HLA and asthma phenotypes/endotypes: A review

Human Immunology

Volumn 75, Issue 8, 2014, Pages 930-939

  Kontakioti, Eirini ^a   Domvri, Kalliopi ^a   Papakosta, Despina ^a   Daniilidis, Michail ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Allergic; Aspirin; Asthma; HLA; Occupational

Indexed keywords

ACETYLSALICYLIC ACID; ALLERGEN; HLA DPB1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; HLA ANTIGEN CLASS 2;

ALLERGIC ASTHMA; ASPIRIN EXACERBATED RESPIRATORY DISEASE; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HLA SYSTEM; HLA TYPING; HUMAN; OCCUPATIONAL ASTHMA; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TH2 CELL; CHROMOSOME 6; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; PATHOPHYSIOLOGY;

ASTHMA, ASPIRIN-INDUCED; ASTHMA, OCCUPATIONAL; CHROMOSOMES, HUMAN, PAIR 6; GENE EXPRESSION REGULATION; GENETIC HETEROGENEITY; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LINKAGE DISEQUILIBRIUM; PHENOTYPE;

EID: 84905088815     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2014.06.022     Document Type: Review

References (132)

1. Arruda L.K., Sole D., Baena-Cagnani C.E., Naspitz C.K. Risk factors for asthma and atopy. Curr Opin Allergy Clin Immunol 2005, 5:153-159.
2. Kroegel C. Global initiative for asthma (GINA) guidelines: 15 years of application. Exp Rev Clin Immunol 2009, 5:239-249.
3. Shiina T., Hosomichi K., Inoko H., Kulski J.K. The HLA genomic loci map: expression, interaction, diversity and disease. J Hum Genet 2009, 54:15-39.
4. Shiina T., Inoko H., Kulski J.K. An update of the HLA genomic region, locus information and disease associations: 2004. Tissue Antigens 2004, 64:631-649.
5. Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy 2012, 42:650-658.
6. Green R.H., Brightling C.E., Bradding P. The reclassification of asthma based on subphenotypes. Curr Opin Allergy Clin Immunol 2007, 7:43-50.
7. Lotvall J., Akdis C.A., Bacharier L.B., et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011, 127:355-360.
8. Deichmann K.A., Starke B., Schlenther S., et al. Linkage and association studies of atopy and the chromosome 11q13 region. J Med Genet 1999, 36:379-382.
9. Li X., Howard T.D., Zheng S.L., et al. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol 2010, 125(328-35):e11.
10. Ramasamy A., Kuokkanen M., Vedantam S., et al. Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One 2012, 7:e44008.
11. Tamari M., Tanaka S., Hirota T. Genome-wide association studies of allergic diseases. Allergol Int 2013, 62:21-28.
12. Song G.G., Lee Y.H. Pathway analysis of genome-wide association study on asthma. Hum Immunol 2012.
13. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The collaborative study on the genetics of asthma (CSGA). Nat Genet 1997, 15:389-392.
14. Moffatt M.F., Gut I.G., Demenais F., et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010, 363:1211-1221.
15. Choo S.Y. The HLA system: genetics, immunology, clinical testing, and clinical implications. Yonsei Med J 2007, 48:11-23.
16. Bruce C.A., Bias W.B., Norman P.S., et al. Studies of HLA antigen frequencies, IgE levels, and specific allergic sensitivities in patients having ragweed hayfever, with and without asthma. Clin Exp Immunol 1976, 25:67-72.
17. Brostoff J., Mowbray J.F., Kapoor A., et al. 80% of patients with intrinsic asthma are homozygous for HLA W6. Is intrinsic asthma a recessive disease?. Lancet 1976, 2:872-873.
18. Morris M.J., Vaughan H., Lane D.J., Morris P.J. HLA in asthma. Monogr Allergy 1977, 11:30-34.
19. Huang L.S., Hsieh K.H., Liu S.Y. HLA and childhood asthma (author's transl). Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1981, 14:102-106.
20. Wang W.X., Yang S.Z., Chui X.W., Zhang H.L. Association of HLA-Bw61 with asthma in the Chinese. Tissue Antigens 1988, 32:215-217.
21. Caraballo L., Marrugo J., Jimenez S., et al. Frequency of DPB1*0401 is significantly decreased in patients with allergic asthma in a mulatto population. Hum Immunol 1991, 32:157-161.
22. Hsieh K.H., Shieh C.C., Hsieh R.P., Liu W.J. Association of HLA-DQw2 with Chinese childhood asthma. Tissue Antigens 1991, 38:181-182.
