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Volumn 32, Issue 4, 2016, Pages 589-600

Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice

Author keywords

Acetaminophen; hepatotoxicity; kidney toxicity; nitric oxide; silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; NITRIC OXIDE; PARACETAMOL; SILYMARIN; ANTIOXIDANT;

EID: 84962384777     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713502841     Document Type: Article
Times cited : (59)

References (77)
  • 2
    • 33845941617 scopus 로고    scopus 로고
    • Anticancer potential of silymarin: From bench to bed side
    • Agarwal R, Agarwal C, Ichikawa H, (2006) Anticancer potential of silymarin: from bench to bed side. Anticancer Research 26: 4457-4498.
    • (2006) Anticancer Research , vol.26 , pp. 4457-4498
    • Agarwal, R.1    Agarwal, C.2    Ichikawa, H.3
  • 3
    • 70449465144 scopus 로고    scopus 로고
    • Effect of carvacrol on hepatic marker enzymes and antioxidant status in d -galactosamine-induced hepatotoxicity in rats
    • Aristatile B, Al-Numair KS, Veeramani C, Pugalendi KV, (2009) Effect of carvacrol on hepatic marker enzymes and antioxidant status in d -galactosamine-induced hepatotoxicity in rats. Fundamental and Clinical Pharmacology 23: 757-765.
    • (2009) Fundamental and Clinical Pharmacology , vol.23 , pp. 757-765
    • Aristatile, B.1    Al-Numair, K.S.2    Veeramani, C.3    Pugalendi, K.V.4
  • 5
    • 0029871839 scopus 로고    scopus 로고
    • Histopathology of acetaminophen-induced liver changes: Role of interleukin 1α and tumor necrosis factor alpha
    • Blazka ME, Elwell MR, Holladay SD, Wilson RE, Luster MI, (1996) Histopathology of acetaminophen-induced liver changes: role of interleukin 1α and tumor necrosis factor alpha. Toxicologic Pathology 24 (2): 181-189.
    • (1996) Toxicologic Pathology , vol.24 , Issue.2 , pp. 181-189
    • Blazka, M.E.1    Elwell, M.R.2    Holladay, S.D.3    Wilson, R.E.4    Luster, M.I.5
  • 8
    • 84871993621 scopus 로고    scopus 로고
    • Therapeutic efficacy of silymarin from milk thistle in reducing manganese-induced hepatic damage and apoptosis in rats
    • Chtourou Y, Garoui E, Boudawara T, Zeghal N, (2012) Therapeutic efficacy of silymarin from milk thistle in reducing manganese-induced hepatic damage and apoptosis in rats. Human and Experimental Toxicology 32: 70-81.
    • (2012) Human and Experimental Toxicology , vol.32 , pp. 70-81
    • Chtourou, Y.1    Garoui, E.2    Boudawara, T.3    Zeghal, N.4
  • 9
    • 0033027841 scopus 로고    scopus 로고
    • Nitric oxide in liver injury
    • Clemens MG, (2003) Nitric oxide in liver injury. Hepatology 30: 1-5.
    • (2003) Hepatology , vol.30 , pp. 1-5
    • Clemens, M.G.1
  • 10
    • 0025125066 scopus 로고
    • Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method
    • Cortas NK, Wakid NW, (1990) Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clinical Chemistry 36: 1440-1443.
    • (1990) Clinical Chemistry , vol.36 , pp. 1440-1443
    • Cortas, N.K.1    Wakid, N.W.2
  • 11
    • 77949503909 scopus 로고    scopus 로고
    • Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation
    • Das J, Ghosh J, Manna P, Sil PC, (2010) Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology 269: 24-34.
    • (2010) Toxicology , vol.269 , pp. 24-34
    • Das, J.1    Ghosh, J.2    Manna, P.3    Sil, P.C.4
  • 12
    • 0016138336 scopus 로고
    • Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen
    • Davis DC, Potter WZ, Jollow DJ, Mitchell JR, (1974) Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen. Life Sciences 14: 2099-2109.
