. S.W. Ryter, J. Alam, and A.M. Choi Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications Physiol Rev 86 2006 583 650
15. E.H. Carchman, J. Rao, P.A. Loughran, M.R. Rosengart, and B.S. Zuckerbraun Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice Hepatology 53 2011 2053 2062
16. H.J. Lee, N.Y. Kim, M.K. Jang, H.J. Son, K.M. Kim, and D.H. Sohn et al. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages Planta Med 65 1999 104 108 (Pubitemid 29138139)
17. H.C. Chen, C.K. Chou, S.D. Lee, J.C. Wang, and S.F. Yeh Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells Antiviral Res 27 1995 99 109
18. M. Taniguchi, T. Kataoka, H. Suzuki, M. Uramoto, M. Ando, and K. Arao et al. Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes Biosci Biotechnol Biochem 59 1995 2064 2067 (Pubitemid 3019222)
19. S. Yuuya, H. Hagiwara, T. Suzuki, M. Ando, A. Yamada, and K. Suda et al. Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives J Nat Prod 62 1999 22 30 (Pubitemid 29071370)
20. E. Butturini, E. Cavalieri, A.C. de Prati, E. Darra, A. Rigo, and K. Shoji et al. Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation PLoS One 6 2011 e20174
21. G.S. Jeong, H.O. Pae, S.O. Jeong, Y.C. Kim, T.O. Kwon, and H.S. Lee et al. The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells Eur J Pharmacol 565 2007 37 44 (Pubitemid 46782776)
22. Y.J. Kang, E.B. Koo, Y.S. Lee, H.S. Yun-Choi, and K.C. Chang Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages Br J Pharmacol 128 1999 357 364 (Pubitemid 29458594)
23. J. Alam, D. Stewart, C. Touchard, S. Boinapally, A.M. Choi, and J.L. Cook Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene J Biol Chem 274 1999 26071 26078
24. E. Butturini, R. Di Paola, H. Suzuki, I. Paterniti, A. Ahmad, and S. Mariotto et al. Costunolide and dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice Eur J Pharmacol 730 2014 107 115
25. H.J. Jang, Y.M. Kim, K. Tsoyi, E.J. Park, Y.S. Lee, and H.J. Kim et al. Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals Antioxid Redox Signal 17 2012 878 889
26. E.J. Park, H.J. Jang, K. Tsoyi, Y.M. Kim, S.W. Park, and H.J. Kim et al. The heme oxygenase-1 inducer THI-56 negatively regulates iNOS expression and HMGB1 release in LPS-activated RAW 264.7 cells and CLP-induced septic mice PLoS One 8 2013 e76293
27. J.S. Hwa, Y.C. Jin, Y.S. Lee, Y.S. Ko, Y.M. Kim, and L.Y. Shi et al. 2-Methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction J Ethnopharmacol 139 2012 605 615
28. K. Tsoyi, H.J. Jang, Y.S. Lee, Y.M. Kim, H.J. Kim, and H.G. Seo et al. (+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction J Ethnopharmacol 137 2011 1311 1317
29. S. Naidu, V. Vijayan, S. Santoso, T. Kietzmann, and S. Immenschuh Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2 J Immunol 182 2009 7048 7057
30. P. Pullikotil, H. Chen, R. Muniyappa, C.C. Greenberg, S. Yang, and C.E. Reiter et al. Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-alpha J Nutr Biochem 23 2012 1134 1145
31. Y.M. Ha, M.Y. Kim, M.K. Park, Y.S. Lee, Y.M. Kim, and H.J. Kim et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways Apoptosis 17 2012 463 474
32. M.R. Reboll, A.T. Schweda, M. Bartels, R. Franke, R. Frank, and M. Nourbakhsh Mapping of NRF binding motifs of NF-kappaB p65 subunit J Biochem 150 2011 553 562
33. I. Niedick, N. Froese, A. Oumard, P.P. Mueller, M. Nourbakhsh, and H. Hauser et al. Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF J Cell Sci 117 2004 3447 3458 (Pubitemid 39206385)