Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA 2by human macrophages and triggers eicosanoid generation in vivo

FASEB Journal

Volumn 28, Issue 8, 2014, Pages 3456-3467

  Wan, Min ^a   Soehnlein, Oliver ^b,c,d   Tang, Xiao ^a   Van Der Does, Anne M ^a   Smedler, Erik ^a   Uhleń, Per ^a   Lindbom, Lennart ^a   Agerberth, Birgitta ^a   Haeggström, Jesper Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Antimicrobial peptides; Inflammation; Leukotriene; Thromboxane

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ICOSANOID; LEUKOTRIENE B4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2; PURINERGIC P2X7 RECEPTOR; THROMBOXANE A2; THROMBOXANE B2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; HUMAN MONOCYTE DERIVED MACROPHAGE; IN VIVO STUDY; INFLAMMATION; INTERNALIZATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANTIMICROBIAL PEPTIDES; INFLAMMATION; LEUKOTRIENE; P2X7R; THROMBOXANE;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ARACHIDONATE 5-LIPOXYGENASE; CALCIUM SIGNALING; CATHELICIDINS; CELLS, CULTURED; EICOSANOIDS; HUMANS; INFLAMMATION; LEUKOTRIENE B4; MACROPHAGES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PERITONITIS; PHOSPHOLIPASES A2, CYTOSOLIC; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, PURINERGIC P2X7; RECOMBINANT PROTEINS; THROMBOXANE A2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84905252173     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-251306     Document Type: Article

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