Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: From GWAS to replication

Human Genetics

Volumn 132, Issue 6, 2013, Pages 657-668

  Park, Byung Lae ^a   Kim, Jee Wook ^b   Cheong, Hyun Sub ^a   Kim, Lyoung Hyo ^a,c   Lee, Boung Chul ^b   Seo, Cheong Hoon ^b   Kang, Tae Cheon ^b   Nam, Young Woo ^c   Kim, Goon Bo ^c   Shin, Hyoung Doo ^a,c   Choi, Ihn Geun ^b  

^a SNP Genetics Inc   (South Korea)

^b Hallym University   (South Korea)

^c Sogang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADH1A GENE; ADH1B GENE; ADH4 GENE; ADH5 GENE; ADH6 GENE; ADH7 GENE; ADULT; ALCOHOLISM; ARTICLE; CHROMOSOME; CHROMOSOME 4Q; FEMALE; FOLLOW UP; GENE CLUSTER; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC RISK; GENOME; GENOTYPE; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALCOHOLISM; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 4; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MIDDLE AGED; MULTIGENE FAMILY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; YOUNG ADULT;

EID: 84878248033     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-013-1281-8     Document Type: Article

References (41)

1. Baik I, Cho NH, Kim SH, Han BG, Shin C (2011) Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. Am J Clin Nutr 93(4):809-816
2. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-265
3. Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E, Fisher S, Fox L, Howells W, Bertelsen S, Hinrichs AL, Almasy L, Breslau N, Culverhouse RC, Dick DM, Edenberg HJ, Foroud T, Grucza RA, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Krueger RF, Kuperman S, Lynskey M, Mann K, Neuman RJ, Nothen MM, Nurnberger JI Jr, Porjesz B, Ridinger M, Saccone NL, Saccone SF, Schuckit MA, Tischfield JA, Wang JC, Rietschel M, Goate AM, Rice JP (2010) A genome-wide association study of alcohol dependence. Proc Natl Acad Sci USA 107(11):5082-5087
4. Birley AJ, James MR, Dickson PA, Montgomery GW, Heath AC, Whitfield JB, Martin NG (2008) Association of the gastric alcohol dehydrogenase gene ADH7 with variation in alcohol metabolism. Hum Mol Genet 17(2):179-189
5. Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ (1999) Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 65(3):795-807
6. Choi IG, Son HG, Yang BH, Kim SH, Lee JS, Chai YG, Son BK, Kee BS, Park BL, Kim LH, Choi YH, Shin HD (2005) Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism. Hum Mutat 26(3):224-234
7. Edenberg HJ (2007) The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 30(1):5-13
8. Edenberg HJ, Xuei X, Chen HJ, Tian H, Wetherill LF, Dick DM, Almasy L, Bierut L, Bucholz KK, Goate A, Hesselbrock V, Kuperman S, Nurnberger J, Porjesz B, Rice J, Schuckit M, Tischfield J, Begleiter H, Foroud T (2006) Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet 15(9):1539-1549
9. Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI Jr, Rice JP, Schuckit MA, Taylor R, Todd Webb B, Tischfield JA, Porjesz B, Foroud T (2010) Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res 34(5):840-852
10. Enoch MA, Goldman D (2002) Problem drinking and alcoholism: diagnosis and treatment. Am Fam Physician 65(3):441-448
11. Fan JB, Gunderson KL, Bibikova M, Yeakley JM, Chen J, Wickham Garcia E, Lebruska LL, Laurent M, Shen R, Barker D (2006) Illumina universal bead arrays. Methods Enzymol 410:57-73
12. Farres J, Moreno A, Crosas B, Peralba JM, Allali-Hassani A, Hjelmqvist L, Jornvall H, Pares X (1994) Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach: cDNA sequence and structure/function relationships. Eur J Biochem 224(2):549-557
13. Frank J, Cichon S, Treutlein J, Ridinger M, Mattheisen M, Hoffmann P, Herms S, Wodarz N, Soyka M, Zill P, Maier W, Mossner R, Gaebel W, Dahmen N, Scherbaum N, Schmal C, Steffens M, Lucae S, Ising M, Muller-Myhsok B, Nothen MM, Mann K, Kiefer F, Rietschel M (2011) Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. Addict Biol 17(1):171-180
14. Han Y, Gu S, Oota H, Osier MV, Pakstis AJ, Speed WC, Kidd JR, Kidd KK (2007) Evidence of positive selection on a class I ADH locus. Am J Hum Genet 80(3):441-456
15. Higuchi S (1994) Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. Alcohol Alcohol Suppl 2:29-34
