Silymarin inhibits cytokine-stimulated pancreatic beta cells by blocking the ERK1/2 pathway

Biomolecules and Therapeutics

Volumn 22, Issue 4, 2014, Pages 282-287

  Kim, Eun Jeong ^a   Kim, Jeeho ^a   Lee, Min Young ^a   Sudhanva, Muddenahalli Srinivasa ^a   Devakumar, Sundaravinayagam ^a   Jeon, Young Jin ^a  

^a Chosun University College of Medicine   (South Korea)

Author keywords

Beta cells; ERK1 2; INOS; NO; Silymarin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; NITRITE; PROTEIN P42; PROTEIN P44; SILYMARIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; MIN6N8A CELL LINE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SILYBUM MARIANUM; WESTERN BLOTTING;

EID: 84905219580     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2014.072     Document Type: Article

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