    • (1974) Life Sciences , vol.14 , pp. 2099-2109
    • Davis, D.C.1    Potter, W.Z.2    Jollow, D.J.3    Mitchell, J.R.4
  • 13
    • 0031839464 scopus 로고    scopus 로고
    • Tissue injury by reactive oxygen species and the protective effects of flavonoids
    • De Groot H, Raven U, (1998) Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundamental and Clinical Pharmacology 12: 249-255.
    • (1998) Fundamental and Clinical Pharmacology , vol.12 , pp. 249-255
    • De Groot, H.1    Raven, U.2
  • 14
    • 40049104526 scopus 로고    scopus 로고
    • Assessment of drug-drug interaction for silymarin
    • Doehmer J, Tewesa B, Klein KU, (2008) Assessment of drug-drug interaction for silymarin. Toxicology in Vitro 22: 610-617.
    • (2008) Toxicology in Vitro , vol.22 , pp. 610-617
    • Doehmer, J.1    Tewesa, B.2    Klein, K.U.3
  • 15
    • 0018195033 scopus 로고
    • Serum enzymes are indications of chemical induced liver damage
    • Drotman R, Lawhan G, (1978) Serum enzymes are indications of chemical induced liver damage. Drug and Chemical Toxicology 1: 163-171.
    • (1978) Drug and Chemical Toxicology , vol.1 , pp. 163-171
    • Drotman, R.1    Lawhan, G.2
  • 16
    • 44749083056 scopus 로고    scopus 로고
    • Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats
    • El-Shitanya NA, El-Haggarb S, El-Desoky K, (2008) Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats. Food and Chemical Toxicology 46: 2422-2428.
    • (2008) Food and Chemical Toxicology , vol.46 , pp. 2422-2428
    • El-Shitanya, N.A.1    El-Haggarb, S.2    El-Desoky, K.3
  • 17
    • 48449086178 scopus 로고    scopus 로고
    • Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals
    • ((Lond.)
    • Eminzade S, Uraz F, Izzettin FV, (2008) Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals. Nutrition and Metabolism (. Lond.) 5: 18.
    • (2008) Nutrition and Metabolism , vol.5 , pp. 18
    • Eminzade, S.1    Uraz, F.2    Izzettin, F.V.3
  • 20
    • 77953761200 scopus 로고    scopus 로고
    • The effect of the aqueous extract of Kohautia grandiflora on paracetamol induced liver damage in albino rats
    • Garba SH, Sambo N, Bala U, (2009) The effect of the aqueous extract of Kohautia grandiflora on paracetamol induced liver damage in albino rats. Nigerian Journal of Physiological Sciences 24 (1): 17-23.
    • (2009) Nigerian Journal of Physiological Sciences , vol.24 , Issue.1 , pp. 17-23
    • Garba, S.H.1    Sambo, N.2    Bala, U.3
  • 22
    • 14944339649 scopus 로고    scopus 로고
    • In vivo mechanisms of tissue-selective drug toxicity: Effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung and nasal mucosa
    • Gu J, Cui H, Behr M, Zhang L, Zhang Q, Yang W, et al. (2005) In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung and nasal mucosa. Molecular Pharmacology 67: 623-630.
    • (2005) Molecular Pharmacology , vol.67 , pp. 623-630
    • Gu, J.1    Cui, H.2    Behr, M.3    Zhang, L.4    Zhang, Q.5    Yang, W.6
  • 23
    • 0036304261 scopus 로고    scopus 로고
    • Mode of cell death after acetaminophen overdose in mice: Apoptosis or oncotic necrosis?
    • Gujral JS, Knight TR, Farhood A, (2002) Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicological Sciences 67: 322-328.
    • (2002) Toxicological Sciences , vol.67 , pp. 322-328
    • Gujral, J.S.1    Knight, T.R.2    Farhood, A.3
  • 24
    • 68849120724 scopus 로고    scopus 로고
    • Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers
    • Han Y, Guo D, Chen Y, (2009) Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers. European Journal of Clinical Pharmacology 65: 585-591.
