Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 8, 2014, Pages 4747-4758

  Kim, Leo A ^a,b   Amarnani, Dhanesh ^a,b   Gnanaguru, Gopalan ^a,b   Tseng, Wen Allen ^a,b   Vavvas, Demetrios G ^a   D'Amore, Patricia A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

Apoptosis; Necroptosis; Pyroptosis; RPE; Tamoxifen

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 1; TAMOXIFEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; CYTOTOXICITY ASSAY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LYSOSOME; NECROPTOSIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PYROPTOSIS; WESTERN BLOTTING;

APOPTOSIS; NECROPTOSIS; PYROPTOSIS; RPE; TAMOXIFEN;

BLOTTING, WESTERN; CASPASES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; ESTROGEN ANTAGONISTS; HUMANS; INTERLEUKIN-1BETA; LYSOSOMES; RETINAL DISEASES; RETINAL PIGMENT EPITHELIUM; TAMOXIFEN;

EID: 84905230333     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13662     Document Type: Article

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