23. Taylor A.N. Role of human leukocyte antigen phenotype and exposure in development of occupational asthma. Curr Opin Allergy Clin Immunol 2001, 1:157-161.
24. Moffatt M.F., Schou C., Faux J.A., et al. Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. Eur J Hum Genet 2001, 9:341-346.
25. Siroux V., Gonzalez J.R., Bouzigon E., et al. Genetic heterogeneity of asthma phenotypes identified by a clustering approach. Eur Respir J 2014, 43:439-452.
26. Li X., Ampleford E.J., Howard T.D., et al. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol 2012, 130(861-8):e7.
27. Silverberg M.S., Cho J.H., Rioux J.D., et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet 2009, 41:216-220.
28. Bonnelykke K., Matheson M.C., Pers T.H., et al. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet 2013, 45:902-906.
29. White S.R. Human leucocyte antigen-G: expression and function in airway allergic disease. Clin Exp Allergy 2012, 42:208-217.
30. Muro M., Mondejar-Lopez P., Moya-Quiles M.R., et al. HLA-DRB1 and HLA-DQB1 genes on susceptibility to and protection from allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Microbiol Immunol 2013, 57:193-197.
31. Schubert M.S., Hutcheson P.S., Graff R.J., et al. HLA-DQB1*03 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders. J Allergy Clin Immunol 2004, 114:1376-1383.
32. Mathias R.A., Weinberg A., Boguniewicz M., et al. Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-gamma-producing CD8+ T cells. Br J Dermatol 2013, 169:700-703.
33. Shawkatova I., Javor J., Parnicka Z., et al. HLA-C, DRB1 and DQB1 alleles involved in genetic predisposition to psoriasis vulgaris in the Slovak population. Folia Microbiol 2013, 58:319-324.
34. Fleva A., Daniilidis M., Sidiropoulos J., et al. Can HLA typing predict the outcome of grass pollen immunotherapy?. Exp Clin Immunogenet 2001, 18:13-23.
35. Wang C.M., Chuang J.J. Effect of mite allergen immunotherapy on the altered phenotype of dendritic cells in allergic asthmatic children. Ann Allergy Asthma Immunol 2013, 110:107-112.
36. Campbell J.D., Buckland K.F., McMillan S.J., et al. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med 2009, 206:1535-1547.
37. Worm M., Lee H.H., Kleine-Tebbe J., et al. Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy. J Allergy Clin Immunol 2011, 127(89-97):e1-14.
38. Etto T., de Boer C., Prickett S., et al. Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1. Int Arch Allergy Immunol 2012, 159:355-366.
39. Till S.J., Raynsford E.J., Reynolds C.J., et al. Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation. Thorax 2013.
40. Schulten V., Oseroff C., Alam R., et al. The identification of potentially pathogenic and therapeutic epitopes from common human allergens. Ann Allergy Asthma Immunol 2013, 110:7-10.
41. Holt P.G., Macaubas C., Stumbles P.A., Sly P.D. The role of allergy in the development of asthma. Nature 1999, 402:B12-7.
42. Gilmour M.I., Jaakkola M.S., London S.J., et al. How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect 2006, 114:627-633.
43. Bush R.K. Indoor allergens, environmental avoidance, and allergic respiratory disease. Allergy Asthma Proc 2008, 29:575-579.
44. Illi S., von Mutius E., Lau S., et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006, 368:763-770.
45. Sporik R., Squillace S.P., Ingram J.M., et al. Mite, cat, and cockroach exposure, allergen sensitisation, and asthma in children: a case-control study of three schools. Thorax 1999, 54:675-680.
46. Movahedi M., Moin M., Gharagozlou M., et al. Association of HLA class II alleles with childhood asthma and Total IgE levels. Iran J Allergy Asthma Immunol 2008, 7:215-220.
47. Ostergaard P.A., Eriksen J. Association between HLA-A1, B8 in children with extrinsic asthma and IgA deficiency. Eur J Pediatr 1979, 131:263-270.
48. Morris M.J., Faux J.A., Ting A., et al. HLA-A, B and C and HLA-DR antigens in intrinsic and allergic asthma. Clin Allergy 1980, 10:173-179.
49. Turton C.W., Morris L., Buckingham J.A., et al. Histocompatibility antigens in asthma: population and family studies. Thorax 1979, 34:670-676.
50. Flaherty D.K., Geller M., Surfus J.E., et al. HLA antigen frequencies and natural history in Alternaria-sensitive and perennial nonallergic asthmatics. J Allergy Clin Immunol 1980, 66:408-416.