    • (2009) European Journal of Clinical Pharmacology , vol.65 , pp. 585-591
    • Han, Y.1    Guo, D.2    Chen, Y.3
  • 26
    • 0020626421 scopus 로고
    • Flavonoids, a class of natural products of high pharmacological potency
    • Havsteen B, (1983) Flavonoids, a class of natural products of high pharmacological potency. Biochemical Pharmacology 32: 1141-1148.
    • (1983) Biochemical Pharmacology , vol.32 , pp. 1141-1148
    • Havsteen, B.1
  • 30
    • 0033860297 scopus 로고    scopus 로고
    • Reactive oxygen and mechanisms of inflammatory liver injury
    • Jaeschke H, (2000) Reactive oxygen and mechanisms of inflammatory liver injury. Journal of Gastroenterology and Hepatology 15: 718-724.
    • (2000) Journal of Gastroenterology and Hepatology , vol.15 , pp. 718-724
    • Jaeschke, H.1
  • 31
    • 0043135016 scopus 로고    scopus 로고
    • The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity
    • Jaeschke H, Knighta T, Bajta M, (2003) The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicology Letters 144: 279-288.
    • (2003) Toxicology Letters , vol.144 , pp. 279-288
    • Jaeschke, H.1    Knighta, T.2    Bajta, M.3
  • 34
    • 24344479620 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity and protection by milk thistle extract in rats
    • Karimi G, Ramezani M, Tahoonian Z, (2005) Cisplatin nephrotoxicity and protection by milk thistle extract in rats. eCAM 2: 383-386.
    • (2005) ECAM , vol.2 , pp. 383-386
    • Karimi, G.1    Ramezani, M.2    Tahoonian, Z.3
  • 36
    • 33744971866 scopus 로고    scopus 로고
    • Silybin and silymarin - New effects and applications
    • Kren V, Walterova D, (2005) Silybin and silymarin-new effects and applications. Biomedical Papers 149: 29-41.
    • (2005) Biomedical Papers , vol.149 , pp. 29-41
    • Kren, V.1    Walterova, D.2
  • 39
    • 0030994766 scopus 로고    scopus 로고
    • Serum sialic acid and its correlates in community samples from Akita, Japan, and Minneapolis, USA
    • Lindberg G, Iso H, Rastam L, Lundblad A, (1997) Serum sialic acid and its correlates in community samples from Akita, Japan, and Minneapolis, USA. Intertional Journal of Epidemiology 26: 58-63.
    • (1997) Intertional Journal of Epidemiology , vol.26 , pp. 58-63
    • Lindberg, G.1    Iso, H.2    Rastam, L.3    Lundblad, A.4
  • 41
    • 0032715311 scopus 로고    scopus 로고
    • Silymarin suppresses TNF-induced activation of NF-kB, c-Jun N-terminal kinase and apoptosis
    • Manna SK, Mukhopadhyay A, Van NT, (1999) Silymarin suppresses TNF-induced activation of NF-kB, c-Jun N-terminal kinase and apoptosis. Journal of Immunology 163: 6800-6809.
    • (1999) Journal of Immunology , vol.163 , pp. 6800-6809
    • Manna, S.K.1    Mukhopadhyay, A.2    Van, N.T.3
  • 42
    • 62549132116 scopus 로고    scopus 로고
    • Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol-induced liver damage
    • Marotta F, Yadav H, Gumaste U, Helmy Jain S, Minelli E, (2009) Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol-induced liver damage. Annals of Hepatology 8: 50-56.
