The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6

Infection and Immunity

Volumn 67, Issue 5, 1999, Pages 2561-2566

  Nilsson, Margareta Frohm ^a   Sandstedt, Bengt ^a   Sørensen, Ole ^b   Weber, Günther ^a   Borregaard, Niels ^b   Ståhle Bäckdahl, Mona ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CATIONIC ANTIMICROBIAL PROTEIN; INTERLEUKIN 6; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SQUAMOUS CELL;

EID: 0032903987     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.5.2561-2566.1999     Document Type: Article

References (30)

1. Agerberth, B. A., H. Gunne, J. Odeberg, P. Kogner, H. G. Boman, and G. H. Gudmundsson. 1995. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc. Natl. Acad. Sci. USA 92:195-199.
2. Akira, S, H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897-1906.
3. Akira, S., Y. Nishio, M. Inoue, X.-J. Wang, S. Wei, T. Matsusaka, K. Yoshida, T. Sudo, M. Naruto, and T. Kishimoto. 1994. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77:63-71.
4. Andersson, M., H. Gunne, B. A. Agerberth, T. Bergman, R. Slllard, H. Jörnvall, V. Mutt, B. Olsson, H. Wigzell, Å. Dagerlind, H. G. Boman, and G. H. Gudmundsson. 1995. NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity. EMBO J. 14:1615-1625.
5. Bals, R., X. Wang, M. Zasloff, and J. M. Wilson. 1998. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc. Natl. Acad. Sci. USA 95:9541-9546.
6. Boman, H. G. 1995. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 13:61-92.
7. Bos, J. D., and L. Kapsenberg. 1993. The skin immune system: progress in cutaneous biology. Immunol. Today 14:75-78.
8. Brakenhoff, J. P., F. D. de Hon, V. Fontaine, E. ten Boekel, H. Schooltink, S. Rose-John, P. C. Heinrich, J. Content, and L. A. Aarden. 1994. Development of a human interleukin-6 receptor antagonist. J. Biol. Chem. 269:86-93.
9. Cowland, J. B., A. H. Johnson, and N. Borregaard. 1995. hCAP-18, a cathelin/bactenecin like protein of human neutrophil specific granules. FEBS Lett. 368:173-176.
10. Diamond, G., J. P. Russell, and C. L. Bevins. 1996. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc. Natl. Acad. Sci. USA 93:5156-5160.
11. Fletcher, M. A., M. A. Kloczewiak, P. M. Loiselle, M. Ogata, M. W. Vermeulen, E. M. Zanzot, and H. S. Warren. 1997. A novel peptide-IgG conjugate, CAP18 106-138-IgG that binds and neutralizes endotoxin and kills gram-negative bacteria. J. Infect. Dis. 175:621-632.
12. Frohm, M., B. A. Agerberth, G. Ahangari, M. Ståhle-Bäckdahl, S. Lidén, H. Wlgzell, and G. H. Gudmundsson. 1997. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J. Biol. Chem. 272:15258-15263.
13. Fulton, C., M. G. Anderson, M. Zasloff, R. Bull, and A. Quinn. 1997. Expression of natural peptide antibiotics in human skin. Lancet 350:1750-1751.
14. Gallo, R. L., M. Ono, T. Povsic, C. Page, E. Eriksson, M. Klagsbrun, and M. Bernfield. 1994. Syndecans, cell surface heparan sulfate proteoglycans, are induced by proline-rich antimicrobial peptide from wounds. Proc. Natl. Acad. Sci. USA 91:11035-11039.
15. Gudmundsson, G. H., B. A. Agerberth, J. Odeberg, T. Bergman, B. Olsson, and R. Salcedo. 1996. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur. J. Biochem. 238:325-332.
16. Harder, J., J. Bartels, E. Christophers, and J.-M. Schröder. 1997. A peptide antibiotic from human skin. Nature 387:861.
17. Hsu, S. M., L. Raine, and H. Fanger. 1981. Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PA) procedures. J. Histochem. Cytochem. 29:577-580.
18. Johansson, J., G. H. Gudmundsson, M. E. Rottenberg, K. D. Berndt, and B. Agerberth. 1998. Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 273:3718-3724.
19. Krisanaprakornkit, S., A. Weinberg, C. N. Perez, and B. A. Dale. 1998. Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect. Immun. 66:4222-4228.
20. Larrick, J. W., M. Hirata, Y. Shimomoura, M. Yoshidi, H. Zheng, J. Zhong, and S. C. Wright. 1993. Antimicrobial activity of rabbit CAP 18-derived peptides. Antimicrob. Agents Chemother. 37:2534-2539.
21. Larrick, J. W., M. Hirata, H. Zheng, J. Zhong, D. Bolin, J.-M. Cavaillon, S. H. Warren, and S. C. Wright. 1994. A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity. J. Immunol. 152:231-240.
22. Le, M., and J. Vilcek. 1989. Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response. Lab. Invest. 61:588-602.
23. Schonwetter, B. S., E. D. Stolzenberg, and M. A. Zasloff. 1995. Epithelial antibiotics induced at sites of inflammation. Science 267:1645-1648.
24. Selsted, M. E., D. M. Brown, R. J. DeLange, and R. I. Lehrer. 1983. Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J. Biol. Chem. 258:14485-14489.
25. Steiner, U., D. Hultmark, Å. Engström, H. Bennich, and H. G. Boman. 1981. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292:246-248.
26. Ståhle-Bäckdahl, M., B. D. Sudbeck, A. Z. Eisen, H. G. Welgus, and W. C. Parks. 1992. Expression of 92 kDa type IV collagenase in eosinophils associated with basal cell carcinoma. J. Invest. Dermatol. 99:497-503.
27. Sørensen, O., J. B. Cowland, J. Askaa, and N. Borregaard. 1997. An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma. J. Immunol. Methods 206:53-59.
28. Turner, J., Y. Cho, N. N. Dinh, A. J. Waring, and R. Lehrer. 1998. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agents Chemother. 42:2206-2214.
29. VanderMeer, T. J., M. J. Menconi, J. Zhuang, H. Wang, R. Murtaugh, C. Bouza, P. Stevens, and M. P. Fink. 1995. Protective effects of a novel 32-amino acid C-terminal fragment of CAP18 in endotoxemic pigs. Surgery 117:656-662.
30. Zhao, C., I. Wang, and R. I. Lehrer. 1996. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396:319-322.