-
2
-
-
0026874127
-
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
-
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-74.
-
(1992)
Crit Care Med
, vol.20
, pp. 864-874
-
-
-
3
-
-
77954651382
-
Molecular biology of liver ischemia/reperfusion injury: Established mechanisms and recent advancements
-
Klune JR, Tsung A. Molecular biology of liver ischemia/reperfusion injury: established mechanisms and recent advancements. Surg Clin North Am 2010;90:665-77.
-
(2010)
Surg Clin North Am
, vol.90
, pp. 665-677
-
-
Klune, J.R.1
Tsung, A.2
-
4
-
-
0033961638
-
Sepsis syndrome
-
Fry DE. Sepsis syndrome. Am Surg 2000;66:126-32. (Pubitemid 30106294)
-
(2000)
American Surgeon
, vol.66
, Issue.2
, pp. 126-132
-
-
Fry, D.E.1
-
5
-
-
1442310594
-
Tissue Factor: A Key Molecule in Hemostatic and Nonhemostatic Systems
-
Morrissey JH. Tissue factor: a key molecule in hemostatic and nonhemostatic systems. Int J Hematol 2004;79:103-8. (Pubitemid 38281807)
-
(2004)
International Journal of Hematology
, vol.79
, Issue.2
, pp. 103-108
-
-
Morrissey, J.H.1
-
6
-
-
51349169451
-
The elusive physiologic role of Factor XII
-
Schmaier AH. The elusive physiologic role of Factor XII. J Clin Invest 2008;118:3006-9.
-
(2008)
J Clin Invest
, vol.118
, pp. 3006-3009
-
-
Schmaier, A.H.1
-
7
-
-
33845951211
-
DAMPs, PAMPs and alarmins: All we need to know about danger
-
DOI 10.1189/jlb.0306164
-
Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007;81:1-5. (Pubitemid 46028489)
-
(2007)
Journal of Leukocyte Biology
, vol.81
, Issue.1
, pp. 1-5
-
-
Bianchi, M.E.1
-
8
-
-
27744453362
-
Understanding RAGE, the receptor for advanced glycation end products
-
DOI 10.1007/s00109-005-0688-7
-
Bierhaus A, Humpert PM, Morcos M, et al. Understanding RAGE, the receptor for advanced glycation end products. J Mol Med 2005;83:876-86. (Pubitemid 41598688)
-
(2005)
Journal of Molecular Medicine
, vol.83
, Issue.11
, pp. 876-886
-
-
Bierhaus, A.1
Humpert, P.M.2
Morcos, M.3
Wendt, T.4
Chavakis, T.5
Arnold, B.6
Stern, D.M.7
Nawroth, P.P.8
-
9
-
-
66449088641
-
Pathogen recognition and inflammatory signaling in innate immune defenses
-
Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009;22: 240-73.
-
(2009)
Clin Microbiol Rev
, vol.22
, pp. 240-273
-
-
Mogensen, T.H.1
-
10
-
-
63649108380
-
The roles of TLRs, RLRs, and NLRs in pathogen recognition
-
Kawai T, Akira S. The roles of TLRs, RLRs, and NLRs in pathogen recognition. Int Immunol 2009;21:317-37.
-
(2009)
Int Immunol
, vol.21
, pp. 317-337
-
-
Kawai, T.1
Akira, S.2
-
12
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010;140:805-20.
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
13
-
-
32144454172
-
Mechanisms of disease: The many roles of chemokines and chemokine receptors in inflammation
-
DOI 10.1056/NEJMra052723
-
Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354:610-21. (Pubitemid 43209108)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.6
, pp. 610-621
-
-
Charo, I.F.1
Ransohoff, R.M.2
-
14
-
-
0015788993
-
Sequential system failure after rupture of abdominal aortic aneurysms: An unsolved problem in postoperative care
-
Tilney NL, Bailey GL, Morgan AP. Sequential system failure after rupture of abdominal aortic aneurysms: an unsolved problem in postoperative care. Ann Surg 1973;178:117-22.