51. Nicolae D., Cox N.J., Lester L.A., et al. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet 2005, 76:349-357.
52. Rich S.S. Results of genetic studies in man. Clin Exp Allergy 1995, 95-96.
53. Marsh D.G., Meyers D.A., Bias W.B. The epidemiology and genetics of atopic allergy. N Engl J Med 1981, 305:1551-1559.
54. Moffatt M.F., Kabesch M., Liang L., et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007, 448:470-473.
55. Lasky-Su J., Himes B.E., Raby B.A., et al. HLA-DQ strikes again: Genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy 2012, 42:1724-1733.
56. Chung K.F., Zhang J., Zhong N. Outdoor air pollution and respiratory health in Asia. Respirology 2011, 16:1023-1026.
57. Krstev S., Ji B.T., Shu X.O., et al. Occupation and adult-onset asthma among Chinese women in a population-based cohort. Am J Ind Med 2007, 50:265-273.
58. Yue W., Pan X.C., Ding J. Risk factors for allergic asthma in a case-control study among adults. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2004, 25:706-709.
59. Gao J., Lin YQiu C., et al. Relationship between HLA-DQA1, -DQB1 genes polymorphism and susceptibility to bronchial asthma among Northern Hans. Zhonghua Yi Xue Za Zhi 2002, 82:379-383.
60. Gao J., Lin Y. Qiu C. Zhonghua Yi Xue Za Zhi 1998, 78:591-594.
61. Wang C., Peng ZLi J., et al. Comparative study of HLA-DRB1 allele in patients with chronic bronchitis and bronchial asthma. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 1999, 16:371-373.
62. Guo X., Ni P., Li L. Association between asthma and the polymorphism of HLA-DQ genes. Zhonghua Jie He He Hu Xi Za Zhi 2001, 24:139-141.
63. Li P.K., Lai C.K., Poon A.S., et al. Lack of association between HLA-DQ and -DR genotypes and asthma in southern Chinese patients. Clin Exp Allergy 1995, 25:323-331.
64. Custovic A., Taggart S.C., Francis H.C., et al. Exposure to house dust mite allergens and the clinical activity of asthma. J Allergy Clin Immunol 1996, 98:64-72.
65. Ohshima Y., Yamada A., Hiraoka M., et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: results of a 4-year followup study. Ann Allergy Asthma Immunol 2002, 89:265-270.
66. Tovey E.R., Almqvist C., Li Q., et al. Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort. J Allergy Clin Immunol 2008, 122:114-118. [8 e1-5].
67. Caraballo L.R., Hernandez M. HLA haplotype segregation in families with allergic asthma. Tissue Antigens 1990, 35:182-186.
68. Lara-Marquez M.L., Yunis J.J., Layrisse Z., et al. Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. Clin Exp Allergy 1999, 29:60-71.
69. Aron Y., Swierczewski E., Lockhart A. HLA class II haplotype in atopic asthmatic and non-atopic control subjects. Clin Exp Allergy 1995, 25(Suppl. 2):65-67. [discussion 95-6].
70. Moffatt M.F., Faux J.A., Lester S., et al. Atopy, respiratory function and HLA-DR in Aboriginal Australians. Hum Mol Genet 2003, 12:625-630.
71. Hizawa N., Collins G., Rafnar T., et al. Linkage analysis of Dermatophagoides pteronyssinus-specific IgE responsiveness with polymorphic markers on chromosome 6p21 (HLA-D region) in Caucasian families by the transmission/disequilibrium test. Collaborative Study on the Genetics of Asthma (CSGA). J Allergy Clin Immunol 1998, 102:443-448.
72. Hizawa N., Freidhoff L.R., Chiu Y.F., et al. Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. Collaborative Study on the Genetics of Asthma (CSGA). J Allergy Clin Immunol 1998, 102:436-442.
73. Cho S.H., Kim Y.K., Oh H.B., et al. Association of HLA-DRB1(*)07 and DRB1(*)04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma. Clin Exp Allergy 2000, 30:1568-1575.
74. Howell W.M., Standring P., Warner J.A., Warner J.O. HLA class II genotype, HLA-DR B cell surface expression and allergen specific IgE production in atopic and non-atopic members of asthmatic family pedigrees. Clin Exp Allergy 1999, 29(Suppl. 4):35-38.
75. Moffatt M.F., James A., Ryan G., et al. Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample. Thorax 1999, 54:757-761.
76. Lin Y.C., Lu C.C., Su H.J., et al. The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents. Allergy 2002, 57:831-834.
