HLA-DRA polymorphisms associated with risk of nasal polyposis in asthmatic patients

American Journal of Rhinology and Allergy

Volumn 26, Issue 1, 2012, Pages 12-17

  Kim, Jeong Hyun ^a   Park, Byung Lae ^b   Cheong, Hyun Sub ^b   Pasaje, Charisse Flerida A ^a   Bae, Joon Seol ^a   Park, Jong Sook ^c   Uh, Soo Taek ^c   Kim, Yong Hoon ^c   Kim, Mi Kyeong ^d   Choi, Inseon S ^e   Choi, Byoung Whui ^f   Park, Choon Sik ^c   Shin, Hyoung Doo ^a,b  

^a Sogang University   (South Korea)

^b SNP Genetics Inc   (South Korea)

^c Soonchunhyang University   (South Korea)

^d Chungbuk National University   (South Korea)

^e Chonnam National University   (South Korea)

^f Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; HLA DR ANTIGEN;

5' UNTRANSLATED REGION; ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; ASTHMA; BINDING SITE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE SEQUENCE; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NOSE POLYP; RNA STABILITY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; ASTHMA; ASTHMA, ASPIRIN-INDUCED; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HLA-DR ALPHA-CHAINS; HUMANS; MALE; MIDDLE AGED; NASAL POLYPS; POLYMORPHISM, SINGLE NUCLEOTIDE; REGULATORY SEQUENCES, NUCLEIC ACID; REPUBLIC OF KOREA; YOUNG ADULT;

EID: 84863254700     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2012.26.3692     Document Type: Article

References (27)

1. Hedman J, Kaprio J, Poussa T, et al. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 28:717-722, 1999. (Pubitemid 29401332)
2. Rehl RM, Balla AA, Cabay RJ, et al. Mucosal remodeling in chronic rhinosinusitis. Am J Rhinol 21:651-657, 2007.
3. Picado C. Aspirin intolerance and nasal polyposis. Curr Allergy Asthma Rep 2:488-493, 2002.
4. Castano R, Bosse Y, Endam LM, et al. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. Am J Rhinol Allergy 23:377-384, 2009.
5. Kilty SJ, Bosse Y, Cormier C, et al. Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy. Am J Rhinol Allergy 24: e4-e9, 2010.
6. Ediger D, Sin BA, Heper A, et al. Airway inflammation in nasal polyposis: Immunopathological aspects of relation to asthma. Clin Exp Allergy 35:319-326, 2005. (Pubitemid 40516658)
7. Papon JF, Coste A, Gendron MC, et al. HLA-DR and ICAM-1 expression and modulation in epithelial cells from nasal polyps. Laryngoscope 112:2067-2075, 2002. (Pubitemid 35283476)
8. Rioux JD, Goyette P, Vyse TJ, et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 106:18680-18685, 2009.
9. Schwiebert LM, Hughes A, Monos DS, et al. HLA-DRA promoter polymorphism and diversity generation within the immune system. Hum Genet 99:801-805, 1997. (Pubitemid 27243762)
10. Kim BS, Park SM, Uhm TG, et al. Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity. Pharmacogenet Genomics 20:748-758, 2010.
11. Nyholt DR. A simple correction for multiple testing for SNPs in linkage disequilibrium with each other. Am J Hum Genet 74:765-769, 2004. (Pubitemid 38420107)
12. Prestridge DS. SIGNAL SCAN: a computer program that scans DNA sequences for eukaryotic transcriptional elements. Comput Appl Biosci 7:203-206, 1991.
13. Cohen NA, Widelitz JS, Chiu AG, et al. Familial aggregation of sinonasal polyps correlates with severity of disease. Otolaryngol Head Neck Surg 134:601-604, 2006.
14. Erbek SS, Yurtcu E, Erbek S, et al. Matrix metalloproteinase-9 promoter gene polymorphism (-1562C>T) in nasal polyposis. Am J Rhinol Allergy 23:568-570, 2009.
15. Sachse F, Becker K, and Rudack C. Incidence of staphylococcal colonization and of the 753Q Toll-like receptor 2 variant in nasal polyposis. Am J Rhinol Allergy 24:e10-e13, 2010.
16. Cheong HS, Park SM, Kim MO, et al. Genome-wide methylation profile of nasal polyps: Relation to aspirin hypersensitivity in asthmatics. Allergy 66:637-644, 2011.
17. Sekigawa T, Tajima A, Hasegawa T, et al. Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma. Clin Exp Allergy 39:972-981, 2009.
18. Park JH, Chang HS, Park CS, et al. Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. Am J Respir Crit Care Med 175:775-782, 2007.
19. Pujols L, Alobid I, Benitez P, et al. Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids. Allergy 63:1377-1386, 2008.
20. Eggert M, Michel J, Schneider S, et al. The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U. J Biol Chem 272:28471-28478, 1997. (Pubitemid 27517795)
21. Chen JM, Ferec C, and Cooper DN. A systematic analysis of diseaseassociated variants in the 3′ regulatory regions of human proteincoding genes II: The importance of mRNA secondary structure in assessing the functionality of 3′ UTR variants. Hum Genet 120:301-333, 2006. (Pubitemid 44400467)
22. Pagani F, and Baralle FE. Genomic variants in exons and introns: identifying the splicing spoilers. Nat Rev Genet 5:389-396, 2004. (Pubitemid 38529410)
23. Keles B, Cora T, Acar H, et al. Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis. Otolaryngol Head Neck Surg 139:580-585, 2008.
24. Luxenberger W, Posch U, Berghold A, et al. HLA patterns in patients with nasal polyposis. Eur Arch Otorhinolaryngol 257:137-139, 2000. (Pubitemid 30218975)
25. Molnar-Gabor E, Endreffy E, and Rozsasi A. HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Laryngoscope 110:422-425, 2000. (Pubitemid 30143687)
26. Ramirez-Anguiano J, Yamamoto-Furusho JK, Barquera R, et al. Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos. Otolaryngol Head Neck Surg 135:90-93, 2006. (Pubitemid 43946541)
27. Zhai L, Sun Y, Tang L, et al. Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps. Ann Otol Rhinol Laryngol 116:66-68, 2007. (Pubitemid 46174128)