-
(1973)
Ann Surg
, vol.178
, pp. 117-122
-
-
Tilney, N.L.1
Bailey, G.L.2
Morgan, A.P.3
-
16
-
-
0018839893
-
Multiple system organ failure. The role of uncontrolled infection
-
Fry DE, Pearlstein L, Fulton RL, Polk HC Jr. Multiple system organ failure: the role of uncontrolled infection. Arch Surg 1980;115:136-40. (Pubitemid 10162823)
-
(1980)
Archives of Surgery
, vol.115
, Issue.2
, pp. 136-140
-
-
Fry, D.E.1
Pearlstein, L.2
Fulton, R.L.3
Polk Jr., H.C.4
-
17
-
-
0008373397
-
The nature of irreversible shock: Experimental and clinical observations
-
Lillehei RC, Longerbeam JK, Bloch JH, Manax WG. The nature of irreversible shock: experimental and clinical observations. Ann Surg 1964;160:682-708.
-
(1964)
Ann Surg
, vol.160
, pp. 682-708
-
-
Lillehei, R.C.1
Longerbeam, J.K.2
Bloch, J.H.3
Manax, W.G.4
-
18
-
-
0021184906
-
The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study
-
Sprung CL, Caralis PV, Marcial EH, et al. The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. N Engl J Med 1984;311:1137-43. (Pubitemid 14012580)
-
(1984)
New England Journal of Medicine
, vol.311
, Issue.18
, pp. 1137-1143
-
-
Sprung, C.L.1
Caralis, P.V.2
Marcial, E.H.3
-
19
-
-
0023252009
-
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock
-
Bone RC, Fisher CJ Jr, Clemmer TP, et al. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987;317:653-8. (Pubitemid 17138189)
-
(1987)
New England Journal of Medicine
, vol.317
, Issue.11
, pp. 653-658
-
-
Bone, R.C.1
Fisher Jr., C.J.2
Clemmer, T.P.3
-
20
-
-
0023239471
-
Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis
-
Hinshaw L, Peduzzi P, Young E, et al. The Veterans administration systemic sepsis cooperative study group. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987;317:659-65. (Pubitemid 17138190)
-
(1987)
New England Journal of Medicine
, vol.317
, Issue.11
, pp. 659-665
-
-
Hinshaw, L.1
Peduzzi, P.2
Young, E.3
-
21
-
-
0023549919
-
High-dose corticosteroids in patients with the adult respiratory distress syndrome
-
Bernard GR, Luce JM, Sprung CL, et al. High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med 1987;317:653-8.
-
(1987)
N Engl J Med
, vol.317
, pp. 653-658
-
-
Bernard, G.R.1
Luce, J.M.2
Sprung, C.L.3
-
22
-
-
0029036182
-
Steroid controversy in sepsis and septic shock: A meta-analysis
-
Lefering R, Neugebauer EA. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit Care Med 1995;23:1294-303.
-
(1995)
Crit Care Med
, vol.23
, pp. 1294-1303
-
-
Lefering, R.1
Neugebauer, E.A.2
-
23
-
-
0037151571
-
Effect of treatment with low doses of hydrocortisone and fludrocortisones on mortality in patients with septic shock
-
Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisones on mortality in patients with septic shock. JAMA 2002;288:862-71.
-
(2002)
JAMA
, vol.288
, pp. 862-871
-
-
Annane, D.1
Sebille, V.2
Charpentier, C.3
-
24
-
-
65449188293
-
The effects of steroids during sepsis depend on dose and severity of illness: An updated meta-analysis
-
Minneci PC, Deans KJ, Eichacker PQ, Natanson C. The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis. Clin Microbiol Infect 2009;15: 308-18.
-
(2009)
Clin Microbiol Infect
, vol.15
, pp. 308-318
-
-
Minneci, P.C.1
Deans, K.J.2
Eichacker, P.Q.3
Natanson, C.4
-
25
-
-
67049108021
-
Corticosteroids in the treatment of severe sepsis and septic shock in adults: A systematic review
-
Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA 2009;301:2362-75.