77. Torio A., Sanchez-Guerrero I., Muro M., et al. HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma. Hum Immunol 2003, 64:811-815.
78. Woszczek G., Kowalski M.L., Borowiec M. Association of asthma and total IgE levels with human leucocyte antigen-DR in patients with grass allergy. Eur Respir J 2002, 20:79-85.
79. Blumenthal M., Marcus-Bagley D., Awdeh Z., et al. HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. J Immunol 1992, 148:411-416.
80. Dzurilla M., Vrlik M., Homolova M., Buc M. No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population. Bratisl Lek Listy 2013, 114:93-95.
81. Young R.P., Dekker J.W., Wordsworth B.P., et al. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy 1994, 24:431-439.
82. Torio A., Sanchez-Guerrero I., Muro M., et al. Analysis of the phenotypic distribution of HLA class I and class II in atopic and non-atopic asthma patients. Eur J Immunogenet 2000, 27:81-85.
83. Kauppinen A., Perasaari J., Taivainen A., et al. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 2012, 217:8-12.
84. Juhn Y.J., Kita H., Lee L.A., et al. Childhood asthma and human leukocyte antigen type. Tissue Antigens 2007, 69:38-46.
85. Juhn Y.J., Kita H., Bagniewski S.M., et al. Severity of childhood asthma and human leukocyte antigens type. J Asthma 2007, 44:163-168.
86. Martyn M.B., Molis W., Jacobson R.M., et al. Human leukocyte antigen type and progression from onset of symptoms to development of asthma. Allergy Asthma Proc 2010, 31:120-125.
87. Hanchard N.A., Jacobson R.M., Poland G.A., Juhn Y.J. An assessment of the association between childhood asthma and HLA DRB1*03 using extended haplotype analysis. Tissue Antigens 2010, 76:491-494.
88. Noguchi E., Sakamoto H., Hirota T., et al. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genet 2011, 7:e1002170.
89. Ivkovic-Jurekovic I., Zunec R., Balog V., Grubic Z. The distribution of HLA alleles among children with atopic asthma in Croatia. Coll Antropol 2011, 35:1243-1249.
90. Parapanissiou E., Papastavrou T., Deligiannidis A., et al. HLA antigens in Greek children with allergic bronchial asthma. Tissue Antigens 2005, 65:481-484.
91. Munthe-Kaas M.C., Carlsen K.L., Carlsen K.H., et al. HLA Dr-Dq haplotypes and the TNFA-308 polymorphism: associations with asthma and allergy. Allergy 2007, 62:991-998.
92. Shreffler W.G., Charlop-Powers Z., Sicherer S.H. Lack of association of HLA class II alleles with peanut allergy. Ann Allergy Asthma Immunol 2006, 96:865-869.
93. Knutsen A.P., Vijay H.M., Kumar V., et al. Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ. Allergy 2010, 65:1367-1375.
94. Knutsen A.P., Vijay H.M., Kariuki B., et al. Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma. Clin Mol Allergy 2010, 8:5.
95. Mapp C.E., Boschetto P., Maestrelli P., Fabbri L.M. Occupational asthma. Am J Respir Crit Care Med 2005, 172:280-305.
96. Malo J.L., Lemiere C., Gautrin D., Labrecque M. Occupational asthma. Curr Opin Pulm Med 2004, 10:57-61.
97. Taylor A.J. HLA phenotype and exposure in development of occupational asthma. Ann Allergy Asthma Immunol 2003, 90:24-27.
98. Mapp C.E., Beghe B., Balboni A., et al. Association between HLA genes and susceptibility to toluene diisocyanate-induced asthma. Clin Exp Allergy 2000, 30:651-656.
99. Kim S.H., Oh H.B., Lee K.W., et al. HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma?. Allergy 2006, 61:891-894.
100. Choi J.H., Lee K.W., Kim C.W., et al. The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma. Int Arch Allergy Immunol 2009, 150:156-163.
101. Mapp C.E. Occupational asthma: interactions between genetic factors and adverse environment?. Med Lav 1994, 85:187-192.
102. Fabbri L.M., Mapp C.E., Balboni A., Baricordi R. HLA class II molecules and asthma induced by toluene diisocyanate. Int Arch Allergy Immunol 1995, 107:400-401.
103. Mapp C.E., Balboni A., Baricordi R., Fabbri L.M. Human leukocyte antigen associations in occupational asthma induced by isocyanates. Am J Respir Crit Care Med 1997, 156:S139-43.
104. Balboni A., Baricordi O.R., Fabbri L.M., et al. Association between toluene diisocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57. Eur Respir J 1996, 9:207-210.
