-
1
-
-
0036888556
-
Present status on the genetic studies of asthma
-
Hoffjan S., and Ober C. Present status on the genetic studies of asthma. Curr Opin Immunol 14 (2002) 709-717
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 709-717
-
-
Hoffjan, S.1
Ober, C.2
-
2
-
-
33644774556
-
Asthma genetics 2006: the long and winding road to gene discovery
-
Ober C., and Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 7 (2006) 95-100
-
(2006)
Genes Immun
, vol.7
, pp. 95-100
-
-
Ober, C.1
Hoffjan, S.2
-
3
-
-
45549093604
-
Meta-analysis of genome-wide linkage studies of asthma and related traits
-
Denham S., Koppelman G.H., Blakey J., Wjst M., Ferreira M.A., Hall I.P., et al. Meta-analysis of genome-wide linkage studies of asthma and related traits. Respir Res 9 (2008) 38
-
(2008)
Respir Res
, vol.9
, pp. 38
-
-
Denham, S.1
Koppelman, G.H.2
Blakey, J.3
Wjst, M.4
Ferreira, M.A.5
Hall, I.P.6
-
4
-
-
0037173639
-
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
-
Van Eerdewegh P., Little R.D., Dupuis J., Del Mastro R.G., Falls K., Simon J., et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418 (2002) 426-430
-
(2002)
Nature
, vol.418
, pp. 426-430
-
-
Van Eerdewegh, P.1
Little, R.D.2
Dupuis, J.3
Del Mastro, R.G.4
Falls, K.5
Simon, J.6
-
5
-
-
0242329880
-
Positional cloning of a novel gene influencing asthma from chromosome 2q14
-
Allen M., Heinzmann A., Noguchi E., Abecasis G., Broxholme J., Ponting C.P., et al. Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet 35 (2003) 258-263
-
(2003)
Nat Genet
, vol.35
, pp. 258-263
-
-
Allen, M.1
Heinzmann, A.2
Noguchi, E.3
Abecasis, G.4
Broxholme, J.5
Ponting, C.P.6
-
6
-
-
0037603549
-
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma
-
Zhang Y., Leaves N.I., Anderson G.G., Ponting C.P., Broxholme J., Holt R., et al. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet 34 (2003) 181-186
-
(2003)
Nat Genet
, vol.34
, pp. 181-186
-
-
Zhang, Y.1
Leaves, N.I.2
Anderson, G.G.3
Ponting, C.P.4
Broxholme, J.5
Holt, R.6
-
7
-
-
11144357144
-
Characterization of a common susceptibility locus for asthma-related traits
-
Laitinen T., Polvi A., Rydman P., Vendelin J., Pulkkinen V., Salmikangas P., et al. Characterization of a common susceptibility locus for asthma-related traits. Science 304 (2004) 300-304
-
(2004)
Science
, vol.304
, pp. 300-304
-
-
Laitinen, T.1
Polvi, A.2
Rydman, P.3
Vendelin, J.4
Pulkkinen, V.5
Salmikangas, P.6
-
8
-
-
19944433619
-
Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21
-
Nicolae D., Cox N.J., Lester L.A., Schneider D., Tan Z., Billstrand C., et al. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet 76 (2005) 349-357
-
(2005)
Am J Hum Genet
, vol.76
, pp. 349-357
-
-
Nicolae, D.1
Cox, N.J.2
Lester, L.A.3
Schneider, D.4
Tan, Z.5
Billstrand, C.6
-
9
-
-
22144482763
-
Positional identification of an asthma susceptibility gene on human chromosome 5q33
-
Noguchi E., Yokouchi Y., Zhang J., Shibuya K., Shibuya A., Bannai M., et al. Positional identification of an asthma susceptibility gene on human chromosome 5q33. Am J Respir Crit Care Med 172 (2005) 183-188
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 183-188