-
(2009)
JAMA
, vol.301
, pp. 2362-2375
-
-
Annane, D.1
Bellissant, E.2
Bollaert, P.E.3
-
26
-
-
0020261616
-
Immunotherapy of gram-negative bacterial sepsis: Enhanced surivival in a guinea pig model by use of rabbit antiserum to Escherichia coli J5
-
Dunn DL, Ferguson RM. Immunotherapy of gram-negative bacterial sepsis: enhanced survival in a guinea pig model by use of rabbit antiserum to Escherichia coli J5. Surgery 1982;92:212-9. (Pubitemid 13091504)
-
(1982)
Surgery
, vol.92
, Issue.2
, pp. 212-219
-
-
Dunn, D.L.1
Ferguson, R.M.2
-
27
-
-
0023191214
-
Antibody immunotherapy of gram-negative bacterial sepsis
-
Dunn DL. Antibody immunotherapy of gram-negative bacterial sepsis. Pharmacotherapy 1987;7:S31-5. (Pubitemid 17117106)
-
(1987)
Pharmacotherapy
, vol.7
, Issue.2
-
-
Dunn, D.L.1
-
28
-
-
0019906260
-
Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli
-
Ziegler EJ, McCutchan JA, Fierer J, et al. Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. N Engl J Med 1982;307:1225-30. (Pubitemid 12001356)
-
(1982)
New England Journal of Medicine
, vol.307
, Issue.20
, pp. 1225-1230
-
-
Ziegler, E.J.1
McCutchan, J.A.2
Fierer, J.3
-
29
-
-
0026016470
-
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial
-
The HA-1A sepsis study group
-
Ziegler EJ, Fisher CJ Jr, Sprung CL, et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A sepsis study group. N Engl J Med 1991;324:429-36.
-
(1991)
N Engl J Med
, vol.324
, pp. 429-436
-
-
Ziegler, E.J.1
Fisher Jr., C.J.2
Sprung, C.L.3
-
30
-
-
0028557981
-
Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial
-
CHESS trial study group
-
McCloskey RV, Straube RC, Sanders C, et al. Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS trial study group. Ann Intern Med 1994;121:1-5.
-
(1994)
Ann Intern Med
, vol.121
, pp. 1-5
-
-
McCloskey, R.V.1
Straube, R.C.2
Sanders, C.3
-
31
-
-
0024556554
-
Recombinant human tumor necrosis factor produces hemodynamic changes characteristic of sepsis and endotoxemia
-
Schirmer WJ, Schirmer JM, Fry DE. Recombinant human tumor necrosis factor produces hemodynamic changes characteristic of sepsis and endotoxemia. Arch Surg 1989;124:445-8. (Pubitemid 19106434)
-
(1989)
Archives of Surgery
, vol.124
, Issue.4
, pp. 445-448
-
-
Schirmer, W.J.1
Schirmer, J.M.2
Fry, D.E.3
-
32
-
-
0022411888
-
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
-
Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effects of endotoxin. Science 1985;229:869-71. (Pubitemid 16246587)
-
(1985)
Science
, vol.229
, Issue.4716
, pp. 869-871
-
-
Beutler, B.1
Milsark, I.W.2
Cerami, A.C.3
-
33
-
-
0023491364
-
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
-
DOI 10.1038/330662a0
-
Tracey KJ, Fong Y, Hesse DG, et al. Anticachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. Nature 1987;330:662-4. (Pubitemid 18005583)
-
(1987)
Nature
, vol.330
, Issue.6149
, pp. 662-664
-
-
Tracey, K.J.1
Fong, Y.2
Hesse, D.G.3
Manogue, K.R.4
Lee, A.T.5
Kuo, G.C.6
Lowry, S.F.7
Cerami, A.8
-
34
-
-
0028957549
-
Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial
-
TNF-alpha MAb Sepsis Study Group
-
Abraham E, Wunderink R, Silverman H, et al. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA 1995;273:934-41.
-
(1995)
JAMA
, vol.273
, pp. 934-941
-
-
Abraham, E.1
Wunderink, R.2
Silverman, H.3
-
35
-
-
9344246862
-
Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose ranging study
-
Reinhart K, Wiegand-Lohnert C, Grimminger F, et al. Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose ranging study. Crit Care Med 1996;24:733-42.
