The relationship between CD4+CD25+CD127- regulatory T cells and inflammatory response and outcome during shock states

Critical Care

Volumn 14, Issue 1, 2010, Pages

  Hein, François ^a   Massin, Frédéric ^b   Cravoisy Popovic, Aurélie ^a   Barraud, Damien ^a   Levy, Bruno ^c   Bollaert, Pierre Edouard ^a   Gibot, Sébastien ^a,c  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b CHU NANCY BRABOIS   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PREDNISOLONE; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR ALPHA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CD4+ CD25+ CD127+ T LYMPHOCYTE; CELL KINETICS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LYMPHOCYTE COUNT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REGULATORY T LYMPHOCYTE; SEPSIS; SEPTIC SHOCK; SPLEEN CELL; AGED; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CASE CONTROL STUDY; DISEASE MODEL; FLOW CYTOMETRY; IMMUNOLOGY; MIDDLE AGED;

AGED; ANIMALS; ANTIGENS, CD4; CASE-CONTROL STUDIES; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; HUMANS; INFLAMMATION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; SHOCK, SEPTIC; T-LYMPHOCYTES, REGULATORY;

EID: 77949473424     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc8876     Document Type: Article

References (21)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States; analysis of incidence, outcome and associated costs of care. Crit Care Med 2001, 29:1303-1310. 10.1097/00003246-200107000-00002, 11445675.
2. Brun-Buisson C, Meshaka P, Pinton P, Vallet B, . EPISEPSIS Study Group EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 2004, 30:580-588. 10.1007/s00134-003-2121-4, 14997295, EPISEPSIS Study Group.
3. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003, 348:138-150. 10.1056/NEJMra021333, 12519925.
4. Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 1997, 25:1298-1307. 10.1097/00003246-199708000-00015, 9267941.
5. Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006, 212:8-27. 10.1111/j.0105-2896.2006.00427.x, 16903903.
6. Fehérvari Z, Sakaguchi S. CD4+ Tregs and immune control. J Clin Invest 2004, 114:1209-1217. 524236, 15520849.
7. Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000, 18:423-449. 10.1146/annurev.immunol.18.1.423, 10837065.
8. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008, 8:523-532. 10.1038/nri2343, 2665249, 18566595.
9. Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med 2008, 14:64-78. 10.2119/2007-00102.Monneret, 2078557,2078557, 18026569.
10. Venet F, Pachot A, Debard AL, Bohé J, Bienvenu J, Lepape A, Monneret G. Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes. Crit Care Med 2004, 32:2329-2331.
11. Heuer JG, Zhang T, Zhao J, Ding C, Cramer M, Justen KL, Vonderfecht SL, Na S. Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis. J Immunol 2005, 174:7141-7146.
12. Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol 2006, 177:7943-7949.
13. Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohé J, Lepape A, Ayala A, Monneret G. Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 2009, 35:678-686. 10.1007/s00134-008-1337-8, 18946659, 2789433.
14. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
15. Antonelli M, Levy M, Andrews PJD, Chastre J, Hudson LD, Manthous C, Meduri GU, Moreno RP, Putensen C, Stewart T, Torres A. Hemodynamic monitoring in shock and implications for management. International consensus conference, Paris, France, 27-28 April 2006. Intensive Care Med 2007, 33:575-590. 10.1007/s00134-007-0531-4, 17285286.
16. McCabe WR, Jackson GG. Gram negative bacteremia: I. Etiology and ecology. Arch Intern Med 1962, 110:845-847.
17. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 271:2957-2963. 10.1001/jama.270.24.2957, 8254858.
18. Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM, Sprung CL, Colardyn F, Blecher S. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998, 26:1793-1800.
19. Monneret G, Debard AL, Venet F, Bohe J, Hequet O, Bienvenu J, Lepape A. Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 2003, 31:2068-2071. 10.1097/01.CCM.0000069345.78884.0F, 12847405.
20. Oberholzer A, Oberholzer C, Moldawer LL. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 2001, 16:83-96. 10.1097/00024382-200116020-00001, 11508871.
21. Giamarellos-Bourboulis EJ, Tsaganos T, Spyridaki E, Mouktaroudi M, Plachouras D, Vaki I, Karagianni V, Antonopoulou A, Veloni V, Giamarellou H. Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis. Crit Care 2006, 10:R166. 10.1186/cc5111, 1794479, 17129388.