-
-
Noguchi, E.1
Yokouchi, Y.2
Zhang, J.3
Shibuya, K.4
Shibuya, A.5
Bannai, M.6
-
10
-
-
40049100646
-
Discovering susceptibility genes for asthma and allergy
-
Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 8 (2008) 169-182
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 169-182
-
-
Vercelli, D.1
-
13
-
-
34547216747
-
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
-
Moffatt M.F., Kabesch M., Liang L., Dixon A.L., Strachan D., Heath S., et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448 (2007) 470-473
-
(2007)
Nature
, vol.448
, pp. 470-473
-
-
Moffatt, M.F.1
Kabesch, M.2
Liang, L.3
Dixon, A.L.4
Strachan, D.5
Heath, S.6
-
14
-
-
42249103640
-
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
-
Ober C., Tan Z., Sun Y., Possick J.D., Pan L., Nicolae R., et al. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 358 (2008) 1682-1691
-
(2008)
N Engl J Med
, vol.358
, pp. 1682-1691
-
-
Ober, C.1
Tan, Z.2
Sun, Y.3
Possick, J.D.4
Pan, L.5
Nicolae, R.6
-
15
-
-
50849120030
-
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
-
e1000166
-
Weidinger S., Gieger C., Rodriguez E., Baurecht H., Mempel M., Klopp N., et al. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet 4 (2008) e1000166
-
(2008)
PLoS Genet
, vol.4
-
-
Weidinger, S.1
Gieger, C.2
Rodriguez, E.3
Baurecht, H.4
Mempel, M.5
Klopp, N.6
-
16
-
-
65549123032
-
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
-
Himes B.E., Hunninghake G.M., Baurley J.W., Rafaels N.M., Sleiman P., Strachan D.P., et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet 84 (2009) 581-593
-
(2009)
Am J Hum Genet
, vol.84
, pp. 581-593
-
-
Himes, B.E.1
Hunninghake, G.M.2
Baurley, J.W.3
Rafaels, N.M.4
Sleiman, P.5
Strachan, D.P.6
-
17
-
-
9144268928
-
Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma
-
Dolan C.M., Fraher K.E., Bleecker E.R., Borish L., Chipps B., Hayden M.L., et al. Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 92 (2004) 32-39
-
(2004)
Ann Allergy Asthma Immunol
, vol.92
, pp. 32-39
-
-
Dolan, C.M.1
Fraher, K.E.2
Bleecker, E.R.3
Borish, L.4
Chipps, B.5
Hayden, M.L.6
-
18
-
-
25444532059
-
Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma
-
Borish L., Chipps B., Deniz Y., Gujrathi S., Zheng B., and Dolan C.M. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 95 (2005) 247-253
-
(2005)
Ann Allergy Asthma Immunol
, vol.95
, pp. 247-253
-
-
Borish, L.1
Chipps, B.2
Deniz, Y.3
Gujrathi, S.4
Zheng, B.5
Dolan, C.M.6
-
19
-
-
27644542140
-
Severity assessment in asthma: an evolving concept
-
Miller M.K., Johnson C., Miller D.P., Deniz Y., Bleecker E.R., and Wenzel S.E. Severity assessment in asthma: an evolving concept. J Allergy Clin Immunol 116 (2005) 990-995
-
(2005)
J Allergy Clin Immunol
, vol.116
, pp. 990-995
-
-
Miller, M.K.1
Johnson, C.2
Miller, D.P.3
Deniz, Y.4
Bleecker, E.R.5
Wenzel, S.E.6
-
20
-
-
34548292504
-
PLINK: a tool set for whole-genome association and population-based linkage analyses
-
Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81 (2007) 559-575
-
(2007)
Am J Hum Genet
, vol.81
, pp. 559-575
-
-
Purcell, S.1
Neale, B.2
Todd-Brown, K.3
Thomas, L.4
Ferreira, M.A.5
Bender, D.6