-
(1996)
Crit Care Med
, vol.24
, pp. 733-742
-
-
Reinhart, K.1
Wiegand-Lohnert, C.2
Grimminger, F.3
-
36
-
-
0029835023
-
INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis
-
Cohen J, Carlet J. INTERSEPT: an international, multi-center, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996;24:1431-40. (Pubitemid 26313741)
-
(1996)
Critical Care Medicine
, vol.24
, Issue.9
, pp. 1431-1440
-
-
Cohen, J.1
Carlet, J.2
-
37
-
-
0032495658
-
Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
-
DOI 10.1016/S0140-6736(00)80009-4
-
Abraham E, Anzueto A, Gutierrez G, et al. Double-blind randomized controlled trial of monoclonal antibody to human tumor necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet 1998;351:929-33. (Pubitemid 28138465)
-
(1998)
Lancet
, vol.351
, Issue.9107
, pp. 929-933
-
-
Abraham, E.1
Anzueto, A.2
Gutierrez, G.3
Tessler, S.4
San, P.G.5
Wunderink, R.6
Dal, N.A.7
Nasraway, S.8
Berman, S.9
Cooney, R.10
Levy, H.11
Baughman, R.12
Rumbak, M.13
Light, R.B.14
Poole, L.15
Allred, R.16
Constant, J.17
Pennington, J.18
Porter, S.19
-
38
-
-
0345036008
-
Recombinant 55-kDa tumor necrosis factor (TNF) receptor: Stoichiometry of binding to TNFa and TNFb and inhibition of TNF activity
-
Loetscher H, Gentz R, Zulauf M, et al. Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNFa and TNFb and inhibition of TNF activity. J Biol Chem 1991; 226:18324-9. (Pubitemid 21908083)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.27
, pp. 18324-18329
-
-
Loetscher, H.1
Gentz, R.2
Zulauf, M.3
Lustig, A.4
Tabuchi, H.5
Schlaeger, E.-J.6
Brockhaus, M.7
Gallati, H.8
Manneberg, M.9
Lesslauer, W.10
-
39
-
-
13344270905
-
Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081
-
Van Zee KJ, Moldawer LL, Oldenburg HAS, et al. Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDA TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081. J Immunol 1996;156: 2221-30. (Pubitemid 26088573)
-
(1996)
Journal of Immunology
, vol.156
, Issue.6
, pp. 2221-2230
-
-
Van Zee, K.J.1
Moldawer, L.L.2
Oldenburg, H.S.A.3
Thompson, W.A.4
Stackpole, S.A.5
Montegut, W.J.6
Rogy, M.A.7
Meschter, C.8
Gallati, H.9
Schiller, C.-D.10
Richter, W.F.11
Loetscher, H.12
Ashkenazi, A.13
Chamow, S.M.14
Wurm, F.15
Calvano, S.E.16
Lowry, S.F.17
Lesslauer, W.18
-
40
-
-
0029900294
-
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein
-
DOI 10.1056/NEJM199606273342603
-
Fisher CJ Jr, Agosti JM, Opal SM, et al. Treatment of septic shock with the tumor necrosis factor receptor:FC fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996;334:1697-702. (Pubitemid 26193621)
-
(1996)
New England Journal of Medicine
, vol.334
, Issue.26
, pp. 1697-1702
-
-
Fisher Jr., C.J.1
Agosti, J.M.2
Opal, S.M.3
Lowry, S.F.4
Balk, R.A.5
Sadoff, J.C.6
Abraham, E.7
Schein, R.M.H.8
Benjamin, E.9
-
41
-
-
8244235133
-
p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock: A randomized controlled multicenter trial
-
Abraham E, Glauser MP, Butler T, et al. p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. JAMA 1997;277: 1531-8. (Pubitemid 27213302)
-
(1997)
Journal of the American Medical Association
, vol.277
, Issue.19
, pp. 1531-1538
-
-
Abraham, E.1
Glauser, M.P.2
Butler, T.3
Garbino, J.4
Gelmont, D.5
Laterre, P.F.6
Kudsk, K.7
Bruining, H.A.8
Otto, C.9
Tobin, E.10
Zwingelstein, C.11
Lesslauer, W.12
Leighton, A.13
-
42
-
-
0035100346
-
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
-
Abraham E, Laterre PF, Garbino J, et al. Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients. Crit Care Med 2001; 29:503-10. (Pubitemid 32225290)
-
(2001)
Critical Care Medicine
, vol.29
, Issue.3
, pp. 503-510
-
-
Abraham, E.1
Laterre, P.-F.2
Garbino, J.3
Pingleton, S.4
Butler, T.5
Dugernier, T.6
Margolis, B.7
Kudsk, K.8
Zimmerli, W.9
Anderson, P.10
Reynaert, M.11
Lew, D.12
Lesslauer, W.13
Passe, S.14
Cooper, P.15
Burdeska, A.16
Modi, M.17
Leighton, A.18
Salgo, M.19
Van Der, A.P.20
more..