    • (2009) Annals of Hepatology , vol.8 , pp. 50-56
    • Marotta, F.1    Yadav, H.2    Gumaste, U.3    Helmy Jain, S.4    Minelli, E.5
  • 43
    • 0025041309 scopus 로고
    • Structure activity relationships of polymetoxyflavones and other flavonoids as inhibitors of non-enzymatic lipid peroxidation
    • Mora A, Paya M, Rios J, Alcaraz M, (1990) Structure activity relationships of polymetoxyflavones and other flavonoids as inhibitors of non-enzymatic lipid peroxidation. Biochemical Pharmacology 40: 793-794.
    • (1990) Biochemical Pharmacology , vol.40 , pp. 793-794
    • Mora, A.1    Paya, M.2    Rios, J.3    Alcaraz, M.4
  • 44
    • 0025712673 scopus 로고
    • Effects of silymarin (Legalon) therapy on the antioxidant defense mechanism and lipid peroxidation in alcoholic liver disease
    • Muzes G, Deak G, Lang I, Nékám K, Niederland V, Fehér J, (1990) Effects of silymarin (Legalon) therapy on the antioxidant defense mechanism and lipid peroxidation in alcoholic liver disease. Orvosi Hetilap 131: 863-866.
    • (1990) Orvosi Hetilap , vol.131 , pp. 863-866
    • Muzes, G.1    Deak, G.2    Lang, I.3    Nékám, K.4    Niederland, V.5    Fehér, J.6
  • 45
    • 47949108472 scopus 로고    scopus 로고
    • Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose
    • Myers RP, Shaheen AA, Li B, Dean S, Quan H, (2008) Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. Clinical Gastroenterology and Hepatology 6: 918-925.
    • (2008) Clinical Gastroenterology and Hepatology , vol.6 , pp. 918-925
    • Myers, R.P.1    Shaheen, A.A.2    Li, B.3    Dean, S.4    Quan, H.5
  • 47
    • 43049097150 scopus 로고    scopus 로고
    • Propolis reverses acetaminophen induced acute hepatorenal alterations: A biochemical and histopathological approach
    • Nirala SK, Bhadauria M, (2008) Propolis reverses acetaminophen induced acute hepatorenal alterations: a biochemical and histopathological approach. Archives of Pharmacal Research 31: 451-461.
    • (2008) Archives of Pharmacal Research , vol.31 , pp. 451-461
    • Nirala, S.K.1    Bhadauria, M.2
  • 48
    • 33846267264 scopus 로고    scopus 로고
    • Alchornea cordifolia extract protects wistar albino rats against acetaminophen-induced liver damage
    • Olaleye MT, Adegboye OO, Akindahunsi AA, (2006) Alchornea cordifolia extract protects wistar albino rats against acetaminophen-induced liver damage. African Journal of Biotechnology 5 (24): 2439-2445.
    • (2006) African Journal of Biotechnology , vol.5 , Issue.24 , pp. 2439-2445
    • Olaleye, M.T.1    Adegboye, O.O.2    Akindahunsi, A.A.3
  • 50
    • 77952891323 scopus 로고    scopus 로고
    • Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver
    • Patel N, Joseph C, Corcoran GB, Ray SD, (2010) Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver. Toxicology and Applied Pharmacology 245: 143-152.
    • (2010) Toxicology and Applied Pharmacology , vol.245 , pp. 143-152
    • Patel, N.1    Joseph, C.2    Corcoran, G.B.3    Ray, S.D.4
  • 51
    • 0029160914 scopus 로고
    • Role of reactive metabolites in drug-induced hepatitis
    • Pessayre D, (1995) Role of reactive metabolites in drug-induced hepatitis. Journal of Hepatology 23: 16-24.
    • (1995) Journal of Hepatology , vol.23 , pp. 16-24
    • Pessayre, D.1
  • 52
    • 33846519345 scopus 로고    scopus 로고
    • Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
    • Pradhan SC, Girish C, (2006) Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research 124: 491-504.
    • (2006) Indian Journal of Medical Research , vol.124 , pp. 491-504
    • Pradhan, S.C.1    Girish, C.2
  • 53
    • 84864955663 scopus 로고    scopus 로고
    • Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats
    • Qin R, Zhang J, Li C, Zhang X, Xiong A, Huang F, et al. (2012) Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Archives of Pharmacal Research 35: 1241-1250.
