Silymarin's protective effects and possible mechanisms on alcoholic fatty liver for rats

Biomolecules and Therapeutics

Volumn 21, Issue 4, 2013, Pages 264-269

  Zhang, Wei ^a   Hong, Rutao ^a   Tian, Tulie ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Alcoholic; Fatty liver; ICAM 1; IL 6; NF B; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MALONALDEHYDE; SILYMARIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE CONTROL; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PROTEIN EXPRESSION; RAT; SPECTROPHOTOMETRY;

EID: 84881068296     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2013.020     Document Type: Article

References (22)

1. Arteel, G. E. (2003) Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124, 778-790.
2. Ajamieh, H. H., Menéndez, S., Marténez-Sánchez, G., Candelario-Jalil, E., Re, L., Giuliani, A. and Fernández, O. S. (2004) Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver Int. 24, 55-62.
3. Barnes, P. J. and Karin, M. (1997) Nuclear factor κB-a pivotal factor in chronic inflammatory diseases. N. Engl. J. Med. 336, 1066-1071.
4. Banerjee, A., Rose, R., Johnson, G. A., Burghardt, R. C. and Ramaiah, S. K. (2009) The influence of estrogen on hepatobiliary osteopontin (SPP1) expression in a female rodent model of alcoholic steato-hepatitis. Toxicol. Pathol. 37, 492-501.
5. Chen, F., Castranova, V., Shi, X. and Demers, L. M. (1999) New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem. 45, 7-17.
6. Chen, S. L., Hong, R. T., Diao, L., Ruan, H. L., Xu, J. and Mei, Q. (2010) Silymarin protects against acute ethanol-induced liver injury in rats. Acta Universitatis Medicinalis Anhui. 45, 209-212.
7. Eagon, P. K. (2010) Alcoholic liver injury: Influence of gender and hormones. World J. Gastroenterol. 16,1377-1384.
8. Fraschini, F., Demartini, G. and Esposti, D. (2002) Pharmacology of silymarin. Clin. Drug Invest. 22, 51-65.
9. Kiruthiga, P. V., Shafreen, R. B., Pandian, S. K. and Devi, K. P. (2007) Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes. Basic Clin. Pharmacol. Toxicol. 100, 414-419.
10. Luper, S. (1998) A review of plants used in the treatment of liver disease: part 1. Altern. Med. Rev. 3, 410-421.
11. Nanji, A. A. (2004) Role of different dietary fatty acids in the patho-genesis of experimental alcoholic liver disease. Alcohol 34, 21-25.
12. Nanji, A. A., Jokelainen, K., Rahemtulla, A., Miao, L., Fogt, F., Matsu-moto, H., Tahan, S. R. and Su, G. L. (1999) Activation of nuclear factor κappa b and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology 30, 934-943.
13. Nanji, A. A., Jokelainen, K., Tipoe, G. L., Rahemtulla, A., Thomas, P. and Dannenberg, A. J. (2003) Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κappa B-dependent genes. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G321-327.
14. Neurath, M. F., Pettersson, S., Meyer zum Büschenfelde, K. H. and Strober W. (1996) Local administration of antisense phosphorothio-ate oligonucleotides to the p65 subunit of NF-κappa B abrogates established experimental colitis in mice. Nat. Med. 2, 998-1004.
15. Polyak, S. J., Morishima, C., Lohmann, V., Pal, S., Lee, D. Y., Liu, Y., Graf, T. N. and Oberlies, N. H. (2010) Identification of hepatopro-tective flavonolignans from silymarin. Proc. Natl. Acad Sci. U.S.A. 107, 5995-5999.
16. Purohit, V., Russo, D. and Coates, P. M. (2004) Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. Alcohol 34, 3-8.
17. Polavarapu, R., Spitz, D. R., Sim, J. E., Follansbee, M. H., Oberley, L. W., Rahemtulla, A. and Nanji, A. A. (1998) Increased lipid peroxida-tion and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil. Hepatology 27,1317-1323.
18. Song, Z., Deaciuc, I., Song, M., Lee, D. Y., Liu, Y., Ji, X. and McClain, C. (2006) Silymarin protects against acute ethanol-induced hepa-totoxicity in mice. Alcohol Clin. Exp. Res. 30, 407-413.
19. Saller, R., Meier, R. and Brignoli, R. (2001) The use of silymarin in the treatment of liver diseases. Drugs 61, 2035-2063.
20. Shi, Q. Z., Wang, L. W., Zhang, W. and Gong, Z. J. (2010) Betaine inhibits Toll-like receptor 4 expression in rats with ethanol-induced liver injury. World J. Gastroenterol. 16, 897-903.
21. Tilg, H. and Diehl, A. M. (2000) Cytokines in alcoholic and nonalcoholic steatohepatitis. N. Engl. J. Med. 343,1467-1476.
22. Zhou, J., Zhai, Y., Mu, Y., Gong, H., Uppal, H., Toma, D., Ren, S., Evans, R. M. and Xie, W. (2006) A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J. Biol. Chem. 281, 15013-15020.