-
43
-
-
0025713953
-
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
-
Hannum CH, Wilcox CJ, Arend WP, et al. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 1990;343:336-40. (Pubitemid 120028524)
-
(1990)
Nature
, vol.343
, Issue.6256
, pp. 336-340
-
-
Hannum, C.H.1
Wilcox, C.J.2
Arend, W.P.3
Joslin, F.G.4
Dripps, D.J.5
Heimdal, P.L.6
Armes, L.G.7
Sommer, A.8
Eisenberg, S.P.9
Thompson, R.C.10
-
44
-
-
0028239555
-
Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome: Results from a randomized, double-blind, placebo-controlled trial
-
DOI 10.1001/jama.271.23.1836
-
Fisher CJ Jr, Dhainaut JF, Opal SM, et al. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA 1994;271:1836-43. (Pubitemid 24169697)
-
(1994)
Journal of the American Medical Association
, vol.271
, Issue.23
, pp. 1836-1843
-
-
Fisher Jr., C.J.1
Dhainaut, J.-F.A.2
Opal, S.M.3
Pribble, J.P.4
Balk, R.A.5
Slotman, G.J.6
Iberti, T.J.7
Rackow, E.C.8
Shapiro, M.J.9
Greenman, R.L.10
Reines, H.D.11
Shelly, M.P.12
Thompson, B.W.13
LaBrecque, J.F.14
Catalano, M.A.15
Knaus, W.A.16
Sadoff, J.C.17
-
45
-
-
0026772736
-
Interleukin-1 receptor blockade improves survival in hemodynamic performance in E. coli septic shock, but fails to alter host responses to sublethal endotoxemia
-
Fischer E, Marano MA, Van Zee KJ, et al. Interleukin-1 receptor blockade improves survival in hemodynamic performance in E. coli septic shock, but fails to alter host responses to sublethal endotoxemia. J Clin Invest 1992;89:1551-7.
-
(1992)
J Clin Invest
, vol.89
, pp. 1551-1557
-
-
Fischer, E.1
Marano, M.A.2
Van Zee, K.J.3
-
46
-
-
0026534242
-
Septic shock, multiple organ failure, and disseminated intravascular coagulation: Compared patterns of antithrombin III, protein C, and protein S deficiencies
-
Fourrier F, Chopin C, Goudemand J, et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation: compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 1992;101:816-23.
-
(1992)
Chest
, vol.101
, pp. 816-823
-
-
Fourrier, F.1
Chopin, C.2
Goudemand, J.3
-
47
-
-
0023122016
-
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
-
Taylor FB Jr, Chang A, Esmon CT, et al. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 1987;79:918-25. (Pubitemid 17050920)
-
(1987)
Journal of Clinical Investigation
, vol.79
, Issue.3
, pp. 918-925
-
-
Taylor Jr., F.B.1
Chang, A.2
Esmon, C.T.3
-
48
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
DOI 10.1056/NEJM200103083441001
-
Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709. (Pubitemid 32204987)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.10
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.-L.2
Laterre, P.-F.3
LaRosa, S.P.4
Dhainaut, J.-F.5
Lopez-Rodriguez, A.6
Steingrub, J.S.7
Garber, G.E.8
Helterbrand, J.D.9
Ely, E.W.10
Fisher, C.J.11
-
49
-
-
25444492831
-
Administration of drotrecogin alfa (activated) in early stage severe sepsis (ADDRESS) study group
-
Abraham E, Laterre PF, Garg R, et al. Administration of drotrecogin alfa (activated) in early stage severe sepsis (ADDRESS) study group. N Engl J Med 2005;353:1332-41.
-
(2005)
N Engl J Med
, vol.353
, pp. 1332-1341
-
-
Abraham, E.1
Laterre, P.F.2
Garg, R.3
-
51
-
-
37549020378
-
Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008
-
Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327.