-
21
-
-
33746512512
-
Principal components analysis corrects for stratification in genome-wide association studies
-
Price A.L., Patterson N.J., Plenge R.M., Weinblatt M.E., Shadick N.A., and Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38 (2006) 904-909
-
(2006)
Nat Genet
, vol.38
, pp. 904-909
-
-
Price, A.L.1
Patterson, N.J.2
Plenge, R.M.3
Weinblatt, M.E.4
Shadick, N.A.5
Reich, D.6
-
22
-
-
27644546712
-
Population structure, differential bias and genomic control in a large-scale, case-control association study
-
Clayton D.G., Walker N.M., Smyth D.J., Pask R., Cooper J.D., Maier L.M., et al. Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet 37 (2005) 1243-1246
-
(2005)
Nat Genet
, vol.37
, pp. 1243-1246
-
-
Clayton, D.G.1
Walker, N.M.2
Smyth, D.J.3
Pask, R.4
Cooper, J.D.5
Maier, L.M.6
-
23
-
-
13444269543
-
Haploview: analysis and visualization of LD and haplotype maps
-
Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
-
(2005)
Bioinformatics
, vol.21
, pp. 263-265
-
-
Barrett, J.C.1
Fry, B.2
Maller, J.3
Daly, M.J.4
-
24
-
-
18444369013
-
The structure of haplotype blocks in the human genome
-
Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., et al. The structure of haplotype blocks in the human genome. Science 296 (2002) 2225-2229
-
(2002)
Science
, vol.296
, pp. 2225-2229
-
-
Gabriel, S.B.1
Schaffner, S.F.2
Nguyen, H.3
Moore, J.M.4
Roy, J.5
Blumenstiel, B.6
-
25
-
-
57249114505
-
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
-
Johnson A.D., Handsaker R.E., Pulit S.L., Nizzari M.M., O'Donnell C.J., and de Bakker P.I. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 24 (2008) 2938-2939
-
(2008)
Bioinformatics
, vol.24
, pp. 2938-2939
-
-
Johnson, A.D.1
Handsaker, R.E.2
Pulit, S.L.3
Nizzari, M.M.4
O'Donnell, C.J.5
de Bakker, P.I.6
-
26
-
-
35348983887
-
A second generation human haplotype map of over 3.1 million SNPs
-
Frazer K.A., Ballinger D.G., Cox D.R., Hinds D.A., Stuve L.L., Gibbs R.A., et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449 (2007) 851-861
-
(2007)
Nature
, vol.449
, pp. 851-861
-
-
Frazer, K.A.1
Ballinger, D.G.2
Cox, D.R.3
Hinds, D.A.4
Stuve, L.L.5
Gibbs, R.A.6
-
27
-
-
37549064336
-
Mach 1.0: rapid haplotype reconstruction and missing genotype inference
-
Li Y., and Abecasis G.R. Mach 1.0: rapid haplotype reconstruction and missing genotype inference. Am J Hum Genet S79 (2006) 2290
-
(2006)
Am J Hum Genet
, vol.S79
, pp. 2290
-
-
Li, Y.1
Abecasis, G.R.2
-
28
-
-
33846978695
-
Relative impact of nucleotide and copy number variation on gene expression phenotypes
-
Stranger B.E., Forrest M.S., Dunning M., Ingle C.E., Beazley C., Thorne N., et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315 (2007) 848-853
-
(2007)
Science
, vol.315
, pp. 848-853
-
-
Stranger, B.E.1
Forrest, M.S.2
Dunning, M.3
Ingle, C.E.4
Beazley, C.5
Thorne, N.6
-
29
-
-
41649083448
-
WGAViewer: software for genomic annotation of whole genome association studies
-
Ge D., Zhang K., Need A.C., Martin O., Fellay J., Urban T.J., et al. WGAViewer: software for genomic annotation of whole genome association studies. Genome Res 18 (2008) 640-643
-
(2008)
Genome Res
, vol.18
