Silibinin suppresses TNF-α-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway

Molecules

Volumn 14, Issue 11, 2009, Pages 4300-4311

  Kim, Sangmin ^a   Choi, Min Gew ^a   Lee, Hye Sook ^a   Lee, Se Kyung ^a   Kim, Sung Hoon ^a   Kim, Wan Wook ^a   Hur, Sung Mo ^a   Kim, Jung Han ^a   Choe, Jun Ho ^a   Nam, Seok Jin ^a   Yang, Jung Hyun ^a   Kem, Sung ^a   Lee, Jeong Eon ^a   Kim, Jee Soo ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Gastric cancer; MMP 9; Silibinin; TNF

Indexed keywords

GELATINASE B; SILIBININ; SILYMARIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL PROLIFERATION; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH TUMOR; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 9; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SILYMARIN; STOMACH NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 73349135948     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14114300     Document Type: Article

References (39)

1. Singh, R. P.; Agarwal, R. Flavonoid antioxidant silymarin and skin cancer. Antioxid Redox Signal 2002, 4, 655-663.
2. Kim, S.; Choi, J. H.; Lim, H. I.; Lee, S. K.; Kim, W. W.; Kim, J. S.; Kim, J. H.; Choe, J. H.; Yang, J. H.; Nam, S. J.; Lee, J. E., Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells. Phytomedicine 2009, 16, 573-580.
3. Sharma, G.; Singh, R. P.; Chan, D. C.; Agarwal, R. Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res. 2003, 23, 2649-2655.
4. Agarwal, R.; Agarwal, C.; Ichikawa, H.; Singh, R. P.; Aggarwal, B. B. Anticancer potential of silymarin: from bench to bed side. Anticancer Res. 2006, 26, 4457-4498.
5. Locksley, R. M.; Killeen, N.; Lenardo, M. J. The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell 2001, 104, 487-501.
6. Bussolino, F.; Camussi, G.; Baglioni, C. Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha. J. Biol. Chem. 1988, 263, 11856-11861.
7. Yoshida, S.; Ono, M.; Shono, T.; Izumi, H.; Ishibashi, T.; Suzuki, H.; Kuwano, M., Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol. Cell Biol. 1997, 17, 4015-4023.
8. Leber, T. M.; Balkwill, F. R. Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor (MMPSF). Br. J. Cancer 1998, 78, 724-732.
9. Rosen, E. M.; Goldberg, I. D.; Liu, D.; Setter, E.; Donovan, M. A.; Bhargava, M.; Reiss, M.; Kacinski, B. M. Tumor necrosis factor stimulates epithelial tumor cell motility. Cancer Res. 1991, 51, 5315-5321.
10. Deryugina, E. I.; Quigley, J. P. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 2006, 25, 9-34.
11. Overall, C. M.; Dean, R. A. Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer. Cancer Metastasis Rev. 2006, 25, 69-75.
12. Chambers, A. F.; Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst. 1997, 89, 1260-1270.
13. Egeblad, M.; Werb, Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002, 2, 161-174.
14. Murphy, G.; Docherty, A. J. The matrix metalloproteinases and their inhibitors. Am. J. Respir. Cell Mol. Biol. 1992, 7, 120-125.
15. Sato, H.; Seiki, M. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 1993, 8, 395-405.
16. Jones, J. L.; Glynn, P.; Walker, R. A. Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas. J. Pathol. 1999, 189, 161-168.
17. Emara, M.; Cheung, P. Y.; Grabowski, K.; Sawicki, G.; Wozniak, M. Serum levels of matrix metalloproteinase-2 and-9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers. Clin. Chem. Lab. Med. 2009, 47, 993-1000.
18. Wu, C. Y.; Wu, M. S.; Chiang, E. P.; Chen, Y. J.; Chen, C. J.; Chi, N. H.; Shih, Y. T.; Chen, G. H.; Lin, J. T. Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution. Clin. Cancer Res. 2007, 13, 2054-2060.
19. Chen, P. N.; Hsieh, Y. S.; Chiang, C. L.; Chiou, H. L.; Yang, S. F.; Chu, S. C. Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway. J. Dent. Res. 2006, 85, 220-225.