    • (2012) Archives of Pharmacal Research , vol.35 , pp. 1241-1250
    • Qin, R.1    Zhang, J.2    Li, C.3    Zhang, X.4    Xiong, A.5    Huang, F.6
  • 55
    • 84870598217 scopus 로고    scopus 로고
    • Attenuation of oxidative stress by syringic acid on acetaminophen-induced nephrotoxic rats
    • Ramachandran V, Saravanan R, Raja B, (2011) Attenuation of oxidative stress by syringic acid on acetaminophen-induced nephrotoxic rats. Comparative Clinical Pathology 21: 1559-1564.
    • (2011) Comparative Clinical Pathology , vol.21 , pp. 1559-1564
    • Ramachandran, V.1    Saravanan, R.2    Raja, B.3
  • 56
    • 0034960753 scopus 로고    scopus 로고
    • Long term effect of aflatoxin B1 on lipid peroxidation in rat liver and kidney: Effect of picroliv and silymarin
    • Rastogi R, Srivastava A, Rastogi A, (2001) Long term effect of aflatoxin B1 on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytotherapy Research 15: 307-310.
    • (2001) Phytotherapy Research , vol.15 , pp. 307-310
    • Rastogi, R.1    Srivastava, A.2    Rastogi, A.3
  • 59
    • 0034460429 scopus 로고    scopus 로고
    • In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract
    • Ray SD, Patel D, Wong V, Bagchi D, (2000) In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract. Research Communications in Molecular Pathology and Pharmacology 107: 137-166.
    • (2000) Research Communications in Molecular Pathology and Pharmacology , vol.107 , pp. 137-166
    • Ray, S.D.1    Patel, D.2    Wong, V.3    Bagchi, D.4
  • 60
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • Sailer R, Meier R, Brignoli R, (2001) The use of silymarin in the treatment of liver diseases. Drugs 61: 2035-2063.
    • (2001) Drugs , vol.61 , pp. 2035-2063
    • Sailer, R.1    Meier, R.2    Brignoli, R.3
  • 61
    • 0032573394 scopus 로고    scopus 로고
    • Selective inhibition of NF-kB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways
    • Saliou C, Rihn B, Cillard J, (1998) Selective inhibition of NF-kB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways. FEBS Letters 440: 8-12.
    • (1998) FEBS Letters , vol.440 , pp. 8-12
    • Saliou, C.1    Rihn, B.2    Cillard, J.3
  • 62
    • 13244253962 scopus 로고    scopus 로고
    • Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice
    • Sener G, Sehirli AO, Cetinel S, Yeǧen BG, Gedik N, Ayanoǧlu-Dülger G, (2005) Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice. Journal of Applied Toxicology 25: 20-29.
    • (2005) Journal of Applied Toxicology , vol.25 , pp. 20-29
    • Sener, G.1    Sehirli, A.O.2    Cetinel, S.3    Yeǧen, B.G.4    Gedik, N.5    Ayanoǧlu-Dülger, G.6
  • 63
    • 50249145691 scopus 로고    scopus 로고
    • Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney
    • Senturk H, Kabay S, Bayramoglu G, Ozden H, Yaylak F, Yucel M, et al. (2008) Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney. World Journal of Urology 26: 401-407.
    • (2008) World Journal of Urology , vol.26 , pp. 401-407
    • Senturk, H.1    Kabay, S.2    Bayramoglu, G.3    Ozden, H.4    Yaylak, F.5    Yucel, M.6
  • 65
    • 18044380084 scopus 로고    scopus 로고
    • Protective effect of catechin on ischemiareperfusion-induced renal injury in rats
    • Singh D, Chander V, Chopra K, (2005) Protective effect of catechin on ischemiareperfusion-induced renal injury in rats. Pharmacological Reports 57: 70-76.