, pp. 640-643
-
-
Ge, D.1
Zhang, K.2
Need, A.C.3
Martin, O.4
Fellay, J.5
Urban, T.J.6
-
30
-
-
22144485580
-
The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions
-
Yabuki M., Fujii M.M., and Maizels N. The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions. Nat Immunol 6 (2005) 730-736
-
(2005)
Nat Immunol
, vol.6
, pp. 730-736
-
-
Yabuki, M.1
Fujii, M.M.2
Maizels, N.3
-
31
-
-
0034162827
-
Genetic variants of IL-13 signalling and human asthma and atopy
-
Heinzmann A., Mao X.Q., Akaiwa M., Kreomer R.T., Gao P.S., Ohshima K., et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 9 (2000) 549-559
-
(2000)
Hum Mol Genet
, vol.9
, pp. 549-559
-
-
Heinzmann, A.1
Mao, X.Q.2
Akaiwa, M.3
Kreomer, R.T.4
Gao, P.S.5
Ohshima, K.6
-
32
-
-
0034102759
-
A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
-
Graves P.E., Kabesch M., Halonen M., Holberg C.J., Baldini M., Fritzsch C., et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 105 (2000) 506-513
-
(2000)
J Allergy Clin Immunol
, vol.105
, pp. 506-513
-
-
Graves, P.E.1
Kabesch, M.2
Halonen, M.3
Holberg, C.J.4
Baldini, M.5
Fritzsch, C.6
-
33
-
-
0033188305
-
An IL-13 promoter polymorphism associated with increased risk of allergic asthma
-
van der Pouw Kraan T.C., van Veen A., Boeije L.C., van Tuyl S.A., de Groot E.R., Stapel S.O., et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1 (1999) 61-65
-
(1999)
Genes Immun
, vol.1
, pp. 61-65
-
-
van der Pouw Kraan, T.C.1
van Veen, A.2
Boeije, L.C.3
van Tuyl, S.A.4
de Groot, E.R.5
Stapel, S.O.6
-
34
-
-
0042029642
-
Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
-
Liu X., Beaty T.H., Deindl P., Huang S.K., Lau S., Sommerfeld C., et al. Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J Allergy Clin Immunol 112 (2003) 382-388
-
(2003)
J Allergy Clin Immunol
, vol.112
, pp. 382-388
-
-
Liu, X.1
Beaty, T.H.2
Deindl, P.3
Huang, S.K.4
Lau, S.5
Sommerfeld, C.6
-
35
-
-
0037963472
-
Regulation of the Th2 cytokine locus by a locus control region
-
Lee G.R., Fields P.E., Griffin T.J., and Flavell R.A. Regulation of the Th2 cytokine locus by a locus control region. Immunity 19 (2003) 145-153
-
(2003)
Immunity
, vol.19
, pp. 145-153
-
-
Lee, G.R.1
Fields, P.E.2
Griffin, T.J.3
Flavell, R.A.4
-
36
-
-
5444237577
-
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
-
Spilianakis C.G., and Flavell R.A. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol 5 (2004) 1017-1027
-
(2004)
Nat Immunol
, vol.5
, pp. 1017-1027
-
-
Spilianakis, C.G.1
Flavell, R.A.2
-
37
-
-
10344234192
-
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region
-
Fields P.E., Lee G.R., Kim S.T., Bartsevich V.V., and Flavell R.A. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21 (2004) 865-876
-
(2004)
Immunity
, vol.21
, pp. 865-876
-
-
Fields, P.E.1
Lee, G.R.2
Kim, S.T.3
Bartsevich, V.V.4
Flavell, R.A.5
-
38
-
-
8644220507
-
Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3
-
Lee D.U., and Rao A. Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A 101 (2004) 16010-16015
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 16010-16015
-
-
Lee, D.U.1
Rao, A.2
-
39
-
-
12344250807
-