16. Hurley TD, Edenberg HJ, Li TK (2002) Pharmacogenomics of alcoholism. In: Licinio J, Wong ML (eds) Pharmacogenomics: the search for individualized therapies. Wiley, Weinheim, pp 417-441
17. Ji YB, Tae K, Ahn TH, Lee SH, Kim KR, Park CW, Park BL, Shin HD (2011) ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population. Oral Oncol 47(7):583-587
18. Joe KH, Kim DJ, Park BL, Yoon S, Lee HK, Kim TS, Cheon YH, Gwon DH, Cho SN, Lee HW, Namgung S, Shin HD (2008) Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients. Biochem Biophys Res Commun 371(4):591-595
19. Kaiser R, Holmquist B, Vallee BL, Jornvall H (1991) Human class III alcohol dehydrogenase/glutathione-dependent formaldehyde dehydrogenase. J Protein Chem 10(1):69-73
20. Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ (1992) A population-based twin study of alcoholism in women. JAMA 268(14):1877-1882
21. Kendler KS, Neale MC, Heath AC, Kessler RC, Eaves LJ (1994) A twin-family study of alcoholism in women. Am J Psychiatry 151(5):707-715
22. Kendler KS, Prescott CA, Neale MC, Pedersen NL (1997) Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Arch Gen Psychiatry 54(2):178-184
23. Kim DJ, Choi IG, Park BL, Lee BC, Ham BJ, Yoon S, Bae JS, Cheong HS, Shin HD (2008) Major genetic components underlying alcoholism in Korean population. Hum Mol Genet 17(6):854-858
24. Lee SL, Hoog JO, Yin SJ (2004) Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. Pharmacogenetics 14(11):725-732
25. Li TK, Yin SJ, Crabb DW, O'Connor S, Ramchandani VA (2001) Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res 25(1):136-144
26. Li H, Mukherjee N, Soundararajan U, Tarnok Z, Barta C, Khaliq S, Mohyuddin A, Kajuna SL, Mehdi SQ, Kidd JR, Kidd KK (2007) Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. Am J Hum Genet 81(4):842-846
27. Lin CH, Yeakley JM, McDaniel TK, Shen R (2009) Medium- to high-throughput SNP genotyping using VeraCode microbeads. Methods Mol Biol 496:129-142
28. Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J (2005) ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. Pharmacogenet Genomics 15(11):755-768
29. Nakamura K, Iwahashi K, Matsuo Y, Miyatake R, Ichikawa Y, Suwaki H (1996) Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2. I. A comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. Alcohol Clin Exp Res 20(1):52-55
30. Osier M, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, Edenberg HJ, Lu RB, Kidd KK (1999) Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet 64(4):1147-1157
31. Osier MV, Pakstis AJ, Soodyall H, Comas D, Goldman D, Odunsi A, Okonofua F, Parnas J, Schulz LO, Bertranpetit J, Bonne-Tamir B, Lu RB, Kidd JR, Kidd KK (2002) A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet 71(1):84-99
32. Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H (2009) Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. Cancer Epidemiol Biomarkers Prev 18(11):3097-3102
33. Peng Y, Shi H, Qi XB, Xiao CJ, Zhong H, Ma RL, Su B (2010) The ADH1B Arg47His polymorphism in East Asian populations and expansion of rice domestication in history. BMC Evol Biol 10:15
34. Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry 156(1):34-40
35. Shen YC, Fan JH, Edenberg HJ, Li TK, Cui YH, Wang YF, Tian CH, Zhou CF, Zhou RL, Wang J, Zhao ZL, Xia GY (1997) Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res 21(7):1272-1277
36. Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68(4):978-989
37. Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N (2011) Confirmation of ALDH2 as a major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. Circ J 75(4):911-918
38. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48(4):677-681
39. Tolstrup JS, Nordestgaard BG, Rasmussen S, Tybjaerg-Hansen A, Gronbaek M (2008) Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. Pharmacogenomics J 8(3):220-227
40. Whitfield JB (2002) Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations. Am J Hum Genet 71(5):1247-1250 author reply 1250-1241
41. Zuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X (2011) A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. PLoS One 6(11):e26726