    • (2005) Pharmacological Reports , vol.57 , pp. 70-76
    • Singh, D.1    Chander, V.2    Chopra, K.3
  • 66
    • 0022583887 scopus 로고
    • Biochemical effects of the flavonolignan silibinin on RNA, protein, and DNA synthesis in rat liver
    • Sonnenbichler J, Zetl I, (1986) Biochemical effects of the flavonolignan silibinin on RNA, protein, and DNA synthesis in rat liver. Progress in Clinical and Biological Research 213: 319-331.
    • (1986) Progress in Clinical and Biological Research , vol.213 , pp. 319-331
    • Sonnenbichler, J.1    Zetl, I.2
  • 67
    • 0023192120 scopus 로고
    • A comparative study of the efficacy of Pavetta indica and Osbeckia octanda in the treatment of liver dysfunction
    • Thabrew M, Joice P, (1987) A comparative study of the efficacy of Pavetta indica and Osbeckia octanda in the treatment of liver dysfunction. Planta Medica 53: 239-241.
    • (1987) Planta Medica , vol.53 , pp. 239-241
    • Thabrew, M.1    Joice, P.2
  • 70
    • 0030907984 scopus 로고    scopus 로고
    • Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients
    • Velussi M, Cernigoi AM, De Monte A, Dapas F, Caffau C, Zilli M, (1997) Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. Journal of Hepatology 26: 871-879.
    • (1997) Journal of Hepatology , vol.26 , pp. 871-879
    • Velussi, M.1    Cernigoi, A.M.2    De Monte, A.3    Dapas, F.4    Caffau, C.5    Zilli, M.6
  • 71
    • 0033782925 scopus 로고    scopus 로고
    • Thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures
    • Venkataramanan R, Ramachandran V, BJ KomoroskI, (2000) Thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Drug Metabolism and Disposition 28: 1270-1273.
    • (2000) Drug Metabolism and Disposition , vol.28 , pp. 1270-1273
    • Venkataramanan, R.1    Ramachandran, V.2    Bj, K.3
  • 73
    • 0035200385 scopus 로고    scopus 로고
    • Role of ginsenoside-Rd in cisplatin-induced renal injury: Special reference to DNA fragmentation
    • Yokozawa T, Dong E, (2001) Role of ginsenoside-Rd in cisplatin-induced renal injury: special reference to DNA fragmentation. Nephrology 89: 433-438.
    • (2001) Nephrology , vol.89 , pp. 433-438
    • Yokozawa, T.1    Dong, E.2
  • 74
    • 24344458570 scopus 로고    scopus 로고
    • Natural antioxidants for neurodegenerative diseases
    • Zhao B, (2005) Natural antioxidants for neurodegenerative diseases. Molecular Neurobiology 31: 283-294.
    • (2005) Molecular Neurobiology , vol.31 , pp. 283-294
    • Zhao, B.1
  • 75
    • 79951916380 scopus 로고    scopus 로고
    • Paracetamol metabolism and related genetic differences
    • Zhao L, Pickering G, (2011) Paracetamol metabolism and related genetic differences. Drug metabolism reviews 43: 41-52.
    • (2011) Drug Metabolism Reviews , vol.43 , pp. 41-52
    • Zhao, L.1    Pickering, G.2
  • 76
    • 0032717556 scopus 로고    scopus 로고
    • Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: Implications in cancer chemoprevention
    • Zhao J, Agarwal R, (1999) Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 20: 2101-2108.
    • (1999) Carcinogenesis , vol.20 , pp. 2101-2108
    • Zhao, J.1    Agarwal, R.2
  • 77
    • 0036846701 scopus 로고    scopus 로고
    • Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities
    • Zuber R, Modriansky M, Dvorak Z, (2002) Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities. Phytotherapy Research 16: 632-638.
    • (2002) Phytotherapy Research , vol.16 , pp. 632-638
    • Zuber, R.1    Modriansky, M.2    Dvorak, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.