-
(2008)
Crit Care Med
, vol.36
, pp. 296-327
-
-
Dellinger, R.P.1
Levy, M.M.2
Carlet, J.M.3
-
52
-
-
0008021312
-
Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127): Results of a randomized, double-blind, placebo-controlled trial
-
Fein AM, Bernard GR, Criner GJ, et al. Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127). Results of a randomized, double-blind, placebo-controlled trial. CP-0127 SIRS and Sepsis Study Group. JAMA 1997;277:482-7. (Pubitemid 27074333)
-
(1997)
Journal of the American Medical Association
, vol.277
, Issue.6
, pp. 482-487
-
-
Fein, A.M.1
Bernard, G.R.2
Criner, G.J.3
Fletcher, E.C.4
Good Jr., J.T.5
Knaus, W.A.6
Levy, H.7
Matuschak, G.M.8
Shanies, H.M.9
Taylor Jr., R.W.10
Rodell, T.C.11
-
53
-
-
0034304768
-
Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: A prospective, multicenter, double-blind, randomized phase II trial
-
TCV-309 Septic Shock Study Group
-
Poeze M, Froon AH, Ramsay G, et al. Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. Shock 2000;14:421-8.
-
(2000)
Shock
, vol.14
, pp. 421-428
-
-
Poeze, M.1
Froon, A.H.2
Ramsay, G.3
-
54
-
-
0033994026
-
A double-blind placebo-controlled study of an infusion of lexipafant (platelet-activating factor receptor antagonist) in patients with severe sepsis
-
DOI 10.1128/AAC.44.3.693-696.2000
-
Suputtamongkol Y, Intaranongpai S, Smith MD, et al. A double-blind placebo-controlled study of an infusion of lexipafant (Platelet-activating factor receptor antagonist) in patients with severe sepsis. Antimicrob Agents Chemother 2000;44:693-6. (Pubitemid 30117963)
-
(2000)
Antimicrobial Agents and Chemotherapy
, vol.44
, Issue.3
, pp. 693-696
-
-
Suputtamongkol, Y.1
Intaranongpai, S.2
Smith, M.D.3
Angus, B.4
Chaowagul, W.5
Permpikul, C.6
Simpson, J.A.7
Leelarasamee, A.8
Curtis, L.9
White, N.J.10
-
55
-
-
0037352612
-
2, in patients with suspected sepsis and organ failure
-
DOI 10.1097/01.CCM.0000053648.42884.89
-
Abraham E, Naum C, Bandi V, et al. Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure. Crit Care Med 2003;31:718-28. (Pubitemid 36379574)
-
(2003)
Critical Care Medicine
, vol.31
, Issue.3
, pp. 718-728
-
-
Abraham, E.1
Naum, C.2
Bandi, V.3
Gervich, D.4
Lowry, S.F.5
Wunderink, R.6
Schein, R.M.7
Macias, W.8
Skerjanec, S.9
Dmitrienko, A.10
Farid, N.11
Forgue, S.T.12
Jiang, F.13
-
56
-
-
23844502308
-
2, fails to improve clinical outcome for patients with severe sepsis
-
DOI 10.1097/01.CCM.0000171540.54520.69
-
Zeiher BG, Steingrub J, Laterre PF, et al. LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis. Crit Care Med 2005;33:1741-8. (Pubitemid 41153699)
-
(2005)
Critical Care Medicine
, vol.33
, Issue.8
, pp. 1741-1748
-
-
Zeiher, B.G.1
Steingrub, J.2
Laterre, P.-F.3
Dmitrienko, A.4
Fukiishi, Y.5
Abraham, E.6
-
57
-
-
4444273012
-
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock
-
López A, Lorente JA, Steingrub J, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 2004;32:21-30. (Pubitemid 38125559)
-
(2004)
Critical Care Medicine
, vol.32
, Issue.1
, pp. 21-30
-
-
Lopez, A.1
Lorente, J.A.2
Steingrub, J.3
Bakker, J.4
McLuckie, A.5
Willatts, S.6
Brockway, M.7
Anzueto, A.8
Holzapfel, L.9
Breen, D.10
Silverman, M.S.11
Takala, J.12
Donaldson, J.13
Arneson, C.14
Grove, G.15
Grossman, S.16
Grover, R.17
-
58
-
-
38549139528
-
Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock
-
DOI 10.1097/01.CCM.0B013E318161E480, PII 0000324620080200000012
-
Stephens DP, Thomas JH, Higgins A, et al. Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock. Crit Care Med 2008;36:448-54. (Pubitemid 351158618)
-
(2008)
Critical Care Medicine
, vol.36
, Issue.2
, pp. 448-454
-
-
Stephens, D.P.1
Thomas, J.H.2
Higgins, A.3
Bailey, M.4
Anstey, N.M.5
Currie, B.J.6
Cheng, A.C.7
-
59
-
-
0035904368
-
High-dose antithrombin III in severe sepsis: A randomized controlled trial
-
Warren BL, Eid A, Singer P, et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 2001;286:1869-78. (Pubitemid 33010239)
-
(2001)
Journal of the American Medical Association
, vol.286
, Issue.15
, pp. 1869-1878
-
-
Warren, B.L.1
Eid, A.2
Singer, P.3
Pillay, S.S.4
Carl, P.5
Novak, I.6
Chalupa, P.7
Atherstone, A.8
Penzes, I.9
Kubler, A.10
Knaub, S.11
Keinecke, H.-O.12
Heinrichs, H.13
Schindel, F.14
Juers, M.15
Bone, R.C.16
Opal, S.M.17
-
60
-
-
77954953617
-
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
-
Rice TW, Wheeler AP, Bernard GR, et al. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med 2010;38:1685-94.