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions
-
Lee G.R., Spilianakis C.G., and Flavell R.A. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol 6 (2005) 42-48
-
(2005)
Nat Immunol
, vol.6
, pp. 42-48
-
-
Lee, G.R.1
Spilianakis, C.G.2
Flavell, R.A.3
-
40
-
-
20444494936
-
Interchromosomal associations between alternatively expressed loci
-
Spilianakis C.G., Lalioti M.D., Town T., Lee G.R., and Flavell R.A. Interchromosomal associations between alternatively expressed loci. Nature 435 (2005) 637-645
-
(2005)
Nature
, vol.435
, pp. 637-645
-
-
Spilianakis, C.G.1
Lalioti, M.D.2
Town, T.3
Lee, G.R.4
Flavell, R.A.5
-
41
-
-
58849104457
-
The HLA genomic loci map: expression, interaction, diversity and disease
-
Shiina T., Hosomichi K., Inoko H., and Kulski J.K. The HLA genomic loci map: expression, interaction, diversity and disease. J Hum Genet 54 (2009) 15-39
-
(2009)
J Hum Genet
, vol.54
, pp. 15-39
-
-
Shiina, T.1
Hosomichi, K.2
Inoko, H.3
Kulski, J.K.4
-
42
-
-
10744222654
-
HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma
-
Torio A., Sanchez-Guerrero I., Muro M., Villar L.M., Minguela A., Marin L., et al. HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma. Hum Immunol 64 (2003) 811-815
-
(2003)
Hum Immunol
, vol.64
, pp. 811-815
-
-
Torio, A.1
Sanchez-Guerrero, I.2
Muro, M.3
Villar, L.M.4
Minguela, A.5
Marin, L.6
-
43
-
-
0036724719
-
The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents
-
Lin Y.C., Lu C.C., Su H.J., Shen C.Y., Lei H.Y., and Guo Y.L. The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents. Allergy 57 (2002) 831-834
-
(2002)
Allergy
, vol.57
, pp. 831-834
-
-
Lin, Y.C.1
Lu, C.C.2
Su, H.J.3
Shen, C.Y.4
Lei, H.Y.5
Guo, Y.L.6
-
44
-
-
0033709445
-
Association of HLA-DRB1(*)07 and DRB1(*)04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma
-
Cho S.H., Kim Y.K., Oh H.B., Jung J.W., Son J.W., Lee M.H., et al. Association of HLA-DRB1(*)07 and DRB1(*)04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma. Clin Exp Allergy 30 (2000) 1568-1575
-
(2000)
Clin Exp Allergy
, vol.30
, pp. 1568-1575
-
-
Cho, S.H.1
Kim, Y.K.2
Oh, H.B.3
Jung, J.W.4
Son, J.W.5
Lee, M.H.6
-
45
-
-
34548805282
-
A genome-wide association study of global gene expression
-
Dixon A.L., Liang L., Moffatt M.F., Chen W., Heath S., Wong K.C., et al. A genome-wide association study of global gene expression. Nat Genet 39 (2007) 1202-1207
-
(2007)
Nat Genet
, vol.39
, pp. 1202-1207
-
-
Dixon, A.L.1
Liang, L.2
Moffatt, M.F.3
Chen, W.4
Heath, S.5
Wong, K.C.6
-
46
-
-
0029147735
-
Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1
-
Beaty J.S., West K.A., and Nepom G.T. Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. Mol Cell Biol 15 (1995) 4771-4782
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4771-4782
-
-
Beaty, J.S.1
West, K.A.2
Nepom, G.T.3
-
47
-
-
38349100266
-
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project
-
Horton R., Gibson R., Coggill P., Miretti M., Allcock R.J., Almeida J., et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics 60 (2008) 1-18
-
(2008)
Immunogenetics
, vol.60
, pp. 1-18
-
-
Horton, R.1
Gibson, R.2
Coggill, P.3
Miretti, M.4
Allcock, R.J.5
Almeida, J.6
|