105. Bignon J.S., Aron Y., Ju L.Y., et al. HLA class II alleles in isocyanate-induced asthma. Am J Respir Crit Care Med 1994, 149:71-75.
106. Rihs H.P., Barbalho-Krolls T., Huber H., Baur X. No evidence for the influence of HLA class II in alleles in isocyanate-induced asthma. Am J Ind Med 1997, 32:522-527.
107. Bernstein J.A., Munson J., Lummus Z.L., et al. T-cell receptor V beta gene segment expression in diisocyanate-induced occupational asthma. J Allergy Clin Immunol 1997, 99:245-250.
108. Beghe B., Padoan M., Moss C.T., et al. Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma. Allergy 2004, 59:61-64.
109. Horne C., Quintana P.J., Keown P.A., et al. Distribution of DRB1 and DQB1 HLA class II alleles in occupational asthma due to western red cedar. Eur Respir J 2000, 15:911-914.
110. Christiani D.C., Mehta A.J., Yu C.L. Genetic susceptibility to occupational exposures. Occup Environ Med 2008, 65:430-436. [quiz 6, 397].
111. Palikhe N.S., Kim J.H., Park H.S. Biomarkers predicting isocyanate-induced asthma. Allergy Asthma Immunol Res 2011, 3:21-26.
112. Hedman J., Kaprio J., Poussa T., Nieminen M.M. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 1999, 28:717-722.
113. Specjalski K., Chelminska M. Pathogenesis of aspirin-induced asthma. Pol Arch Med Wewn 2006, 115:265-270.
114. Cowburn A.S., Sladek K., Soja J., et al. Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Investig 1998, 101:834-846.
115. Dahlen B., Nizankowska E., Szczeklik A., et al. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. Am J Respir Crit Care Med 1998, 157:1187-1194.
116. Mullarkey M.F., Thomas P.S., Hansen J.A., et al. Association of aspirin-sensitive asthma with HLA-DQw2. Am Rev Respir Dis 1986, 133:261-263.
117. Lympany P.A., Welsh K.I., Christie P.E., et al. An analysis with sequence-specific oligonucleotide probes of the association between aspirin-induced asthma and antigens of the HLA system. J Allergy Clin Immunol 1993, 92:114-123.
118. Dekker J.W., Nizankowska E., Schmitz-Schumann M., et al. Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes. Clin Exp Allergy 1997, 27:574-577.
119. Moloney J.R., Oliver R.T. HLA antigens, nasal polyps and asthma. Clin Otolaryngol Allied Sci 1980, 5:183-189.
120. Choi J.H., Lee K.W., Oh H.B., et al. HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population. J Allergy Clin Immunol 2004, 113:562-564.
121. Kim S.H., Ye Y.M., Lee S.K., et al. Association of TNF-alpha genetic polymorphism with HLA DPB1*0301. Clin Exp Allergy 2006, 36:1247-1253.
122. Park B.L., Kim J.W., Cheong H.S., et al. Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. Hum Genet 2013, 132:657-668.
123. Kim J.H., Park B.L., Cheong H.S., et al. HLA-DRA polymorphisms associated with risk of nasal polyposis in asthmatic patients. Am J Rhinol Allergy 2012, 26:12-17.
124. Jones D.H., May A.G., Condemi J.J. HLA DR typing of aspirin sensitive asthmatics. Ann Allergy 1984, 52:87-89.
125. Palikhe N.S., Kim J.H., Park H.S. Update on recent advances in the management of aspirin exacerbated respiratory disease. Yonsei Med J 2009, 50:744-750.
126. Park H.S., Kim S.H., Sampson A.P., et al. The HLA-DPB1*0301 marker might predict the requirement for leukotriene receptor antagonist in patients with aspirin-intolerant asthma. J Allergy Clin Immunol 2004, 114:688-689.
127. Hansbro P.M., Scott G.V., Essilfie A.T., et al. Th2 cytokine antagonists: potential treatments for severe asthma. Expert Opin Investig Drugs 2013, 22:49-69.
128. Wang P., Sidney J., Kim Y., et al. Peptide binding predictions for HLA DR, DP and DQ molecules. BMC Bioinform 2010, 11:568.
129. Verhoef A., Alexander C., Kay A.B., Larche M. T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. PLoS Med 2005, 2:e78.
130. Larche M., Wraith D.C. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 2005, 11:S69-76.
131. Papouchado B.G., Chapoval S.P., Marietta E.V., et al. HLA-DQ/human CD4-restricted immune response to cockroach allergens in transgenic mice. Tissue Antigens 2000, 55:303-311.
132. Rajagopalan G., Tilahun A.Y., Iijima K., et al. HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation. Tissue Antigens 2011, 77:589-592.