-
(2010)
Crit Care Med
, vol.38
, pp. 1685-1694
-
-
Rice, T.W.1
Wheeler, A.P.2
Bernard, G.R.3
-
61
-
-
0029903114
-
Sir Isaac Newton, sepsis, SIRS, and CARS
-
Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med 1996;24:1125-8.
-
(1996)
Crit Care Med
, vol.24
, pp. 1125-1128
-
-
Bone, R.C.1
-
62
-
-
60849114014
-
Compensatory anti-inflammatory response syndrome
-
Adib-Conquy M, Cavaillon J-M. Compensatory anti-inflammatory response syndrome. Thromb Haemost 2009;101: 36-47.
-
(2009)
Thromb Haemost
, vol.101
, pp. 36-47
-
-
Adib-Conquy, M.1
Cavaillon, J.-M.2
-
63
-
-
54049130105
-
The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients
-
Ward NS, Casserly B, Ayala A. The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients. Clin Chest Med 2008;29:617-25.
-
(2008)
Clin Chest Med
, vol.29
, pp. 617-625
-
-
Ward, N.S.1
Casserly, B.2
Ayala, A.3
-
64
-
-
0016526956
-
Multiple, progressive, or sequential systems failure. A syndrome of the 1970s
-
Baue AE. Multiple, progressive, or sequential systems failure. A syndrome of the 1970s. Arch Surg 1975;110:779-81.
-
(1975)
Arch Surg
, vol.110
, pp. 779-781
-
-
Baue, A.E.1
-
65
-
-
0037180778
-
The inflammatory reflex
-
DOI 10.1038/nature01321
-
Tracey KJ. The inflammatory reflex. Nature 2002;420: 853-9. (Pubitemid 36019638)
-
(2002)
Nature
, vol.420
, Issue.6917
, pp. 853-859
-
-
Tracey, K.J.1
-
66
-
-
33846817498
-
Physiology and immunology of the cholinergic antiinflammatory pathway
-
DOI 10.1172/JCI30555
-
Tracey KJ. Physiology and immunology of the cholinergic anti-inflammatory pathway. J Clin Invest 2007;117:289-96. (Pubitemid 46203953)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.2
, pp. 289-296
-
-
Tracey, K.J.1
-
67
-
-
66149103723
-
Cholinergic control of inflammation
-
Rosa-Ballina M, Tracey KJ. Cholinergic control of inflammation. J Intern Med 2009;265:663-79.
-
(2009)
J Intern Med
, vol.265
, pp. 663-679
-
-
Rosa-Ballina, M.1
Tracey, K.J.2
-
68
-
-
69549126289
-
The inflammatory reflex and the role of complementary and alternative medical therapies
-
Oke SL, Tracey KJ. The inflammatory reflex and the role of complementary and alternative medical therapies. Ann N Y Acad Sci 2009;1172:172-80.
-
(2009)
Ann N Y Acad Sci
, vol.1172
, pp. 172-180
-
-
Oke, S.L.1
Tracey, K.J.2
-
69
-
-
77953796760
-
Understanding immunity requires more than immunology
-
Tracey KJ. Understanding immunity requires more than immunology. Nat Immunol 2010;11:561-4.
-
(2010)
Nat Immunol
, vol.11
, pp. 561-564
-
-
Tracey, K.J.1
|