Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives

Journal of Natural Products

Volumn 62, Issue 1, 1999, Pages 22-30

  Yuuya, Saori ^a   Hagiwara, Hisahiro ^a   Suzuki, Toshio ^a   Ando, Masayoshi ^a   Yamada, Atsushi ^b   Suda, Kouji ^b   Kataoka, Takao ^b   Nagai, Kazuo ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA,10ALPHA EPOXYGUAIA 4(14),11(12) DIENO 13,6ALPHA LACTONE; 1BETA,10BETA EPOXYGUAIA 4(14),7(11) DIENO 13,6ALPHA LACTONE; 9ALPHA,10ALPHA EPOXYGUAIA 4(14),11(12) DIENO 13,6ALPHA LACTONE; DEHYDROCOSTUS LACTONE; EREMANTHINE; GUAIA 1(10),4(14),11(12) TRIENO 13,6ALPHA LACTONE; GUAIANOLIDE DERIVATIVE; IMMUNOMODULATING AGENT; INTERCELLULAR ADHESION MOLECULE 1; MITOMYCIN C; SAUSSUREA LAPPA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOMA CELL; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; SPLEEN CELL; STRUCTURE ACTIVITY RELATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; RATS; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

ANIMALIA; SAUSSUREA; SAUSSUREA LAPPA;

EID: 0032912528     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np980092u     Document Type: Article

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31. 2 (437 mg, 1.61 mmol) and 0.5 M HCl (4 mL) were added, and after being stirred for 5 min, the aqueous solution was decanted. The residue in the flask was used for the reaction immediately.