20. Chu, S. C.; Chiou, H. L.; Chen, P. N.; Yang, S. F.; Hsieh, Y. S. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol. Carcinog. 2004, 40, 143-149.
21. Zi, X.; Mukhtar, H.; Agarwal, R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF alpha. Biochem. Biophys. Res. Commun. 1997, 239, 334-339.
22. Schumann, J.; Wolf, D.; Pahl, A.; Brune, K.; Papadopoulos, T.; van Rooijen, N.; Tiegs, G. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am. J. Pathol. 2000, 157, 1671-1683.
23. Wu, K. J.; Zeng, J.; Zhang, L. L.; Zhang, D.; Li, L.; Fan, J. H.; Wang, X. Y.; He, D. L. Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression. Acta Pharmcol. Sin. 2009, 30, 1162-1168.
24. Lin, C. J.; Sukarieh, R.; Pelletier, J. Silibinin inhibits translation initiation: Implications for anticancer therapy. Mol. Cancer Ther. 2009, 8, 1606-1612.
25. Infection with Helicobacter pylori. IARC Monogr. Eval. Carcinog. Risks Hum. 1994, 61, 177-240.
26. Harris, P. R.; Mobley, H. L.; Perez-Perez, G. I.; Blaser, M. J.; Smith, P. D. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology 1996, 111, 419-425.
27. Machado, J. C.; Figueiredo, C.; Canedo, P.; Pharoah, P.; Carvalho, R.; Nabais, S.; Castro Alves, C.; Campos, M. L.; Van Doorn, L. J.; Caldas, C.; Seruca, R.; Carneiro, F.; Sobrinho-Simoes, M. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003, 125, 364-371.
28. Vilcek, J.; Lee, T. H. Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. J. Biol. Chem. 1991, 266, 7313-7316.
29. Firestein, G. S.; Boyle, D.; Bullough, D. A.; Gruber, H. E.; Sajjadi, F. G.; Montag, A.; Sambol, B.; Mullane, K. M. Protective effect of an adenosine kinase inhibitor in septic shock. J. Immunol. 1994, 152, 5853-5859.
30. Fujiki, H.; Suganuma, M.; Okabe, S.; Sueoka, E.; Suga, K.; Imai, K.; Nakachi, K., A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-) - epigallocatechin gallate and green tea-A review. Cancer Detect. Prev. 2000, 24, 91-99.
31. Tanimura, Y.; Kokuryo, T.; Tsunoda, N.; Yamazaki, Y.; Oda, K.; Nimura, Y.; Naing Mon, N.; Huang, P.; Nakanuma, Y.; Chen, M. F.; Jan, Y. Y.; Yeh, T. S.; Chiu, C. T.; Hsieh, L. L.; Hamaguchi, M. Tumor necrosis factor alpha promotes invasiveness of cholangiocarcinoma cells via its receptor, TNFR2. Cancer Lett. 2005, 219, 205-213.
32. Ohira, S.; Sasaki, M.; Harada, K.; Sato, Y.; Zen, Y.; Isse, K.; Kozaka, K.; Ishikawa, A.; Oda, K.; Nimura, Y.; Nakanuma, Y. Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. Am. J. Pathol. 2006, 168, 1155-1168.
33. Himelstein, B. P.; Lee, E. J.; Sato, H.; Seiki, M.; Muschel, R. J. Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat. Clin. Exp. Metastasis 1998, 16, 169-177.
34. Kim, S.; Choi, J. H.; Kim, J. B.; Nam, S. J.; Yang, J. H.; Kim, J. H.; Lee, J. E. Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. Molecules 2008, 13, 2975-2985.
35. Bond, M.; Fabunmi, R. P.; Baker, A. H.; Newby, A. C. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett. 1998, 435, 29-34.
36. Lee, S. J.; Park, S. S.; Lee, U. S.; Kim, W. J.; Moon, S. K. Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. Int. Immunopharmacol. 2008, 8, 1821-1826.
37. Yao, J.; Xiong, S.; Klos, K.; Nguyen, N.; Grijalva, R.; Li, P.; Yu, D. Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene 2001, 20, 8066-8074.
38. Hwang, M. K.; Song, N. R.; Kang, N. J.; Lee, K. W.; Lee, H. J. Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin. Int. J. Biochem. Cell Biol. 2009, 41, 1592-1600.
39. Kim, S.; Kim, Y.; Lee, Y.; Cho, K. H.; Kim, K. H.; Chung, J. H. Cholesterol inhibits MMP-9 expression in human epidermal keratinocytes and HaCaT cells. FEBS Lett. 2007, 581, 3869-3874. © 2009